TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 508.752 | Formula: C26H52O7S
H donors: 4 H acceptors: 4 LogP: 6.27 Rotable bonds: 22
Rule of 5 violations (Lipinski): 2
SMILES: CCCCCCCCCCCCCCCCOC[C@H](CS[C@H]1O[C@@H](CO)[C@H]([C@@H]([C@H]1O)O)O)OC
InChi: 1S/C26H52O7S/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-32-19-21(31-2)20-34-26-25(30)24(29)23(28)22(18-27)33-26/h21-30H,3-20H2,1-2H3/t21-,22+,23-,24+,25-,26-/m1/s1
InChiKey: KMNKDRDLSLQCIW-DJZLDEFYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	cysteine proteinase, putative	0.0647	0.5102	0.4938
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0647	0.5102	0.5093
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0232	0.1763	0.1747
Leishmania major	cathepsin L-like protease	0.1257	1	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0067	0.0067
Brugia malayi	Protein kinase domain containing protein	0.0224	0.17	0.1644
Trypanosoma cruzi	major cysteine proteinase, putative	0.0232	0.1763	0.17
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0339	0.2627	0.2627
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1257	1	1
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0232	0.1763	0.1486
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1257	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1257	1	1
Brugia malayi	Cathepsin L-like precursor	0.1257	1	1
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0232	0.1763	0.1486
Giardia lamblia	Cathepsin B precursor	0.0232	0.1763	1
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0232	0.1763	0.1747
Trypanosoma cruzi	cysteine peptidase, putative	0.0416	0.3238	0.3186
Plasmodium falciparum	cysteine proteinase falcipain 3	0.1257	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1257	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0841	0.6661	0.6548
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0232	0.1763	1
Giardia lamblia	Cathepsin B precursor	0.0232	0.1763	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0232	0.1763	0.1486
Loa Loa (eye worm)	ctsf protein	0.1257	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1257	1	1
Trypanosoma cruzi	cruzipain precursor, putative	0.1257	1	1
Giardia lamblia	Cysteine protease	0.0232	0.1763	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1257	1	1
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0232	0.1763	0.17
Schistosoma mansoni	cathepsin s	0.0416	0.3238	0.3225
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0021	0.0067	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0195	0.1463	0.1463
Schistosoma mansoni	cell adhesion molecule	0.0028	0.0121	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0841	0.6661	0.6661
Onchocerca volvulus	Cathepsin L homolog	0.0232	0.1763	0.167
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1257	1	1
Plasmodium vivax	serine-repeat antigen (SERA)	0.0232	0.1763	0.1486
Schistosoma mansoni	cathepsin F (C01 family)	0.1257	1	1
Toxoplasma gondii	cathepsin CPC2	0.0232	0.1763	0.1486
Toxoplasma gondii	cathepsin B	0.0232	0.1763	0.1486
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0232	0.1763	0.1486
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0232	0.1763	0.1747
Entamoeba histolytica	hypothetical protein	0.0232	0.1763	0.1486
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0232	0.1763	0.1747
Mycobacterium tuberculosis	Conserved protein	0.0022	0.0077	0.5
Schistosoma mansoni	cathepsin S (C01 family)	0.0232	0.1763	0.1747
Leishmania major	protein kinase, putative	0.0053	0.0325	0.0251
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.0053	0.0325	0.0261
Brugia malayi	cathepsin F-like cysteine proteinase	0.0232	0.1763	0.1708
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1257	1	1
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0232	0.1763	0.1486
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0416	0.3238	0.3193
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0021	0.0067	0.0047
Trichomonas vaginalis	conserved hypothetical protein	0.0232	0.1763	0.1486
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1257	1	1
Entamoeba histolytica	cysteine proteinase 2	0.0647	0.5102	0.4938
Loa Loa (eye worm)	AUR protein kinase	0.0053	0.0325	0.0325
Schistosoma mansoni	hypothetical protein	0.0026	0.0112	0.0093
Trypanosoma cruzi	cysteine protease, putative	0.0647	0.5102	0.5065
Loa Loa (eye worm)	hypothetical protein	0.0232	0.1763	0.1763
Plasmodium vivax	vivapain-2	0.1257	1	1
Echinococcus granulosus	cysteine protease	0.0647	0.5102	0.507
Giardia lamblia	Cysteine protease	0.0232	0.1763	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0112	0.0112
