Detailed information for compound 1674952

Basic information

Technical information
  • TDR Targets ID: 1674952
  • Name: 5-methyl-7-phenyl-3H-indolizin-4-ium perchlor ate
  • MW: 307.729 | Formula: C15H14ClNO4
  • H donors: 1 H acceptors: 4 LogP: 5.76 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][Cl](=O)(=O)=O.Cc1cc(cc2[n+]1CC=C2)c1ccccc1
  • InChi: 1S/C15H14N.ClHO4/c1-12-10-14(13-6-3-2-4-7-13)11-15-8-5-9-16(12)15;2-1(3,4)5/h2-8,10-11H,9H2,1H3;(H,2,3,4,5)/q+1;/p-1
  • InChiKey: FTUKHQPWHQETNG-UHFFFAOYSA-M  


Substructure search Similarity search

Network

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Synonyms

  • NSC622506

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans dehydrogenase/reductase 0.0061 0.1568 0.3045
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0199 0.6916 0.8837
Mycobacterium ulcerans short chain dehydrogenase 0.0061 0.1568 0.3045
Schistosoma mansoni pyruvate kinase 0.0034 0.0541 0.0541
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0061 0.1568 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.013 0.4264 1
Entamoeba histolytica hypothetical protein 0.0061 0.1568 1
Leishmania major pteridine reductase 1 0.0061 0.1568 0.3045
Leishmania major short chain dehydrogenase, putative 0.0061 0.1568 0.3045
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0061 0.1568 0.3045
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0541 0.1384
Loa Loa (eye worm) hypothetical protein 0.0061 0.1568 0.1896
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0061 0.1568 0.1568
Plasmodium vivax glutathione reductase, putative 0.0087 0.2593 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.013 0.4264 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0683 0.1338
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0061 0.1568 0.1896
Leishmania major hypothetical protein, conserved 0.0061 0.1568 0.3045
Schistosoma mansoni carbonyl reductase 0.0061 0.1568 0.1568
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0966 0.1168
Trypanosoma brucei short-chain dehydrogenase, putative 0.0061 0.1568 0.5353
Mycobacterium ulcerans ketoacyl reductase 0.0061 0.1568 0.3045
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0529 0.0192
Echinococcus granulosus pyruvate kinase 0.0034 0.0541 0.0654
Trypanosoma cruzi hypothetical protein, conserved 0.0061 0.1568 0.5353
Mycobacterium tuberculosis Probable short chain alcohol dehydrogenase/reductase 0.0061 0.1568 0.1598
Onchocerca volvulus 0.0061 0.1568 0.4012
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0061 0.1568 0.5353
Mycobacterium tuberculosis Probable short-chain dehydrogenase/reductase 0.0061 0.1568 0.1598
Mycobacterium ulcerans short chain dehydrogenase 0.0061 0.1568 0.3045
Mycobacterium ulcerans oxidoreductase 0.0061 0.1568 0.3045
Leishmania major 3-keto-dihydrosphingosine reductase 0.0061 0.1568 0.3045
Leishmania major trypanothione reductase 0.0087 0.2593 0.5688
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0541 0.0695
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0966 0.1168
Loa Loa (eye worm) hypothetical protein 0.0061 0.1568 0.1896
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0061 0.1568 0.1896
Schistosoma mansoni short chain dehydrogenase 0.0061 0.1568 0.1568
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0061 0.1568 0.5353
Mycobacterium ulcerans aldehyde dehydrogenase 0.013 0.4264 1
Schistosoma mansoni steroid dehydrogenase 0.0061 0.1568 0.1568
Trypanosoma cruzi hypothetical protein, conserved 0.0061 0.1568 0.5353
Trypanosoma brucei pyruvate kinase 1 0.0034 0.0541 0.0695
Echinococcus multilocularis pyruvate kinase 0.0034 0.0541 0.0654
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0683 0.3797
Mycobacterium leprae ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE 0.0061 0.1568 0.1434
Brugia malayi Dehydrogenases, short chain protein 30 0.0061 0.1568 0.1896
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0061 0.1568 0.3045
Echinococcus granulosus WW domain containing oxidoreductase 0.0061 0.1568 0.1896
Trypanosoma cruzi hypothetical protein, conserved 0.0061 0.1568 0.5353
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0061 0.1568 0.1896
Echinococcus multilocularis survival motor neuron protein 1 0.0233 0.827 1
Loa Loa (eye worm) dehydrogenase 0.0061 0.1568 0.1896
Mycobacterium tuberculosis Probable short-chain type oxidoreductase 0.0061 0.1568 0.1598
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.003 0.0388 0.0388
