Detailed information for compound 1680650

Basic information

Technical information
  • TDR Targets ID: 1680650
  • Name: 2-[4-[[4-oxo-2-(phenoxymethyl)quinazolin-3-yl ]iminomethyl]phenoxy]acetic acid
  • MW: 429.425 | Formula: C24H19N3O5
  • H donors: 1 H acceptors: 3 LogP: 3.77 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)COc1ccc(cc1)/C=N/n1c(COc2ccccc2)nc2c(c1=O)cccc2
  • InChi: 1S/C24H19N3O5/c28-23(29)16-32-19-12-10-17(11-13-19)14-25-27-22(15-31-18-6-2-1-3-7-18)26-21-9-5-4-8-20(21)24(27)30/h1-14H,15-16H2,(H,28,29)/b25-14+
  • InChiKey: DIMCFYCVDIHDGT-AFUMVMLFSA-N  

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[4-[(E)-[4-oxo-2-(phenoxymethyl)quinazolin-3-yl]iminomethyl]phenoxy]acetic acid
  • 2-[4-[[4-oxo-2-(phenoxymethyl)-3-quinazolinyl]iminomethyl]phenoxy]acetic acid
  • 2-[4-[(E)-[4-oxo-2-(phenoxymethyl)-3-quinazolinyl]iminomethyl]phenoxy]acetic acid
  • 2-[4-[(E)-[4-keto-2-(phenoxymethyl)quinazolin-3-yl]iminomethyl]phenoxy]acetic acid
  • 2-[4-[[4-keto-2-(phenoxymethyl)quinazolin-3-yl]iminomethyl]phenoxy]acetic acid
  • 2-[4-[(E)-[4-oxo-2-(phenoxymethyl)quinazolin-3-yl]iminomethyl]phenoxy]ethanoic acid
  • 2-[4-[[4-oxo-2-(phenoxymethyl)quinazolin-3-yl]iminomethyl]phenoxy]ethanoic acid
  • (4-{[(4-oxo-2-(phenoxymethyl)-3(4H)-quinazolinyl)imino]methyl}phenoxy)acetic acid
  • MLS000705464
  • SMR000230513
  • AE-848/15341142

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Plasmodium falciparum 3D7 M1-family aminopeptidase Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Toxoplasma gondii aminopeptidase n, putative Get druggable targets OG5_130542 All targets in OG5_130542
Plasmodium vivax M1-family alanyl aminopeptidase, putative Get druggable targets OG5_130542 All targets in OG5_130542
Neospora caninum hypothetical protein Get druggable targets OG5_130542 All targets in OG5_130542
Plasmodium knowlesi M1-family alanyl aminopeptidase, putative Get druggable targets OG5_130542 All targets in OG5_130542
Plasmodium yoelii m1-family aminopeptidase Get druggable targets OG5_130542 All targets in OG5_130542
Toxoplasma gondii aminopeptidase N protein Get druggable targets OG5_130542 All targets in OG5_130542
Cryptosporidium hominis aminopeptidase N Get druggable targets OG5_130542 All targets in OG5_130542
Plasmodium berghei M1-family alanyl aminopeptidase, putative Get druggable targets OG5_130542 All targets in OG5_130542
Neospora caninum Aminopeptidase N (EC 3.4.11.2), related Get druggable targets OG5_130542 All targets in OG5_130542
Plasmodium falciparum M1-family alanyl aminopeptidase Get druggable targets OG5_130542 All targets in OG5_130542
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Babesia bovis aminopeptidase, putative Get druggable targets OG5_130542 All targets in OG5_130542
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Cryptosporidium parvum zincin/aminopeptidase N like metalloprotease Get druggable targets OG5_130542 All targets in OG5_130542
Toxoplasma gondii aminopeptidase N, putative Get druggable targets OG5_130542 All targets in OG5_130542
Theileria parva alpha-aminoacylpeptide hydrolase, putative Get druggable targets OG5_130542 All targets in OG5_130542
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable acyl carrier protein AcpA (ACP) 0.0392 0.0506 0.0641
Schistosoma mansoni polyhomeotic 0.005 0.0038 0.0168
Plasmodium vivax ataxin-2 like protein, putative 0.0127 0.0144 0.1099
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0241 0.03 0.0299
Entamoeba histolytica hypothetical protein 0.0041 0.0026 0.0497
Schistosoma mansoni myst histone acetyltransferase 0.0034 0.0017 0.0075
Loa Loa (eye worm) hypothetical protein 0.0079 0.0078 0.0087
Schistosoma mansoni RAR-like nuclear receptor 0.0025 0.0004 0.0017
Brugia malayi Muscleblind-like protein 0.0631 0.0832 0.0831
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0001 0.0009
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0974 0.1301 1
Brugia malayi N-terminal motif family protein 0.0163 0.0193 0.0192
Plasmodium vivax SNF2 family N-terminal domain containing protein 0.0034 0.0017 0.0124
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0044 0.0031 0.0134
Mycobacterium ulcerans polyketide synthase 0.3865 0.5253 0.667
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0023 0.0001 0.0006
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0163 0.0193 0.0201
Echinococcus multilocularis Chromo domain 0.0023 0.0001 0.0008
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0086 0.0089 0.0487
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0396 0.0512 0.0511
Leishmania major zinc binding dehydrogenase-like protein 0.0241 0.03 0.1912
Trichomonas vaginalis Heterochromatin protein, putative 0.0023 0.0001 0.0009
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0025 0.0004 0.0021
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0241 0.03 0.2304
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0025 0.0004 0.0003
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.3107 0.4217 0.5354
Echinococcus granulosus chromobox protein 1 0.0023 0.0001 0.0008
Brugia malayi PHD-finger family protein 0.0034 0.0017 0.0016
Brugia malayi kinase, mitochondrial precursor 0.0086 0.0089 0.0087
Loa Loa (eye worm) hypothetical protein 0.0595 0.0784 0.0884
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0025 0.0004 0.0021
Mycobacterium ulcerans quinone oxidoreductase 0.0241 0.03 0.0379
Brugia malayi mbt repeat family protein 0.0903 0.1205 0.1204
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0098 0.0104 0.0131
Trypanosoma cruzi PAB1-binding protein , putative 0.0127 0.0144 0.1106
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0025 0.0004 0.0003
