Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | RNA recognition motif domain containing protein | 0.0127 | 0.5322 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.097 | 0.1275 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0036 | 0.0157 | 0.507 |
Echinococcus multilocularis | tar DNA binding protein | 0.0127 | 0.5322 | 0.6993 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 0.7611 | 1 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0033 | 0 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0127 | 0.5322 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0048 | 0.009 |
Loa Loa (eye worm) | RNA binding protein | 0.0127 | 0.5322 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0033 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0048 | 0.0063 |
Schistosoma mansoni | chromobox protein | 0.0064 | 0.1735 | 0.228 |
Mycobacterium leprae | conserved hypothetical protein | 0.0033 | 0 | 0.5 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0064 | 0.1735 | 0.326 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.5322 | 0.6993 |
Echinococcus granulosus | chromobox protein 1 | 0.0064 | 0.1735 | 0.228 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0127 | 0.5322 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.097 | 0.1275 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0033 | 0 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0929 | 0.1746 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0033 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.5322 | 0.6993 |
Echinococcus multilocularis | geminin | 0.0168 | 0.7611 | 1 |
Echinococcus granulosus | chromobox protein 1 | 0.0064 | 0.1735 | 0.228 |
Trichomonas vaginalis | chromobox protein, putative | 0.0038 | 0.031 | 0.1787 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.5322 | 0.6993 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.5322 | 0.6993 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0033 | 0 | 0.5 |
Mycobacterium ulcerans | lipase LipD | 0.0033 | 0 | 0.5 |
Toxoplasma gondii | ABC1 family protein | 0.0033 | 0 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.097 | 0.1275 |
Brugia malayi | chromobox protein homolog 3 | 0.0036 | 0.0157 | 0.0295 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.005 | 0.097 | 0.1823 |
Brugia malayi | RNA binding protein | 0.0127 | 0.5322 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0038 | 0.031 | 0.1787 |
Echinococcus granulosus | tar DNA binding protein | 0.0127 | 0.5322 | 0.6993 |
Echinococcus multilocularis | chromobox protein 1 | 0.0064 | 0.1735 | 0.228 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.097 | 0.1275 |
Trichomonas vaginalis | chromobox protein, putative | 0.0064 | 0.1735 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0064 | 0.1735 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0033 | 0 | 0.5 |
Mycobacterium leprae | Probable lipase LipE | 0.0033 | 0 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0127 | 0.5322 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.097 | 0.1275 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0048 | 0.009 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 0.7611 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0036 | 0.0157 | 0.0906 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.5322 | 0.6993 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.097 | 0.1275 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0036 | 0.0157 | 0.0906 |
Brugia malayi | Heterochromatin protein 1 | 0.0064 | 0.1735 | 0.326 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0038 | 0.031 | 1 |
Echinococcus granulosus | geminin | 0.0168 | 0.7611 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0033 | 0 | 0.5 |
Schistosoma mansoni | chromobox protein | 0.0064 | 0.1735 | 0.228 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0929 | 0.1746 |
Mycobacterium ulcerans | beta-lactamase | 0.0033 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0157 | 0.0295 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0929 | 0.1746 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.005 | 0.097 | 0.1823 |
Plasmodium vivax | hypothetical protein, conserved | 0.0033 | 0 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0929 | 0.1746 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.097 | 0.1275 |
Echinococcus multilocularis | chromobox protein 1 | 0.0064 | 0.1735 | 0.228 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 22770529 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.