Leishmania major pyruvate kinase 0.0034 0.0541 0.0395
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0061 0.1568 0.1896
Loa Loa (eye worm) dehydrogenase 0.0061 0.1568 0.1896
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0541 0.0654
Mycobacterium ulcerans short chain dehydrogenase 0.0061 0.1568 0.3045
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0061 0.1568 1
Schistosoma mansoni carbonyl reductase 0.0061 0.1568 0.1568
Echinococcus granulosus retinol dehydrogenase 11 0.0061 0.1568 0.1896
Trypanosoma cruzi hypothetical protein, conserved 0.0061 0.1568 0.5353
Echinococcus multilocularis retinol dehydrogenase 13 0.0061 0.1568 0.1896
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0061 0.1568 0.3045
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0966 0.1168
Giardia lamblia Oxidoreductase, short chain dehydrogenase/reductase family 0.0061 0.1568 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0061 0.1568 0.3045
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0061 0.1568 0.1896
Schistosoma mansoni short chain dehydrogenase 0.0061 0.1568 0.1568
Plasmodium falciparum steroid dehydrogenase, putative 0.0061 0.1568 0.6048
Echinococcus multilocularis pyruvate kinase 0.0034 0.0541 0.0654
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0061 0.1568 0.1896
Toxoplasma gondii pyruvate kinase PyK1 0.0034 0.0541 0.0395
Entamoeba histolytica short chain dehydrogenase family protein 0.0061 0.1568 1
Schistosoma mansoni short chain dehydrogenase 0.0061 0.1568 0.1568
Mycobacterium ulcerans oxidoreductase 0.0061 0.1568 0.3045
Onchocerca volvulus 0.0061 0.1568 0.4012
Onchocerca volvulus 0.0061 0.1568 0.4012
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0061 0.1568 0.1434
Schistosoma mansoni short chain dehydrogenase 0.0061 0.1568 0.1568
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0061 0.1568 0.1568
Mycobacterium tuberculosis Probable oxidoreductase 0.0221 0.7775 1
Echinococcus multilocularis conserved hypothetical protein 0.0061 0.1568 0.1896
Mycobacterium ulcerans short chain dehydrogenase 0.0061 0.1568 0.3045
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0061 0.1568 0.1598
Leishmania major short chain dehydrogenase/reductase, putative 0.0061 0.1568 0.3045
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0061 0.1568 0.3045
Trypanosoma brucei short-chain dehydrogenase, putative 0.0061 0.1568 0.5353
Treponema pallidum NADH oxidase 0.003 0.0388 0.5
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0541 0.0654
Leishmania major hypothetical protein, conserved 0.0061 0.1568 0.3045
Schistosoma mansoni inositol monophosphatase 0.0038 0.0683 0.0683
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0061 0.1568 0.1896
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0087 0.2593 0.2985
Loa Loa (eye worm) oxidoreductase 0.0061 0.1568 0.1896
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0061 0.1568 0.5353
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0061 0.1568 0.3045
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0061 0.1568 0.1568
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0061 0.1568 0.1896
Loa Loa (eye worm) hypothetical protein 0.0061 0.1568 0.1896
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0199 0.6916 0.8837
Trypanosoma brucei trypanothione reductase 0.0087 0.2593 1
Mycobacterium tuberculosis Possible iron-regulated short-chain dehydrogenase/reductase 0.0061 0.1568 0.1598
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0541 0.0654
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0061 0.1568 0.1598
Schistosoma mansoni aldehyde dehydrogenase 0.013 0.4264 0.4264
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0061 0.1568 0.1598
Loa Loa (eye worm) hypothetical protein 0.0061 0.1568 0.1896
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.0061 0.1568 0.6048
Loa Loa (eye worm) glutathione reductase 0.0087 0.2593 0.3135
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0541 0.1298
Loa Loa (eye worm) hypothetical protein 0.0061 0.1568 0.1896
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0061 0.1568 0.4012
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0061 0.1568 0.1896
Leishmania major hypothetical protein, conserved 0.0061 0.1568 0.3045
Giardia lamblia Short-chain dehydrogenase, putative 0.0061 0.1568 1
Giardia lamblia Pyruvate kinase 0.0034 0.0541 0.1298
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0061 0.1568 0.1896
