Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | mitogen-activated protein kinase 13 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | mitogen-activated protein kinase 13 | 365 aa | 366 aa | 30.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | mitogen activated protein kinase 11 | 0.0152 | 1 | 1 |
Onchocerca volvulus | 0.001 | 0 | 0.5 | |
Onchocerca volvulus | 0.001 | 0 | 0.5 | |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0045 | 0.2455 | 0.2455 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.0052 | 0.296 | 0.296 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.001 | 0 | 0.5 |
Onchocerca volvulus | 0.001 | 0 | 0.5 | |
Mycobacterium tuberculosis | Conserved protein | 0.0045 | 0.2463 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0152 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.2455 | 0.2455 |
Onchocerca volvulus | 0.001 | 0 | 0.5 | |
Schistosoma mansoni | immunophilin | 0.0045 | 0.2455 | 0.8294 |
Plasmodium vivax | 70 kDa peptidylprolyl isomerase, putative | 0.0052 | 0.296 | 0.5 |
Leishmania major | mitogen-activated protein kinase 3, putative,map kinase 3, putative | 0.0152 | 1 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0052 | 0.296 | 0.0659 |
Echinococcus granulosus | mitogen activated protein kinase 14 | 0.0152 | 1 | 1 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0052 | 0.296 | 0.296 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0052 | 0.296 | 0.0659 |
Giardia lamblia | 70 kDa peptidylprolyl isomerase, putative | 0.0052 | 0.296 | 0.5 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0052 | 0.296 | 0.5 |
Onchocerca volvulus | 0.001 | 0 | 0.5 | |
Leishmania major | peptidylprolyl isomerase-like protein | 0.0052 | 0.296 | 0.0659 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0052 | 0.296 | 0.0659 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.0052 | 0.296 | 0.5 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.001 | 0 | 0.5 |
Onchocerca volvulus | 0.001 | 0 | 0.5 | |
Treponema pallidum | peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) | 0.0052 | 0.296 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0052 | 0.296 | 0.0659 |
Onchocerca volvulus | 0.001 | 0 | 0.5 | |
Onchocerca volvulus | 0.001 | 0 | 0.5 | |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase FKBP35 | 0.0052 | 0.296 | 1 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0052 | 0.296 | 0.5 |
Onchocerca volvulus | 0.001 | 0 | 0.5 | |
Onchocerca volvulus | 0.001 | 0 | 0.5 | |
Mycobacterium ulcerans | FK-506 binding protein, peptidyl-prolyl cis-trans isomerase | 0.0052 | 0.296 | 1 |
Leishmania major | fk506-binding protein 1-like protein | 0.0052 | 0.296 | 0.0659 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative | 0.0052 | 0.296 | 0.5 |
Schistosoma mansoni | immunophilin | 0.0052 | 0.296 | 1 |
Onchocerca volvulus | 0.001 | 0 | 0.5 | |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0045 | 0.2455 | 0.2455 |
Onchocerca volvulus | 0.001 | 0 | 0.5 | |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0152 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0152 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0152 | 1 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/P38 protein kinase | 0.0152 | 1 | 1 |
Trypanosoma brucei | mitogen-activated protein kinase 3, putative | 0.0152 | 1 | 1 |
Loa Loa (eye worm) | FKBP5 protein | 0.0052 | 0.296 | 0.296 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.0052 | 0.296 | 1 |
Onchocerca volvulus | 0.001 | 0 | 0.5 | |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0152 | 1 | 1 |
Onchocerca volvulus | 0.001 | 0 | 0.5 | |
Onchocerca volvulus | 0.001 | 0 | 0.5 | |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.0052 | 0.296 | 0.296 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0052 | 0.296 | 0.296 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type, putative | 0.0052 | 0.296 | 0.5 |
Onchocerca volvulus | 0.001 | 0 | 0.5 | |
Schistosoma mansoni | immunophilin | 0.0052 | 0.296 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0152 | 1 | 1 |
Trichomonas vaginalis | immunophilin, putative | 0.0052 | 0.296 | 0.5 |
Onchocerca volvulus | 0.001 | 0 | 0.5 | |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.0052 | 0.296 | 0.296 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0052 | 0.296 | 0.5 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 | 0.0052 | 0.296 | 0.296 |
Echinococcus multilocularis | fk506 binding protein | 0.0052 | 0.296 | 0.296 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 22521646 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.