Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Angiotensin-converting enzyme | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | Get druggable targets OG5_131988 | All targets in OG5_131988 |
Brugia malayi | Angiotensin-converting enzyme family protein | Get druggable targets OG5_131988 | All targets in OG5_131988 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | 70 kDa peptidylprolyl isomerase, putative | 0.1565 | 1 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0741 | 0.207 | 0.207 |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase FKBP35 | 0.1565 | 1 | 0.5 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.1565 | 1 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.1565 | 1 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0741 | 0.207 | 0.207 |
Loa Loa (eye worm) | hypothetical protein | 0.0741 | 0.207 | 0.207 |
Brugia malayi | hypothetical protein | 0.0741 | 0.207 | 0.207 |
Loa Loa (eye worm) | hypothetical protein | 0.0741 | 0.207 | 0.207 |
Treponema pallidum | peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) | 0.1565 | 1 | 0.5 |
Trichomonas vaginalis | immunophilin, putative | 0.1565 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0741 | 0.207 | 0.207 |
Brugia malayi | Animal haem peroxidase family protein | 0.0741 | 0.207 | 0.207 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.1565 | 1 | 0.5 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.135 | 0.7928 | 0.7387 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.1565 | 1 | 1 |
Echinococcus multilocularis | fk506 binding protein | 0.1565 | 1 | 1 |
Giardia lamblia | 70 kDa peptidylprolyl isomerase, putative | 0.1565 | 1 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0741 | 0.207 | 0.207 |
Brugia malayi | Animal haem peroxidase family protein | 0.0741 | 0.207 | 0.207 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.1565 | 1 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0741 | 0.207 | 0.207 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0741 | 0.207 | 0.207 |
Leishmania major | fk506-binding protein 1-like protein | 0.1565 | 1 | 0.5 |
Trypanosoma brucei | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.1565 | 1 | 0.5 |
Onchocerca volvulus | 0.0741 | 0.207 | 0.5 | |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.1565 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0741 | 0.207 | 0.207 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.1565 | 1 | 1 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.1565 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0741 | 0.207 | 0.207 |
Brugia malayi | Animal haem peroxidase family protein | 0.0741 | 0.207 | 0.207 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.1565 | 1 | 0.5 |
Mycobacterium ulcerans | FK-506 binding protein, peptidyl-prolyl cis-trans isomerase | 0.1565 | 1 | 0.5 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.135 | 0.7928 | 0.7387 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.1565 | 1 | 1 |
Brugia malayi | Peroxidasin | 0.0741 | 0.207 | 0.207 |
Onchocerca volvulus | Peroxidasin homolog | 0.0741 | 0.207 | 0.5 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.1565 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0741 | 0.207 | 0.207 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.1565 | 1 | 0.5 |
Schistosoma mansoni | immunophilin | 0.1565 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0741 | 0.207 | 0.207 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0741 | 0.207 | 0.207 |
Loa Loa (eye worm) | hypothetical protein | 0.0741 | 0.207 | 0.207 |
Loa Loa (eye worm) | FKBP5 protein | 0.1565 | 1 | 1 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type, putative | 0.1565 | 1 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0741 | 0.207 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0741 | 0.207 | 0.207 |
Onchocerca volvulus | 0.0741 | 0.207 | 0.5 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0741 | 0.207 | 0.207 |
Loa Loa (eye worm) | hypothetical protein | 0.0741 | 0.207 | 0.207 |
Schistosoma mansoni | immunophilin | 0.135 | 0.7928 | 0.7387 |
Brugia malayi | Angiotensin-converting enzyme family protein | 0.0749 | 0.2145 | 0.2145 |
Loa Loa (eye worm) | hypothetical protein | 0.0741 | 0.207 | 0.207 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative | 0.1565 | 1 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0741 | 0.207 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0741 | 0.207 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0741 | 0.207 | 0.207 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.1565 | 1 | 0.5 |
Leishmania major | peptidylprolyl isomerase-like protein | 0.1565 | 1 | 0.5 |
Onchocerca volvulus | 0.0741 | 0.207 | 0.5 | |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.1565 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0741 | 0.207 | 0.207 |
Loa Loa (eye worm) | hypothetical protein | 0.0741 | 0.207 | 0.207 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0741 | 0.207 | 0.5 |
Schistosoma mansoni | immunophilin | 0.1565 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.135 | 0.7928 | 0.7928 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.1565 | 1 | 0.5 |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | 0.0749 | 0.2145 | 0.2145 |
Loa Loa (eye worm) | hypothetical protein | 0.0741 | 0.207 | 0.207 |
Onchocerca volvulus | Peroxidasin homolog | 0.0741 | 0.207 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.