TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 458.476 | Formula: C24H25F3N4O2
H donors: 2 H acceptors: 3 LogP: 3.25 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: N#CC1(CC1)NC(=O)[C@@H]1CCCC[C@H]1C(=O)N1CCc2c(C1)c1cccc(c1[nH]2)C(F)(F)F
InChi: 1S/C24H25F3N4O2/c25-24(26,27)18-7-3-6-14-17-12-31(11-8-19(17)29-20(14)18)22(33)16-5-2-1-4-15(16)21(32)30-23(13-28)9-10-23/h3,6-7,15-16,29H,1-2,4-5,8-12H2,(H,30,32)/t15-,16-/m1/s1
InChiKey: YRLSAGVJGNJNON-HZPDHXFCSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cathepsin B	Starlite/ChEMBL	References
Homo sapiens	cathepsin K	Starlite/ChEMBL	References
Homo sapiens	cathepsin S	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01363 cathepsin B [EC3.4.22.1], putative	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Neospora caninum	Cathepsin B-like protease (Precursor), related	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania infantum	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania donovani	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin B-like cysteine proteinase	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei gambiense	cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	SmCB2 peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127800	All targets in OG5_127800
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	dipeptidyl aminopeptidase 1	cathepsin B	339 aa	368 aa	26.9 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin K	329 aa	349 aa	33.2 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin S	281 aa	226 aa	34.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0053	0.1659	0.1659
Entamoeba histolytica	cysteine proteinase 2	0.0033	0.0286	0.1389
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0053	0.1659	0.1659
Loa Loa (eye worm)	fibroinase	0.0059	0.2062	0.2062
Brugia malayi	Cation transporter family protein	0.0053	0.1659	0.1659
Schistosoma mansoni	nAChR subunit	0.0053	0.1659	0.1659
Loa Loa (eye worm)	LGC-31 protein	0.0053	0.1659	0.1659
Loa Loa (eye worm)	hypothetical protein	0.0053	0.1659	0.1659
Echinococcus granulosus	cathepsin b	0.0176	1	1
Echinococcus multilocularis	cysteine protease	0.0059	0.2062	0.2062
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0053	0.1659	0.1659
Onchocerca volvulus		0.0059	0.2062	0.3007
Brugia malayi	Cathepsin L-like precursor	0.0059	0.2062	0.2062
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0059	0.2062	0.8189
Onchocerca volvulus		0.0053	0.1659	0.242
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0059	0.2062	0.8189
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0059	0.2062	0.2062
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0059	0.2062	0.8189
Schistosoma mansoni	cathepsin F (C01 family)	0.0059	0.2062	0.2062
Echinococcus multilocularis	cysteine protease	0.0059	0.2062	0.2062
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0053	0.1659	0.1659
Entamoeba histolytica	cysteine protease, putative	0.0033	0.0286	0.1389
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0053	0.1659	0.1659
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0059	0.2062	0.8189
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0053	0.1659	0.1659
Echinococcus granulosus	cathepsin b	0.0176	1	1
Entamoeba histolytica	cysteine protease, putative	0.0059	0.2062	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.2062	0.8189
Brugia malayi	Papain family cysteine protease containing protein	0.0033	0.0286	0.0286
Brugia malayi	Cation transporter family protein	0.013	0.6857	0.6857
Loa Loa (eye worm)	hypothetical protein	0.013	0.6857	0.6857
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0059	0.2062	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0059	0.2062	0.8189
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.2062	0.8189
Loa Loa (eye worm)	hypothetical protein	0.0053	0.1659	0.1659
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0053	0.1659	0.1659
Giardia lamblia	Cathepsin B precursor	0.0065	0.2454	0.5
Brugia malayi	Papain family cysteine protease containing protein	0.0033	0.0286	0.0286
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0053	0.1659	0.1659
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0176	1	1
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0053	0.1659	0.1659
Schistosoma mansoni	nAChR subunit	0.0053	0.1659	0.1659
Echinococcus multilocularis	cathepsin b	0.0176	1	1
Loa Loa (eye worm)	hypothetical protein	0.0053	0.1659	0.1659
Echinococcus granulosus	nAChR subunit	0.0053	0.1659	0.1659
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0053	0.1659	0.1659
