Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0065 | 0.1322 | 1 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0246 | 0.6454 | 1 |
Echinococcus granulosus | Thymidine kinase 2 mitochondrial | 0.024 | 0.6285 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0065 | 0.1322 | 0.2103 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0065 | 0.1322 | 0.2103 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0065 | 0.1322 | 0.2103 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0065 | 0.1322 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0134 | 0.3277 | 0.5214 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0246 | 0.6454 | 1 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0246 | 0.6454 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0065 | 0.1322 | 1 |
Echinococcus multilocularis | thymidine kinase | 0.024 | 0.6285 | 1 |
Echinococcus granulosus | thymidine kinase | 0.024 | 0.6285 | 1 |
Echinococcus granulosus | geminin | 0.0184 | 0.4709 | 0.7492 |
Schistosoma mansoni | thyroid hormone receptor | 0.0134 | 0.3277 | 0.5214 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0065 | 0.1322 | 1 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0124 | 0.2995 | 0.4765 |
Schistosoma mansoni | hypothetical protein | 0.0184 | 0.4709 | 0.7492 |
Schistosoma mansoni | hypothetical protein | 0.0184 | 0.4709 | 0.7492 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0246 | 0.6454 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.092 | 0.1464 |
Echinococcus granulosus | thymidine kinase | 0.024 | 0.6285 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0124 | 0.2995 | 0.4765 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0 | 0.5 |
Trypanosoma brucei | thymidine kinase | 0.0246 | 0.6454 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0 | 0.5 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0246 | 0.6454 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0065 | 0.1322 | 1 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0124 | 0.2995 | 0.4765 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0065 | 0.1322 | 0.2048 |
Schistosoma mansoni | thyroid hormone receptor | 0.0134 | 0.3277 | 0.5214 |
Giardia lamblia | Thymidine kinase | 0.0246 | 0.6454 | 0.6454 |
Entamoeba histolytica | thymidine kinase, putative | 0.0246 | 0.6454 | 1 |
Echinococcus multilocularis | transfer RNA-Ile | 0.024 | 0.6285 | 1 |
Echinococcus multilocularis | geminin | 0.0184 | 0.4709 | 0.7492 |
Schistosoma mansoni | thymidine kinase | 0.024 | 0.6285 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0065 | 0.1322 | 0.2103 |
Echinococcus multilocularis | thymidine kinase | 0.024 | 0.6285 | 1 |
Leishmania major | thymidine kinase, putative | 0.0246 | 0.6454 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 65 uM | Compound was evaluated for the cytotoxicity by the inhibition of KB cell growth. | ChEMBL. | 9575044 |
IC50 (functional) | = 100 uM | Compound was evaluated for the cytotoxicity scored on HFF cells at time of HCMV plaque enumeration. | ChEMBL. | 9575044 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.