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0061 0.1568 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0683 0.1338
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0061 0.1568 0.5353
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.003 0.0388 0.1495
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0061 0.1568 0.5353
Toxoplasma gondii oxidoreductase, putative 0.0061 0.1568 0.3045
Mycobacterium ulcerans short-chain type oxidoreductase 0.0061 0.1568 0.3045
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.013 0.4264 0.5156
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0221 0.7775 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0199 0.6916 0.8837
Mycobacterium tuberculosis Probable shortchain dehydrogenase 0.0061 0.1568 0.1598
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0061 0.1568 0.3045
Plasmodium falciparum glutathione reductase 0.0087 0.2593 1
Echinococcus multilocularis carbonyl reductase 1 0.0061 0.1568 0.1896
Mycobacterium tuberculosis Possible oxidoreductase 0.0061 0.1568 0.1598
Echinococcus multilocularis pyruvate kinase 0.0027 0.0262 0.0317
Leishmania major quinonoid dihydropteridine reductase 0.0061 0.1568 0.3045
Mycobacterium ulcerans short-chain dehydrogenase 0.0061 0.1568 0.3045
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0061 0.1568 0.1896
Mycobacterium tuberculosis Possible ketoacyl reductase 0.0061 0.1568 0.1598
Onchocerca volvulus Sepiapterin reductase homolog 0.0061 0.1568 0.4012
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0061 0.1568 0.5353
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0061 0.1568 0.3045
Schistosoma mansoni lipoxygenase 0.0121 0.3894 0.3894
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0061 0.1568 0.3045
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0061 0.1568 0.1568
Mycobacterium ulcerans short chain dehydrogenase 0.0061 0.1568 0.3045
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0061 0.1568 0.1896
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0061 0.1568 0.3045
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0061 0.1568 0.5353
Mycobacterium leprae PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE 0.0061 0.1568 0.1434
Toxoplasma gondii aldehyde dehydrogenase 0.013 0.4264 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0061 0.1568 0.3045
Brugia malayi Pyruvate kinase, muscle isozyme 0.0034 0.0541 0.0654
Leishmania major quinonoid dihydropteridine reductase 0.0061 0.1568 0.3045
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0061 0.1568 1
Brugia malayi Retinol dehydrogenase 12 0.0061 0.1568 0.1896
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0541 0.0695
Brugia malayi dehydrogenases, short chain protein 9 0.0061 0.1568 0.1896
Echinococcus granulosus oxidoreductase 0.0061 0.1568 0.1896
Trypanosoma brucei short-chain dehydrogenase, putative 0.0061 0.1568 0.5353
Onchocerca volvulus 0.0061 0.1568 0.4012
Brugia malayi hypothetical protein 0.0061 0.1568 0.1896
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.0061 0.1568 1
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0683 0.0825
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0541 0.1384
Schistosoma mansoni short chain dehydrogenase 0.0061 0.1568 0.1568
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0061 0.1568 1
Brugia malayi Thioredoxin reductase 0.0087 0.2593 0.3135
Leishmania major dehydrogenase-like protein 0.0061 0.1568 0.3045
Brugia malayi glutathione reductase 0.0087 0.2593 0.3135
Leishmania major quinonoid dihydropteridine reductase 0.0061 0.1568 0.3045
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.0061 0.1568 0.3045
Mycobacterium leprae Probable oxidoreductase 0.0061 0.1568 0.1434
Trypanosoma brucei short-chain dehydrogenase, putative 0.0061 0.1568 0.5353
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0061 0.1568 0.1896
Onchocerca volvulus 0.0061 0.1568 0.4012
Mycobacterium ulcerans short chain dehydrogenase 0.0061 0.1568 0.3045
Trypanosoma cruzi trypanothione reductase, putative 0.0087 0.2593 1
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0061 0.1568 0.5353
Toxoplasma gondii oxidoreductase, putative 0.0061 0.1568 0.3045
Schistosoma mansoni steroid dehydrogenase 0.0061 0.1568 0.1568
Mycobacterium tuberculosis Probable oxidoreductase 0.0061 0.1568 0.1598
Entamoeba histolytica short chain dehydrogenase family protein 0.0061 0.1568 1
Onchocerca volvulus 0.0061 0.1568 0.4012
Mycobacterium ulcerans short chain dehydrogenase 0.0061 0.1568 0.3045
