Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0036 | 0 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 0.8604 | 0.8604 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0036 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.8604 | 0.8604 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.8604 | 1 |
Entamoeba histolytica | ubiquitin carboxyl-terminal hydrolase domain containing protein | 0.0036 | 0 | 0.5 |
Trypanosoma brucei | ubiquitin carboxyl-terminal hydrolase, putative | 0.0036 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.8604 | 0.8604 |
Leishmania major | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative | 0.0036 | 0 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.8604 | 1 |
Schistosoma mansoni | P2X receptor subunit | 0.0066 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0036 | 0 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.8604 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 0.8604 | 1 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0036 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.8604 | 0.8604 |
Brugia malayi | RNA binding protein | 0.0062 | 0.8604 | 1 |
Brugia malayi | TAR-binding protein | 0.0062 | 0.8604 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.8604 | 0.8604 |
Giardia lamblia | Ubiquitin carboxyl-terminal hydrolase 4 | 0.0036 | 0 | 0.5 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0066 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0036 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.8604 | 0.8604 |
Schistosoma mansoni | P2X receptor subunit | 0.0066 | 1 | 1 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0066 | 1 | 1 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0066 | 1 | 1 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0066 | 1 | 1 |
Schistosoma mansoni | P2X receptor subunit | 0.0066 | 1 | 1 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0066 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 0.8604 | 0.8604 |
Schistosoma mansoni | P2X receptor subunit | 0.0066 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 20 uM | PUBCHEM_BIOASSAY: Late-stage fluorescence-based dose response cell-based screening assay to identify antagonists of the G-protein coupled receptor 7 (GPR7) Set 6. (Class of assay: confirmatory) | ChEMBL. | No reference |
IC50 (functional) | > 20 uM | PUBCHEM_BIOASSAY: Late-stage fluorescence-based counterscreen for antagonists of the G-protein coupled receptor 7 (GPR7): cell-based dose response assay to identify antagonists of the melanin-concentrating hormone receptor 1 (MCHR1) Set 6. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.