Detailed information for compound 167545

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 339.88 | Formula: C18H28ClN2O2-
  • H donors: 1 H acceptors: 1 LogP: 4.03 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(CCOC(=O)C1(CCCC1)c1ccc(cc1)N)CC.[Cl-]
  • InChi: 1S/C18H28N2O2.ClH/c1-3-20(4-2)13-14-22-17(21)18(11-5-6-12-18)15-7-9-16(19)10-8-15;/h7-10H,3-6,11-14,19H2,1-2H3;1H/p-1
  • InChiKey: IYZFNZSVUFXTFQ-UHFFFAOYSA-M  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.005 0.0093 0.0195
Entamoeba histolytica hypothetical protein 0.0256 0.1028 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.009 0.0266
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0093 0.0252
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.005 0.0093 0.0195
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0349 0.1451 0.352
Schistosoma mansoni tar DNA-binding protein 0.0273 0.1103 0.2934
Schistosoma mansoni hypothetical protein 0.0063 0.0151 0.0352
Onchocerca volvulus 0.0349 0.1451 0.6696
Loa Loa (eye worm) hypothetical protein 0.0131 0.0459 0.1187
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.005 0.0093 0.0113
Schistosoma mansoni hypothetical protein 0.0136 0.0483 0.1254
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0063 0.0151 0.0205
Loa Loa (eye worm) hypothetical protein 0.0199 0.077 0.2031
Echinococcus granulosus lamin 0.0109 0.0362 0.0537
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0052 0.014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.005 0.0093 0.0195
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.005 0.0093 0.0113
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0052 0.014
Echinococcus granulosus peptidase Clp S14 family 0.0052 0.01 0.0125
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0052 0.014
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0098 0.0311 1
Entamoeba histolytica acetyltransferase, GNAT family 0.0076 0.0211 0.1263
Echinococcus granulosus beta LACTamase domain containing family member 0.0349 0.1451 0.2255
Brugia malayi ecdysteroid receptor 0.005 0.0093 0.0195
Plasmodium vivax hypothetical protein, conserved 0.0349 0.1451 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0167 0.0624 0.4034
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.005 0.0093 0.0195
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0011 0.0029
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0201 0.0775 0.2045
Trichomonas vaginalis esterase, putative 0.0349 0.1451 0.3911
Loa Loa (eye worm) hypothetical protein 0.0051 0.0095 0.0201
Brugia malayi Calcitonin receptor-like protein seb-1 0.0199 0.077 0.2031
Schistosoma mansoni tar DNA-binding protein 0.0273 0.1103 0.2934
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.005 0.0093 0.0291
Schistosoma mansoni hypothetical protein 0.0063 0.0151 0.0352
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0349 0.1451 0.1364
Echinococcus granulosus lamin dm0 0.0109 0.0362 0.0537
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.005 0.0093 0.0195
Loa Loa (eye worm) hypothetical protein 0.0209 0.0815 0.2154
Echinococcus granulosus nuclear receptor 2DBD gamma 0.005 0.0093 0.0113
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0041 0.0112
Loa Loa (eye worm) hypothetical protein 0.0063 0.0151 0.0352
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0353 0.1469 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0349 0.1451 0.3911
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0063 0.0149 0.0201
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0069 0.0178 0.0886
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0079 0.0224 0.5
Schistosoma mansoni retinoic acid receptor RXR 0.005 0.0093 0.0195
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.005 0.0093 0.0113
Schistosoma mansoni RAR-like nuclear receptor 0.005 0.0093 0.0195
Brugia malayi hypothetical protein 0.0153 0.0559 0.146
Echinococcus multilocularis musashi 0.0109 0.0362 0.0537
Onchocerca volvulus 0.0349 0.1451 0.6696
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.005 0.0093 0.0195
Brugia malayi nuclear receptor NHR-88 0.005 0.0093 0.0195
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0061 0.0139 0.0615
Mycobacterium ulcerans glutaminase 0.0846 0.3709 1
Trichomonas vaginalis set domain proteins, putative 0.0497 0.2121 0.5718
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0083 0.0243 0.0725
Mycobacterium leprae conserved hypothetical protein 0.0349 0.1451 1
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0627 0.2711 0.4243
Echinococcus multilocularis GPCR, family 2 0.0063 0.0151 0.0205
Schistosoma mansoni hypothetical protein 0.0063 0.0151 0.0352
