Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mycobacterium tuberculosis | Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) | Get druggable targets OG5_129569 | All targets in OG5_129569 |
Mycobacterium leprae | Probable pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) | Get druggable targets OG5_129569 | All targets in OG5_129569 |
Toxoplasma gondii | pantoate-beta-alanine ligase | Get druggable targets OG5_129569 | All targets in OG5_129569 |
Neospora caninum | pantoate--beta-alanine ligase, putative | Get druggable targets OG5_129569 | All targets in OG5_129569 |
Mycobacterium ulcerans | pantoate--beta-alanine ligase | Get druggable targets OG5_129569 | All targets in OG5_129569 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.0031 | 0.5 |
Onchocerca volvulus | 0.004 | 0.0031 | 0.5 | |
Trichomonas vaginalis | esterase, putative | 0.004 | 0.0031 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.0031 | 1 |
Loa Loa (eye worm) | beta-lactamase | 0.004 | 0.0031 | 0.0226 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0133 | 0.1386 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0031 | 0.0226 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.004 | 0.0031 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.004 | 0.0031 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.004 | 0.0031 | 0.0226 |
Brugia malayi | beta-lactamase family protein | 0.004 | 0.0031 | 0.0226 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0031 | 0.0226 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.004 | 0.0031 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0031 | 0.0226 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.004 | 0.0031 | 0.0226 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0031 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.004 | 0.0031 | 0.5 |
Onchocerca volvulus | 0.004 | 0.0031 | 0.5 | |
Toxoplasma gondii | pantoate-beta-alanine ligase | 0.0725 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0056 | 0.0256 | 0.1849 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0031 | 0.5 |
Mycobacterium tuberculosis | Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) | 0.0725 | 1 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0031 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0133 | 0.1386 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.004 | 0.0031 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.0031 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0256 | 0.1849 |
Brugia malayi | beta-lactamase | 0.004 | 0.0031 | 0.0226 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0031 | 0.0226 |
Leishmania major | hypothetical protein, conserved | 0.004 | 0.0031 | 0.5 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0257 | 0.3183 | 0.3162 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0133 | 0.1386 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0056 | 0.0256 | 0.1849 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.0031 | 1 |
Mycobacterium ulcerans | pantoate--beta-alanine ligase | 0.0725 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0031 | 0.0226 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0031 | 0.0226 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0056 | 0.0256 | 0.1849 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.004 | 0.0031 | 0.0226 |
Plasmodium vivax | hypothetical protein, conserved | 0.004 | 0.0031 | 0.5 |
Onchocerca volvulus | 0.004 | 0.0031 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2.74 uM | Inhibition of Mycobacterium tuberculosis pantothenate synthetase expressed in Escherichia coli BL21 (DE3) by spectrophotometry | ChEMBL. | 24953948 |
Inhibition (ADMET) | = 24.5 % | Cytotoxicity against mouse RAW264.7 cells assessed as inhibition of cell viability at 50 uM after 72 hrs by MTT assay | ChEMBL. | 24953948 |
MIC (functional) | = 23.5 uM | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 assessed as growth inhibition after 28 days by agar dilution method | ChEMBL. | 24953948 |
MIC50 (functional) | = 0.2 uM | Antimycobacterial activity against Mycobacterium tuberculosis assessed as inhibition of bacterial growth measured in glycerol-containing medium | ChEMBL. | 25577708 |
MIC50 (functional) | = 1.86 uM | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 after 28 days by agar dilution method | ChEMBL. | 27184765 |
MIC90 (functional) | = 2 uM | GSK_TB: Intracellular minimum inhibitory concentration (MIC) H37Rv assay | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.