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0053	0.1659	0.1659
Brugia malayi	Cathepsin L-like precursor	0.0059	0.2062	0.2062
Entamoeba histolytica	cysteine proteinase, putative	0.0033	0.0286	0.1389
Loa Loa (eye worm)	ACC-1 protein	0.0053	0.1659	0.1659
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0053	0.1659	0.1659
Loa Loa (eye worm)	hypothetical protein	0.0053	0.1659	0.1659
Onchocerca volvulus		0.0059	0.2062	0.3007
Entamoeba histolytica	cysteine protease, putative	0.0033	0.0286	0.1389
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0176	1	1
Loa Loa (eye worm)	cathepsin B	0.0065	0.2454	0.2454
Loa Loa (eye worm)	hypothetical protein	0.0053	0.1659	0.1659
Entamoeba histolytica	cysteine protease, putative	0.0033	0.0286	0.1389
Onchocerca volvulus	Cathepsin L homolog	0.0059	0.2062	0.3007
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0053	0.1659	0.1659
Entamoeba histolytica	cysteine protease, putative	0.0033	0.0286	0.1389
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0041	0.0851	0.2606
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0053	0.1659	0.1659
Entamoeba histolytica	cysteine proteinase, putative	0.0059	0.2062	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0059	0.2062	0.2062
Onchocerca volvulus		0.013	0.6857	1
Echinococcus granulosus	cathepsin L cysteine protease	0.0033	0.0286	0.0286
Plasmodium vivax	vivapain-2	0.0059	0.2062	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0059	0.2062	0.2062
Brugia malayi	Cathepsin L-like precursor	0.0059	0.2062	0.2062
Entamoeba histolytica	cysteine protease, putative	0.0033	0.0286	0.1389
Loa Loa (eye worm)	hypothetical protein	0.0053	0.1659	0.1659
Loa Loa (eye worm)	hypothetical protein	0.0176	1	1
Onchocerca volvulus		0.013	0.6857	1
Giardia lamblia	Cathepsin B precursor	0.0065	0.2454	0.5
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0053	0.1659	0.1659
Trypanosoma cruzi	cysteine peptidase, putative	0.0059	0.2062	0.1828
Entamoeba histolytica	cysteine protease, putative	0.0033	0.0286	0.1389
Loa Loa (eye worm)	hypothetical protein	0.0053	0.1659	0.1659
Onchocerca volvulus		0.0053	0.1659	0.242
Brugia malayi	Cathepsin L-like precursor	0.0041	0.0851	0.0851
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0053	0.1659	0.1659
Echinococcus multilocularis	cathepsin L	0.0033	0.0286	0.0286
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0065	0.2454	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0059	0.2062	0.1828
Entamoeba histolytica	cysteine protease, putative	0.0033	0.0286	0.1389
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0059	0.2062	0.8189
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0059	0.2062	0.8189
Echinococcus multilocularis	glycine receptor subunit beta	0.0053	0.1659	0.1659
Toxoplasma gondii	cathepsin B	0.0065	0.2454	1
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0053	0.1659	0.1659
Schistosoma mansoni	nAChR subunit	0.0053	0.1659	0.1659
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0059	0.2062	0.8189
Onchocerca volvulus		0.0059	0.2062	0.3007
Entamoeba histolytica	cysteine protease, putative	0.0033	0.0286	0.1389
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0053	0.1659	0.1659
Onchocerca volvulus		0.0059	0.2062	0.3007
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0053	0.1659	0.1659
Brugia malayi	cathepsin L-like precursor	0.0041	0.0851	0.0851
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0053	0.1659	0.1659
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0059	0.2062	0.8189
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0053	0.1659	0.1659
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0053	0.1659	0.1659
Entamoeba histolytica	cysteine protease, putative	0.0033	0.0286	0.1389
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0053	0.1659	0.1659
Brugia malayi	Cathepsin L-like precursor	0.0059	0.2062	0.2062
Entamoeba histolytica	cysteine proteinase, putative	0.0041	0.0851	0.4129
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0053	0.1659	0.1659
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0053	0.1659	0.1659
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0053	0.1659	0.1659
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0176	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.2062	0.8189
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0053	0.1659	0.1659
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0053	0.1659	0.1659
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.2062	0.8189
Onchocerca volvulus		0.0059	0.2062	0.3007
