Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | mercuric reductase, putative | 0.0013 | 0.0768 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0037 | 0.2881 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.001 | 0.0512 | 0.1591 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0512 | 0.1615 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0013 | 0.0768 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0512 | 0.1615 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.001 | 0.0512 | 0.1615 |
Echinococcus granulosus | cpg binding protein | 0.0029 | 0.2242 | 0.7624 |
Brugia malayi | Thioredoxin reductase | 0.0037 | 0.2881 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.001 | 0.0512 | 0.0512 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.001 | 0.0512 | 0.2229 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.0512 | 0.1591 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0013 | 0.0768 | 0.5 |
Loa Loa (eye worm) | glutathione reductase | 0.0037 | 0.2881 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.001 | 0.0512 | 0.1615 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0007 | 0.0258 | 0.0705 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0013 | 0.0768 | 0.5 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0005 | 0.0055 | 0.0055 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.001 | 0.0512 | 0.0512 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.001 | 0.0512 | 0.1615 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0013 | 0.0768 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.001 | 0.0512 | 0.2229 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.0512 | 0.0512 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.0512 | 0.1591 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0013 | 0.0768 | 0.0768 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0084 | 0.7022 | 0.8837 |
Echinococcus granulosus | FTZ F1 alpha | 0.001 | 0.0512 | 0.1591 |
Schistosoma mansoni | cpg binding protein | 0.0028 | 0.2102 | 0.2102 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0512 | 0.1615 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0084 | 0.7022 | 0.8837 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0093 | 0.7844 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0005 | 0.0104 | 0.0173 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.001 | 0.0512 | 0.0512 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.2242 | 0.2242 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0053 | 0.4297 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0037 | 0.2881 | 1 |
Loa Loa (eye worm) | histone methyltransferase | 0.0009 | 0.0407 | 0.1246 |
Brugia malayi | nuclear hormone receptor | 0.001 | 0.0512 | 0.1615 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0407 | 0.1227 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0512 | 0.1615 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0.0104 | 0.0173 |
Brugia malayi | glutathione reductase | 0.0037 | 0.2881 | 1 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0009 | 0.0471 | 0.1471 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0009 | 0.0471 | 0.1471 |
Treponema pallidum | NADH oxidase | 0.0013 | 0.0768 | 0.5 |
Plasmodium falciparum | glutathione reductase | 0.0037 | 0.2881 | 1 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0005 | 0.0055 | 0.0055 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0005 | 0.0104 | 0.0104 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.001 | 0.0512 | 0.1591 |
Schistosoma mansoni | coup transcription factor | 0.001 | 0.0512 | 0.0512 |
Leishmania major | trypanothione reductase | 0.0037 | 0.2881 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.001 | 0.0512 | 0.1591 |
Brugia malayi | hypothetical protein | 0.0005 | 0.0104 | 0.0173 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.001 | 0.0512 | 0.1591 |
Echinococcus multilocularis | cpg binding protein | 0.0029 | 0.2242 | 0.7624 |
Plasmodium falciparum | thioredoxin reductase | 0.0037 | 0.2881 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0.0104 | 0.0173 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.001 | 0.0512 | 0.1591 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0093 | 0.7844 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0084 | 0.7022 | 0.8837 |
Mycobacterium tuberculosis | Probable reductase | 0.0084 | 0.7022 | 0.8837 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0084 | 0.7022 | 0.8837 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0.0104 | 0.0173 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0008 | 0.0398 | 0.1211 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0037 | 0.2924 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.0512 | 0.1615 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.0512 | 0.1615 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.0512 | 0.1591 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.0512 | 0.1591 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0059 | 0.4854 | 0.4854 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.0512 | 0.1591 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0.0104 | 0.0173 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.001 | 0.0512 | 0.1615 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.001 | 0.0512 | 0.1615 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0512 | 0.1615 |
Loa Loa (eye worm) | steroid hormone receptor | 0.001 | 0.0512 | 0.1615 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.001 | 0.0512 | 0.0512 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.001 | 0.0512 | 0.0512 |
