Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | cytochrome p450-like protein | 0.0014 | 1 | 0.5 |
Trypanosoma brucei | cytochrome P450, putative | 0.0014 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0014 | 1 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0014 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0014 | 1 | 0.5 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0014 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0014 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0014 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0014 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 26 uM | Cytotoxicity against human SKBR3 cells after 48 hrs by MTT assay | ChEMBL. | 22559865 |
Inhibition (binding) | = 30 % | Inhibition of FASN in human SK-BR-3 cells assessed as oxidation of NADPH at 26 uM after 24 hrs by Spectrophotometric analysis relative to control | ChEMBL. | 22559865 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.