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0061 0.1568 0.1896
Leishmania major short chain dehydrogenase/reductase, putative 0.0061 0.1568 0.3045
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0966 0.0966
Schistosoma mansoni short chain dehydrogenase 0.0061 0.1568 0.1568
Loa Loa (eye worm) hypothetical protein 0.0061 0.1568 0.1896
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0061 0.1568 0.3045
Mycobacterium ulcerans short-chain membrane-associated dehydrogenase 0.0061 0.1568 0.3045
Mycobacterium ulcerans short chain dehydrogenase 0.0061 0.1568 0.3045
Plasmodium falciparum glutathione reductase 0.003 0.0388 0.1495
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0061 0.1568 0.1896
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0966 0.1168
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0061 0.1568 0.5353
Echinococcus granulosus hypothetical protein 0.0061 0.1568 0.1896
Leishmania major oxidoreductase-like protein 0.0061 0.1568 0.3045
Loa Loa (eye worm) oxidoreductase 0.0061 0.1568 0.1896
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0061 0.1568 0.5353
Echinococcus granulosus retinol dehydrogenase 11 0.0061 0.1568 0.1896
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0061 0.1568 0.3045
Schistosoma mansoni steroid dehydrogenase 0.0061 0.1568 0.1568
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0061 0.1568 0.1896
Leishmania major quinonoid dihydropteridine reductase 0.0061 0.1568 0.3045
Onchocerca volvulus 0.0061 0.1568 0.4012
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0683 0.0825
Schistosoma mansoni short chain dehydrogenase 0.0061 0.1568 0.1568
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0061 0.1568 0.1896
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0061 0.1568 0.1896
Loa Loa (eye worm) hypothetical protein 0.0061 0.1568 0.1896
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0199 0.6916 0.8837
Mycobacterium ulcerans short chain dehydrogenase 0.0061 0.1568 0.3045
Mycobacterium ulcerans short chain dehydrogenase 0.0061 0.1568 0.3045
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0541 0.1298
Brugia malayi Inositol-1 0.0038 0.0683 0.0825
Loa Loa (eye worm) hypothetical protein 0.0061 0.1568 0.1896
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0061 0.1568 0.1598
Loa Loa (eye worm) hypothetical protein 0.0121 0.3908 0.4725
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0061 0.1568 0.5353
Onchocerca volvulus 0.0061 0.1568 0.4012
Schistosoma mansoni short chain dehydrogenase 0.0061 0.1568 0.1568
Mycobacterium ulcerans short chain dehydrogenase 0.0061 0.1568 0.3045
Schistosoma mansoni steroid dehydrogenase 0.0061 0.1568 0.1568
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0061 0.1568 0.1896
Entamoeba histolytica hypothetical protein, conserved 0.0061 0.1568 1
Plasmodium vivax thioredoxin reductase, putative 0.0087 0.2593 1
Brugia malayi Dehydrogenases, short chain protein 2 0.0061 0.1568 0.1896
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0061 0.1568 0.5353
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0061 0.1568 1
Mycobacterium ulcerans short chain dehydrogenase 0.0061 0.1568 0.3045
Echinococcus granulosus carbonyl reductase 1 0.0061 0.1568 0.1896
Loa Loa (eye worm) hypothetical protein 0.0061 0.1568 0.1896
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0199 0.6916 0.8814
Schistosoma mansoni hypothetical protein 0.0048 0.1065 0.1065
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0061 0.1568 0.5353
Onchocerca volvulus 0.0061 0.1568 0.4012
Schistosoma mansoni survival motor neuron protein 0.0048 0.1065 0.1065
Chlamydia trachomatis pyruvate kinase 0.0034 0.0541 1
Schistosoma mansoni short chain dehydrogenase 0.0061 0.1568 0.1568
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0061 0.1568 0.1598
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.003 0.0388 0.1495
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0683 0.2499
Onchocerca volvulus 0.0061 0.1568 0.4012
Mycobacterium ulcerans short chain dehydrogenase 0.0061 0.1568 0.3045
Loa Loa (eye worm) inositol-1 0.0038 0.0683 0.0825
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.013 0.4264 0.5248
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0221 0.7775 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.003 0.0388 0.1495
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0061 0.1568 1
Mycobacterium tuberculosis Possible oxidoreductase 0.0061 0.1568 0.1598
