Detailed information for compound 1677571

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 337.372 | Formula: C19H19N3O3
  • H donors: 1 H acceptors: 2 LogP: 3.11 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(/C=N/c2c(C)n(n(c2=O)c2ccccc2)C)ccc1O
  • InChi: 1S/C19H19N3O3/c1-13-18(20-12-14-9-10-16(23)17(11-14)25-3)19(24)22(21(13)2)15-7-5-4-6-8-15/h4-12,23H,1-3H3/b20-12+
  • InChiKey: BKVIERAQXDUEEP-UDWIEESQSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0124 0.1481 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0029 0.0207 0.0196
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0052 0.0513 0.0502
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0029 0.0207 0.1023
Loa Loa (eye worm) hypothetical protein 0.0483 0.635 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0062 0.0342
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0124 0.1481 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0124 0.1481 0.3834
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0424 0.0424
Brugia malayi cathepsin L-like cysteine proteinase 0.0029 0.0207 0.0323
Loa Loa (eye worm) hypothetical protein 0.0038 0.0325 0.051
Brugia malayi hypothetical protein 0.0483 0.635 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0124 0.1481 0.3834
Leishmania major cathepsin L-like protease 0.0124 0.1481 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0424 0.0424
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.003 0.003
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0029 0.0207 0.1023
Leishmania major cathepsin L-like protease 0.0124 0.1481 1
Brugia malayi MH1 domain containing protein 0.0016 0.003 0.0045
Loa Loa (eye worm) jmjC domain-containing protein 0.0066 0.0698 0.1096
Echinococcus multilocularis cysteine protease 0.0124 0.1481 0.1481
Giardia lamblia Cathepsin L precursor 0.0029 0.0207 0.1168
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0045 0.0413 0.2734
Toxoplasma gondii cathepsin CPC1 0.0029 0.0207 0.1023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0135 0.0323
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0068 0.0724 0.1857
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0029 0.0207 0.1168
Trypanosoma brucei cysteine peptidase C (CPC) 0.0111 0.1305 0.8799
Plasmodium falciparum cysteine proteinase falcipain 1 0.0068 0.0724 0.4662
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.0011 0.0015
Entamoeba histolytica hypothetical protein 0.0029 0.0207 0.1023
Schistosoma mansoni tsg101-related 0.0063 0.0664 0.0653
Schistosoma mansoni hypothetical protein 0.0032 0.0239 0.0228
Plasmodium vivax vivapain-2 0.0124 0.1481 1
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0024 0.0137 0.0855
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.007 0.0058
Entamoeba histolytica cysteine protease, putative 0.0029 0.0207 0.1023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0258 0.0644
Plasmodium vivax unspecified product 0.0029 0.0207 0.1023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0258 0.0644
Echinococcus multilocularis lysine specific demethylase 5A 0.0038 0.033 0.033
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0019 0.007 0.007
Schistosoma mansoni ap endonuclease 0.0019 0.0062 0.005
Echinococcus granulosus cathepsin b 0.0292 0.3757 0.3757
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0036 0.029 0.1895
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0166 0.0166
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0011 0.0015
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0029 0.0207 0.051
Brugia malayi Cathepsin L-like precursor 0.0124 0.1481 0.2331
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0076 0.0836 0.0836
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0044 0.0399 0.1011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0124 0.1481 0.3834
Leishmania major cathepsin L-like protease 0.0124 0.1481 1
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0095 0.0566
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0062 0.0094
Loa Loa (eye worm) hypothetical protein 0.0042 0.0375 0.0588
Echinococcus multilocularis SAM and MBT domain containing protein 0.0052 0.0513 0.0513
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0239 0.1251
Entamoeba histolytica cysteine proteinase, putative 0.0085 0.0965 0.6361
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0062 0.0134
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0029 0.0207 0.1168
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0234 0.0234
Brugia malayi serine/threonine-protein kinase plk-2 0.0103 0.1204 0.1893
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0289 0.0725
Giardia lamblia Cysteine protease 0.0029 0.0207 0.1168
Loa Loa (eye worm) hypothetical protein 0.0029 0.0207 0.0323
Trichomonas vaginalis glutaminase, putative 0.0298 0.3846 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.006 0.0049
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.1204 0.3109
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0292 0.3757 0.375
Trypanosoma brucei ISWI complex protein 0.0017 0.0035 0.0158
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0122 0.0753