Schistosoma mansoni sex comb on midleg homolog 0.0525 0.0688 0.2998
Loa Loa (eye worm) hypothetical protein 0.009 0.0093 0.0104
Mycobacterium tuberculosis Probable replicative DNA helicase DnaB 0.1111 0.1489 0.1889
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0034 0.0017 0.0095
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0001 0.0009
Brugia malayi coiled-coil like protein 1 0.005 0.0038 0.0037
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0023 0.0001 0.0006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0025 0.0004 0.0003
Schistosoma mansoni SET domain protein 0.0042 0.0028 0.0121
Plasmodium falciparum ataxin-2 like protein, putative 0.0127 0.0144 0.1096
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0241 0.03 0.2304
Loa Loa (eye worm) AIDA-1b 0.005 0.0038 0.0042
Echinococcus granulosus acyl carrier protein mitochondrial 0.0392 0.0506 0.2782
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0001 0.0009
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0241 0.03 0.1912
Schistosoma mansoni [ACP] S-malonyltransferase 0.0245 0.0305 0.133
Mycobacterium leprae PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4 0.0595 0.0784 0.0994
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0089 0.0092 0.0401
Onchocerca volvulus Matrix metalloproteinase homolog 0.0025 0.0005 0.0004
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.005 0.0039 0.0301
Echinococcus multilocularis sterile alpha and tir motif containing protein 0.005 0.0038 0.0212
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.0215 0.1372
Loa Loa (eye worm) twinkle helicase 0.0071 0.0068 0.0075
Echinococcus multilocularis Zinc finger, DBF type 0.0034 0.0017 0.0095
Echinococcus multilocularis polyhomeotic proximal chromatin protein 0.005 0.0038 0.0212
Onchocerca volvulus 0.6757 0.9205 0.9661
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0025 0.0004 0.0003
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0396 0.0512 0.0649
Echinococcus granulosus chromobox protein 2 0.0389 0.0503 0.2763
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0283 0.0357 0.0356
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0025 0.0004 0.0017
Toxoplasma gondii histone lysine methyltransferase SET1 0.0081 0.0081 0.0145
Mycobacterium ulcerans polyketide synthase MbtC 0.0974 0.1301 0.1651
Echinococcus granulosus endonuclease exonuclease phosphatase 0.1036 0.1386 0.7622
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0022 0.0143
Trichomonas vaginalis D-aminoacylase, putative 0.0022 0.0001 0.0007
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.003 0.0011 0.0076
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.003 0.0011 0.0013
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0025 0.0004 0.0003
Leishmania major trypanothione reductase 0.0043 0.0029 0.0185
Entamoeba histolytica hypothetical protein 0.0023 0.0001 0.0028
Schistosoma mansoni tar DNA-binding protein 0.0172 0.0205 0.0895
Echinococcus granulosus Chromo domain 0.0023 0.0001 0.0008
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0023 0.0001 0.0008
Echinococcus multilocularis AMP dependent ligase 0.0393 0.0507 0.2787
Mycobacterium ulcerans malonyl CoA-acyl carrier protein transacylase FabD 0.0245 0.0305 0.0386
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0048 0.0035 0.0195
Loa Loa (eye worm) latrophilin receptor protein 2 0.009 0.0093 0.0104
Schistosoma mansoni hypothetical protein 0.009 0.0093 0.0405
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0396 0.0512 0.0649
Loa Loa (eye worm) RNA binding protein 0.0172 0.0205 0.023
Toxoplasma gondii PHD-finger domain-containing protein 0.0034 0.0017 0.003
Echinococcus granulosus fetal alzheimer antigen falz 0.0048 0.0035 0.0195
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0028 0.0008 0.0053
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0045 0.0032 0.0039
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0025 0.0004 0.0021
Brugia malayi bicaudal-C 0.005 0.0038 0.0037
Echinococcus multilocularis 3 oxoacyl (acyl carrier protein) synthase 0.0974 0.1301 0.7155
Echinococcus granulosus NADH dehydrogenase 0.0392 0.0506 0.2782
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.3865 0.5253 0.667
Schistosoma mansoni hypothetical protein 0.0034 0.0017 0.0075
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0023 0.0002 0.0012
Loa Loa (eye worm) matrixin family protein 0.0074 0.0071 0.0079
Echinococcus granulosus mitochondrial trans 2 enoyl coenzyme A reductase 0.0241 0.03 0.1648
Schistosoma mansoni myelin transcription factor 1 myt1 0.0189 0.0229 0.0999
Mycobacterium ulcerans aldehyde dehydrogenase 0.0111 0.0122 0.0153
Mycobacterium tuberculosis Probable NADPH quinone oxidoreductase FadB4 (NADPH:quinone reductase) (zeta-crystallin) 0.0241 0.03 0.0379
Schistosoma mansoni hypothetical protein 0.009 0.0093 0.0405
Plasmodium vivax acyl carrier protein, putative 0.0392 0.0506 0.3883
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.005 0.0039 0.0048
Loa Loa (eye worm) hypothetical protein 0.0241 0.03 0.0337
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.005 0.0039 0.0301
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.005 0.0039 0.025
Echinococcus granulosus liprin alpha 2 0.005 0.0038 0.0212
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0001 0.0009
Schistosoma mansoni hypothetical protein 0.0037 0.0021 0.009
Brugia malayi sterile alpha and TIR motif containing protein 1 isoform a 0.005 0.0038 0.0037
Loa Loa (eye worm) hypothetical protein 0.0058 0.0049 0.0054
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0241 0.03 0.1912
Toxoplasma gondii PHD-finger domain-containing protein 0.0034 0.0017 0.003