Mycobacterium tuberculosis Probable dehydrogenase 0.0061 0.1568 0.1598
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0061 0.1568 0.1598
Schistosoma mansoni lipoxygenase 0.0084 0.2487 0.2487
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.0061 0.1568 0.4012
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0061 0.1568 0.3045
Plasmodium vivax steroid dehydrogenase, putative 0.0061 0.1568 0.6048
Echinococcus multilocularis thioredoxin glutathione reductase 0.0088 0.2613 0.3159
Echinococcus granulosus pyruvate kinase 0.0034 0.0541 0.0654
Trypanosoma cruzi hypothetical protein, conserved 0.0061 0.1568 0.5353
Leishmania major short chain dehydrogenase-like protein 0.0061 0.1568 0.3045
Schistosoma mansoni steroid dehydrogenase 0.0061 0.1568 0.1568
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.1065 0.1287
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0061 0.1568 0.1896
Echinococcus multilocularis steroid dehydrogenase 0.0061 0.1568 0.1896
Plasmodium falciparum thioredoxin reductase 0.0087 0.2593 1
Mycobacterium ulcerans short chain dehydrogenase 0.0061 0.1568 0.3045
Mycobacterium ulcerans pyruvate kinase 0.0034 0.0541 0.0395
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0061 0.1568 0.1896
Toxoplasma gondii carbonyl reductase 1, putative 0.0061 0.1568 0.3045
Echinococcus granulosus hypothetical protein 0.0061 0.1568 0.1896
Giardia lamblia Reductase, putative 0.0061 0.1568 1
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0541 0.1384
Onchocerca volvulus 0.0061 0.1568 0.4012
Loa Loa (eye worm) oxidoreductase 0.0061 0.1568 0.1896
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0966 0.0966
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0061 0.1568 0.1896
Mycobacterium ulcerans short chain dehydrogenase 0.0061 0.1568 0.3045
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0061 0.1568 0.3045
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0061 0.1568 0.1434
Loa Loa (eye worm) oxidoreductase 0.0061 0.1568 0.1896
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0061 0.1568 0.5353
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0966 0.1168
Mycobacterium tuberculosis Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 0.0061 0.1568 0.1598
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0061 0.1568 0.4012
Schistosoma mansoni steroid dehydrogenase 0.0061 0.1568 0.1568
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0061 0.1568 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0541 0.0654
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0061 0.1568 0.1598
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0683 0.1338
Echinococcus multilocularis retinol dehydrogenase 11 0.0061 0.1568 0.1896
Onchocerca volvulus Huntingtin homolog 0.0121 0.3908 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0061 0.1568 0.1896
Schistosoma mansoni steroid dehydrogenase 0.0061 0.1568 0.1568
Plasmodium falciparum thioredoxin reductase 0.003 0.0388 0.1495
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0061 0.1568 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0966 0.1168
Toxoplasma gondii thioredoxin reductase 0.0087 0.2593 0.5688
Loa Loa (eye worm) oxidoreductase 0.0061 0.1568 0.1896
Schistosoma mansoni short chain dehydrogenase 0.0061 0.1568 0.1568
Brugia malayi hypothetical protein 0.0061 0.1568 0.1896
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0061 0.1568 0.1896
Echinococcus granulosus steroid dehydrogenase 0.0061 0.1568 0.1896
Leishmania major quinonoid dihydropteridine reductase 0.0061 0.1568 0.3045
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0061 0.1568 0.1896
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0966 0.0966
Trypanosoma brucei oxidoreductase-like protein 0.0061 0.1568 0.5353
Schistosoma mansoni carbonyl reductase 0.0061 0.1568 0.1568
Brugia malayi hypothetical protein 0.0233 0.827 1
Plasmodium vivax pyruvate kinase, putative 0.0034 0.0541 0.2086
Plasmodium falciparum pyruvate kinase 0.0034 0.0541 0.2086
Mycobacterium ulcerans short chain dehydrogenase 0.0061 0.1568 0.3045
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0683 0.0761
Mycobacterium ulcerans carveol-like dehydrogenase 0.0061 0.1568 0.3045
Onchocerca volvulus 0.0061 0.1568 0.4012
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0061 0.1568 0.1598
Mycobacterium ulcerans dehydrogenase/decarboxylase protein 0.0061 0.1568 0.3045
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0061 0.1568 0.1434