Brugia malayi	Papain family cysteine protease containing protein	0.0232	0.1763	0.1708
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0841	0.6661	0.6548
Brugia malayi	cathepsin L-like cysteine proteinase	0.0232	0.1763	0.1708
Echinococcus multilocularis	neuroglian	0.0026	0.0109	0.0043
Trypanosoma cruzi	cysteine peptidase, putative	0.1257	1	1
Onchocerca volvulus		0.1257	1	1
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0053	0.0325	0.0251
Plasmodium falciparum	serine repeat antigen 1	0.0232	0.1763	0.17
Onchocerca volvulus		0.1257	1	1
Schistosoma mansoni	cathepsin C	0.0232	0.1763	0.1747
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0647	0.5102	0.4938
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0647	0.5102	0.5065
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0232	0.1763	0.1486
Entamoeba histolytica	cysteine protease, putative	0.0647	0.5102	0.4938
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0647	0.5102	0.5093
Loa Loa (eye worm)	AUR protein kinase	0.0053	0.0325	0.0325
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0232	0.1763	0.1763
Plasmodium falciparum	serine repeat antigen 4	0.0232	0.1763	0.17
Schistosoma mansoni	serine/threonine protein kinase	0.0053	0.0325	0.0306
Echinococcus multilocularis	MAM	0.0026	0.0112	0.0046
Brugia malayi	fibroinase precursor	0.0232	0.1763	0.1708
Echinococcus granulosus	cathepsin L	0.0232	0.1763	0.1708
Giardia lamblia	Cathepsin B precursor	0.0232	0.1763	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0416	0.3238	0.3186
Loa Loa (eye worm)	hypothetical protein	0.0232	0.1763	0.1763
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0067	0.0067
Brugia malayi	Cathepsin L-like precursor	0.1257	1	1
Echinococcus granulosus	neuroglian	0.0026	0.0109	0.0043
Giardia lamblia	Cathepsin B precursor	0.0232	0.1763	1
Giardia lamblia	Cathepsin L precursor	0.0232	0.1763	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1257	1	1
Echinococcus multilocularis	roundabout 2	0.0033	0.0164	0.0098
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.1257	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0647	0.5102	0.507
Brugia malayi	Cathepsin L-like precursor	0.1257	1	1
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0232	0.1763	0.1763
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0232	0.1763	0.1486
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0647	0.5102	0.4938
Loa Loa (eye worm)	cysteine protease	0.1257	1	1
Brugia malayi	Cathepsin L-like precursor	0.0841	0.6661	0.6638
Onchocerca volvulus		0.0232	0.1763	0.167
Echinococcus multilocularis	cathepsin L cysteine protease	0.1257	1	1
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0232	0.1763	0.1708
Onchocerca volvulus		0.1257	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.1257	1	1
Loa Loa (eye worm)	TK/ALK protein kinase	0.0224	0.1699	0.1699
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1257	1	1
Schistosoma mansoni	vesicular amine transporter	0.0021	0.0067	0.0048
Entamoeba histolytica	cysteine protease, putative	0.0232	0.1763	0.1486
Brugia malayi	Cathepsin L-like precursor	0.1257	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1257	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1257	1	1
Echinococcus multilocularis	cathepsin b	0.0232	0.1763	0.1708
Entamoeba histolytica	cysteine proteinase, putative	0.0647	0.5102	0.4938
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0232	0.1763	0.1747
Giardia lamblia	Encystation-specific protease	0.0232	0.1763	1
Leishmania major	cathepsin L-like protease	0.1257	1	1
Entamoeba histolytica	cysteine protease, putative	0.0647	0.5102	0.4938
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0232	0.1763	0.1747
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0647	0.5102	0.4938
Echinococcus multilocularis	cathepsin b	0.0232	0.1763	0.1708
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0841	0.6661	0.6638
Echinococcus granulosus	roundabout 2	0.0033	0.0164	0.0098
Entamoeba histolytica	cysteine protease, putative	0.0647	0.5102	0.4938
Loa Loa (eye worm)	hypothetical protein	0.0841	0.6661	0.6661
Plasmodium falciparum	serine repeat antigen 5	0.0232	0.1763	0.17
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1257	1	1
Brugia malayi	cathepsin B-like cysteine proteinase	0.0232	0.1763	0.1708
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1257	1	1
Echinococcus granulosus	cathepsin L	0.0647	0.5102	0.507
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0232	0.1763	0.1486
Onchocerca volvulus		0.1257	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1257	1	1
Toxoplasma gondii	cathepsin CPL	0.1257	1	1