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0098 0.0104 0.0131
Entamoeba histolytica hypothetical protein 0.0041 0.0026 0.0497
Schistosoma mansoni hypothetical protein 0.0034 0.0017 0.0075
Entamoeba histolytica hypothetical protein 0.0023 0.0001 0.0028
Loa Loa (eye worm) hypothetical protein 0.0025 0.0004 0.0003
Trypanosoma brucei developmentally regulated phosphoprotein 0.0086 0.0089 0.068
Echinococcus granulosus tar DNA binding protein 0.0172 0.0205 0.1129
Echinococcus multilocularis thyroid hormone receptor alpha 0.0025 0.0004 0.0021
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.003 0.0011 0.0087
Toxoplasma gondii hypothetical protein 0.0051 0.0039 0.007
Echinococcus multilocularis phd finger protein 10 0.0034 0.0017 0.0095
Schistosoma mansoni coup transcription factor 0.0025 0.0004 0.0017
Brugia malayi PHD-finger family protein 0.0034 0.0017 0.0016
Schistosoma mansoni tar DNA-binding protein 0.0172 0.0205 0.0895
Loa Loa (eye worm) cytochrome P450 family protein 0.0034 0.0017 0.0018
Trypanosoma brucei PAB1-binding protein , putative 0.0127 0.0144 0.1106
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0974 0.1301 0.1651
Loa Loa (eye worm) hypothetical protein 0.0241 0.03 0.0337
Brugia malayi hypothetical protein 0.0127 0.0144 0.0143
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0001 0.0009
Loa Loa (eye worm) glutathione reductase 0.0043 0.0029 0.0032
Schistosoma mansoni cpg binding protein 0.0076 0.0074 0.0323
Trypanosoma cruzi Kinesin-13 5, putative 0.005 0.0038 0.0296
Trichomonas vaginalis glucosylceramidase, putative 0.0118 0.0131 0.0836
Schistosoma mansoni inositol monophosphatase 0.005 0.0039 0.0171
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.003 0.0011 0.0013
Mycobacterium ulcerans polyketide synthase Pks13 0.5784 0.7875 1
Brugia malayi hypothetical protein 0.0034 0.0017 0.0016
Leishmania major hypothetical protein, conserved 0.1169 0.1568 1
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0241 0.03 0.2304
Entamoeba histolytica myo-inositol monophosphatase, putative 0.005 0.0039 0.0743
Mycobacterium ulcerans quinone oxidoreductase 0.0241 0.03 0.0379
Plasmodium vivax protein kinase, putative 0.005 0.0038 0.0287
Trichomonas vaginalis ap endonuclease, putative 0.003 0.0011 0.0072
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.007 0.0066 0.0118
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.1193 0.1601 0.2031
Echinococcus granulosus AMP dependent ligase 0.0393 0.0507 0.2787
Entamoeba histolytica acyl-CoA synthetase, putative 0.0393 0.0507 0.9619
Trypanosoma cruzi acyl transferase-like protein, putative 0.0245 0.0305 0.2345
Mycobacterium tuberculosis S-nitrosomycothiol reductase MscR 0.0241 0.03 0.0379
Onchocerca volvulus 0.0034 0.0017 0.0017
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.2551 0.3457 0.4389
Mycobacterium leprae Conserved hypothetical protein 0.0327 0.0417 0.0528
Mycobacterium ulcerans oxidoreductase 0.0241 0.03 0.0379
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0017 0.011
Entamoeba histolytica hypothetical protein 0.0041 0.0026 0.0497
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.5784 0.7875 1
Chlamydia trachomatis acyl carrier protein 0.0392 0.0506 0.2016
Echinococcus granulosus Zinc finger DBF type 0.0034 0.0017 0.0095
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0025 0.0004 0.0003
Schistosoma mansoni hypothetical protein 0.0041 0.0026 0.0114
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0375 0.0483 0.3709
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.4106 0.5582 0.7088
Onchocerca volvulus Acyl carrier protein, mitochondrial homolog 0.0392 0.0506 0.053
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0025 0.0004 0.0003
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0086 0.0089 0.0487
Toxoplasma gondii acyl carrier protein ACP 0.0392 0.0506 0.0906
Trichomonas vaginalis glucosylceramidase, putative 0.0124 0.014 0.0891
Brugia malayi Nuclear hormone receptor-like 1 0.0025 0.0004 0.0003
Loa Loa (eye worm) hypothetical protein 0.005 0.0038 0.0042
Trypanosoma brucei Acyl carrier protein, mitochondrial 0.0392 0.0506 0.3888
Plasmodium falciparum ataxin-2 like protein, putative 0.0127 0.0144 0.1096
Brugia malayi ADP-specific Phosphofructokinase/Glucokinase conserved region family protein 0.0245 0.0305 0.0304
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.1961 0.2651 0.4748
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0134 0.0154 0.0173
Loa Loa (eye worm) hypothetical protein 0.004 0.0026 0.0028
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase AdhE2 0.0241 0.03 0.0379
Schistosoma mansoni hypothetical protein 0.0023 0.0001 0.0006
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0025 0.0004 0.0021
Onchocerca volvulus 0.0024 0.0004 0.0003
Loa Loa (eye worm) matrixin family protein 0.0025 0.0005 0.0004
Loa Loa (eye worm) phosphopantetheine attachment site family protein 0.0392 0.0506 0.057
Mycobacterium tuberculosis Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase) 0.0241 0.03 0.0379
Schistosoma mansoni DNAj-like protein 0.005 0.0038 0.0168
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.1036 0.1386 0.7622
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0241 0.03 0.0299
Echinococcus granulosus Sterile alpha motif SAM 0.005 0.0038 0.0212
Loa Loa (eye worm) hypothetical protein 0.0189 0.0229 0.0257
Brugia malayi AIDA-1b 0.005 0.0038 0.0037
Brugia malayi Matrixin family protein 0.0074 0.0071 0.007
Onchocerca volvulus Putative alcohol dehydrogenase 0.0241 0.03 0.0313
Schistosoma mansoni hypothetical protein 0.0037 0.0021 0.009
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0043 0.0029 0.0035