Loa Loa (eye worm) hypothetical protein 0.0107 0.0353 0.0899
Loa Loa (eye worm) hypothetical protein 0.005 0.0093 0.0195
Brugia malayi Nuclear hormone receptor family member nhr-3 0.005 0.0093 0.0195
Mycobacterium ulcerans esterase/lipase LipP 0.0349 0.1451 0.352
Brugia malayi hypothetical protein 0.0256 0.1028 0.273
Echinococcus multilocularis beta LACTamase domain containing family member 0.0349 0.1451 0.2255
Loa Loa (eye worm) hypothetical protein 0.005 0.0093 0.0195
Loa Loa (eye worm) MH2 domain-containing protein 0.0507 0.2165 0.5815
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.005 0.0093 0.0195
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0079 0.0224 0.5
Mycobacterium leprae Probable lipase LipE 0.0349 0.1451 1
Schistosoma mansoni thyroid hormone receptor 0.0677 0.294 0.7914
Trichomonas vaginalis D-aminoacylase, putative 0.0349 0.1451 0.3911
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.005 0.0093 0.0114
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.005 0.0093 0.0195
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.005 0.0093 0.0113
Loa Loa (eye worm) hypothetical protein 0.0051 0.0095 0.0201
Entamoeba histolytica hypothetical protein 0.0256 0.1028 1
Brugia malayi beta-lactamase family protein 0.0349 0.1451 0.3877
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0053 0.0104 0.0131
Brugia malayi beta-lactamase family protein 0.0349 0.1451 0.3877
Trichomonas vaginalis D-aminoacylase, putative 0.0349 0.1451 0.3911
Echinococcus multilocularis lamin dm0 0.0109 0.0362 0.0537
Brugia malayi Steroid receptor seven-up type 2 0.005 0.0093 0.0195
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0069 0.0178 0.0886
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0069 0.0178 0.0479
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.005 0.0093 0.0195
Brugia malayi Nuclear hormone receptor family member nhr-19 0.005 0.0093 0.0195
Loa Loa (eye worm) latrophilin receptor protein 2 0.0063 0.0151 0.0352
Brugia malayi Nuclear hormone receptor family member nhr-31 0.005 0.0093 0.0195
Loa Loa (eye worm) TAR-binding protein 0.0273 0.1103 0.2934
Schistosoma mansoni glutaminase 0.0846 0.3709 1
Onchocerca volvulus 0.0109 0.0362 0.1326
Brugia malayi Intermediate filament tail domain containing protein 0.0109 0.0362 0.0924
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0022 0.006
Giardia lamblia GTOR 0.005 0.0093 0.0275
Schistosoma mansoni tar DNA-binding protein 0.0273 0.1103 0.2934
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0201 0.0775 0.5104
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.005 0.0093 0.0195
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0131 0.0459 0.0691
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0041 0.0112
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.006 0.0138 0.0185
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0256 0.1028 0.1588
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0174 0.0655 0.1719
Echinococcus granulosus histone lysine methyltransferase setb 0.0063 0.0149 0.0201
Entamoeba histolytica hypothetical protein 0.0256 0.1028 1
Trypanosoma cruzi hypothetical protein, conserved 0.0349 0.1451 0.9872
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0349 0.1451 0.1364
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0079 0.0224 0.0917
Entamoeba histolytica hypothetical protein 0.016 0.0592 0.5335
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0283 0.1152 0.1784
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.005 0.0093 0.0196
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0063 0.0151 0.0205
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0273 0.1103 0.2934
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0059 0.0131 0.0297
Mycobacterium tuberculosis Conserved protein 0.0349 0.1451 0.1364
Echinococcus multilocularis tumor protein p63 0.143 0.6361 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.005 0.0093 0.0113
Loa Loa (eye worm) acetyltransferase 0.0283 0.1152 0.3067
Loa Loa (eye worm) hypothetical protein 0.005 0.0093 0.0195
Loa Loa (eye worm) transcription factor SMAD2 0.0507 0.2165 0.5815
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0349 0.1451 0.3877
Trypanosoma cruzi hypothetical protein, conserved 0.0349 0.1451 0.9872
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0069 0.0178 0.0479
Echinococcus multilocularis lamin 0.0109 0.0362 0.0537
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0063 0.0151 0.0352
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0063 0.0149 0.076
Brugia malayi Nuclear hormone receptor family member nhr-25 0.005 0.0093 0.0195
