Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.7319 | 0.724 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.2772 | 0.2772 |
Brugia malayi | TAR-binding protein | 0.0063 | 1 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.2772 | 0.2772 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.7319 | 0.7319 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0016 | 0.0548 | 0.0548 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.2772 | 0.2772 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0014 | 0.0285 | 0.0285 |
Echinococcus multilocularis | tar DNA binding protein | 0.0063 | 1 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0548 | 0.0548 |
Schistosoma mansoni | lamin | 0.0027 | 0.2772 | 0.2353 |
Loa Loa (eye worm) | RNA binding protein | 0.0063 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0063 | 1 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0548 | 0.0548 |
Onchocerca volvulus | 0.0027 | 0.2772 | 0.5 | |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0016 | 0.0548 | 0.0271 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0063 | 1 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0548 | 0.0548 |
Loa Loa (eye worm) | TAR-binding protein | 0.0063 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0063 | 1 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0016 | 0.0548 | 0.0271 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.7319 | 0.7319 |
Echinococcus multilocularis | lamin | 0.0027 | 0.2772 | 0.2772 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.2772 | 0.2561 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.2772 | 0.2561 |
Echinococcus granulosus | lamin | 0.0027 | 0.2772 | 0.2772 |
Echinococcus granulosus | GPCR family 2 | 0.0016 | 0.0548 | 0.0548 |
Echinococcus multilocularis | musashi | 0.0027 | 0.2772 | 0.2772 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.4185 | 0.3848 |
Onchocerca volvulus | 0.0027 | 0.2772 | 0.5 | |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.2772 | 0.2772 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.4185 | 0.4185 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.4185 | 0.4015 |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 0.2772 | 0.2353 |
Schistosoma mansoni | lamin | 0.0027 | 0.2772 | 0.2353 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.2772 | 0.2772 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0548 | 0.0548 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.2674 | 0.2674 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0548 | 0.0548 |
Echinococcus multilocularis | GPCR, family 2 | 0.0016 | 0.0548 | 0.0548 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.2772 | 0.2772 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.7319 | 0.724 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 45 % | Inhibition of human MRP1 mediated uptake of [3H]E2-17betaG in HEK cell membrane vesicles at 30 uM by liquid scintillation counting relative to control | ChEMBL. | 22533905 |
Km (binding) | = 30 uM | Induction of ATPase activity of human His10-tagged P-gp expressed in BHK cells assessed as inorganic phosphate release after 30 mins by Michaelis-Menten analysis | ChEMBL. | 22533905 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.