Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | kinase insert domain protein receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Onchocerca volvulus | Get druggable targets OG5_130320 | All targets in OG5_130320 | |
Onchocerca volvulus | Tyrosine kinase homolog | Get druggable targets OG5_130320 | All targets in OG5_130320 |
Brugia malayi | Immunoglobulin I-set domain containing protein | Get druggable targets OG5_130320 | All targets in OG5_130320 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | Get druggable targets OG5_130320 | All targets in OG5_130320 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | transcription factor LCR-F1 | 0.0038 | 0.0301 | 0.0301 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0002 | 0.0002 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.0507 | 0.0517 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0719 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0273 | 0.0273 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0071 | 0.0781 | 0.0796 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.0781 | 0.0781 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 0.0301 | 0.0301 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0016 | 0.0002 | 0.0002 |
Echinococcus granulosus | dihydrofolate reductase | 0.0706 | 0.9808 | 0.9808 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0507 | 0.0517 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0002 | 0.0002 |
Brugia malayi | RNA binding protein | 0.0071 | 0.0781 | 0.0796 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.0507 | 0.0517 |
Schistosoma mansoni | hypothetical protein | 0.0131 | 0.1634 | 0.1634 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0706 | 0.9808 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0706 | 0.9808 | 0.5 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0131 | 0.1634 | 0.1634 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0428 | 0.586 | 0.5975 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0706 | 0.9808 | 0.5 |
Onchocerca volvulus | 0.0417 | 0.5693 | 0.9763 | |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0002 | 0.0002 |
Echinococcus multilocularis | GPCR, family 2 | 0.0016 | 0.0002 | 0.0002 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.0781 | 0.0781 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0131 | 0.1634 | 0.1634 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0426 | 0.5832 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0016 | 0.0002 | 0.0002 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0142 | 0.1784 | 0.1784 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0002 | 0.0002 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0301 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0016 | 0.0002 | 0.0002 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.027 | 0.3607 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0301 | 0.0301 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0273 | 0.0278 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.0781 | 0.0781 |
Schistosoma mansoni | tyrosine kinase | 0.0019 | 0.0036 | 0.0036 |
Echinococcus granulosus | tar DNA binding protein | 0.0071 | 0.0781 | 0.0781 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0301 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0142 | 0.1784 | 0.1784 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0428 | 0.586 | 0.5975 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.0781 | 0.0781 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.0781 | 0.0781 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 0.0301 | 0.0301 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.0507 | 0.0517 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.0273 | 0.0278 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0706 | 0.9808 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.0706 | 0.9808 | 0.9808 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0706 | 0.9808 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.0706 | 0.9808 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 0.0706 | 0.9808 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.027 | 0.3607 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0071 | 0.0781 | 0.0796 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0002 | 0.0002 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0301 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0706 | 0.9808 | 0.9808 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0301 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0002 | 0.0002 |
Echinococcus multilocularis | tar DNA binding protein | 0.0071 | 0.0781 | 0.0781 |
Loa Loa (eye worm) | TAR-binding protein | 0.0071 | 0.0781 | 0.0796 |
Loa Loa (eye worm) | RNA binding protein | 0.0071 | 0.0781 | 0.0796 |
Brugia malayi | hypothetical protein | 0.0038 | 0.0301 | 0.0307 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.027 | 0.3607 | 0.5 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0719 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.027 | 0.3607 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0002 | 0.0002 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0002 | 0.0002 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.027 | 0.3607 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.027 | 0.3607 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0002 | 0.0002 |
Schistosoma mansoni | thyroid hormone receptor | 0.0142 | 0.1784 | 0.1784 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0071 | 0.0781 | 0.0796 |
Echinococcus granulosus | GPCR family 2 | 0.0016 | 0.0002 | 0.0002 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.35 | Inhibitory activity against vascular endothelial growth factor receptor 2 (FLK1) | ChEMBL. | 10956210 |
Log IC50 (binding) | = 5.35 | Inhibitory activity against vascular endothelial growth factor receptor 2 (FLK1) | ChEMBL. | 10956210 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.