Mycobacterium tuberculosis Conserved hypothetical protein 0.0392 0.0506 0.0641
Echinococcus multilocularis transcription factor Dp 1 0.0026 0.0005 0.0029
Loa Loa (eye worm) MH2 domain-containing protein 0.0165 0.0196 0.022
Echinococcus granulosus histone acetyltransferase myst3 0.0084 0.0085 0.0469
Onchocerca volvulus 0.0036 0.0019 0.0019
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0189 0.0229 0.126
Echinococcus multilocularis Niemann Pick C1 protein 0.0127 0.0144 0.079
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0014 0.0092
Brugia malayi MH2 domain containing protein 0.0165 0.0196 0.0195
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0903 0.1205 0.1263
Brugia malayi hypothetical protein 0.0082 0.0082 0.0081
Loa Loa (eye worm) hypothetical protein 0.0034 0.0017 0.0018
Schistosoma mansoni methyltransferase-related 0.1169 0.1568 0.6833
Echinococcus granulosus polyhomeotic proximal chromatin protein 0.005 0.0038 0.0212
Echinococcus multilocularis cpg binding protein 0.0076 0.0074 0.0408
Echinococcus granulosus uro adherence factor A 0.0034 0.0017 0.0095
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0017 0.011
Plasmodium vivax thioredoxin reductase, putative 0.0043 0.0029 0.0215
Treponema pallidum acyl carrier protein 0.0392 0.0506 1
Brugia malayi Methyltransferase-like protein 4 0.1169 0.1568 0.1567
Schistosoma mansoni hypothetical protein 0.0037 0.0021 0.009
Plasmodium falciparum EELM2 domain-containing protein, putative 0.0034 0.0017 0.0121
Loa Loa (eye worm) hypothetical protein 0.0025 0.0004 0.0003
Loa Loa (eye worm) hypothetical protein 0.0026 0.0006 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0017 0.011
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0014 0.0092
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0241 0.03 0.2304
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0064 0.0058 0.0057
Trichomonas vaginalis glucosylceramidase, putative 0.0118 0.0131 0.0836
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0001 0.0009
Echinococcus multilocularis TAF3 RNA polymerase II, TATA box binding protein 0.0034 0.0017 0.0095
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.003 0.0011 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0001 0.0009
Echinococcus multilocularis survival motor neuron protein 1 0.0316 0.0402 0.221
Onchocerca volvulus 0.0034 0.0017 0.0017
Mycobacterium tuberculosis Polyketide synthase Pks12 0.4106 0.5582 0.7088
Loa Loa (eye worm) hypothetical protein 0.0241 0.03 0.0337
Mycobacterium ulcerans NADPH quinone oxidoreductase FadB4 0.0241 0.03 0.0379
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0974 0.1301 1
Trypanosoma cruzi oxidoreductase, putative 0.0241 0.03 0.2304
Mycobacterium tuberculosis Probable polyketide synthase Pks17 0.0948 0.1266 0.1606
Toxoplasma gondii SWI2/SNF2-containing PHD finger protein 0.0034 0.0017 0.003
Leishmania major acyl carrier protein, putative 0.0392 0.0506 0.3227
Echinococcus granulosus sterol regulatory element binding protein 0.0038 0.0022 0.0123
Mycobacterium tuberculosis Probable quinone reductase Qor (NADPH:quinone reductase) (zeta-crystallin homolog protein) 0.0241 0.03 0.0379
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0025 0.0004 0.0017
Echinococcus multilocularis liprin alpha 2 0.005 0.0038 0.0212
Schistosoma mansoni thyroid hormone receptor 0.0025 0.0004 0.0017
Brugia malayi exodeoxyribonuclease III family protein 0.003 0.0011 0.001
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0044 0.0031 0.0236
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.003 0.0012 0.009
Toxoplasma gondii type I fatty acid synthase, putative 0.2762 0.3745 0.6707
Loa Loa (eye worm) steroid hormone receptor 0.0025 0.0004 0.0003
Schistosoma mansoni cpg binding protein 0.0042 0.0027 0.0119
Mycobacterium ulcerans Type I modular polyketide synthase 0.3865 0.5253 0.667
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0109 0.0119 0.015
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0001 0.0009
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0025 0.0004 0.0003
Echinococcus granulosus beta LACTamase domain containing family member 0.0022 0.0001 0.0006
Echinococcus multilocularis jumonji domain containing protein 0.0026 0.0006 0.0034
Brugia malayi follicle stimulating hormone receptor 0.0161 0.0191 0.019
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0025 0.0004 0.0003
Leishmania major developmentally regulated phosphoprotein-like protein 0.0086 0.0089 0.0565
Echinococcus granulosus thioredoxin glutathione reductase 0.0043 0.003 0.0164
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0001 0.0009
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0057 0.0048 0.0266
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.003 0.0012 0.009
Onchocerca volvulus 0.005 0.0038 0.0039
Echinococcus multilocularis lysine specific demethylase 5B 0.0034 0.0017 0.0095
Mycobacterium ulcerans polyketide synthase Pks9 0.2551 0.3457 0.4389
Onchocerca volvulus 0.005 0.0038 0.0039
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0109 0.0119 0.015
Schistosoma mansoni jumonji/arid domain-containing protein 0.021 0.0258 0.1123
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0023 0.0001 0.0008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0025 0.0004 0.0003
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.3865 0.5253 0.667
Brugia malayi latrophilin 2 splice variant baaae 0.0194 0.0235 0.0234
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0032 0.0014 0.0092
Schistosoma mansoni retinoic acid receptor RXR 0.0025 0.0004 0.0017
Brugia malayi Protein kinase domain containing protein 0.0188 0.0228 0.0227
Echinococcus granulosus chromobox protein 1 0.0023 0.0001 0.0008