Mycobacterium ulcerans ketoacyl reductase 0.0061 0.1568 0.3045
Echinococcus granulosus survival motor neuron protein 1 0.0233 0.827 1
Echinococcus multilocularis transient receptor potential cation channel 0.0061 0.1568 0.1896
Loa Loa (eye worm) oxidoreductase 0.0061 0.1568 0.1896
Mycobacterium ulcerans short-chain dehydrogenase 0.0061 0.1568 0.3045
Schistosoma mansoni short chain dehydrogenase 0.0061 0.1568 0.1568
Mycobacterium ulcerans short chain dehydrogenase 0.0061 0.1568 0.3045
Schistosoma mansoni short chain dehydrogenase 0.0061 0.1568 0.1568
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.003 0.0388 0.0469
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0683 0.0761
Mycobacterium tuberculosis Probable oxidoreductase 0.0061 0.1568 0.1598
Schistosoma mansoni short chain dehydrogenase 0.0061 0.1568 0.1568
Echinococcus granulosus carbonyl reductase 1 0.0061 0.1568 0.1896
Plasmodium vivax hypothetical protein, conserved 0.0061 0.1568 0.6048
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0061 0.1568 1
Trypanosoma cruzi short chain dehydrogenase, putative 0.0061 0.1568 0.5353
Brugia malayi Pyruvate kinase, M2 isozyme 0.0034 0.0541 0.0654
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0061 0.1568 0.5353
Loa Loa (eye worm) thioredoxin reductase 0.0087 0.2593 0.3135
Loa Loa (eye worm) hypothetical protein 0.0121 0.3908 0.4725
Echinococcus multilocularis steroid dehydrogenase 0.0061 0.1568 0.1896
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0061 0.1568 0.1896
Trichomonas vaginalis steroid dehydrogenase, putative 0.0061 0.1568 1
Schistosoma mansoni retinal dehydrogenase 0.0061 0.1568 0.1568
Onchocerca volvulus Huntingtin homolog 0.0121 0.3908 1
Leishmania major hypothetical protein, conserved 0.0061 0.1568 0.3045
Loa Loa (eye worm) hypothetical protein 0.0061 0.1568 0.1896
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0061 0.1568 0.1598
Echinococcus granulosus carbonyl reductase 1 0.0061 0.1568 0.1896
Echinococcus granulosus carbonyl reductase 1 0.0061 0.1568 0.1896
Mycobacterium tuberculosis Possible fatty acyl-CoA reductase 0.0061 0.1568 0.1598
Echinococcus multilocularis carbonyl reductase 1 0.0061 0.1568 0.1896
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0061 0.1568 0.1598
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0034 0.0541 0.0207
Mycobacterium leprae Probable pyruvate kinase PykA 0.0034 0.0541 0.0016
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0061 0.1568 0.3045
Schistosoma mansoni steroid dehydrogenase 0.0061 0.1568 0.1568
Schistosoma mansoni short chain dehydrogenase 0.0061 0.1568 0.1568
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0061 0.1568 1
Onchocerca volvulus 0.0061 0.1568 0.4012
Loa Loa (eye worm) hypothetical protein 0.0024 0.0141 0.017
Mycobacterium tuberculosis Probable oxidoreductase 0.0061 0.1568 0.1598
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0061 0.1568 0.1896
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0121 0.3894 0.4709
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0022 0.0077 0.0093
Mycobacterium tuberculosis Probable dehydrogenase 0.0199 0.6916 0.8837
Mycobacterium tuberculosis Probable oxidoreductase 0.0061 0.1568 0.1598
Loa Loa (eye worm) oxidoreductase 0.0061 0.1568 0.1896
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0061 0.1568 0.3045
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0683 0.0761
Schistosoma mansoni aldehyde dehydrogenase 0.013 0.4264 0.4264
Mycobacterium tuberculosis Probable oxidoreductase 0.0061 0.1568 0.1598
Trypanosoma cruzi hypothetical protein, conserved 0.0061 0.1568 0.5353
Leishmania major pyruvate kinase 0.0034 0.0541 0.0395
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0061 0.1568 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0061 0.1568 0.3045
Trypanosoma cruzi short chain dehydrogenase, putative 0.0061 0.1568 0.5353
Loa Loa (eye worm) hypothetical protein 0.0061 0.1568 0.1896
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0221 0.7775 1
Mycobacterium ulcerans short-chain dehydrogenase 0.0061 0.1568 0.3045
Echinococcus multilocularis retinol dehydrogenase 11 0.0061 0.1568 0.1896
Mycobacterium ulcerans short chain dehydrogenase 0.0061 0.1568 0.3045
Leishmania major hypothetical protein, conserved 0.0061 0.1568 0.3045
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0683 0.2499
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.0061 0.1568 0.3045
