TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 308.417 | Formula: C20H24N2O
H donors: 1 H acceptors: 1 LogP: 4.23 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C(C(c1ccccc1)(C)C)Nc1ccccc1N1CCCC1
InChi: 1S/C20H24N2O/c1-20(2,16-10-4-3-5-11-16)19(23)21-17-12-6-7-13-18(17)22-14-8-9-15-22/h3-7,10-13H,8-9,14-15H2,1-2H3,(H,21,23)
InChiKey: VNNYBLRNBZUSOJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	inositol monophosphatase	0.0042	0.0057	0.0066
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0321	0.3662	0.3641
Loa Loa (eye worm)	hypothetical protein	0.0151	0.1472	0.1444
Loa Loa (eye worm)	inositol-1	0.0042	0.0057	0.0024
Loa Loa (eye worm)	voltage-gated potassium channel	0.0137	0.1282	0.1254
Loa Loa (eye worm)	pyruvate kinase	0.004	0.0037	0.0005
Schistosoma mansoni	pyruvate kinase	0.004	0.0037	0.0014
Onchocerca volvulus	Bile acid receptor homolog	0.0321	0.3662	1
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0321	0.3662	0.3641
Echinococcus multilocularis	pyruvate kinase	0.004	0.0037	0.0014
Schistosoma mansoni	thyroid hormone receptor	0.0321	0.3662	1
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0247	0.0215
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0044	0.0081	0.0134
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0197	0.206	0.2034
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0321	0.3662	0.4666
Onchocerca volvulus	Protein ultraspiracle homolog	0.0321	0.3662	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0321	0.3662	0.3641
Brugia malayi	nuclear hormone receptor	0.0321	0.3662	0.3641
Trichomonas vaginalis	inositol monophosphatase, putative	0.0042	0.0057	0.4382
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0321	0.3662	0.4666
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0042	0.0057	0.4382
Brugia malayi	Nuclear hormone receptor E75	0.0151	0.1472	0.1444
Brugia malayi	jmjC domain containing protein	0.0108	0.0912	0.0883
Schistosoma mansoni	retinoic acid receptor RXR	0.0321	0.3662	1
Loa Loa (eye worm)	hypothetical protein	0.0169	0.1706	0.1679
Loa Loa (eye worm)	hypothetical protein	0.0151	0.1472	0.1444
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0151	0.1472	0.3958
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0042	0.0057	0.4382
Brugia malayi	Nuclear hormone receptor-like 1	0.0169	0.1706	0.1679
Loa Loa (eye worm)	hypothetical protein	0.0321	0.3662	0.3641
Schistosoma mansoni	nuclear receptor	0.0151	0.1472	0.3966
Echinococcus granulosus	potassium voltage gated channel subfamily KQT	0.0062	0.0325	0.0376
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0321	0.3662	0.3641
Plasmodium falciparum	pyruvate kinase	0.004	0.0037	0.5
Echinococcus granulosus	thyroid hormone receptor alpha	0.0642	0.781	1
Echinococcus granulosus	inositol monophosphatase 1	0.0042	0.0057	0.0031
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0321	0.3662	1
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0321	0.3662	0.4666
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0321	0.3662	0.3641
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0169	0.1706	0.4613
Loa Loa (eye worm)	hypothetical protein	0.0169	0.1706	0.1679
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0042	0.0057	0.4382
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0321	0.3662	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0231	0.0546
Onchocerca volvulus		0.0151	0.1472	0.3958
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0044	0.0081	0.0049
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0321	0.3662	1
Brugia malayi	nuclear receptor RXR	0.0151	0.1472	0.1444
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0321	0.3662	0.3641
Schistosoma mansoni	nuclear hormone receptor	0.0151	0.1472	0.3966
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0321	0.3662	0.3641
Trichomonas vaginalis	alpha-glucosidase, putative	0.0044	0.0081	1
Echinococcus multilocularis	inositol monophosphatase 1	0.0042	0.0057	0.0066
Brugia malayi	orphan nuclear receptor NR2E1	0.0151	0.1472	0.1444
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0321	0.3662	0.3641
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0169	0.1706	0.2152
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0231	0.0546
Brugia malayi	nuclear hormone receptor family member odr-7	0.0151	0.1472	0.1444
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0325	0.0293
Brugia malayi	hypothetical protein	0.0151	0.1472	0.1444
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0151	0.1472	0.3966
Brugia malayi	hypothetical protein	0.0169	0.1706	0.1679
Loa Loa (eye worm)	hypothetical protein	0.004	0.0037	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0151	0.1472	0.1444
Loa Loa (eye worm)	nuclear hormone receptor	0.0151	0.1472	0.1444
Echinococcus multilocularis	jumonji domain containing protein	0.0046	0.011	0.0213
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0042	0.0057	1
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0151	0.1472	0.1444
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0042	0.0057	0.5
Brugia malayi	Steroid receptor seven-up type 2	0.0321	0.3662	0.3641
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0321	0.3662	0.3641
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.0231	0.0199
Schistosoma mansoni	voltage-gated potassium channel KCNQ	0.0139	0.1312	0.3527
