Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | serotonin transporter | 0.0398 | 0.5314 | 0.5446 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0237 | 0.2658 | 0.4649 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0158 | 0.1342 | 0.1342 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0158 | 0.1342 | 0.1375 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0158 | 0.1342 | 0.1342 |
Echinococcus granulosus | nmda type glutamate receptor | 0.013 | 0.0875 | 0.0875 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0143 | 0.1097 | 0.1172 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0143 | 0.1097 | 0.0725 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.0237 | 0.2658 | 0.4158 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0356 | 0.4616 | 0.8539 |
Echinococcus granulosus | leukotriene A 4 hydrolase | 0.0237 | 0.2658 | 0.2658 |
Schistosoma mansoni | glutamate receptor kainate | 0.0143 | 0.1097 | 0.0725 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.013 | 0.0875 | 0.0897 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0356 | 0.4616 | 0.5 |
Echinococcus granulosus | glutamate receptor 2 | 0.0105 | 0.0467 | 0.0467 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0158 | 0.1342 | 0.1375 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0356 | 0.4616 | 0.5 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0304 | 0.3758 | 0.3851 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0105 | 0.0474 | 0.5 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0158 | 0.1342 | 0.1375 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0105 | 0.0474 | 0.5 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0158 | 0.1342 | 0.1342 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.0143 | 0.1097 | 0.1505 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0234 | 0.2609 | 0.405 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0143 | 0.1097 | 0.1505 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0304 | 0.3758 | 0.3758 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0143 | 0.1097 | 0.1124 |
Echinococcus multilocularis | conserved hypothetical protein | 0.0667 | 0.9758 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0356 | 0.4616 | 0.8594 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.0237 | 0.2658 | 0.2724 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0398 | 0.5314 | 1 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0398 | 0.5314 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0158 | 0.1342 | 0.1375 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0356 | 0.4616 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0091 | 0.0245 | 0.0251 |
Schistosoma mansoni | glutamate receptor kainate | 0.0143 | 0.1097 | 0.0725 |
Echinococcus granulosus | glutamate receptor 2 | 0.0158 | 0.1342 | 0.1342 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0113 | 0.0596 | 0.0123 |
Schistosoma mansoni | ATP-binding cassette transporter | 0.0143 | 0.1097 | 0.0725 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0143 | 0.1097 | 0.0725 |
Loa Loa (eye worm) | serotonin transporter b | 0.0398 | 0.5314 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.174 | 0.28 |
Echinococcus granulosus | serotonin transporter | 0.0398 | 0.5314 | 0.5314 |
Loa Loa (eye worm) | hypothetical protein | 0.0398 | 0.5314 | 1 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0143 | 0.1097 | 0.1172 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0304 | 0.3758 | 0.6577 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0113 | 0.0596 | 0.0596 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0158 | 0.1342 | 0.1375 |
Loa Loa (eye worm) | hypothetical protein | 0.0398 | 0.5314 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0113 | 0.0596 | 0.0611 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0091 | 0.0245 | 0.0245 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0105 | 0.0467 | 0.0479 |
Schistosoma mansoni | glutamate receptor kainate | 0.0143 | 0.1097 | 0.0725 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0398 | 0.5314 | 1 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0113 | 0.0596 | 0.0496 |
Onchocerca volvulus | 0.0398 | 0.5314 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0398 | 0.5314 | 1 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0398 | 0.5314 | 1 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0398 | 0.5314 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0158 | 0.1342 | 0.1342 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0398 | 0.5314 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 28 uM | Cytotoxicity against human melanoma MM96L cell line | ChEMBL. | 15163181 |
IC50 (functional) | = 28 uM | Cytotoxicity against human melanoma MM96L cell line | ChEMBL. | 15163181 |
IC50 (ADMET) | > 100 uM | Cytotoxicity against human normal neonatal foreskin fibroblasts (NFF) | ChEMBL. | 15163181 |
IC50 (ADMET) | > 100 uM | Cytotoxicity against human normal neonatal foreskin fibroblasts (NFF) | ChEMBL. | 15163181 |
logP (ADMET) | = 2.2 | Partition coefficient (logP) | ChEMBL. | 15163181 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.