Trichomonas vaginalis myo inositol monophosphatase, putative 0.005 0.0039 0.025
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0001 0.0009
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.003 0.0011 0.0078
Toxoplasma gondii PHD-finger domain-containing protein 0.0034 0.0017 0.003
Mycobacterium ulcerans thioesterase 0.3233 0.4389 0.5572
Echinococcus multilocularis dnaJ subfamily B 0.0264 0.0331 0.1822
Echinococcus multilocularis PHD finger protein 14 0.0034 0.0017 0.0095
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0001 0.0009
Plasmodium falciparum zinc finger protein, putative 0.0037 0.0021 0.0148
Schistosoma mansoni chromobox protein 0.0023 0.0001 0.0006
Schistosoma mansoni serine/threonine protein kinase 0.0188 0.0228 0.0993
Loa Loa (eye worm) PHD-finger family protein 0.0034 0.0017 0.0018
Mycobacterium ulcerans fatty acid synthase Fas 0.1219 0.1636 0.2076
Schistosoma mansoni jumonji domain containing protein 0.0099 0.0106 0.0462
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0241 0.03 0.5689
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0035 0.0018 0.0032
Brugia malayi hypothetical protein 0.005 0.0038 0.0037
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0026 0.0144
Schistosoma mansoni acyl carrier protein 0.0392 0.0506 0.2205
Mycobacterium leprae conserved hypothetical protein 0.0392 0.0506 0.0641
Brugia malayi PHD-finger family protein 0.0049 0.0038 0.0036
Mycobacterium ulcerans acyl-CoA synthetase 0.0396 0.0512 0.0649
Chlamydia trachomatis replicative DNA helicase 0.0249 0.0311 0.0063
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.3158 0.4286 0.5443
Onchocerca volvulus 0.005 0.0038 0.0039
Trypanosoma brucei Present in the outer mitochondrial membrane proteome 24 0.005 0.0038 0.0296
Echinococcus multilocularis muscleblind protein 1 0.0631 0.0832 0.4577
Mycobacterium tuberculosis Possible dehydrogenase 0.0241 0.03 0.0379
Trypanosoma brucei SAM domain (Sterile alpha motif), putative 0.005 0.0038 0.0296
Echinococcus multilocularis histone acetyltransferase myst4 0.0034 0.0017 0.0095
Trichomonas vaginalis c2h2 zinc finger protein, putative 0.005 0.0038 0.0246
Echinococcus multilocularis Niemann Pick C1 protein 0.0089 0.0092 0.0504
Schistosoma mansoni SET domain protein 0.0022 0.0001 0.0002
Brugia malayi photoreceptor-specific nuclear receptor 0.0025 0.0004 0.0003
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0025 0.0004 0.0021
Echinococcus multilocularis chromobox protein 1 0.0023 0.0001 0.0008
Toxoplasma gondii acyl transferase domain-containing protein 0.0245 0.0305 0.0546
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.076 0.101 0.44
Loa Loa (eye worm) hypothetical protein 0.0034 0.0017 0.0018
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0044 0.0031 0.0236
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0025 0.0004 0.0021
Brugia malayi AMP-binding enzyme family protein 0.3629 0.493 0.493
Plasmodium falciparum malonyl CoA-acyl carrier protein transacylase 0.0245 0.0305 0.2336
Echinococcus granulosus transcription factor Dp 1 0.0026 0.0005 0.0029
Trichomonas vaginalis hypothetical protein 0.0023 0.0001 0.0009
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase 0.0241 0.03 0.0379
Schistosoma mansoni phd finger protein 0.0084 0.0085 0.0372
Brugia malayi RNA binding protein 0.0172 0.0205 0.0204
Toxoplasma gondii Zn-containing alcohol dehydrogenase 0.0241 0.03 0.0536
Loa Loa (eye worm) hypothetical protein 0.005 0.0038 0.0042
Trypanosoma cruzi Kinesin-13 5, putative 0.005 0.0038 0.0296
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0396 0.0512 0.0649
Echinococcus multilocularis peregrin 0.0026 0.0007 0.0036
Schistosoma mansoni microtubule-associated protein tau 0.1352 0.1819 0.7927
Loa Loa (eye worm) hypothetical protein 0.0025 0.0004 0.0004
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0111 0.0122 0.0153
Trichomonas vaginalis penicillin-binding protein, putative 0.0022 0.0001 0.0007
Echinococcus multilocularis thioredoxin glutathione reductase 0.0043 0.003 0.0164
Onchocerca volvulus 0.005 0.0038 0.0039
Leishmania major hypothetical protein, conserved 0.0127 0.0144 0.0918
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0241 0.03 0.1912
Trypanosoma cruzi oxidoreductase, putative 0.0241 0.03 0.2304
Entamoeba histolytica exodeoxyribonuclease III, putative 0.003 0.0011 0.0214
Loa Loa (eye worm) hypothetical protein 0.0079 0.0078 0.0087
Loa Loa (eye worm) toll and interleukin 1 receptor domain-containing protein isoform f 0.005 0.0038 0.0042
Plasmodium vivax heterochromatin protein 1, putative 0.0023 0.0001 0.0003
Brugia malayi Shank2E 0.005 0.0038 0.0037
Echinococcus granulosus SAM and MBT domain containing protein 0.076 0.101 0.5551
Onchocerca volvulus 0.0025 0.0004 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0008 0.0053
Onchocerca volvulus 0.3629 0.493 0.5174
Brugia malayi Hypothetical C28H8.9 in chromosome III 0.0034 0.0017 0.0016
Loa Loa (eye worm) PHD-finger family protein 0.0034 0.0017 0.0018
Mycobacterium ulcerans Zn-dependent alcohol dehydrogenase, AdhX 0.0241 0.03 0.0379
Loa Loa (eye worm) hypothetical protein 0.0034 0.0017 0.0018
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0014 0.0092
Giardia lamblia Kinesin-13 0.005 0.0038 0.0246
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0025 0.0004 0.0017
Trypanosoma cruzi oxidoreductase, putative 0.0241 0.03 0.2304
Toxoplasma gondii thioredoxin reductase 0.0043 0.0029 0.0051
Toxoplasma gondii PLU-1 family protein 0.0087 0.0089 0.0159
Plasmodium vivax hypothetical protein, conserved 0.0034 0.0017 0.0124
Trichomonas vaginalis cgi-62, putative 0.005 0.0038 0.0246
