Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Cytochrome P450 family protein | 0.0014 | 1 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0014 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0014 | 1 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0014 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0014 | 1 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0014 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0014 | 1 | 0.5 |
Trypanosoma brucei | cytochrome P450, putative | 0.0014 | 1 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0014 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 29 uM | Cytotoxicity against human SKBR3 cells after 48 hrs by MTT assay | ChEMBL. | 22559865 |
IC50 (functional) | = 29 uM | Cytotoxicity against human SKBR3 cells after 48 hrs by MTT assay | ChEMBL. | 21726077 |
Inhibition (binding) | = 69 % | Inhibition of FASN in human SK-BR-3 cells assessed as oxidation of NADPH at 29 uM after 24 hrs by Spectrophotometric analysis relative to control | ChEMBL. | 22559865 |
Inhibition (binding) | = 69 % | Inhibition of FASN in human SKBR3 cells at 29 uM after 3 mins by spectrophotometric analysis relative to control | ChEMBL. | 21726077 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.