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.005 0.0093 0.0196
Schistosoma mansoni intermediate filament proteins 0.0109 0.0362 0.0924
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.005 0.009 0.0266
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0012 0.0032
Echinococcus multilocularis peptidase Clp (S14 family) 0.0052 0.01 0.0125
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.005 0.0093 0.0113
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0375 0.1566 0.419
Brugia malayi Nuclear hormone receptor family member nhr-19 0.005 0.0093 0.0195
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.005 0.0093 0.0114
Toxoplasma gondii ABC1 family protein 0.0349 0.1451 1
Mycobacterium ulcerans lipase LipD 0.0349 0.1451 0.352
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0041 0.0112
Schistosoma mansoni hypothetical protein 0.0627 0.2711 0.7295
Loa Loa (eye worm) hypothetical protein 0.0063 0.0149 0.0346
Loa Loa (eye worm) hypothetical protein 0.0136 0.0483 0.1254
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0375 0.1566 0.2437
Brugia malayi Nuclear hormone receptor family member nhr-14 0.005 0.0093 0.0195
Mycobacterium tuberculosis Conserved hypothetical protein 0.0186 0.0709 0.0616
Onchocerca volvulus 0.0209 0.0815 0.3562
Loa Loa (eye worm) hypothetical protein 0.0349 0.1451 0.3877
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0079 0.0224 0.032
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0201 0.0775 0.5104
Giardia lamblia Histone acetyltransferase GCN5 0.0076 0.0211 0.5559
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0353 0.1469 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0069 0.0178 0.0479
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.005 0.0093 0.0291
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.005 0.0093 0.0113
Toxoplasma gondii hypothetical protein 0.0057 0.0123 0.0579
Echinococcus multilocularis ecdysone induced protein 78C 0.005 0.0093 0.0113
Echinococcus granulosus nuclear receptor 2DBD gamma 0.005 0.0093 0.0113
Mycobacterium tuberculosis Conserved protein 0.0349 0.1451 0.1364
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0349 0.1451 0.1364
Brugia malayi latrophilin 2 splice variant baaae 0.0136 0.0483 0.1254
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0079 0.0224 0.5
Brugia malayi nuclear hormone receptor 0.005 0.0093 0.0195
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0201 0.0775 0.209
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.005 0.0093 0.0291
Loa Loa (eye worm) hypothetical protein 0.005 0.0093 0.0195
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.005 0.009 0.0266
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0149 0.0346
Loa Loa (eye worm) phosphatidylinositol 3 0.005 0.0093 0.0196
Brugia malayi Pre-SET motif family protein 0.0063 0.0149 0.0346
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0436 0.1847 0.4951
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0192 0.0736 0.6873
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0201 0.0775 0.209
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0139 0.0494 0.1332
Loa Loa (eye worm) hypothetical protein 0.0349 0.1451 0.3877
Onchocerca volvulus 0.0497 0.2121 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0052 0.014
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.005 0.0093 0.0113
Echinococcus granulosus ecdysone induced protein 78C 0.005 0.0093 0.0113
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0041 0.0112
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.005 0.0093 0.0291
Echinococcus granulosus tumor protein p63 0.143 0.6361 1
Brugia malayi Latrophilin receptor protein 2 0.0063 0.0151 0.0352
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0199 0.077 0.2031
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0131 0.0459 0.0691
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0093 0.0252
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.005 0.0093 0.0291
Schistosoma mansoni cellular tumor antigen P53 0.0209 0.0815 0.2154
Loa Loa (eye worm) hypothetical protein 0.005 0.0093 0.0195
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0069 0.0178 0.0425
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0139 0.0494 0.1332
Brugia malayi steroid hormone receptor 0.005 0.0093 0.0195
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0053 0.0104 0.0131
Trichomonas vaginalis glutaminase, putative 0.0846 0.3709 1
Mycobacterium tuberculosis Probable lipase LipE 0.0349 0.1451 0.1364
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0063 0.0151 0.0205