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0258 0.1385
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0201 0.0495
Entamoeba histolytica cysteine protease, putative 0.0068 0.0724 0.4662
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0029 0.0207 0.051
Brugia malayi Smad1 0.0016 0.003 0.0045
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0045 0.0413 0.2476
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0062 0.0131
Giardia lamblia Cathepsin L-like protease 0.0029 0.0207 0.1168
Echinococcus granulosus SAM and MBT domain containing protein 0.0052 0.0513 0.0513
Brugia malayi Cathepsin L-like precursor 0.0124 0.1481 0.2331
Plasmodium vivax serine-repeat antigen (SERA) 0.0029 0.0207 0.1023
Plasmodium falciparum serine repeat antigen 7 0.0029 0.0207 0.1023
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0044 0.0399 0.2636
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0122 0.0189
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0045 0.0413 0.2734
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0234 0.1217
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0045 0.0413 0.1073
Plasmodium falciparum serine repeat antigen 8 0.0029 0.0207 0.1023
Loa Loa (eye worm) hypothetical protein 0.0076 0.0836 0.1314
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0029 0.0207 0.1168
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0124 0.1481 0.3834
Schistosoma mansoni ran 0.0023 0.0122 0.0111
Brugia malayi PHD-finger family protein 0.0029 0.0201 0.0313
Plasmodium falciparum serine repeat antigen 6 0.0029 0.0207 0.1023
Entamoeba histolytica Ran family GTPase 0.0023 0.0122 0.0426
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0029 0.0207 0.051
Plasmodium falciparum serine repeat antigen 9 0.0029 0.0207 0.1023
Loa Loa (eye worm) PHD-finger family protein 0.0032 0.0239 0.0374
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0062 0.0134
Giardia lamblia Cathepsin L-like protease 0.0029 0.0207 0.1168
Brugia malayi Bromodomain containing protein 0.0034 0.0274 0.0429
Trypanosoma cruzi ISWI complex protein 0.0017 0.0035 0.0062
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0124 0.1481 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0029 0.0207 0.051
Echinococcus granulosus cathepsin L 0.0068 0.0724 0.0724
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0207 0.051
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0029 0.0207 0.1023
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0424 0.0413
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0045 0.0413 0.0413
Schistosoma mansoni microtubule-associated protein tau 0.0753 1 1
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0045 0.0413 0.0413
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0166 0.0166
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.1204 0.3109
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0234 0.1518
Plasmodium vivax vivapain-1 0.0068 0.0724 0.4662
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0024 0.0137 0.0336
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0044 0.0399 0.1035
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0029 0.0207 0.0196
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0122 0.0426
Echinococcus multilocularis histone acetyltransferase MYST2 0.0059 0.0611 0.0611
Trypanosoma cruzi cruzipain precursor, putative 0.0124 0.1481 0.3925
Loa Loa (eye worm) hypothetical protein 0.0077 0.0853 0.1341
Loa Loa (eye worm) Smad1 0.0016 0.003 0.0045
Entamoeba histolytica cysteine protease, putative 0.0068 0.0724 0.4662
Plasmodium vivax serine-repeat antigen (SERA) 0.0029 0.0207 0.1023
Schistosoma mansoni hypothetical protein 0.032 0.4142 0.4135
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0424 0.0424
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0059 0.0611 0.0959
Loa Loa (eye worm) hypothetical protein 0.0029 0.0207 0.0323
Giardia lamblia Hypothetical protein 0.0029 0.0207 0.1168
Onchocerca volvulus Cathepsin F homolog 0.0124 0.1481 0.2075
Plasmodium vivax unspecified product 0.0068 0.0724 0.4662
Loa Loa (eye worm) hypothetical protein 0.0085 0.0965 0.1517
Schistosoma mansoni cathepsin F (C01 family) 0.0085 0.0965 0.0954
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.003 0.003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0166 0.0404
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0019 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0032 0.0239 0.0374
Echinococcus granulosus cysteine protease 0.0068 0.0724 0.0724
Echinococcus granulosus cathepsin L cysteine proteinase 0.0124 0.1481 0.1481
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0154 0.0372
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0336 0.4355 0.6857
Schistosoma mansoni serine/threonine protein kinase 0.0103 0.1204 0.1194
Plasmodium falciparum serine repeat antigen 4 0.0029 0.0207 0.1023
Giardia lamblia Cathepsin B precursor 0.0029 0.0207 0.1168
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0029 0.0207 0.051
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0124 0.1481 0.3834
Loa Loa (eye worm) hypothetical protein 0.0292 0.3757 0.5915