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase AdhC 0.0241 0.03 0.0379
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.4106 0.5582 0.7088
Loa Loa (eye worm) hypothetical protein 0.0046 0.0033 0.0036
Brugia malayi Latrophilin receptor protein 2 0.009 0.0093 0.0092
Echinococcus granulosus Sterile alpha motif type 0.005 0.0038 0.0212
Loa Loa (eye worm) hypothetical protein 0.0034 0.0017 0.0018
Echinococcus multilocularis phd finger protein 12 0.0034 0.0017 0.0095
Echinococcus multilocularis Malonyl coenzyme A acyl carrier protein transacylase 0.0245 0.0305 0.1677
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0974 0.1301 0.13
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0057 0.0048 0.0266
Mycobacterium ulcerans zinc-type alcohol dehydrogenase AdhD 0.0241 0.03 0.0379
Schistosoma mansoni hypothetical protein 0.0194 0.0235 0.1024
Loa Loa (eye worm) hypothetical protein 0.0316 0.0402 0.0453
Loa Loa (eye worm) hypothetical protein 0.0283 0.0357 0.0402
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 0.0393 0.0507 0.0642
Echinococcus granulosus remodeling and spacing factor 1 0.0034 0.0017 0.0095
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0044 0.0031 0.0169
Plasmodium falciparum SNF2 helicase, putative 0.0034 0.0017 0.0121
Toxoplasma gondii type I fatty acid synthase 0.0595 0.0784 0.1403
Echinococcus granulosus lysine specific demethylase 5B 0.0034 0.0017 0.0095
Schistosoma mansoni ap endonuclease 0.003 0.0011 0.0049
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.4106 0.5582 0.7088
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0188 0.0228 0.0256
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.3629 0.493 0.626
Trichomonas vaginalis glucosylceramidase, putative 0.0118 0.0131 0.0836
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.005 0.0039 0.0301
Trichomonas vaginalis ap endonuclease, putative 0.003 0.0011 0.0072
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0025 0.0004 0.0021
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0396 0.0512 0.0649
Entamoeba histolytica hypothetical protein 0.0037 0.0021 0.0393
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0109 0.0119 0.015
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0025 0.0004 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0025 0.0004 0.0003
Brugia malayi Cytochrome P450 family protein 0.0034 0.0017 0.0016
Mycobacterium tuberculosis Probable oxidoreductase 0.0222 0.0274 0.0347
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0023 0.0001 0.0002
Schistosoma mansoni [ACP] S-malonyltransferase 0.0245 0.0305 0.133
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0189 0.0229 0.126
Echinococcus granulosus tumor suppressor p53 binding protein 1 0.0647 0.0854 0.4696
Echinococcus multilocularis Sterile alpha motif type 0.005 0.0038 0.0212
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0595 0.0784 0.0994
Echinococcus multilocularis Chromobox protein 3 0.0023 0.0001 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0025 0.0004 0.0003
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0044 0.0031 0.0583
Plasmodium vivax JmjC domain containing protein 0.0064 0.0057 0.0432
Brugia malayi Niemann-Pick C1 protein precursor 0.0089 0.0092 0.009
Schistosoma mansoni spingomyelin synthetase-related 0.005 0.0038 0.0168
Loa Loa (eye worm) CXXC zinc finger family protein 0.0042 0.0027 0.003
Schistosoma mansoni aldehyde dehydrogenase 0.0111 0.0122 0.0531
Loa Loa (eye worm) acyl carrier protein 0.0392 0.0506 0.057
Echinococcus multilocularis tar DNA binding protein 0.0172 0.0205 0.1129
Echinococcus granulosus Malonyl coenzyme A acyl carrier protein transacylase 0.0245 0.0305 0.1677
Echinococcus granulosus 3 oxoacyl acyl carrier protein synthase 0.0974 0.1301 0.7155
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0396 0.0512 0.0649
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0022 0.0001 0.0005
Toxoplasma gondii aminopeptidase N, putative 0.0375 0.0483 0.0865
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0025 0.0004 0.0021
Echinococcus granulosus expressed conserved protein 0.0083 0.0084 0.0463
Echinococcus multilocularis ecdysone induced protein 78C 0.0025 0.0004 0.0021
Loa Loa (eye worm) beta-ketoacyl synthase domain-containing protein 0.0974 0.1301 0.1468
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.003 0.0011 0.0062
Brugia malayi PHD-finger family protein 0.0034 0.0017 0.0016
Toxoplasma gondii aldehyde dehydrogenase 0.0111 0.0122 0.0217
Toxoplasma gondii aminopeptidase n, putative 0.0375 0.0483 0.0865
Schistosoma mansoni hypothetical protein 0.0034 0.0017 0.0075
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0134 0.0154 0.0847
Leishmania major d-xylulose reductase, putative 0.0241 0.03 0.1912
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.1219 0.1636 0.2076
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0161 0.0191 0.0214
Mycobacterium ulcerans oxidoreductase FadB5 0.0241 0.03 0.0379
Mycobacterium leprae Polyketide synthase Pks13 0.5784 0.7875 1
Onchocerca volvulus 0.0596 0.0785 0.0823
Entamoeba histolytica hypothetical protein 0.0023 0.0001 0.0028
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0025 0.0004 0.0003
Schistosoma mansoni lip-related protein (liprin) alpha 0.005 0.0038 0.0168
Echinococcus granulosus histone acetyltransferase myst4 0.0034 0.0017 0.0095
Echinococcus multilocularis beta LACTamase domain containing family member 0.0022 0.0001 0.0006
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0057 0.0048 0.0265
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0396 0.0512 0.0649
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks3 0.0595 0.0784 0.0994
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0014 0.0092
