Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0039 | 0.0284 | 0.5 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.014 | 0.9627 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0063 | 0.2512 | 0.2512 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.2512 | 0.2512 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0144 | 1 | 1 |
Brugia malayi | RNA binding protein | 0.0063 | 0.2512 | 0.2512 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.006 | 0.2271 | 0.2359 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0042 | 0.061 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.2512 | 0.2512 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.2271 | 0.5 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0042 | 0.061 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.2512 | 0.2512 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0042 | 0.061 | 0.5 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.006 | 0.2271 | 1 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0039 | 0.0284 | 0.5 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0042 | 0.061 | 0.0634 |
Brugia malayi | TAR-binding protein | 0.0063 | 0.2512 | 0.2512 |
Echinococcus granulosus | tar DNA binding protein | 0.0063 | 0.2512 | 0.2609 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.2271 | 0.2271 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.006 | 0.2271 | 0.2271 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.2512 | 0.2512 |
Loa Loa (eye worm) | acetyltransferase | 0.0144 | 1 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.006 | 0.2271 | 0.5 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.006 | 0.2271 | 0.5 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0144 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.2271 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.2271 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0063 | 0.2512 | 0.2512 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0039 | 0.0284 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.2512 | 0.2512 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.2271 | 0.2271 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.