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0124 0.1481 1
Echinococcus multilocularis cathepsin L 0.0029 0.0207 0.0207
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0029 0.0207 0.1023
Entamoeba histolytica cysteine protease, putative 0.0068 0.0724 0.4662
Loa Loa (eye worm) hypothetical protein 0.0029 0.0207 0.0323
Trypanosoma cruzi ISWI complex protein 0.0017 0.0035 0.0062
Entamoeba histolytica cysteine protease, putative 0.0068 0.0724 0.4662
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0029 0.0207 0.1023
Giardia lamblia Cathepsin B precursor 0.0029 0.0207 0.1168
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0111 0.1305 0.3373
Loa Loa (eye worm) cysteine protease 0.0124 0.1481 0.2331
Loa Loa (eye worm) MH2 domain-containing protein 0.024 0.3062 0.482
Entamoeba histolytica cysteine protease, putative 0.0029 0.0207 0.1023
Loa Loa (eye worm) hypothetical protein 0.0029 0.0207 0.0323
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0045 0.0413 0.2734
Giardia lamblia Kinase, PLK 0.0103 0.1204 0.9187
Plasmodium falciparum phd finger protein, putative 0.0032 0.0239 0.1251
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0135 0.0321
Loa Loa (eye worm) hypothetical protein 0.0059 0.0611 0.0959
Brugia malayi F/Y-rich N-terminus family protein 0.0022 0.0107 0.0166
Echinococcus granulosus cathepsin l1 0.0124 0.1481 0.1481
Schistosoma mansoni ran 0.0023 0.0122 0.0111
Brugia malayi mbt repeat family protein 0.0052 0.0513 0.0805
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0292 0.3757 0.375
Trypanosoma cruzi cysteine peptidase, putative 0.0124 0.1481 0.3925
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0044 0.0399 0.2713
Echinococcus multilocularis peregrin 0.0034 0.0274 0.0274
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0068 0.0724 0.1901
Brugia malayi RNA, U transporter 1 0.0089 0.102 0.1603
Echinococcus granulosus jumonji domain containing protein 0.0044 0.0408 0.0408
Loa Loa (eye worm) hypothetical protein 0.0019 0.007 0.0107
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0122 0.0295
Trypanosoma cruzi cysteine proteinase, putative 0.0068 0.0724 0.1901
Loa Loa (eye worm) hypothetical protein 0.0052 0.0513 0.0805
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.003 0.0045
Schistosoma mansoni jumonji/arid domain-containing protein 0.0042 0.0382 0.0371
Loa Loa (eye worm) ctsf protein 0.0124 0.1481 0.2331
Echinococcus multilocularis polycomb protein SCMH1 0.0052 0.0513 0.0513
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0135 0.0321
Brugia malayi Cathepsin L-like precursor 0.0085 0.0965 0.1517
Entamoeba histolytica cysteine protease, putative 0.0068 0.0724 0.4662
Brugia malayi MH1 domain containing protein 0.0016 0.003 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0207 0.051
Plasmodium falciparum serine repeat antigen 2 0.0029 0.0207 0.1023
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.1204 0.3109
Brugia malayi Bromodomain containing protein 0.0084 0.094 0.1479
Brugia malayi MH2 domain containing protein 0.0016 0.003 0.0045
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0209 0.2636 0.2636
Toxoplasma gondii cathepsin CPC2 0.0029 0.0207 0.1023
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0038 0.0325 0.051
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0019 0.006 0.0329
Schistosoma mansoni kinase 0.0052 0.0518 0.0507
Echinococcus multilocularis cathepsin L 0.0068 0.0724 0.0724
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0124 0.1481 0.3834
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0124 0.1481 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0029 0.0207 0.0196
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0029 0.0207 0.0323
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0124 0.1481 0.1481
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0214 0.0529
Brugia malayi MH2 domain containing protein 0.0016 0.003 0.0045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0289 0.0725
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0207 0.051
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0062 0.0062
Brugia malayi Importin beta-1 subunit 0.0031 0.0234 0.0367
Brugia malayi cathepsin L precursor 0.0029 0.0207 0.0323
Trypanosoma cruzi cysteine proteinase, putative 0.0068 0.0724 0.1901
Brugia malayi Papain family cysteine protease containing protein 0.0029 0.0207 0.0323
Loa Loa (eye worm) glutaminase 0.0298 0.3846 0.6055
Loa Loa (eye worm) cathepsin B 0.0111 0.1305 0.2053
Entamoeba histolytica cysteine protease, putative 0.0029 0.0207 0.1023
Brugia malayi Cathepsin L-like cysteine proteinase 0.0085 0.0965 0.1517
Echinococcus multilocularis cathepsin b 0.0292 0.3757 0.3757
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0154 0.0381
Schistosoma mansoni smad 0.0016 0.003 0.0019
Echinococcus multilocularis microtubule associated protein 2 0.0753 1 1
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0045 0.0413 0.2734
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0209 0.2636 0.2636
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.0708 0.0698