Loa Loa (eye worm) intermediate filament protein 0.0109 0.0362 0.0924
Mycobacterium ulcerans hypothetical protein 0.0349 0.1451 0.352
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0063 0.0149 0.0201
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0064 0.0172
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0627 0.2711 0.4243
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0069 0.0178 0.0902
Schistosoma mansoni retinoid-x-receptor (RXR) 0.005 0.0093 0.0195
Trichomonas vaginalis bromodomain-containing protein, putative 0.0083 0.0243 0.0655
Brugia malayi beta-lactamase 0.0349 0.1451 0.3877
Echinococcus granulosus GPCR family 2 0.0063 0.0151 0.0205
Leishmania major mitochondrial DNA polymerase beta 0.0353 0.1469 1
Schistosoma mansoni thyroid hormone receptor 0.0677 0.294 0.7914
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0091 0.0275 0.1949
Loa Loa (eye worm) hypothetical protein 0.0053 0.0104 0.0226
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0375 0.1566 0.2437
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0109 0.0362 0.0924
Echinococcus granulosus histone acetyltransferase KAT2B 0.0083 0.0243 0.035
Schistosoma mansoni coup transcription factor 0.005 0.0093 0.0195
Brugia malayi Nuclear hormone receptor family member nhr-40 0.005 0.0093 0.0195
Schistosoma mansoni transcription factor LCR-F1 0.0256 0.1028 0.273
Brugia malayi TAR-binding protein 0.0273 0.1103 0.2934
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0201 0.0775 0.7297
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0041 0.0112
Brugia malayi photoreceptor-specific nuclear receptor 0.005 0.0093 0.0195
Loa Loa (eye worm) hypothetical protein 0.0349 0.1451 0.3877
Onchocerca volvulus 0.0153 0.0559 0.23
Mycobacterium ulcerans hypothetical protein 0.0186 0.0709 0.1393
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.016 0.0592 0.5335
Brugia malayi Nuclear hormone receptor family member nhr-1 0.005 0.0093 0.0195
Schistosoma mansoni Tr4/Tr2 (homologue) 0.005 0.0093 0.0195
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0283 0.1152 0.3067
Mycobacterium tuberculosis Probable hydrolase 0.0349 0.1451 0.1364
Echinococcus granulosus histone acetyltransferase KAT2B 0.0276 0.1116 0.1727
Brugia malayi acetyltransferase, GNAT family protein 0.0283 0.1152 0.3067
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0012 0.0032
Loa Loa (eye worm) hypothetical protein 0.005 0.0093 0.0195
Loa Loa (eye worm) beta-lactamase 0.0349 0.1451 0.3877
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0167 0.0624 0.4034
Loa Loa (eye worm) hypothetical protein 0.0349 0.1451 0.3877
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0201 0.0775 0.209
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.006 0.0138 0.0606
Brugia malayi Nuclear hormone receptor family member nhr-41 0.005 0.0093 0.0195
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0349 0.1451 0.3877
Loa Loa (eye worm) hypothetical protein 0.0079 0.0224 0.055
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0079 0.0224 0.032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0027 0.0072
Loa Loa (eye worm) hypothetical protein 0.0153 0.0559 0.146
Loa Loa (eye worm) glutaminase 0.0846 0.3709 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0079 0.0224 0.1294
Brugia malayi RNA recognition motif domain containing protein 0.0273 0.1103 0.2934
Loa Loa (eye worm) hypothetical protein 0.005 0.0093 0.0195
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0083 0.0243 0.0655
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0079 0.0224 0.1294
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0079 0.0224 0.0578
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0069 0.0178 0.0425
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0149 0.0346
Brugia malayi glutaminase DH11.1 0.0846 0.3709 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.005 0.0093 0.0195
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.005 0.0093 0.0195
Echinococcus multilocularis tar DNA binding protein 0.0273 0.1103 0.1706
Schistosoma mansoni hypothetical protein 0.0256 0.1028 0.273
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.005 0.0093 0.0195
Trichomonas vaginalis penicillin-binding protein, putative 0.0349 0.1451 0.3911
Mycobacterium tuberculosis Probable esterase LipL 0.0349 0.1451 0.1364
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.005 0.0093 0.0113
Schistosoma mansoni tar DNA-binding protein 0.0273 0.1103 0.2934
Echinococcus multilocularis FTZ F1 alpha 0.005 0.0093 0.0113
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.005 0.0093 0.0195
Onchocerca volvulus 0.0349 0.1451 0.6696
