Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | RNA recognition motif domain containing protein | 0.0074 | 0.2837 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.2837 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0039 | 0.143 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0148 | 0.1001 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0039 | 0.143 | 0.454 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0148 | 0.1001 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0039 | 0.143 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0039 | 0.143 | 1 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0039 | 0.143 | 0.5 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0148 | 0.1001 |
Schistosoma mansoni | cpg binding protein | 0.0033 | 0.1199 | 0.4225 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0053 | 0.2004 | 0.6774 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.2837 | 1 |
Onchocerca volvulus | 0.0039 | 0.143 | 1 | |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0071 | 0.2722 | 0.9595 |
Trichomonas vaginalis | helicase, putative | 0.0008 | 0.0148 | 0.1001 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0039 | 0.143 | 0.471 |
Brugia malayi | beta-lactamase family protein | 0.0039 | 0.143 | 0.4551 |
Echinococcus granulosus | tar DNA binding protein | 0.0074 | 0.2837 | 1 |
Onchocerca volvulus | 0.0039 | 0.143 | 1 | |
Trypanosoma brucei | hypothetical protein, conserved | 0.0039 | 0.143 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0039 | 0.143 | 0.4551 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0148 | 0.1001 |
Brugia malayi | CXXC zinc finger family protein | 0.0033 | 0.1199 | 0.3655 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.2837 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0039 | 0.143 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.143 | 0.454 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.2004 | 0.7064 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0039 | 0.143 | 0.504 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0148 | 0.1001 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.143 | 0.454 |
Entamoeba histolytica | hypothetical protein | 0.0004 | 0 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0039 | 0.143 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0039 | 0.143 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0039 | 0.143 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0074 | 0.2837 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.1276 | 0.4498 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0063 | 0.2414 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0148 | 0.1001 |
Loa Loa (eye worm) | beta-lactamase | 0.0039 | 0.143 | 0.454 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.143 | 0.454 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0039 | 0.143 | 0.504 |
Trichomonas vaginalis | esterase, putative | 0.0039 | 0.143 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0039 | 0.143 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.2004 | 0.6868 |
Mycobacterium ulcerans | lipase LipD | 0.0039 | 0.143 | 0.5 |
Mycobacterium leprae | Probable lipase LipE | 0.0039 | 0.143 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0148 | 0.1001 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0039 | 0.143 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0148 | 0.1001 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0039 | 0.143 | 0.471 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0148 | 0.1001 |
Mycobacterium ulcerans | beta-lactamase | 0.0039 | 0.143 | 0.5 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.001 | 0.026 | 0.0311 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0148 | 0.1001 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0148 | 0.1001 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0148 | 0.1001 |
Brugia malayi | RNA binding protein | 0.0074 | 0.2837 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0039 | 0.143 | 0.5 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.1276 | 0.4498 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0039 | 0.143 | 0.4551 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0039 | 0.143 | 1 |
Plasmodium falciparum | zinc finger protein, putative | 0.0004 | 0 | 0.5 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0005 | 0.0035 | 0.0122 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0148 | 0.1001 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.2837 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0074 | 0.2837 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.2837 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0074 | 0.2837 | 1 |
Brugia malayi | TAR-binding protein | 0.0074 | 0.2837 | 1 |
Brugia malayi | beta-lactamase | 0.0039 | 0.143 | 0.4551 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0148 | 0.1001 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.143 | 0.454 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.2004 | 0.6868 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0148 | 0.1001 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0008 | 0.0177 | 0.0625 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0033 | 0.1199 | 0.3642 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.143 | 0.454 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0053 | 0.2004 | 0.6768 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0148 | 0.1001 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0148 | 0.1001 |
Loa Loa (eye worm) | TAR-binding protein | 0.0074 | 0.2837 | 1 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0039 | 0.143 | 0.5 |
Onchocerca volvulus | 0.0039 | 0.143 | 1 | |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.2004 | 0.6868 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.143 | 0.454 |
Echinococcus granulosus | cpg binding protein | 0.0035 | 0.1276 | 0.4131 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.2004 | 0.7064 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.2004 | 0.6868 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.001 | 0.026 | 0.0311 |
Echinococcus multilocularis | cpg binding protein | 0.0035 | 0.1276 | 0.4131 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.2004 | 0.7064 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5.019 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.72 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.296 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.