Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | CMGC family protein kinase | 0.0121 | 1 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0121 | 1 | 1 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0014 | 0.0301 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0121 | 1 | 1 |
Echinococcus multilocularis | multidrug resistance associated protein 1 | 0.0014 | 0.0301 | 0.0301 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0121 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0121 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.6711 | 0.6707 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0121 | 1 | 0.5 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0014 | 0.0301 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0301 | 0.0291 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0121 | 1 | 1 |
Loa Loa (eye worm) | ABC transporter transmembrane region family protein | 0.0014 | 0.0301 | 0.0291 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.0085 | 0.6711 | 0.6707 |
Entamoeba histolytica | hypothetical protein | 0.0014 | 0.0301 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0085 | 0.6711 | 0.6609 |
Echinococcus multilocularis | multidrug resistance associated protein 7 | 0.0014 | 0.0301 | 0.0301 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0121 | 1 | 1 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0121 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0301 | 0.0291 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0121 | 1 | 0.5 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0014 | 0.0301 | 0.5 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0014 | 0.0301 | 0.5 |
Trypanosoma cruzi | multidrug resistance protein E, putative | 0.0014 | 0.0301 | 0.0301 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.029 | 0.028 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.6711 | 0.6707 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0121 | 1 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0121 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0121 | 1 | 1 |
Echinococcus granulosus | multidrug resistance associated protein 1 | 0.0014 | 0.0301 | 0.0301 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0121 | 1 | 1 |
Giardia lamblia | Multidrug resistance-associated protein 1 | 0.0014 | 0.0301 | 0.0011 |
Trypanosoma cruzi | multidrug resistance-associated protein, putative | 0.0014 | 0.0301 | 0.0301 |
Trypanosoma cruzi | multidrug resistance-associated protein, putative | 0.0014 | 0.0301 | 0.0301 |
Entamoeba histolytica | multidrug resistance protein, putative | 0.0014 | 0.0301 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0121 | 1 | 1 |
Echinococcus granulosus | multidrug resistance associated protein 7 | 0.0014 | 0.0301 | 0.0301 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0121 | 1 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0121 | 1 | 1 |
Giardia lamblia | ABC transporter, putative | 0.0014 | 0.0301 | 0.0011 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0121 | 1 | 1 |
Trypanosoma brucei | protein kinase, putative | 0.0121 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0121 | 1 | 1 |
Entamoeba histolytica | ABC transporter, putative | 0.0014 | 0.0301 | 0.5 |
Giardia lamblia | MRP-like ABC transporter | 0.0014 | 0.0301 | 0.0011 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.6711 | 0.6707 |
Giardia lamblia | Multidrug resistance-associated protein 1 | 0.0014 | 0.0301 | 0.0011 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 100 uM | Compound was evaluated for the cytotoxicity scored on HFF cells at time of HCMV plaque enumeration. | ChEMBL. | 9575044 |
IC50 (functional) | > 100 uM | Compound was evaluated for the cytotoxicity by the inhibition of KB cell growth. | ChEMBL. | 9575044 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.