Schistosoma mansoni tsg101-related 0.0063 0.0664 0.0653
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0239 0.1251
Giardia lamblia Cathepsin B precursor 0.0029 0.0207 0.1168
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0029 0.0207 0.1023
Plasmodium vivax vivapain-3 0.0068 0.0724 0.4662
Leishmania major cathepsin L-like protease 0.0124 0.1481 1
Loa Loa (eye worm) fibroinase 0.0124 0.1481 0.2331
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0124 0.1481 0.2331
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.0647 0.4124
Schistosoma mansoni cathepsin C 0.0029 0.0207 0.0196
Brugia malayi Cathepsin L-like precursor 0.0038 0.0325 0.051
Entamoeba histolytica hypothetical protein 0.0026 0.0154 0.065
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0029 0.0207 0.051
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0062 0.0094
Brugia malayi Papain family cysteine protease containing protein 0.0068 0.0724 0.1137
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0029 0.0207 0.1023
Giardia lamblia Cathepsin L precursor 0.0029 0.0207 0.1168
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0424 0.0665
Echinococcus multilocularis zinc finger protein 0.0023 0.0122 0.0122
Leishmania major cathepsin L-like protease 0.0124 0.1481 1
Giardia lamblia GTOR 0.0045 0.0413 0.2828
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0029 0.0207 0.1023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0258 0.0644
Loa Loa (eye worm) hypothetical protein 0.0124 0.1481 0.2331
Schistosoma mansoni tsg101-related 0.0052 0.0507 0.0496
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0424 0.0413
Onchocerca volvulus 0.0124 0.1481 0.2075
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0239 0.1251
Toxoplasma gondii preprocathepsin c precursor, putative 0.0029 0.0207 0.1023
Loa Loa (eye worm) MBCTL1 0.0059 0.0611 0.0959
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0124 0.1481 0.3834
Schistosoma mansoni smad1 5 8 and 0.0016 0.003 0.0019
Brugia malayi cathepsin B-like cysteine proteinase 0.0292 0.3757 0.5915
Loa Loa (eye worm) hypothetical protein 0.0048 0.0463 0.0726
Schistosoma mansoni jumonji domain containing protein 0.0083 0.0929 0.0919
Toxoplasma gondii cathepsin CPL 0.0124 0.1481 1
Entamoeba histolytica cysteine protease, putative 0.0068 0.0724 0.4662
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0029 0.0207 0.0323
Echinococcus granulosus cathepsin L cysteine protease 0.0068 0.0724 0.0724
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0062 0.5
Echinococcus granulosus polycomb protein SCMH1 0.0052 0.0513 0.0513
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0292 0.3757 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0042 0.0382 0.0371
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0124 0.1481 0.3834
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0044 0.0399 0.0399
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0045 0.0413 0.0402
Trypanosoma cruzi cysteine peptidase, putative 0.0038 0.0325 0.0838
Loa Loa (eye worm) hypothetical protein 0.0044 0.041 0.0643
Giardia lamblia Cathepsin L precursor 0.0029 0.0207 0.1168
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0124 0.1481 0.3834
Mycobacterium ulcerans glutaminase 0.0298 0.3846 1
Entamoeba histolytica cysteine proteinase, putative 0.0124 0.1481 1
Trypanosoma cruzi cysteine protease, putative 0.0068 0.0724 0.1901
Echinococcus multilocularis cpg binding protein 0.0035 0.0285 0.0285
Entamoeba histolytica serine/threonine protein kinase, putative 0.0103 0.1204 0.8044
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0124 0.1481 0.1481
Trypanosoma cruzi cysteine peptidase, putative 0.0124 0.1481 0.3925
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.017 0.0413
Trypanosoma cruzi polo-like protein kinase, putative 0.0103 0.1204 0.3183
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0258 0.0644
Echinococcus multilocularis Protein lozenge 0.0061 0.0629 0.0629
Schistosoma mansoni Smad4 0.0016 0.003 0.0019
Schistosoma mansoni bromodomain containing protein 0.0071 0.0767 0.0757
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0059 0.0611 0.0611
Echinococcus granulosus lysine specific demethylase 5A 0.0042 0.0382 0.0382
Leishmania major cathepsin L-like protease 0.0124 0.1481 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0124 0.1481 0.1481
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0029 0.0207 0.0196
Leishmania major cysteine peptidase A (CPA) 0.0124 0.1481 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0044 0.0399 0.1035
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0044 0.0399 0.0388
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0029 0.0207 0.051
Giardia lamblia Cysteine protease 0.0029 0.0207 0.1168
Loa Loa (eye worm) mbt repeat family protein 0.0052 0.0513 0.0805
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0325 0.0817
Brugia malayi PHD-finger family protein 0.0032 0.0239 0.0374
Entamoeba histolytica cysteine protease, putative 0.0124 0.1481 1
Brugia malayi glutaminase DH11.1 0.0298 0.3846 0.6055
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0029 0.0207 0.051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0166 0.0404