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0169	0.1706	0.1679
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0151	0.1472	0.3958
Loa Loa (eye worm)	hypothetical protein	0.0151	0.1472	0.1444
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0321	0.3662	1
Mycobacterium tuberculosis	Probable pyruvate kinase PykA	0.004	0.0037	1
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0321	0.3662	1
Loa Loa (eye worm)	DR-78	0.0151	0.1472	0.1444
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0151	0.1472	0.3966
Loa Loa (eye worm)	hypothetical protein	0.0169	0.1706	0.1679
Brugia malayi	Pyruvate kinase, M2 isozyme	0.004	0.0037	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0321	0.3662	0.3641
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0321	0.3662	0.3641
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0321	0.3662	0.4666
Brugia malayi	Nuclear hormone receptor-like 1	0.0169	0.1706	0.1679
Loa Loa (eye worm)	hypothetical protein	0.0151	0.1472	0.1444
Giardia lamblia	Pyruvate kinase	0.004	0.0037	0.5
Loa Loa (eye worm)	hypothetical protein	0.0321	0.3662	0.3641
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0321	0.3662	0.3641
Brugia malayi	ecdysone receptor	0.0151	0.1472	0.1444
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0197	0.206	0.5586
Loa Loa (eye worm)	hypothetical protein	0.0169	0.1706	0.1679
Plasmodium vivax	pyruvate kinase, putative	0.004	0.0037	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0321	0.3662	0.3641
Brugia malayi	nuclear receptor NHR-88	0.0321	0.3662	0.3641
Brugia malayi	tailless protein	0.0151	0.1472	0.1444
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0044	0.0081	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.0044	0.0081	1
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0042	0.0057	0.4382
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0321	0.3662	0.3641
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0169	0.1706	0.4613
Echinococcus granulosus	ecdysone induced protein 78C	0.0321	0.3662	0.4666
Loa Loa (eye worm)	hypothetical protein	0.0151	0.1472	0.1444
Echinococcus granulosus	potassium channel KvQLT family member kqt 1	0.0139	0.1312	0.1646
Onchocerca volvulus		0.0114	0.0988	0.2622
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0321	0.3662	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0321	0.3662	1
Echinococcus granulosus	nuclear receptor nhr 48	0.0151	0.1472	0.1851
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0151	0.1472	0.1851
Brugia malayi	nuclear receptor NHR-88	0.0151	0.1472	0.1444
Schistosoma mansoni	nuclear receptor nhr-48	0.0151	0.1472	0.3966
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0321	0.3662	0.3641
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0151	0.1472	0.1851
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0321	0.3662	0.3641
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0169	0.1706	0.4613
Brugia malayi	nuclear receptor RXR	0.0169	0.1706	0.1679
Schistosoma mansoni	alpha-glucosidase	0.0169	0.1706	0.461
Schistosoma mansoni	pyruvate kinase	0.004	0.0037	0.0014
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0321	0.3662	0.4666
Onchocerca volvulus		0.0321	0.3662	1
Schistosoma mansoni	RAR-like nuclear receptor	0.0321	0.3662	1
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0321	0.3662	1
Loa Loa (eye worm)	jmjC domain-containing protein	0.0068	0.0397	0.0365
Loa Loa (eye worm)	hypothetical protein	0.0321	0.3662	0.3641
Loa Loa (eye worm)	hypothetical protein	0.0151	0.1472	0.1444
Trypanosoma cruzi	hypothetical protein, conserved	0.0044	0.0081	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0321	0.3662	0.4666
Brugia malayi	Nuclear hormone receptor E75	0.0151	0.1472	0.1444
Echinococcus granulosus	pyruvate kinase	0.004	0.0037	0.0006
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0042	0.0057	0.4382
Echinococcus granulosus	jumonji domain containing protein	0.0046	0.011	0.0099
Brugia malayi	Nuclear hormone receptor-like 1	0.0321	0.3662	0.3641
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0108	0.0912	0.2424
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0231	0.0546
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0321	0.3662	0.3641
Schistosoma mansoni	nuclear hormone receptor	0.0321	0.3662	1
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0151	0.1472	0.1851
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0231	0.0546
Brugia malayi	nuclear receptor NHR-67	0.0151	0.1472	0.1444
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0151	0.1472	0.1851
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0321	0.3662	0.3641
Loa Loa (eye worm)	potassium voltage-gated channel subfamily Q member 5	0.0062	0.0325	0.0293
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0044	0.0081	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0321	0.3662	1
Schistosoma mansoni	alpha glucosidase	0.0044	0.0081	0.0134
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0231	0.0255
Trypanosoma brucei	glucosidase, putative	0.0044	0.0081	1
Loa Loa (eye worm)	hypothetical protein	0.0321	0.3662	0.3641
Echinococcus granulosus	lysosomal alpha glucosidase	0.0197	0.206	0.2606
Echinococcus granulosus	FTZ F1 alpha	0.0321	0.3662	0.4666
Brugia malayi	Pyruvate kinase, muscle isozyme	0.004	0.0037	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0169	0.1706	0.1679