Schistosoma mansoni	cathepsin B (C01 family)	0.0232	0.1763	0.1747
Giardia lamblia	Cathepsin L-like protease	0.0232	0.1763	1
Entamoeba histolytica	cysteine protease, putative	0.0232	0.1763	0.1486
Loa Loa (eye worm)	hypothetical protein	0.0232	0.1763	0.1763
Onchocerca volvulus		0.1257	1	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0841	0.6661	0.6635
Brugia malayi	Papain family cysteine protease containing protein	0.0232	0.1763	0.1708
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1257	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1257	1	1
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0232	0.1763	0.1486
Giardia lamblia	Cathepsin B precursor	0.0232	0.1763	1
Entamoeba histolytica	cysteine protease, putative	0.0647	0.5102	0.4938
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0232	0.1763	0.1486
Loa Loa (eye worm)	AUR protein kinase	0.0053	0.0325	0.0325
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0232	0.1763	0.1747
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0232	0.1763	0.17
Brugia malayi	serine/threonine protein kinase 6	0.0053	0.0325	0.0261
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1257	1	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0067	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0841	0.6661	0.6661
Schistosoma mansoni	nephrin	0.0026	0.0109	0.009
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0416	0.3238	0.3238
Plasmodium vivax	unspecified product	0.0416	0.3238	0.3011
Giardia lamblia	Cathepsin L precursor	0.0232	0.1763	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1257	1	1
Mycobacterium ulcerans	hypothetical protein	0.0022	0.0077	0.5
Plasmodium vivax	unspecified product	0.0647	0.5102	0.4938
Plasmodium vivax	vivapain-3	0.0647	0.5102	0.4938
Entamoeba histolytica	cysteine protease, putative	0.0647	0.5102	0.4938
Giardia lamblia	Cysteine protease	0.0232	0.1763	1
Leishmania major	cathepsin L-like protease	0.1257	1	1
Leishmania major	cathepsin L-like protease	0.1257	1	1
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0232	0.1763	0.1747
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1257	1	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0112	0.0112
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1257	1	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0067	0.0067
Giardia lamblia	Cathepsin L-like protease	0.0232	0.1763	1
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0647	0.5102	0.5065
Entamoeba histolytica	cysteine protease, putative	0.1257	1	1
Echinococcus granulosus	cathepsin l1	0.1257	1	1
Giardia lamblia	Cathepsin L precursor	0.0232	0.1763	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0232	0.1763	0.1763
Brugia malayi	Papain family cysteine protease containing protein	0.0647	0.5102	0.507
Loa Loa (eye worm)	hypothetical protein	0.0232	0.1763	0.1763
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1257	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0232	0.1763	0.1708
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1257	1	1
Plasmodium vivax	vivapain-1	0.0647	0.5102	0.4938
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0232	0.1763	0.1708
Echinococcus granulosus	twitchin	0.0027	0.0113	0.0047
Brugia malayi	cathepsin L-like precursor	0.0841	0.6661	0.6638
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0232	0.1763	0.1486
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0232	0.1763	0.1486
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0232	0.1763	0.1486
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0232	0.1763	0.1486
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0232	0.1763	0.1747
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0232	0.1763	0.1486
Entamoeba histolytica	cysteine protease, putative	0.0647	0.5102	0.4938
Loa Loa (eye worm)	hypothetical protein	0.0232	0.1763	0.1763
Brugia malayi	Cathepsin L-like precursor	0.1257	1	1
Onchocerca volvulus		0.1257	1	1
Trypanosoma cruzi	major cysteine proteinase, putative	0.0232	0.1763	0.17
Trypanosoma cruzi	cysteine peptidase, putative	0.1257	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1257	1	1
Trypanosoma cruzi	aurora B kinase, putative	0.0053	0.0325	0.0251
Brugia malayi	serine/threonine kinase 12	0.0053	0.0325	0.0261
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0232	0.1763	0.1486
Onchocerca volvulus	Cathepsin L homolog	0.1257	1	1
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0232	0.1763	0.1486
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0339	0.2627	0.2577
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.1257	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1257	1	1