Mycobacterium tuberculosis Probable reductase 0.0199 0.6916 0.8837
Leishmania major short chain dehydrogenase, putative 0.0061 0.1568 0.3045
Brugia malayi dehydrogenases, short chain protein 2 0.0061 0.1568 0.1896
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0061 0.1568 0.1896
Mycobacterium tuberculosis Decaprenylphosphoryl-D-2-keto erythro pentose reductase 0.0061 0.1568 0.1598
Echinococcus multilocularis oxidoreductase 0.0061 0.1568 0.1896
Trypanosoma brucei short-chain dehydrogenase, putative 0.0061 0.1568 0.5353
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0061 0.1568 1
Mycobacterium ulcerans dehydrogenase 0.0061 0.1568 0.3045
Schistosoma mansoni steroid dehydrogenase 0.0061 0.1568 0.1568
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0061 0.1568 0.1896
Mycobacterium ulcerans aldehyde dehydrogenase 0.013 0.4264 1
Trypanosoma brucei pyruvate kinase 1, putative 0.0034 0.0541 0.0695
Onchocerca volvulus 0.0048 0.1065 0.2724
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0061 0.1568 0.1896
Schistosoma mansoni steroid dehydrogenase 0.0061 0.1568 0.1568
Brugia malayi oxidoreductase 0.0061 0.1568 0.1896
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0061 0.1568 1
Loa Loa (eye worm) hypothetical protein 0.0233 0.827 1
Mycobacterium ulcerans ketoacyl reductase 0.0061 0.1568 0.3045
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.013 0.4264 0.5156
Mycobacterium ulcerans short chain dehydrogenase 0.0061 0.1568 0.3045
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0683 0.2499
Schistosoma mansoni pyruvate kinase 0.0034 0.0541 0.0541
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0022 0.0077 0.0093
Leishmania major quinonoid dihydropteridine reductase 0.0061 0.1568 0.3045
Echinococcus multilocularis carbonyl reductase 1 0.0061 0.1568 0.1896
Brugia malayi hypothetical protein 0.0121 0.3908 0.4725
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.003 0.0388 0.1495
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.0061 0.1568 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0061 0.1568 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0061 0.1568 0.1598
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0061 0.1568 0.3045
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0061 0.1568 0.5353
Mycobacterium ulcerans short chain dehydrogenase 0.0061 0.1568 0.3045
Mycobacterium ulcerans short-chain dehydrogenase 0.0061 0.1568 0.3045
Leishmania major quinonoid dihydropteridine reductase 0.0061 0.1568 0.3045
Loa Loa (eye worm) pyruvate kinase-PB 0.0024 0.0141 0.017
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.003 0.0388 0.0469
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0061 0.1568 0.5353
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.003 0.0388 0.0469
Giardia lamblia Hypothetical protein 0.0061 0.1568 1
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0683 0.2499
Loa Loa (eye worm) oxidoreductase 0.0061 0.1568 0.1896
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0061 0.1568 0.1896
Schistosoma mansoni short chain dehydrogenase 0.0061 0.1568 0.1568
Loa Loa (eye worm) oxidoreductase 0.0061 0.1568 0.1896
Echinococcus multilocularis carbonyl reductase 1 0.0061 0.1568 0.1896
Mycobacterium ulcerans short chain dehydrogenase 0.0061 0.1568 0.3045
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0061 0.1568 0.5353
Schistosoma mansoni inositol monophosphatase 0.0038 0.0683 0.0683
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0121 0.3894 0.4709
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0061 0.1568 0.3045
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0061 0.1568 0.5353
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0061 0.1568 0.6048
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0061 0.1568 0.5353
Echinococcus granulosus thioredoxin glutathione reductase 0.0088 0.2613 0.3159
Mycobacterium ulcerans short chain dehydrogenase 0.0061 0.1568 0.3045
Entamoeba histolytica hypothetical protein, conserved 0.0061 0.1568 1

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4.811 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.404 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.289 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.228 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.141 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.02 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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