Schistosoma mansoni	nAChR subunit	0.0053	0.1659	0.1659
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0053	0.1659	0.1659
Onchocerca volvulus		0.0059	0.2062	0.3007
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0033	0.0286	0.0286
Brugia malayi	Cathepsin L-like precursor	0.0059	0.2062	0.2062
Onchocerca volvulus		0.013	0.6857	1
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0053	0.1659	0.1659
Entamoeba histolytica	cysteine proteinase 1, putative	0.0033	0.0286	0.1389
Loa Loa (eye worm)	hypothetical protein	0.0053	0.1659	0.1659
Echinococcus multilocularis	cathepsin L cysteine protease	0.0059	0.2062	0.2062
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0041	0.0851	0.0582
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0059	0.2062	0.8189
Entamoeba histolytica	cysteine proteinase, putative	0.0059	0.2062	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0851	0.0851
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0041	0.0851	0.2606
Loa Loa (eye worm)	hypothetical protein	0.0105	0.5197	0.5197
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0059	0.2062	0.8189
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0851	0.0851
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.013	0.6857	0.6857
Schistosoma mansoni	nAChR subunit	0.0053	0.1659	0.1659
Brugia malayi	Cation transporter family protein	0.0053	0.1659	0.1659
Echinococcus granulosus	cathepsin L	0.0033	0.0286	0.0286
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0059	0.2062	0.8189
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0065	0.2454	0.2232
Echinococcus multilocularis	cathepsin b	0.0176	1	1
Onchocerca volvulus		0.0053	0.1659	0.242
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.013	0.6857	0.6857
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0059	0.2062	0.8189
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.2062	0.8189
Loa Loa (eye worm)	hypothetical protein	0.0053	0.1659	0.1659
Loa Loa (eye worm)	hypothetical protein	0.0053	0.1659	0.1659
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0059	0.2062	0.8189
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0053	0.1659	0.1659
Giardia lamblia	Cathepsin B precursor	0.0065	0.2454	0.5
Entamoeba histolytica	cysteine protease, putative	0.0033	0.0286	0.1389
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0059	0.2062	0.8189
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.2062	0.8189
Echinococcus granulosus	cysteine protease	0.0033	0.0286	0.0286
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0033	0.0286	0.0286
Brugia malayi	Cathepsin L-like precursor	0.0041	0.0851	0.0851
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.2062	0.8189
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0851	0.0851
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0065	0.2454	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0065	0.2454	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0059	0.2062	0.8189
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0053	0.1659	0.1659
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0059	0.2062	0.8189
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0053	0.1659	0.1659
Loa Loa (eye worm)	cysteine protease	0.0059	0.2062	0.2062
Brugia malayi	Cathepsin L-like precursor	0.0059	0.2062	0.2062
Trypanosoma cruzi	cysteine peptidase, putative	0.0059	0.2062	0.1828
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0053	0.1659	0.1659
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0053	0.1659	0.1659
Loa Loa (eye worm)	hypothetical protein	0.0053	0.1659	0.1659
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0053	0.1659	0.1659
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.2062	0.8189
Loa Loa (eye worm)	hypothetical protein	0.0059	0.2062	0.2062
Loa Loa (eye worm)	ctsf protein	0.0059	0.2062	0.2062
Schistosoma mansoni	cathepsin F (C01 family)	0.0041	0.0851	0.0851
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.2062	0.8189
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0053	0.1659	0.1659
Entamoeba histolytica	cysteine proteinase, putative	0.0033	0.0286	0.1389
Echinococcus granulosus	glycine receptor subunit beta	0.0053	0.1659	0.1659
Loa Loa (eye worm)	ACC-1 protein	0.0053	0.1659	0.1659
Echinococcus multilocularis	nAChR subunit	0.0053	0.1659	0.1659
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.2062	0.8189
Loa Loa (eye worm)	hypothetical protein	0.0053	0.1659	0.1659
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0059	0.2062	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0065	0.2454	0.2454