Giardia lamblia Hypothetical protein 0.0029 0.0207 0.1168
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0067 0.0714 0.0714
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0029 0.0207 0.0196
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0124 0.1481 0.3834
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0052 0.0507 0.3139
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0124 0.1481 0.3834
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0124 0.1481 0.3834
Echinococcus multilocularis PHD finger protein rhinoceros 0.0032 0.0239 0.0239
Entamoeba histolytica cysteine protease, putative 0.0068 0.0724 0.4662
Loa Loa (eye worm) hypothetical protein 0.0038 0.0325 0.051
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0122 0.0189
Onchocerca volvulus 0.0124 0.1481 0.2075
Schistosoma mansoni zinc finger protein 0.0023 0.0122 0.0111
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0124 0.1481 0.3834
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0124 0.1481 1
Echinococcus granulosus peregrin 0.0034 0.0274 0.0274
Leishmania major hypothetical protein, conserved 0.0024 0.0137 0.0855
Giardia lamblia Cathepsin L precursor 0.0029 0.0207 0.1168
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.017 0.0413
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0124 0.1481 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0124 0.1481 0.3834
Brugia malayi Papain family cysteine protease containing protein 0.0124 0.1481 0.2331
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.1204 0.3109
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0029 0.0207 0.0323
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0036 0.029 0.1895
Schistosoma mansoni hypothetical protein 0.0023 0.0113 0.0102
Echinococcus multilocularis smad 0.0016 0.003 0.003
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0103 0.1204 0.1204
Giardia lamblia Cathepsin B precursor 0.0111 0.1305 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.003 0.0045
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0015 0.0011 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0289 0.0725
Entamoeba histolytica cysteine proteinase, putative 0.0068 0.0724 0.4662
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0124 0.1481 1
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0029 0.0207 0.1023
Echinococcus multilocularis cathepsin b 0.0292 0.3757 0.3757
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0044 0.0399 0.0399
Brugia malayi Papain family cysteine protease containing protein 0.0068 0.0724 0.1137
Echinococcus multilocularis cysteine protease 0.0124 0.1481 0.1481
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0207 0.051
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0062 0.0131
Brugia malayi Cathepsin L-like precursor 0.0124 0.1481 0.2331
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.0499 0.1272
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0233 0.0364
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0103 0.1204 0.8111
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0124 0.1481 0.3834
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0258 0.0644
Schistosoma mansoni cathepsin s 0.0038 0.0325 0.0314
Brugia malayi Papain family cysteine protease containing protein 0.0029 0.0207 0.0323
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0124 0.1481 1
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0724 0.1901
Loa Loa (eye worm) phosphatidylinositol 3 0.0045 0.0413 0.0648
Plasmodium vivax vivapain-2 0.0124 0.1481 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0124 0.1481 0.3834
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0154 0.0372
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0052 0.0513 0.0499
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0399 0.1011
Giardia lamblia PHD finger protein 15 0.0032 0.0239 0.1428
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0124 0.1481 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0019 0.007 0.007
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0018 0.0055 0.0043
Plasmodium vivax importin-beta 2, putative 0.0031 0.0234 0.1217
Onchocerca volvulus 0.0052 0.0513 0.0499
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0029 0.0207 0.1023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0258 0.0644
Leishmania major GTP-binding protein, putative 0.0023 0.0122 0.0753
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0207 0.051
Loa Loa (eye worm) transcription factor SMAD2 0.024 0.3062 0.482
Brugia malayi Cathepsin L-like precursor 0.0124 0.1481 0.2331
Echinococcus granulosus cathepsin b 0.0292 0.3757 0.3757
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0111 0.1305 0.3453
Entamoeba histolytica cysteine protease, putative 0.0068 0.0724 0.4662
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0124 0.1481 0.3834
Schistosoma mansoni glutaminase 0.0298 0.3846 0.3839
Entamoeba histolytica cysteine proteinase, putative 0.0068 0.0724 0.4662
Entamoeba histolytica cysteine proteinase 2 0.0068 0.0724 0.4662
Echinococcus granulosus cathepsin L 0.0029 0.0207 0.0207