Schistosoma mansoni | zinc finger protein | 0.0005 | 0.0055 | 0.0055 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0007 | 0.0258 | 0.0705 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.001 | 0.0512 | 0.1615 |
Onchocerca volvulus | Bile acid receptor homolog | 0.001 | 0.0512 | 0.2229 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0005 | 0.0104 | 0.0173 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0037 | 0.2881 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0037 | 0.2881 | 0.2985 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.001 | 0.0512 | 0.0512 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.001 | 0.0512 | 0.1615 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.0512 | 0.1591 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0512 | 0.1615 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0028 | 0.2102 | 0.7245 |
Schistosoma mansoni | nuclear hormone receptor | 0.0005 | 0.0055 | 0.0055 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0037 | 0.2881 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0407 | 0.1227 |
Schistosoma mansoni | nuclear receptor | 0.0005 | 0.0055 | 0.0055 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.2242 | 0.2242 |
Brugia malayi | CXXC zinc finger family protein | 0.0028 | 0.2102 | 0.7245 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0005 | 0.0104 | 0.0173 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.001 | 0.0512 | 0.1615 |
Schistosoma mansoni | nuclear hormone receptor | 0.001 | 0.0512 | 0.0512 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0093 | 0.7844 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0013 | 0.0768 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.001 | 0.0512 | 0.1591 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0007 | 0.0258 | 0.0705 |
Brugia malayi | ecdysteroid receptor | 0.001 | 0.0512 | 0.1615 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.0512 | 0.1591 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.0512 | 0.1591 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0512 | 0.1615 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0013 | 0.0768 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.0512 | 0.0512 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0013 | 0.0768 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.001 | 0.0512 | 0.1615 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0037 | 0.2924 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0005 | 0.0055 | 0.0055 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.001 | 0.0512 | 0.1615 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.001 | 0.0512 | 0.1615 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0005 | 0.0055 | 0.0055 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0013 | 0.0768 | 0.2523 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0013 | 0.0768 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0005 | 0.0104 | 0.0173 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0512 | 0.1615 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0007 | 0.0258 | 0.0705 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.001 | 0.0512 | 0.1591 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0093 | 0.7844 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.001 | 0.0512 | 0.1591 |
Plasmodium vivax | glutathione reductase, putative | 0.0037 | 0.2881 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.001 | 0.0512 | 0.1591 |
Toxoplasma gondii | thioredoxin reductase | 0.0037 | 0.2881 | 0.5985 |
Brugia malayi | nuclear receptor NHR-88 | 0.001 | 0.0512 | 0.1615 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.001 | 0.0512 | 0.1615 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.0512 | 0.1615 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.001 | 0.0512 | 0.1615 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.0512 | 0.1615 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.001 | 0.0512 | 0.1615 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.0512 | 0.1615 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0005 | 0.0104 | 0.017 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.001 | 0.0512 | 0.1615 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0005 | 0.0104 | 0.0104 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.001 | 0.0512 | 0.0512 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0007 | 0.0258 | 0.0258 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.001 | 0.0512 | 0.0512 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0084 | 0.7022 | 0.8837 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0013 | 0.0768 | 0.2485 |
Schistosoma mansoni | nuclear receptor | 0.0005 | 0.0055 | 0.0055 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0013 | 0.0768 | 0.2485 |
Onchocerca volvulus | 0.001 | 0.0512 | 0.2229 | |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0.0104 | 0.0173 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.001 | 0.0512 | 0.0512 |
Brugia malayi | steroid hormone receptor | 0.001 | 0.0512 | 0.1615 |
Brugia malayi | hypothetical protein | 0.0005 | 0.0104 | 0.0173 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.001 | 0.0512 | 0.1615 |
Onchocerca volvulus | 0.0028 | 0.2102 | 1 | |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.0512 | 0.1615 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0005 | 0.0104 | 0.017 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.001 | 0.0512 | 0.1615 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.