Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.017 | 0.0524 | 0.0524 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0636 | 0.4055 | 0.3727 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0301 | 0.1514 | 0.1514 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.0524 | 0.0486 |
Loa Loa (eye worm) | excitatory GABA receptor EXP-1A | 0.017 | 0.0524 | 0.0486 |
Trypanosoma brucei | protein kinase, putative | 0.0811 | 0.5379 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.0524 | 0.0486 |
Brugia malayi | phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative | 0.0265 | 0.1242 | 0.1242 |
Brugia malayi | nicotinic acetylcholine receptor beta-1 chain precursor | 0.017 | 0.0524 | 0.0524 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.017 | 0.0524 | 0.0524 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.0524 | 0.0486 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0811 | 0.5379 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.0524 | 0.0486 |
Echinococcus multilocularis | phosphatidylinositol 4,5 bisphosphate 3 kinase | 0.0565 | 0.3517 | 0.3158 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.1 | 0.0964 |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.1593 | 0.1559 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0811 | 0.5379 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0195 | 0.0712 | 0.0675 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.0524 | 0.0486 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0811 | 0.5379 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0239 | 0.1049 | 0.6931 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0504 | 0.3052 | 0.3024 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0311 | 0.1593 | 0.1593 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0811 | 0.5379 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.0524 | 0.0486 |
Trichomonas vaginalis | phosphatidylinositol kinase, putative | 0.0301 | 0.1514 | 0.2814 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0239 | 0.1049 | 0.6931 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.017 | 0.0524 | 0.0524 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.017 | 0.0524 | 0.0524 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1422 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.0524 | 0.0486 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0301 | 0.1514 | 1 |
Schistosoma mansoni | nAChR subunit | 0.017 | 0.0524 | 0.0524 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase class, putative | 0.0206 | 0.0801 | 0.149 |
Onchocerca volvulus | 0.0311 | 0.1593 | 1 | |
Echinococcus multilocularis | phosphatidylinositol 4 phosphate 3 kinase C2 | 0.0195 | 0.0712 | 0.0199 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative | 0.0206 | 0.0801 | 0.149 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.017 | 0.0524 | 0.0524 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit gamma, putative | 0.0301 | 0.1514 | 0.2814 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.017 | 0.0524 | 0.0524 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0811 | 0.5379 | 0.536 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.017 | 0.0524 | 0.0486 |
Trichomonas vaginalis | phopsphatidylinositol 3-kinase, drosophila, putative | 0.0301 | 0.1514 | 0.2814 |
Brugia malayi | acetylcholine receptor, alpha-type subunit unc-38 precursor | 0.017 | 0.0524 | 0.0524 |
Onchocerca volvulus | 0.0311 | 0.1593 | 1 | |
Schistosoma mansoni | nAChR subunit | 0.017 | 0.0524 | 0.0524 |
Loa Loa (eye worm) | glutamate-gated chloride channel alpha3A subunit | 0.017 | 0.0524 | 0.0486 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0301 | 0.1514 | 0.2814 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0811 | 0.5379 | 0.5123 |
Loa Loa (eye worm) | LGC-31 protein | 0.017 | 0.0524 | 0.0486 |
Loa Loa (eye worm) | CMGC/MAPK/JNK protein kinase | 0.1422 | 1 | 1 |
Brugia malayi | Cation transporter family protein | 0.017 | 0.0524 | 0.0524 |
Schistosoma mansoni | phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K | 0.0565 | 0.3517 | 0.3517 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0811 | 0.5379 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0811 | 0.5379 | 1 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0636 | 0.4055 | 0.3727 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.0524 | 0.0486 |
Loa Loa (eye worm) | acetylcholine receptor alpha subunit | 0.017 | 0.0524 | 0.0486 |
Loa Loa (eye worm) | ACC-1 protein | 0.017 | 0.0524 | 0.0486 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0811 | 0.5379 | 0.5 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0301 | 0.1514 | 0.2814 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0811 | 0.5379 | 0.5 |
Onchocerca volvulus | 0.0311 | 0.1593 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.1593 | 0.1559 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.017 | 0.0524 | 0.0524 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.0524 | 0.0486 |
Echinococcus multilocularis | c Jun NH2 terminal kinase | 0.1422 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.0524 | 0.0486 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor non-alpha subunit | 0.017 | 0.0524 | 0.0486 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.017 | 0.0524 | 0.0524 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0811 | 0.5379 | 0.5 |
Loa Loa (eye worm) | ligand-Gated ion Channel family member | 0.017 | 0.0524 | 0.0486 |
Brugia malayi | MAP kinase sur-1 | 0.0811 | 0.5379 | 0.5379 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0811 | 0.5379 | 1 |
Schistosoma mansoni | nAChR subunit | 0.017 | 0.0524 | 0.0524 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0133 | 0.0248 | 0.1637 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.017 | 0.0524 | 0.0524 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.017 | 0.0524 | 0.0524 |
Schistosoma mansoni | nAChR subunit | 0.017 | 0.0524 | 0.0524 |
Brugia malayi | Cation transporter family protein | 0.017 | 0.0524 | 0.0524 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.0524 | 0.0486 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.017 | 0.0524 | 0.0524 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.017 | 0.0524 | 0.0524 |
Echinococcus granulosus | phosphatidylinositol 45 bisphosphate 3 kinase | 0.0565 | 0.3517 | 0.3158 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0811 | 0.5379 | 1 |
Schistosoma mansoni | nAChR subunit | 0.017 | 0.0524 | 0.0524 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.0524 | 0.0486 |
Echinococcus granulosus | phosphatidylinositol 4 phosphate 3 kinase C2 | 0.0195 | 0.0712 | 0.0199 |
Echinococcus granulosus | c-Jun N-terminal kinases | 0.1422 | 1 | 1 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0811 | 0.5379 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0811 | 0.5379 | 0.5123 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0811 | 0.5379 | 0.5123 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0811 | 0.5379 | 0.5123 |
Brugia malayi | Cation transporter family protein | 0.0311 | 0.1593 | 0.1593 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0811 | 0.5379 | 1 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta2-like) | 0.017 | 0.0524 | 0.0524 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.017 | 0.0524 | 0.0524 |
Schistosoma mansoni | nAChR subunit | 0.017 | 0.0524 | 0.0524 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.0524 | 0.0486 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0811 | 0.5379 | 0.5379 |
Entamoeba histolytica | phosphatidylinositol 3-kinase 1, putative | 0.0292 | 0.1446 | 0.9555 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.0524 | 0.0486 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0195 | 0.0712 | 0.0712 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.0524 | 0.0486 |
Brugia malayi | acetylcholine receptor protein, alpha-like chain, putative | 0.017 | 0.0524 | 0.0524 |
Loa Loa (eye worm) | ACC-1 protein | 0.017 | 0.0524 | 0.0486 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.0524 | 0.0486 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.0524 | 0.0486 |
Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.017 | 0.0524 | 0.0524 |
Schistosoma mansoni | nAChR subunit | 0.017 | 0.0524 | 0.0524 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0311 | 0.1593 | 0.1593 |
Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | 0.017 | 0.0524 | 0.0524 |
Brugia malayi | acetylcholine receptor alpha subunit precursor, putative | 0.017 | 0.0524 | 0.0524 |
Brugia malayi | excitatory GABA receptor EXP-1A | 0.017 | 0.0524 | 0.0524 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.