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0052 0.014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0041 0.0112
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0167 0.0624 0.4034
Loa Loa (eye worm) hypothetical protein 0.0349 0.1451 0.3877
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0041 0.0112
Leishmania major hypothetical protein, conserved 0.0349 0.1451 0.9872
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0079 0.0224 0.5
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0083 0.0243 0.143
Brugia malayi Nuclear hormone receptor family member nhr-49 0.005 0.0093 0.0195
Trypanosoma brucei DNA polymerase beta thumb, putative 0.005 0.009 0.0266
Schistosoma mansoni lamin 0.0109 0.0362 0.0924
Loa Loa (eye worm) phosphatidylinositol 3 0.0334 0.1383 0.3692
Schistosoma mansoni peptidase Clp (S14 family) 0.0079 0.0224 0.055
Onchocerca volvulus 0.0063 0.0149 0.0275
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.005 0.0093 0.0291
Echinococcus granulosus intermediate filament protein 0.0109 0.0362 0.0537
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0012 0.0032
Entamoeba histolytica hypothetical protein 0.0256 0.1028 1
Echinococcus granulosus tar DNA binding protein 0.0273 0.1103 0.1706
Loa Loa (eye worm) steroid hormone receptor 0.005 0.0093 0.0195
Brugia malayi RNA binding protein 0.0273 0.1103 0.2934
Loa Loa (eye worm) hypothetical protein 0.0349 0.1451 0.3877
Brugia malayi cytoplasmic intermediate filament protein 0.0059 0.0131 0.0297
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0349 0.1451 0.3877
Loa Loa (eye worm) hypothetical protein 0.0109 0.0362 0.0924
Schistosoma mansoni steroid hormone receptor ad4bp 0.005 0.0093 0.0195
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0349 0.1451 0.3877
Brugia malayi intermediate filament protein 0.0109 0.0362 0.0924
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0083 0.0243 0.143
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0093 0.0252
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0011 0.0029
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0149 0.0346
Brugia malayi Pre-SET motif family protein 0.0436 0.1847 0.4951
Loa Loa (eye worm) glutaminase 2 0.0846 0.3709 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.005 0.0093 0.0113
Mycobacterium tuberculosis Probable lipase LipD 0.0349 0.1451 0.1364
Loa Loa (eye worm) RNA binding protein 0.0273 0.1103 0.2934
Brugia malayi Nuclear hormone receptor-like 1 0.005 0.0093 0.0195
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0063 0.0149 0.0346
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0079 0.0224 1
Brugia malayi MH2 domain containing protein 0.0507 0.2165 0.5815
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0256 0.1028 0.1588
Loa Loa (eye worm) hypothetical protein 0.007 0.0181 0.0433
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0131 0.0459 0.1187
Schistosoma mansoni lamin 0.0109 0.0362 0.0924
Echinococcus granulosus FTZ F1 alpha 0.005 0.0093 0.0113
Schistosoma mansoni nuclear hormone receptor 0.005 0.0093 0.0195
Trichomonas vaginalis D-aminoacylase, putative 0.0349 0.1451 0.3911
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0199 0.077 0.2031
Schistosoma mansoni hypothetical protein 0.0063 0.0151 0.0352
Loa Loa (eye worm) phosphatidylinositol 3 0.006 0.0138 0.0317
Mycobacterium tuberculosis Conserved protein 0.0349 0.1451 0.1364
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.005 0.0093 0.0195
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0353 0.1469 1
Brugia malayi Probable ClpP-like protease 0.0079 0.0224 0.055
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0069 0.0178 0.0902
Mycobacterium ulcerans beta-lactamase 0.0349 0.1451 0.352
Echinococcus multilocularis thyroid hormone receptor alpha 0.0677 0.294 0.4603
Trypanosoma brucei hypothetical protein, conserved 0.0349 0.1451 0.9872
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0063 0.0151 0.0205
Onchocerca volvulus 0.0109 0.0362 0.1326
Schistosoma mansoni tar DNA-binding protein 0.0273 0.1103 0.2934
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.005 0.0093 0.0113

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 20 nM Displacement of [3H]-pirenzepine from muscarinic acetylcholine receptor M1 in rat cortex homogenates ChEMBL. 1920350
Ki (binding) = 116 nM Displacement of [3H]-(-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates ChEMBL. 1920350
Selectivity (binding) = 6 Ratio of Ki (M1 receptor) to Ki (M2 receptor) was determined ChEMBL. 1920350

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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