Brugia malayi	Cathepsin L-like precursor	0.0416	0.3238	0.3193
Loa Loa (eye worm)	hypothetical protein	0.0232	0.1763	0.1763
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.1257	1	1
Entamoeba histolytica	cysteine protease, putative	0.0232	0.1763	0.1486
Loa Loa (eye worm)	hypothetical protein	0.0416	0.3238	0.3238
Onchocerca volvulus	Tyrosine kinase homolog	0.0317	0.2447	0.2362
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0232	0.1763	0.1486
Echinococcus multilocularis	cysteine protease	0.1257	1	1
Entamoeba histolytica	cysteine protease, putative	0.0647	0.5102	0.4938
Brugia malayi	Cathepsin L-like precursor	0.0841	0.6661	0.6638
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0164	0.0164
Brugia malayi	hypothetical protein	0.0026	0.0112	0.0046
Giardia lamblia	Cathepsin L precursor	0.0232	0.1763	1
Plasmodium falciparum	serine repeat antigen 6	0.0232	0.1763	0.17
Entamoeba histolytica	cysteine protease, putative	0.0232	0.1763	0.1486
Giardia lamblia	Cathepsin B precursor	0.0232	0.1763	1
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0232	0.1763	0.1486
Loa Loa (eye worm)	hypothetical protein	0.1257	1	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0647	0.5102	0.5093
Entamoeba histolytica	cysteine protease, putative	0.0647	0.5102	0.4938
Schistosoma mansoni	cathepsin F (C01 family)	0.1257	1	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0647	0.5102	0.5065
Loa Loa (eye worm)	fibroinase	0.1257	1	1
Echinococcus granulosus	aurora kinase A	0.0053	0.0325	0.0261
Plasmodium vivax	unspecified product	0.0232	0.1763	0.1486
Giardia lamblia	Cathepsin B precursor	0.0232	0.1763	1
Entamoeba histolytica	cysteine proteinase, putative	0.0647	0.5102	0.4938
Trypanosoma cruzi	cysteine peptidase, putative	0.1257	1	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0232	0.1763	0.17
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0232	0.1763	0.1747
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0121	0.0121
Entamoeba histolytica	cysteine proteinase 1, putative	0.0647	0.5102	0.4938
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0232	0.1763	1
Plasmodium falciparum	serine repeat antigen 8	0.0232	0.1763	0.17
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0232	0.1763	0.1486
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.0053	0.0325	0.0261
Entamoeba histolytica	cysteine protease, putative	0.0647	0.5102	0.4938
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0647	0.5102	0.4938
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0232	0.1763	0.1486
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0232	0.1763	0.1486
Entamoeba histolytica	cysteine proteinase, putative	0.1257	1	1
Entamoeba histolytica	cysteine protease, putative	0.0647	0.5102	0.4938
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0232	0.1763	0.1486
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1257	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0232	0.1763	0.1486
Echinococcus granulosus	cathepsin b	0.0232	0.1763	0.1708
Echinococcus multilocularis	aurora kinase A	0.0053	0.0325	0.0261
Entamoeba histolytica	cysteine protease, putative	0.0232	0.1763	0.1486
Loa Loa (eye worm)	cathepsin B	0.0232	0.1763	0.1763
Leishmania major	cathepsin L-like protease	0.1257	1	1
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0232	0.1763	1
Onchocerca volvulus	Cathepsin F homolog	0.1257	1	1
Echinococcus multilocularis	cathepsin L	0.0647	0.5102	0.507
Giardia lamblia	Cathepsin L precursor	0.0232	0.1763	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0232	0.1763	0.1486
Entamoeba histolytica	cysteine proteinase, putative	0.0647	0.5102	0.4938
Entamoeba histolytica	cysteine protease, putative	0.0232	0.1763	0.1486
Echinococcus granulosus	cathepsin L cysteine protease	0.0647	0.5102	0.507
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1257	1	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0067	0.0067
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0232	0.1763	0.1486
Plasmodium falciparum	serine repeat antigen 9	0.0232	0.1763	0.17
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.1257	1	1
Echinococcus multilocularis	cathepsin L	0.0232	0.1763	0.1708
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0067	0.0067
Plasmodium vivax	vivapain-2	0.1257	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0232	0.1763	0.1486
Treponema pallidum	mcbG protein	0.0022	0.0077	0.5
Toxoplasma gondii	cathepsin CPC1	0.0232	0.1763	0.1486
Plasmodium vivax	serine-repeat antigen (SERA)	0.0232	0.1763	0.1486
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1257	1	1
Onchocerca volvulus	Cathepsin L homolog	0.1257	1	1
Leishmania major	cathepsin L-like protease	0.1257	1	1