Onchocerca volvulus Alhambra homolog 0.0032 0.0239 0.0053
Onchocerca volvulus 0.0085 0.0965 0.1234
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0029 0.0207 0.1023
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0068 0.0724 0.0713
Entamoeba histolytica cysteine proteinase, putative 0.0068 0.0724 0.4662
Plasmodium falciparum serine repeat antigen 5 0.0029 0.0207 0.1023
Giardia lamblia Cathepsin L precursor 0.0029 0.0207 0.1168
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0413 0.1048
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0104 0.1219 0.1219
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0067 0.0714 0.0714
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0124 0.1481 0.3834
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0289 0.0725
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0124 0.1481 0.3834
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0103 0.1204 0.1204
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0029 0.0207 0.0196
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0044 0.0399 0.0626
Loa Loa (eye worm) hypothetical protein 0.0029 0.0207 0.0323
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0044 0.0399 0.1011
Echinococcus granulosus histone acetyltransferase MYST2 0.0059 0.0611 0.0611
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0085 0.0965 0.2486
Trypanosoma cruzi target of rapamycin kinase 3 0.0036 0.029 0.0744
Leishmania major hypothetical protein, conserved 0.0017 0.0035 0.0158
Schistosoma mansoni lozenge 0.0061 0.0629 0.0619
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0029 0.0207 0.1023
Toxoplasma gondii cathepsin B 0.0111 0.1305 0.8756
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0029 0.0207 0.1023
Loa Loa (eye worm) jmjC domain-containing protein 0.0042 0.0382 0.0599
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0292 0.3757 0.375
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0044 0.0399 0.2636
Giardia lamblia Cathepsin B precursor 0.0029 0.0207 0.1168
Onchocerca volvulus 0.0031 0.0233 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.017 0.0413
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0122 0.0486
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0413 0.1048
Schistosoma mansoni hypothetical protein 0.0336 0.4355 0.4348
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0076 0.0836 0.0836
Schistosoma mansoni ap endonuclease 0.0019 0.0062 0.005
Loa Loa (eye worm) hypothetical protein 0.0085 0.0965 0.1517
Brugia malayi MH2 domain containing protein 0.024 0.3062 0.482
Schistosoma mansoni cathepsin F (C01 family) 0.0124 0.1481 0.1472
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0103 0.1204 0.1893
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0135 0.0323
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.1204 0.3109
Giardia lamblia Cathepsin B precursor 0.0111 0.1305 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0111 0.1305 0.1295
Echinococcus granulosus methyl CpG binding domain protein 2 0.0019 0.006 0.006
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0029 0.0207 0.1168
Giardia lamblia Cysteine protease 0.0029 0.0207 0.1168
Schistosoma mansoni smad1 5 8 and 0.0016 0.003 0.0019
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0154 0.0372
Schistosoma mansoni hypothetical protein 0.0017 0.0035 0.0023
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0029 0.0207 0.051
Brugia malayi fibroinase precursor 0.0029 0.0207 0.0323
Loa Loa (eye worm) hypothetical protein 0.0029 0.0207 0.0323
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.1204 0.3109
Schistosoma mansoni cathepsin F (C01 family) 0.0124 0.1481 0.1472
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0122 0.0426
Echinococcus granulosus smad 0.0016 0.003 0.003
Brugia malayi jmjC domain containing protein 0.0104 0.1219 0.1917
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0044 0.0399 0.0388
Schistosoma mansoni cpg binding protein 0.0035 0.0285 0.0274
Schistosoma mansoni importin beta-1 0.0031 0.0234 0.0223
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0724 0.4845
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0029 0.0207 0.1023
Echinococcus granulosus Smad4 0.0016 0.003 0.003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0135 0.0321
Onchocerca volvulus Cathepsin L homolog 0.0124 0.1481 0.2075
Trypanosoma cruzi cysteine peptidase, putative 0.0124 0.1481 0.3925
Echinococcus multilocularis ubiquitin specific protease 41 0.0044 0.0399 0.0399
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0029 0.0207 0.051
Entamoeba histolytica cysteine proteinase, putative 0.0124 0.1481 1
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0122 0.0426
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0111 0.1305 0.8799
Leishmania major cathepsin L-like protease 0.0124 0.1481 1
Loa Loa (eye worm) glutaminase 2 0.0298 0.3846 0.6055
Brugia malayi hypothetical protein 0.0076 0.0836 0.1314
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.0499 0.1272
Echinococcus granulosus cathepsin l1 0.0085 0.0965 0.0965
Loa Loa (eye worm) hypothetical protein 0.0044 0.0399 0.0626
