Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0525 | 0.0888 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.4678 | 0.4619 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0028 | 0.4393 | 0.7083 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0525 | 0.0888 |
Trichomonas vaginalis | carbon catabolite repressor protein, putative | 0.0007 | 0.0708 | 0.1198 |
Trichomonas vaginalis | ocrl type II inositol 5-phosphatase, putative | 0.0007 | 0.0708 | 0.1198 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0007 | 0.0708 | 0.014 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0037 | 0.5911 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0053 | 0.8867 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0525 | 0.0888 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0525 | 0.0888 |
Schistosoma mansoni | cript-related | 0.0007 | 0.0708 | 0.0605 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0037 | 0.5911 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0525 | 0.0888 |
Schistosoma mansoni | ap endonuclease | 0.0037 | 0.5911 | 0.5866 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0037 | 0.5911 | 0.5 |
Echinococcus granulosus | CCR4 NOT transcription complex subunit 6 | 0.0007 | 0.0708 | 0.014 |
Trichomonas vaginalis | skeletal muscle/kidney enriched inositol 5-phosphatase, putative | 0.0007 | 0.0708 | 0.1198 |
Schistosoma mansoni | synaptojanin | 0.0007 | 0.0708 | 0.0605 |
Toxoplasma gondii | exonuclease III APE | 0.0037 | 0.5911 | 0.6377 |
Echinococcus multilocularis | deoxyribonuclease 1 2 | 0.0007 | 0.0708 | 0.014 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0525 | 0.0888 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0525 | 0.0888 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0006 | 0.0525 | 0.0888 |
Loa Loa (eye worm) | histone methyltransferase | 0.0009 | 0.0939 | 0.0444 |
Schistosoma mansoni | nocturnin | 0.0007 | 0.0708 | 0.0605 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0037 | 0.5911 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0037 | 0.5911 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0037 | 0.5911 | 0.5 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0037 | 0.5911 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0037 | 0.5911 | 1 |
Trichomonas vaginalis | type IV inositol 5-phosphatase, putative | 0.0007 | 0.0708 | 0.1198 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0037 | 0.5911 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0525 | 0.0888 |
Echinococcus granulosus | cpg binding protein | 0.003 | 0.4678 | 0.7664 |
Echinococcus granulosus | traf and tnf receptor associated protein | 0.0007 | 0.0708 | 0.014 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0939 | 0.0578 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0037 | 0.5911 | 1 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0009 | 0.092 | 0.0406 |
Echinococcus multilocularis | traf and tnf receptor associated protein | 0.0007 | 0.0708 | 0.014 |
Echinococcus granulosus | neutral sphingomyelinase | 0.0007 | 0.0708 | 0.014 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0006 | 0.0525 | 0.0888 |
Onchocerca volvulus | 0.0028 | 0.4393 | 1 | |
Trichomonas vaginalis | carbon catabolite repressor protein, putative | 0.0007 | 0.0708 | 0.1198 |
Trichomonas vaginalis | sphingomyelinase C 2 precursor, putative | 0.0007 | 0.0708 | 0.1198 |
Schistosoma mansoni | ocrl type II inositol 5-phosphatase | 0.0007 | 0.0708 | 0.0605 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0037 | 0.5911 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0525 | 0.0888 |
Echinococcus multilocularis | cpg binding protein | 0.003 | 0.4678 | 0.7664 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0525 | 0.0888 |
Trichomonas vaginalis | type II inositol 5-phosphatase, putative | 0.0007 | 0.0708 | 0.1198 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0525 | 0.0888 |
Trichomonas vaginalis | carbon catabolite repressor protein, putative | 0.0007 | 0.0708 | 0.1198 |
Schistosoma mansoni | hypothetical protein | 0.0007 | 0.0708 | 0.0605 |
Echinococcus granulosus | synaptojanin 1 | 0.0007 | 0.0708 | 0.014 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0037 | 0.5911 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0028 | 0.4393 | 0.4331 |
Schistosoma mansoni | carbon catabolite repressor protein | 0.0007 | 0.0708 | 0.0605 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0939 | 0.0578 |
Echinococcus multilocularis | CCR4 NOT transcription complex subunit 6 | 0.0007 | 0.0708 | 0.014 |
Schistosoma mansoni | synaptojanin | 0.0007 | 0.0708 | 0.0605 |
Echinococcus multilocularis | neutral sphingomyelinase | 0.0007 | 0.0708 | 0.014 |
Schistosoma mansoni | ap endonuclease | 0.0037 | 0.5911 | 0.5866 |
Brugia malayi | CXXC zinc finger family protein | 0.0028 | 0.4393 | 0.7083 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0037 | 0.5911 | 1 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.4678 | 0.4619 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0037 | 0.5911 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0525 | 0.0888 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0037 | 0.5911 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0037 | 0.5911 | 1 |
Trichomonas vaginalis | helicase, putative | 0.0006 | 0.0525 | 0.0888 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0525 | 0.0888 |
Echinococcus multilocularis | inositol polyphosphate 5 phosphatase OCRL 1 | 0.0007 | 0.0708 | 0.014 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0007 | 0.0634 | 0.0531 |
Schistosoma mansoni | neutral sphingomyelinase | 0.0007 | 0.0708 | 0.0605 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0037 | 0.5911 | 1 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0007 | 0.0708 | 0.014 |
Trichomonas vaginalis | Phospholipase C precursor, putative | 0.0007 | 0.0708 | 0.1198 |
Echinococcus multilocularis | synaptojanin 1 | 0.0007 | 0.0708 | 0.014 |
Echinococcus granulosus | inositol polyphosphate 5 phosphatase OCRL 1 | 0.0007 | 0.0708 | 0.014 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0037 | 0.5911 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0525 | 0.0888 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0525 | 0.0888 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Agonist activity at human recombinant PPARgamma expressed in CHO cells cotransfected with pGL3-PPRE3-TK-luc reporter assessed as beta-galactosidase activity at after 24 hrs by luciferase based transactivation assay | ChEMBL. | 22424300 | |
Activity (functional) | Agonist activity at human recombinant PPARalpha expressed in CHO cells cotransfected with pGL3-PPRE3-TK-luc reporter assessed as beta-galactosidase activity at 20 uM after 24 hrs by luciferase based transactivation assay | ChEMBL. | 22424300 | |
Activity (functional) | Agonist activity at human recombinant PPARbeta expressed in CHO cells cotransfected with pGL3-PPRE3-TK-luc reporter assessed as beta-galactosidase activity at 20 uM after 24 hrs by luciferase based transactivation assay | ChEMBL. | 22424300 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.