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0134 0.0154 0.0153
Mycobacterium tuberculosis Probable dehydrogenase 0.0098 0.0104 0.0131
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0179 0.0215 0.0214
Loa Loa (eye worm) hypothetical protein 0.005 0.0038 0.0042
Echinococcus granulosus Niemann Pick C1 protein 0.0089 0.0092 0.0504
Echinococcus granulosus histone lysine N methyltransferase NSD3 0.0022 0.0001 0.0003
Brugia malayi Bromodomain containing protein 0.0081 0.0082 0.0081
Mycobacterium tuberculosis Possible oxidoreductase FadB5 0.0241 0.03 0.0379
Echinococcus granulosus Niemann Pick C1 protein 0.0127 0.0144 0.079
Brugia malayi Inositol-1 0.005 0.0039 0.0038
Schistosoma mansoni hypothetical protein 0.005 0.0038 0.0168
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD-dependent AdhB 0.0241 0.03 0.0379
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0001 0.0009
Echinococcus multilocularis polycomb protein SCMH1 0.0525 0.0688 0.3783
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.003 0.0011 0.0072
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0025 0.0004 0.0021
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0058 0.0049 0.0215
Mycobacterium leprae Probable polyketide synthase Pks1 0.4106 0.5582 0.7088
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.003 0.0011 0.0087
Schistosoma mansoni tar DNA-binding protein 0.0172 0.0205 0.0895
Loa Loa (eye worm) thioredoxin reductase 0.0043 0.0029 0.0032
Echinococcus granulosus FTZ F1 alpha 0.0025 0.0004 0.0021
Leishmania major quinone oxidoreductase, putative 0.0241 0.03 0.1912
Echinococcus granulosus liprin alpha 2 0.005 0.0038 0.0212
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0038 0.0246
Mycobacterium tuberculosis Probable reductase 0.0098 0.0104 0.0131
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0172 0.0205 0.023
Treponema pallidum replicative DNA helicase (dnaB) 0.0249 0.0311 0.6066
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0235 0.0292 0.1604
Loa Loa (eye worm) hypothetical protein 0.0036 0.0019 0.0021
Echinococcus multilocularis NADH dehydrogenase 0.0392 0.0506 0.2782
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0014 0.0092
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.3107 0.4217 0.5354
Loa Loa (eye worm) CHromoDomain protein family member 0.0057 0.0048 0.0053
Echinococcus multilocularis histone lysine N methyltransferase NSD3 0.0022 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0034 0.0017 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0017 0.011
Loa Loa (eye worm) hypothetical protein 0.0631 0.0832 0.0939
Plasmodium falciparum glutathione reductase 0.0043 0.0029 0.0212
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0001 0.0028
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.0215 0.1372
Loa Loa (eye worm) hypothetical protein 0.0086 0.0089 0.0099
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0025 0.0004 0.0003
Toxoplasma gondii ABC1 family protein 0.0022 0.0001 0.0001
Schistosoma mansoni Replicative DNA helicase 0.0249 0.0311 0.1357
Loa Loa (eye worm) hypothetical protein 0.0025 0.0004 0.0003
Schistosoma mansoni hypothetical protein 0.0392 0.0506 0.2205
Schistosoma mansoni ap endonuclease 0.003 0.0011 0.0049
Mycobacterium ulcerans oxidoreductase 0.0241 0.03 0.0379
Echinococcus granulosus survival motor neuron protein 1 0.0316 0.0402 0.221
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0025 0.0004 0.0021
Toxoplasma gondii exonuclease III APE 0.003 0.0011 0.0019
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0032 0.0014 0.0092
Schistosoma mansoni cpg binding protein 0.0076 0.0074 0.0323
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0007 0.0047
Mycobacterium tuberculosis Probable alcohol dehydrogenase Adh 0.0241 0.03 0.0379
Brugia malayi PHD-finger family protein 0.004 0.0026 0.0025
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0396 0.0512 0.0649
Loa Loa (eye worm) hypothetical protein 0.0034 0.0017 0.0018
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD dependent AdhB 0.0241 0.03 0.0379
Schistosoma mansoni nuclear hormone receptor 0.0025 0.0004 0.0017
Brugia malayi hypothetical protein 0.0034 0.0017 0.0016
Echinococcus multilocularis inositol monophosphatase 1 0.005 0.0039 0.0215
Onchocerca volvulus Tankyrase homolog 0.005 0.0038 0.0039
Leishmania major nuclear receptor binding factor-like protein 0.0241 0.03 0.1912
Echinococcus multilocularis FTZ F1 alpha 0.0025 0.0004 0.0021
Schistosoma mansoni phd finger protein 0.0034 0.0017 0.0075
Brugia malayi F/Y-rich N-terminus family protein 0.0051 0.0041 0.004
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.009 0.0093 0.051
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 0.0862 0.1148 0.1456
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.3107 0.4217 0.5354
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0111 0.0122 0.067
Echinococcus multilocularis PHD and RING finger domain containing protein 1 0.0034 0.0017 0.0095
Brugia malayi nuclear hormone receptor 0.0025 0.0004 0.0003
Loa Loa (eye worm) hypothetical protein 0.0046 0.0033 0.0036
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0086 0.0089 0.068
Loa Loa (eye worm) hypothetical protein 0.005 0.0038 0.0042
Brugia malayi SET domain containing protein 0.0036 0.0019 0.0018
Leishmania major oxidoreductase-like protein 0.0241 0.03 0.1912
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.003 0.0012 0.002
Brugia malayi acyl carrier protein, mitochondrial precursor, putative 0.0392 0.0506 0.0505
Trichomonas vaginalis conserved hypothetical protein 0.1169 0.1568 1
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0045 0.0032 0.0039