Entamoeba histolytica cysteine proteinase, putative 0.0068 0.0724 0.4662
Schistosoma mansoni cpg binding protein 0.0035 0.0285 0.0274
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0045 0.0413 0.2476
Loa Loa (eye worm) bromodomain containing protein 0.0019 0.007 0.0107
Plasmodium vivax unspecified product 0.0038 0.0325 0.1857
Brugia malayi cathepsin Z-like cysteine proteinase 0.0029 0.0207 0.0323
Brugia malayi jmjC domain containing protein 0.0042 0.0382 0.0599
Echinococcus granulosus zinc finger protein 0.0023 0.0122 0.0122
Onchocerca volvulus Serine\/threonine kinase homolog 0.0103 0.1204 0.1623
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0207 0.051
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0045 0.0413 0.1073
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.007 0.0058
Giardia lamblia Cathepsin B precursor 0.0029 0.0207 0.1168
Onchocerca volvulus 0.0124 0.1481 0.2075
Schistosoma mansoni zinc finger protein 0.0017 0.0035 0.0023
Trypanosoma cruzi major cysteine proteinase, putative 0.0029 0.0207 0.0522
Entamoeba histolytica cysteine protease, putative 0.0029 0.0207 0.1023
Trypanosoma cruzi cysteine peptidase, putative 0.0124 0.1481 0.3925
Giardia lamblia Cathepsin B precursor 0.0111 0.1305 1
Brugia malayi Cathepsin L-like precursor 0.0085 0.0965 0.1517
Leishmania major cathepsin L-like protease 0.0124 0.1481 1
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0029 0.0207 0.0196
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0029 0.0207 0.0196
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0124 0.1481 0.3834
Giardia lamblia Cathepsin L precursor 0.0029 0.0207 0.1168
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0424 0.0413
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0062 0.5
Plasmodium falciparum importin beta, putative 0.0031 0.0234 0.1217
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0062 0.5
Echinococcus multilocularis cathepsin L cysteine protease 0.0124 0.1481 0.1481
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0166 0.0155
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0122 0.0295
Onchocerca volvulus 0.0124 0.1481 0.2075
Trypanosoma cruzi polo-like protein kinase, putative 0.0103 0.1204 0.3183
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0044 0.0399 0.0399
Brugia malayi cathepsin F-like cysteine proteinase 0.0029 0.0207 0.0323
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.003 0.003
Brugia malayi Bromodomain containing protein 0.0042 0.0374 0.0587
Trypanosoma brucei polo-like protein kinase 0.0103 0.1204 0.8111
Schistosoma mansoni smad1 5 8 and 0.0016 0.003 0.0019
Loa Loa (eye worm) runx1 0.0061 0.0629 0.0988
Giardia lamblia Encystation-specific protease 0.0029 0.0207 0.1168
Plasmodium falciparum serine repeat antigen 1 0.0029 0.0207 0.1023
Brugia malayi Cathepsin L-like precursor 0.0124 0.1481 0.2331
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0289 0.0725
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0045 0.0413 0.0648
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0207 0.051
Entamoeba histolytica cysteine protease, putative 0.0068 0.0724 0.4662
Entamoeba histolytica cysteine protease, putative 0.0068 0.0724 0.4662
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0424 0.0424
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0424 0.0665
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0044 0.0399 0.2375
Entamoeba histolytica cysteine proteinase 1, putative 0.0068 0.0724 0.4662
Entamoeba histolytica cysteine protease, putative 0.0068 0.0724 0.4662
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0038 0.0325 0.051
Trypanosoma cruzi major cysteine proteinase, putative 0.0029 0.0207 0.0522
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0207 0.051
Loa Loa (eye worm) hypothetical protein 0.0055 0.0547 0.0859
Brugia malayi CXXC zinc finger family protein 0.0031 0.0233 0.0364
Schistosoma mansoni cathepsin S (C01 family) 0.0029 0.0207 0.0196
Entamoeba histolytica cysteine protease, putative 0.0029 0.0207 0.1023
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0124 0.1481 1
Brugia malayi Cathepsin L-like precursor 0.0124 0.1481 0.2331
Echinococcus multilocularis cathepsin L cysteine protease 0.0124 0.1481 0.1481
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0032 0.0239 0.0228
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0724 0.4845
Loa Loa (eye worm) hypothetical protein 0.0483 0.635 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0258 0.0644
Entamoeba histolytica cysteine protease, putative 0.0029 0.0207 0.1023
Brugia malayi cathepsin L-like precursor 0.0085 0.0965 0.1517
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0068 0.0724 0.1857
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0122 0.0122
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0085 0.0965 0.2486
Brugia malayi cathepsin Z-like cysteine proteinase 0.0029 0.0207 0.0323
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0062 0.0342
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0029 0.0207 0.0196
Loa Loa (eye worm) hypothetical protein 0.0085 0.0965 0.1517