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0044	0.0081	1
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0151	0.1472	0.1444
Loa Loa (eye worm)	hypothetical protein	0.0321	0.3662	0.3641
Chlamydia trachomatis	pyruvate kinase	0.004	0.0037	0.5
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0042	0.0057	0.4382
Brugia malayi	ecdysteroid receptor	0.0321	0.3662	0.3641
Brugia malayi	Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog	0.0139	0.1312	0.1284
Schistosoma mansoni	coup transcription factor	0.0321	0.3662	1
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0044	0.0081	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0325	0.0293
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0151	0.1472	0.3966
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0197	0.206	0.5586
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0044	0.0081	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0321	0.3662	0.3641
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0321	0.3662	0.4666
Schistosoma mansoni	jumonji domain containing protein	0.0086	0.0625	0.1634
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0321	0.3662	1
Loa Loa (eye worm)	pyruvate kinase	0.004	0.0037	0.0005
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0321	0.3662	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.0044	0.0081	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0321	0.3662	1
Echinococcus multilocularis	potassium voltage gated channel subfamily KQT	0.0062	0.0325	0.0805
Echinococcus multilocularis	potassium voltage gated channel subfamily KQT	0.0139	0.1312	0.3527
Echinococcus granulosus	neutral alpha glucosidase AB	0.0044	0.0081	0.0062
Leishmania major	alpha glucosidase II subunit, putative	0.0044	0.0081	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0231	0.0255
Loa Loa (eye worm)	hypothetical protein	0.0151	0.1472	0.1444
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0151	0.1472	0.1444
Schistosoma mansoni	alpha-glucosidase	0.0169	0.1706	0.461
Schistosoma mansoni	inositol monophosphatase	0.0042	0.0057	0.0066
Schistosoma mansoni	thyroid hormone receptor	0.0321	0.3662	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0044	0.0081	1
Loa Loa (eye worm)	hypothetical protein	0.0151	0.1472	0.1444
Echinococcus multilocularis	pyruvate kinase	0.004	0.0037	0.0014
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0151	0.1472	0.3966
Brugia malayi	conserved hypotetical protein	0.0151	0.1472	0.1444
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0108	0.0912	0.1131
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0321	0.3662	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.0044	0.0081	1
Echinococcus multilocularis	ecdysone induced protein 78C	0.0321	0.3662	1
Loa Loa (eye worm)	pyruvate kinase	0.004	0.0037	0.0005
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0321	0.3662	1
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0321	0.3662	1
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0042	0.0057	0.4382
Loa Loa (eye worm)	steroid hormone receptor	0.0811	1	1
Echinococcus multilocularis	nuclear receptor nhr 48	0.0151	0.1472	0.3966
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0151	0.1472	0.3966
Schistosoma mansoni	nuclear receptor	0.0151	0.1472	0.3966
Loa Loa (eye worm)	hypothetical protein	0.0151	0.1472	0.1444
Loa Loa (eye worm)	hypothetical protein	0.0321	0.3662	0.3641
Loa Loa (eye worm)	hypothetical protein	0.0151	0.1472	0.1444
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0044	0.0081	1
Echinococcus granulosus	pyruvate kinase	0.004	0.0037	0.0006
Brugia malayi	hypothetical protein	0.0151	0.1472	0.1444
Onchocerca volvulus		0.0151	0.1472	0.3958
Echinococcus multilocularis	FTZ F1 alpha	0.0321	0.3662	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0231	0.0546
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0151	0.1472	0.3966
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0151	0.1472	0.3966
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0044	0.0081	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.0044	0.0081	1
Loa Loa (eye worm)	hypothetical protein	0.0321	0.3662	0.3641
Brugia malayi	photoreceptor-specific nuclear receptor	0.0321	0.3662	0.3641
Mycobacterium leprae	Probable pyruvate kinase PykA	0.004	0.0037	1
Brugia malayi	hypothetical protein	0.0169	0.1706	0.1679
Brugia malayi	Inositol-1	0.0042	0.0057	0.0024
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0321	0.3662	0.3641
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0321	0.3662	0.3641
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0197	0.206	0.2034
Brugia malayi	nuclear hormone receptor	0.0151	0.1472	0.1444
Schistosoma mansoni	zinc finger protein	0.0151	0.1472	0.3966
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0151	0.1472	0.1444
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0044	0.0081	1
Loa Loa (eye worm)	hypothetical protein	0.0151	0.1472	0.1444
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.0231	0.0199
Schistosoma mansoni	nuclear hormone receptor	0.0151	0.1472	0.3966
Loa Loa (eye worm)	hypothetical protein	0.0151	0.1472	0.1444

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	> 30 uM	Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay	ChEMBL.	22793372

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2164057

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1679314