Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Hydroxyacid oxidase 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium leprae | POSSIBLE L-LACTATE DEHYDROGENASE (CYTOCHROME) LLDD2 | Get druggable targets OG5_126945 | All targets in OG5_126945 |
Mycobacterium tuberculosis | Possible L-lactate dehydrogenase (cytochrome) LldD2 | Get druggable targets OG5_126945 | All targets in OG5_126945 |
Treponema pallidum | hypothetical protein | Get druggable targets OG5_126945 | All targets in OG5_126945 |
Candida albicans | cytochrome b2 precursor | Get druggable targets OG5_126945 | All targets in OG5_126945 |
Candida albicans | cytochrome b2 precursor | Get druggable targets OG5_126945 | All targets in OG5_126945 |
Mycobacterium ulcerans | L-lactate dehydrogenase (cytochrome) LldD2 | Get druggable targets OG5_126945 | All targets in OG5_126945 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium ulcerans | L-lactate dehydrogenase (cytochrome) LldD1 | Hydroxyacid oxidase 2 | 353 aa | 369 aa | 34.4 % |
Mycobacterium tuberculosis | Possible L-lactate dehydrogenase (cytochrome) LldD1 | Hydroxyacid oxidase 2 | 353 aa | 366 aa | 34.7 % |
Trichomonas vaginalis | Maverick transposable element DNA polymerase type B, organellar and viral | Hydroxyacid oxidase 2 | 353 aa | 293 aa | 21.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0138 | 0.2119 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0381 | 0.7584 | 1 |
Mycobacterium tuberculosis | Possible L-lactate dehydrogenase (cytochrome) LldD2 | 0.0209 | 0.37 | 0.5 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0381 | 0.7584 | 1 |
Mycobacterium ulcerans | L-lactate dehydrogenase (cytochrome) LldD2 | 0.0209 | 0.37 | 1 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0138 | 0.2119 | 1 |
Echinococcus multilocularis | serotonin receptor | 0.0138 | 0.2119 | 1 |
Echinococcus multilocularis | serotonin receptor | 0.0138 | 0.2119 | 1 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0381 | 0.7584 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.2119 | 0.2795 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0381 | 0.7584 | 0.5 |
Mycobacterium leprae | POSSIBLE L-LACTATE DEHYDROGENASE (CYTOCHROME) LLDD2 | 0.0209 | 0.37 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.028 | 0.5311 | 0.7003 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.2119 | 0.2795 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0381 | 0.7584 | 0.7584 |
Entamoeba histolytica | isopentenyl-diphosphate delta-isomerase, putative | 0.0075 | 0.0688 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0195 | 0.339 | 0.447 |
Treponema pallidum | hypothetical protein | 0.0209 | 0.37 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.4 uM | Inhibition of rat Hao2-mediated oxidation of 2-hydroxyoctanoic acid assessed as proportionate release of H2O2 | ChEMBL. | 22658862 |
Inhibition (binding) | = 8 % | Inhibition of human Hao2-mediated oxidation of 2-hydroxyoctanoic acid assessed as proportionate release of H2O2 at 1 uM | ChEMBL. | 22658862 |
Inhibition (binding) | = 30 % | Inhibition of human Hao2-mediated oxidation of 2-hydroxyoctanoic acid assessed as proportionate release of H2O2 at 10 uM | ChEMBL. | 22658862 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.