Plasmodium falciparum	serine repeat antigen 3	0.0232	0.1763	0.17
Brugia malayi	cathepsin F-like cysteine proteinase	0.0416	0.3238	0.3193
Trypanosoma cruzi	cysteine peptidase, putative	0.1257	1	1
Giardia lamblia	Hypothetical protein	0.0232	0.1763	1
Schistosoma mansoni	hypothetical protein	0.0026	0.0112	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0416	0.3238	0.3238
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1257	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0232	0.1763	0.1486
Onchocerca volvulus		0.0309	0.2382	0.2295
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0112	0.0112
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0232	0.1763	0.17
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1257	1	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.1257	1	1
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0232	0.1763	0.1486
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1257	1	1
Giardia lamblia	Cathepsin B precursor	0.0232	0.1763	1
Leishmania major	cathepsin L-like protease	0.1257	1	1
Plasmodium falciparum	serine repeat antigen 2	0.0232	0.1763	0.17
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0232	0.1763	0.1486
Echinococcus multilocularis	cathepsin L cysteine protease	0.1257	1	1
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0232	0.1763	0.1486
Onchocerca volvulus		0.0841	0.6661	0.6623
Trypanosoma cruzi	cysteine proteinase, putative	0.0647	0.5102	0.5065
Trypanosoma cruzi	cysteine peptidase, putative	0.0647	0.5102	0.5065
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0232	0.1763	0.1747
Leishmania major	cysteine peptidase A (CPA)	0.1257	1	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0164	0.0164
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0232	0.1763	0.1486
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0232	0.1763	0.1708
Giardia lamblia	Cysteine protease	0.0232	0.1763	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0232	0.1763	0.1747
Entamoeba histolytica	cysteine protease, putative	0.0647	0.5102	0.4938
Onchocerca volvulus		0.1257	1	1
Brugia malayi	cathepsin L precursor	0.0232	0.1763	0.1708
Giardia lamblia	Hypothetical protein	0.0232	0.1763	1
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0232	0.1763	0.1747
Loa Loa (eye worm)	hypothetical protein	0.0416	0.3238	0.3238
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.1257	1	1
Echinococcus granulosus	cathepsin l1	0.0841	0.6661	0.6638
Echinococcus granulosus	MAM	0.0026	0.0112	0.0046
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0232	0.1763	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0841	0.6661	0.6548
Loa Loa (eye worm)	hypothetical protein	0.0232	0.1763	0.1763
Echinococcus granulosus	cathepsin L cysteine proteinase	0.1257	1	1
Entamoeba histolytica	cysteine protease, putative	0.0647	0.5102	0.4938
Giardia lamblia	Cathepsin L precursor	0.0232	0.1763	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1257	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1257	1	1
Plasmodium falciparum	serine repeat antigen 7	0.0232	0.1763	0.17
Schistosoma mansoni	protein kinase	0.0053	0.0325	0.0306
Echinococcus multilocularis	cysteine protease	0.1257	1	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0232	0.1763	0.17
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0232	0.1763	0.1747
Schistosoma mansoni	cathepsin F (C01 family)	0.0841	0.6661	0.6654
Leishmania major	cathepsin L-like protease	0.1257	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.1257	1	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.1257	1	1
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0232	0.1763	0.1486
Echinococcus granulosus	cathepsin b	0.0232	0.1763	0.1708
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0232	0.1763	0.17
Echinococcus granulosus	cathepsin l cysteine peptidase	0.1257	1	1
Brugia malayi	serine/threonine-protein kinase 6	0.0053	0.0325	0.0261
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0028	0.0121	0.0055
Entamoeba histolytica	cysteine proteinase, putative	0.1257	1	1
Entamoeba histolytica	cysteine protease, putative	0.0647	0.5102	0.4938

Activities

Activity type	Activity value	Assay description	Source	Reference
Control (functional)	= 7 %	Antineoplastic activity against WEHI 3B cell line in which [3H]-thymidine was incorporated into DNA	ChEMBL.	2391700
Control (functional)	= 66 %	Antineoplastic activity against R6X-B15 cell line in which [3H]-thymidine was incorporated into DNA	ChEMBL.	2391700

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2115221

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1678123