Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Neuronal acetylcholine receptor protein alpha-7 subunit | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 1 | 1 |
Brugia malayi | Heterochromatin protein 1 | 0.0081 | 0.7516 | 0.7226 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0042 | 0.264 | 0.3265 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0026 | 0.0705 | 0.0441 |
Onchocerca volvulus | 0.0101 | 1 | 1 | |
Onchocerca volvulus | 0.0101 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.9133 | 0.9133 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1872 | 0.1872 |
Onchocerca volvulus | 0.0101 | 1 | 1 | |
Brugia malayi | Bromodomain containing protein | 0.0087 | 0.8286 | 0.8086 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0101 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0045 | 0.3091 | 0.2714 |
Echinococcus granulosus | chromobox protein 1 | 0.0081 | 0.7516 | 1 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0081 | 0.7516 | 0.7516 |
Echinococcus granulosus | chromobox protein 1 | 0.0081 | 0.7516 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0049 | 0.352 | 0.3419 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.7668 | 0.7668 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.3334 | 0.3334 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0101 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.0429 | 0.0157 |
Trichomonas vaginalis | chromobox protein, putative | 0.0081 | 0.7516 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0045 | 0.3091 | 0.2714 |
Brugia malayi | chromobox protein homolog 3 | 0.0045 | 0.3091 | 0.2283 |
Brugia malayi | Bromodomain containing protein | 0.0044 | 0.2982 | 0.2161 |
Schistosoma mansoni | chromobox protein | 0.0081 | 0.7516 | 0.7446 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0069 | 0.6075 | 0.801 |
Echinococcus multilocularis | chromobox protein 1 | 0.0081 | 0.7516 | 1 |
Schistosoma mansoni | chromobox protein | 0.0081 | 0.7516 | 0.7446 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0049 | 0.352 | 0.2028 |
Echinococcus multilocularis | chromobox protein 1 | 0.0081 | 0.7516 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 1 | 1 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0026 | 0.0705 | 0.0592 |
Schistosoma mansoni | bromodomain containing protein | 0.0073 | 0.6593 | 0.6496 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0026 | 0.0705 | 0.0592 |
Trichomonas vaginalis | chromobox protein, putative | 0.0049 | 0.352 | 0.3419 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0042 | 0.264 | 0.3265 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0024 | 0.0429 | 0.0429 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0045 | 0.3091 | 0.15 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.3091 | 0.3091 |
Trichomonas vaginalis | chromobox protein, putative | 0.0081 | 0.7516 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.3611 | 0.3611 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.2992 | 0.2992 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0069 | 0.6075 | 0.801 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Agonist activity at alpha1beta1deltagamma receptor in human TE671 cells by FLIPR assay | ChEMBL. | 22468936 | |
Activity (functional) | Antagonist activity at human 5HT3A receptor expressed in HEK293 cells | ChEMBL. | 22468936 | |
Activity (functional) | Agonist activity at human alpha3 receptor in SH-SY5Y cells | ChEMBL. | 22468936 | |
EC50 (functional) | = 1.22 uM | Agonist activity at rat alpha7 nAChR expressed in GH4C1 cells assessed as calcium influx measured every 1 sec for 1 min followed by every 30 secs for 10 mins by FLIPR assay | ChEMBL. | 22468936 |
Emax (functional) | = 83 % | Agonist activity at rat alpha7 nAChR expressed in GH4C1 cells assessed as calcium influx measured every 1 sec for 1 min followed by every 30 secs for 10 mins by FLIPR assay relative to nicotine | ChEMBL. | 22468936 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.