Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | opiate receptor-like 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | growth hormone secretagogue receptor type 1 | opiate receptor-like 1 | 370 aa | 349 aa | 22.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0069 | 0.16 | 0.1966 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.0069 | 0.16 | 0.1966 |
Plasmodium falciparum | proteasome subunit beta type-1, putative | 0.0069 | 0.16 | 0.1966 |
Trypanosoma brucei | proteasome beta 6 subunit | 0.0069 | 0.16 | 0.1966 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0062 | 0.1351 | 0.1351 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0231 | 0.8137 | 1 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0231 | 0.8137 | 1 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0231 | 0.8137 | 1 |
Plasmodium vivax | proteasome subunit beta type-1, putative | 0.0069 | 0.16 | 0.1966 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0231 | 0.8137 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0158 | 0.5211 | 0.6404 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0091 | 0.2517 | 0.2517 |
Loa Loa (eye worm) | hypothetical protein | 0.0277 | 1 | 1 |
Schistosoma mansoni | proteasome subunit beta 1 (T01 family) | 0.0069 | 0.16 | 0.1966 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0231 | 0.8137 | 1 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0231 | 0.8137 | 1 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0069 | 0.16 | 0.1966 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0231 | 0.8137 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.1351 | 0.1351 |
Schistosoma mansoni | hypothetical protein | 0.0158 | 0.5211 | 0.6404 |
Loa Loa (eye worm) | proteasome subunit beta type 1 | 0.0069 | 0.16 | 0.16 |
Leishmania major | proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative | 0.0069 | 0.16 | 0.1966 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0231 | 0.8137 | 1 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0231 | 0.8137 | 0.5 |
Onchocerca volvulus | 0.0277 | 1 | 0.5 | |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0231 | 0.8137 | 1 |
Brugia malayi | proteasome subunit beta type 1 | 0.0069 | 0.16 | 0.16 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0231 | 0.8137 | 1 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0231 | 0.8137 | 0.8137 |
Echinococcus granulosus | proteasome prosome macropain | 0.0231 | 0.8137 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.2517 | 0.2517 |
Echinococcus granulosus | geminin | 0.0158 | 0.5211 | 0.6404 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0091 | 0.2517 | 0.2517 |
Mycobacterium ulcerans | proteasome PrcB | 0.0231 | 0.8137 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0062 | 0.1351 | 0.166 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0091 | 0.2517 | 0.2517 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0231 | 0.8137 | 1 |
Echinococcus multilocularis | geminin | 0.0158 | 0.5211 | 0.6404 |
Brugia malayi | Proteasome A-type and B-type family protein | 0.0231 | 0.8137 | 0.8137 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.0069 | 0.16 | 0.1966 |
Toxoplasma gondii | proteasome subunit beta type 1, putative | 0.0069 | 0.16 | 0.1966 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0231 | 0.8137 | 1 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0231 | 0.8137 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Kb (functional) | = 5.64 nM | Antagonist at against human cloned NOP receptor expressed in CHO cell membranes after 30 mins by [35S]GTPgammaS binding assay | ChEMBL. | 22541041 |
Kb (functional) | = 5.64 nM | Antagonist activity at human recombinant NOP receptor expressed in CHO cells assessed as inhibition of nociceptin-induced [35S]GTPgammaS binding after 2 hrs by scintillation proximity assay | ChEMBL. | 21438532 |
Ki (binding) | = 4.51 nM | Displacement of [3H]nociceptin from human recombinant NOP receptor expressed in CHO cells after 60 mins by microbeta scintillation counting | ChEMBL. | 21438532 |
Ki (binding) | = 4.54 nM | Displacement of [3H]Nociceptin from human recombinant NOP receptor expressed in CHO cells by scintillation counter | ChEMBL. | 22541041 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.