Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0026 | 0.0007 | 0.0007 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0026 | 0.0007 | 0.0007 |
Brugia malayi | thymidylate synthase | 0.0766 | 0.1279 | 0.1279 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0026 | 0.0007 | 0.0007 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0022 | 0.0022 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0031 | 0.0015 | 0.0015 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.5835 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.5835 | 1 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.5835 | 1 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.5835 | 1 | 1 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0031 | 0.0015 | 0.0015 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0031 | 0.0015 | 0.0026 |
Leishmania major | cytochrome p450-like protein | 0.0044 | 0.0038 | 0.0067 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.3317 | 0.5668 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.0022 | 0.0022 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0019 | 0.0019 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0026 | 0.0007 | 0.0007 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0044 | 0.0038 | 0.0055 |
Echinococcus multilocularis | 0.0026 | 0.0007 | 0.0007 | |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0766 | 0.1279 | 0.1279 |
Brugia malayi | cytochrome P450 | 0.0026 | 0.0007 | 0.0007 |
Brugia malayi | beta-NAC-like protein | 0.0068 | 0.0079 | 0.0079 |
Schistosoma mansoni | cytochrome P450 | 0.0026 | 0.0007 | 0.0007 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0766 | 0.1279 | 0.1279 |
Mycobacterium ulcerans | thymidylate synthase | 0.0766 | 0.1279 | 0.1274 |
Echinococcus granulosus | geminin | 0.0164 | 0.0244 | 0.0244 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0022 | 0.2838 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0026 | 0.0007 | 0.0007 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0031 | 0.0015 | 0.0015 |
Plasmodium vivax | basic transcription factor 3b, putative | 0.0068 | 0.0079 | 0.0139 |
Brugia malayi | Cytochrome P450 family protein | 0.0026 | 0.0007 | 0.0007 |
Entamoeba histolytica | transcription factor BTF3, putative | 0.0068 | 0.0079 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.5835 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.0046 | 0.0046 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.0046 | 0.0046 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0068 | 0.0079 | 0.1338 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3317 | 0.5668 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0026 | 0.0007 | 0.0007 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0026 | 0.0007 | 0.0007 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3317 | 0.5668 | 1 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0787 | 0.1317 | 0.1317 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0026 | 0.0007 | 0.0007 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0022 | 0.0022 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.0244 | 0.0244 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0044 | 0.0038 | 0.0038 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0031 | 0.0015 | 0.0015 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.5835 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0364 | 0.0589 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0031 | 0.0015 | 0.0015 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.3317 | 0.5668 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0031 | 0.0015 | 0.0015 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0022 | 0.2838 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0022 | 0.2838 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0068 | 0.0079 | 0.1338 |
Leishmania major | lanosterol 14-alpha-demethylase, putative | 0.0026 | 0.0007 | 0.0012 |
Onchocerca volvulus | 0.0766 | 0.1279 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0019 | 0.0019 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0044 | 0.0038 | 0.0038 |
Brugia malayi | hypothetical protein | 0.0364 | 0.0589 | 0.0589 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0364 | 0.0589 | 0.0589 |
Plasmodium falciparum | basic transcription factor 3b, putative | 0.0068 | 0.0079 | 0.0139 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0044 | 0.0038 | 0.0055 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.3317 | 0.5668 | 1 |
Toxoplasma gondii | NAC domain-containing protein | 0.0068 | 0.0079 | 0.0139 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0031 | 0.0015 | 0.0026 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.0022 | 0.0022 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0068 | 0.0079 | 0.0127 |
Trypanosoma brucei | transcription factor BTF3, putative | 0.0068 | 0.0079 | 0.0127 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.0046 | 0.0046 |
Schistosoma mansoni | hypothetical protein | 0.0026 | 0.0007 | 0.0007 |
Brugia malayi | Dihydrofolate reductase | 0.5835 | 1 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0026 | 0.0007 | 0.0012 |
Echinococcus multilocularis | geminin | 0.0164 | 0.0244 | 0.0244 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0031 | 0.0015 | 0.0015 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0026 | 0.0007 | 0.0007 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0026 | 0.0007 | 0.0007 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0046 | 0.0046 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0068 | 0.0079 | 0.1338 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0031 | 0.0015 | 0.0026 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0031 | 0.0015 | 0.0026 |
Loa Loa (eye worm) | thymidylate synthase | 0.0766 | 0.1279 | 0.1279 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0022 | 0.2838 |
Echinococcus granulosus | thymidylate synthase | 0.0766 | 0.1279 | 0.1279 |
Trypanosoma brucei | cytochrome P450, putative | 0.0044 | 0.0038 | 0.0055 |
Schistosoma mansoni | transcription factor btf3 | 0.0068 | 0.0079 | 0.0079 |
Loa Loa (eye worm) | ICD-1 protein | 0.0068 | 0.0079 | 0.0079 |
Echinococcus multilocularis | dihydrofolate reductase | 0.5835 | 1 | 1 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0031 | 0.0015 | 0.0026 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0026 | 0.0007 | 0.0007 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.0022 | 0.0022 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0026 | 0.0007 | 0.0007 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0031 | 0.0015 | 0.0015 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0031 | 0.0015 | 0.0015 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0026 | 0.0007 | 0.0007 |
Brugia malayi | Isocitrate dehydrogenase | 0.0031 | 0.0015 | 0.0015 |
Leishmania major | cytochrome p450-like protein | 0.0026 | 0.0007 | 0.0012 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0026 | 0.0007 | 0.0007 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0026 | 0.0007 | 0.0007 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0026 | 0.0007 | 0.0007 |
Brugia malayi | Cytochrome P450 family protein | 0.0044 | 0.0038 | 0.0038 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0031 | 0.0015 | 0.0015 |
Leishmania major | basic transcription factor 3a, putative | 0.0068 | 0.0079 | 0.0139 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0044 | 0.0038 | 0.0038 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0026 | 0.0007 | 0.0007 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0026 | 0.0007 | 0.0007 |
Brugia malayi | isocitrate dehydrogenase | 0.0031 | 0.0015 | 0.0015 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.5835 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0364 | 0.0589 | 0.1029 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0019 | 0.0019 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0031 | 0.0015 | 0.0015 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0026 | 0.0007 | 0.0012 |
Echinococcus multilocularis | transcription factor btf3 | 0.0068 | 0.0079 | 0.0079 |
Echinococcus granulosus | transcription factor btf3 | 0.0068 | 0.0079 | 0.0079 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0026 | 0.0007 | 0.0007 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0026 | 0.0007 | 0.0007 |
Echinococcus multilocularis | thymidylate synthase | 0.0766 | 0.1279 | 0.1279 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0031 | 0.0015 | 0.0015 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0068 | 0.0079 | 0.0127 |
Brugia malayi | Cytochrome P450 family protein | 0.0085 | 0.0109 | 0.0109 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0044 | 0.0038 | 0.0031 |
Brugia malayi | Cytochrome P450 family protein | 0.0044 | 0.0038 | 0.0038 |
Loa Loa (eye worm) | cytochrome P450 | 0.0026 | 0.0007 | 0.0007 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0031 | 0.0015 | 0.0015 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.3317 | 0.5668 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0085 | 0.0109 | 0.0109 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.0244 | 0.0244 |
Entamoeba histolytica | hypothetical protein | 0.0068 | 0.0079 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0766 | 0.1279 | 0.1274 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0026 | 0.0007 | 0.0007 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.