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0059	0.2062	0.2062
Onchocerca volvulus	Cathepsin F homolog	0.0059	0.2062	0.3007
Entamoeba histolytica	cysteine protease, putative	0.0033	0.0286	0.1389
Onchocerca volvulus	Putative nachr subunit	0.0053	0.1659	0.242
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0053	0.1659	0.1659
Echinococcus granulosus	cathepsin l1	0.0041	0.0851	0.0851
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0053	0.1659	0.1659
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0059	0.2062	0.8189
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0053	0.1659	0.1659
Onchocerca volvulus		0.0059	0.2062	0.3007
Brugia malayi	excitatory GABA receptor EXP-1A	0.0053	0.1659	0.1659
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0053	0.1659	0.1659
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0053	0.1659	0.1659
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0053	0.1659	0.1659
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0053	0.1659	0.1659
Loa Loa (eye worm)	hypothetical protein	0.0053	0.1659	0.1659
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.2062	0.8189
Entamoeba histolytica	cysteine proteinase, putative	0.0033	0.0286	0.1389
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0041	0.0851	0.0851
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0053	0.1659	0.1659
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0059	0.2062	0.8189
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0053	0.1659	0.1659
Schistosoma mansoni	nAChR subunit	0.0053	0.1659	0.1659
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0059	0.2062	0.2062
Trypanosoma cruzi	cruzipain precursor, putative	0.0059	0.2062	0.1828
Entamoeba histolytica	cysteine protease, putative	0.0033	0.0286	0.1389
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0059	0.2062	0.2062
Trypanosoma cruzi	cysteine peptidase, putative	0.0059	0.2062	0.1828
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0059	0.2062	0.8189
Loa Loa (eye worm)	hypothetical protein	0.0053	0.1659	0.1659
Entamoeba histolytica	cysteine proteinase, putative	0.0033	0.0286	0.1389
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.2062	0.8189
Loa Loa (eye worm)	hypothetical protein	0.0053	0.1659	0.1659
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0033	0.0286	0.0286
Echinococcus granulosus	cathepsin l1	0.0059	0.2062	0.2062
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0053	0.1659	0.1659
Onchocerca volvulus		0.0041	0.0851	0.1242
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.2062	0.8189
Schistosoma mansoni	nAChR subunit	0.0053	0.1659	0.1659
Loa Loa (eye worm)	hypothetical protein	0.0053	0.1659	0.1659
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0059	0.2062	0.2062
Echinococcus granulosus	glycine receptor subunit beta	0.0053	0.1659	0.1659
Loa Loa (eye worm)	hypothetical protein	0.013	0.6857	0.6857
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0059	0.2062	0.8189
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.2062	0.8189
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0176	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0059	0.2062	0.8189
Brugia malayi	Papain family cysteine protease containing protein	0.0059	0.2062	0.2062
Schistosoma mansoni	cathepsin F (C01 family)	0.0059	0.2062	0.2062
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0176	1	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0059	0.2062	1
Loa Loa (eye worm)	hypothetical protein	0.0053	0.1659	0.1659
Onchocerca volvulus	Cathepsin L homolog	0.0059	0.2062	0.3007
Entamoeba histolytica	cysteine protease, putative	0.0033	0.0286	0.1389
Plasmodium vivax	vivapain-2	0.0059	0.2062	1
Echinococcus multilocularis	glycine receptor subunit beta	0.0053	0.1659	0.1659

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)		Inhibition of human recombinant CatL assessed as suppression of enzyme-mediated Z-Phe-Arg-AMC cleavage by QFRET assay	ChEMBL.	22742641
IC50 (binding)	= 0.005 uM	Inhibition of human recombinant CatK assessed as suppression of enzyme-mediated Z-Phe-Arg-AMC cleavage incubated for 1 hrs by QFRET assay	ChEMBL.	22742641
IC50 (binding)	> 2.9 uM	Inhibition of human recombinant CatB assessed as suppression of enzyme-mediated Z-Arg-Arg-AMC cleavage by QFRET assay	ChEMBL.	22742641
IC50 (binding)	> 4 uM	Inhibition of human recombinant CatS assessed as suppression of enzyme-mediated Z-Val-Val-Arg-AMC cleavage by QFRET assay	ChEMBL.	22742641

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2163586

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1677941