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.003 0.003
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0062 0.0062
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0292 0.3757 0.375
Onchocerca volvulus 0.0124 0.1481 0.2075
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0135 0.0323
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0135 0.0323
Entamoeba histolytica cysteine protease, putative 0.0068 0.0724 0.4662
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0122 0.0122
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0044 0.0399 0.0399
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0085 0.0965 0.2545
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0234 0.1518
Echinococcus multilocularis jumonji domain containing protein 0.0044 0.0408 0.0408
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.1204 0.3109
Trichomonas vaginalis hypothetical protein 0.0037 0.0309 0.0776
Echinococcus granulosus cpg binding protein 0.0035 0.0285 0.0285
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0068 0.0724 0.0713
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0015 0.0011 0.0011
Brugia malayi cathepsin F-like cysteine proteinase 0.0038 0.0325 0.051
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0124 0.1481 0.3834
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0124 0.1481 0.3834
Schistosoma mansoni sex comb on midleg homolog 0.0052 0.0513 0.0502
Plasmodium falciparum cysteine proteinase falcipain 3 0.0124 0.1481 1
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0029 0.0207 0.1023
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0124 0.1481 0.3834
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0039 0.0339 0.0339
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0104 0.1219 0.1219
Leishmania major importin beta-1 subunit, putative 0.0026 0.0154 0.097
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0059 0.0611 0.0611
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0068 0.0724 0.0713
Onchocerca volvulus 0.0483 0.635 1
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0113 0.0176
Onchocerca volvulus Cathepsin L homolog 0.0124 0.1481 0.2075
Entamoeba histolytica cysteine protease, putative 0.0068 0.0724 0.4662
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.003 0.0019
Plasmodium falciparum serine repeat antigen 3 0.0029 0.0207 0.1023
Loa Loa (eye worm) hypothetical protein 0.0031 0.0234 0.0367
Echinococcus multilocularis snurportin 1 0.0336 0.4355 0.4355
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.006 0.0049
Echinococcus granulosus snurportin 1 0.0336 0.4355 0.4355
Giardia lamblia Cysteine protease 0.0029 0.0207 0.1168
Trichomonas vaginalis ran, putative 0.0023 0.0122 0.0289
Brugia malayi mbt repeat family protein 0.0052 0.0513 0.0805
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0039 0.0339 0.0339
Onchocerca volvulus 0.0124 0.1481 0.2075
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0124 0.1481 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0124 0.1481 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0413 0.1048
Onchocerca volvulus 0.0124 0.1481 0.2075
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0124 0.1481 0.2331
Echinococcus granulosus ubiquitin specific protease 41 0.0044 0.0399 0.0399
Echinococcus multilocularis Smad4 0.0016 0.003 0.003
Brugia malayi Papain family cysteine protease containing protein 0.0029 0.0207 0.0323
Schistosoma mansoni sex comb on midleg homolog 0.0052 0.0513 0.0502
Schistosoma mansoni cathepsin B (C01 family) 0.0029 0.0207 0.0196
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0029 0.0207 0.051
Trypanosoma cruzi cruzipain precursor, putative 0.0038 0.0325 0.0838
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0124 0.1481 0.3834
Schistosoma mansoni cpg binding protein 0.0031 0.0233 0.0222
Schistosoma mansoni myelin transcription factor 1 myt1 0.0059 0.0611 0.06
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0029 0.0207 0.0323
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0124 0.1481 0.3834
Echinococcus granulosus importin subunit beta 1 0.0031 0.0234 0.0234
Loa Loa (eye worm) hypothetical protein 0.0038 0.0325 0.051
Echinococcus granulosus PHD finger protein rhinoceros 0.0032 0.0239 0.0239

Activities

Activity type Activity value Assay description Source Reference
-logMIC (functional) = 1.43 Antibacterial activity against Escherichia coli MTCC 1652 after 24 hr by tube dilution method LITERATURE. No reference
-logMIC (functional) = 1.43 Antifungal activity against Candida albicans MTCC 227 after 48 hr by tube dilution method LITERATURE. No reference
IC50 (functional) = 0.27 Cytotoxicity against Homo sapiens (human) HT-29 cells after 72 hr by MTT assay ChEMBL. No reference
IC50 (functional) = 0.5 Cytotoxicity against Mus musculus (mouse) P388 cells after 72 hr by MTT assay ChEMBL. No reference
MBC (functional) > 0.15 uM/ml Bactericidal activity against Escherichia coli MTCC 1652 ChEMBL. No reference
MFC (functional) > 0.15 uM/ml Fungicidal activity against Candida albicans MTCC 227 ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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