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1013 0.1355 0.7451
Mycobacterium ulcerans Type I modular polyketide synthase 0.3865 0.5253 0.667
Toxoplasma gondii quinone oxidoreductase, putative 0.0241 0.03 0.0536
Onchocerca volvulus Protein ultraspiracle homolog 0.0025 0.0004 0.0003
Schistosoma mansoni niemann-pick C1 (NPC1) 0.009 0.0093 0.0407
Loa Loa (eye worm) hypothetical protein 0.005 0.0038 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0017 0.011
Brugia malayi hypothetical protein 0.005 0.0038 0.0037
Trypanosoma cruzi acyl transferase-like protein 0.0245 0.0305 0.2345
Echinococcus granulosus muscleblind protein 0.0631 0.0832 0.4577
Plasmodium vivax hypothetical protein, conserved 0.0571 0.0751 0.5766
Onchocerca volvulus 0.005 0.0038 0.0039
Trypanosoma brucei Ring finger domain/PHD-finger, putative 0.0034 0.0017 0.0133
Loa Loa (eye worm) hypothetical protein 0.0047 0.0034 0.0037
Echinococcus granulosus sterile alpha and tir motif containing protein 0.005 0.0038 0.0212
Echinococcus granulosus phd finger protein 12 0.0034 0.0017 0.0095
Loa Loa (eye worm) hypothetical protein 0.0034 0.0017 0.0018
Plasmodium falciparum acyl carrier protein 0.0392 0.0506 0.3881
Echinococcus multilocularis protein patched 0.0038 0.0022 0.0123
Mycobacterium tuberculosis Polyketide synthase Pks2 0.3761 0.511 0.6488
Trichomonas vaginalis penicillin-binding protein, putative 0.0022 0.0001 0.0007
Trypanosoma cruzi Acyl carrier protein, mitochondrial, putative 0.0392 0.0506 0.3888
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.1319 0.1773 0.2251
Brugia malayi ecdysteroid receptor 0.0025 0.0004 0.0003
Brugia malayi SET domain containing protein 0.0024 0.0004 0.0003
Wolbachia endosymbiont of Brugia malayi acyl carrier protein 0.0392 0.0506 0.3835
Schistosoma mansoni Protein aveugle 0.005 0.0038 0.0168
Schistosoma mansoni zinc finger protein 0.0034 0.0017 0.0075
Schistosoma mansoni myst-related protein 0.0037 0.0021 0.009
Mycobacterium ulcerans replicative DNA helicase DnaB 0.0249 0.0311 0.0394
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0001 0.0009
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0001 0.0009
Trypanosoma brucei trypanothione reductase 0.0043 0.0029 0.0223
Brugia malayi Phosphopantetheine attachment site family protein 0.0392 0.0506 0.0505
Echinococcus granulosus microtubule associated protein 2 0.1352 0.1819 1
Schistosoma mansoni chromobox protein 0.0023 0.0001 0.0006
Plasmodium vivax glutathione reductase, putative 0.0043 0.0029 0.0215
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0396 0.0512 0.0649
Trypanosoma brucei oxidoreductase, putative 0.0241 0.03 0.2304
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0098 0.0104 0.0131
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0057 0.0048 0.0211
Onchocerca volvulus Fatty acid synthase homolog 0.6994 0.9528 1
Leishmania major zinc-binding dehydrogenase-like protein 0.0241 0.03 0.1912
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.3233 0.4389 0.5572
Schistosoma mansoni myst-related protein 0.0037 0.0021 0.009
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0044 0.0031 0.003
Trypanosoma brucei beta-ketoacyl-ACP synthase 0.0974 0.1301 1
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0038 0.0022 0.0024
Schistosoma mansoni tar DNA-binding protein 0.0172 0.0205 0.0895
Schistosoma mansoni zinc finger protein 0.0046 0.0033 0.0143
Echinococcus granulosus jumonji domain containing protein 0.0026 0.0006 0.0034
Trichomonas vaginalis glucosylceramidase, putative 0.0124 0.014 0.0891
Mycobacterium tuberculosis Conserved protein 0.1169 0.1568 0.199
Leishmania major NADP-dependent alcohol dehydrogenase, putative 0.0241 0.03 0.1912
Mycobacterium tuberculosis Possible quinone oxidoreductase (NADPH:quinone oxidoreductase) (zeta-crystallin) 0.0241 0.03 0.0379
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0098 0.0104 0.0131
Echinococcus granulosus phd finger protein 10 0.0034 0.0017 0.0095
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0112 0.0123 0.0678
Onchocerca volvulus Huntingtin homolog 0.0079 0.0078 0.0081
Schistosoma mansoni aldehyde dehydrogenase 0.0111 0.0122 0.0531
Leishmania major oxidoreductase, putative 0.0241 0.03 0.1912
Loa Loa (eye worm) TAR-binding protein 0.0172 0.0205 0.023
Brugia malayi Calcitonin receptor-like protein seb-1 0.0283 0.0357 0.0356
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.3865 0.5253 0.667
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0001 0.0009
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0375 0.0483 0.371
Brugia malayi Steroid receptor seven-up type 2 0.0025 0.0004 0.0003
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0241 0.03 0.2304
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0025 0.0004 0.0017
Brugia malayi hypothetical protein 0.0316 0.0402 0.0401
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.003 0.0011 0.0072
Loa Loa (eye worm) hypothetical protein 0.005 0.0038 0.0042
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0086 0.0089 0.0487
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.0215 0.1372
Schistosoma mansoni hypothetical protein 0.0647 0.0854 0.3722
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0001 0.0009
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0089 0.0092 0.1739
Giardia lamblia Methyltransferase like 2 0.1169 0.1568 1
Loa Loa (eye worm) inositol-1 0.005 0.0039 0.0043
Leishmania major beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative 0.0974 0.1301 0.83
Brugia malayi AMP-binding enzyme family protein 0.1193 0.1601 0.16
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0974 0.1301 0.1651
Mycobacterium tuberculosis Probable alcohol dehydrogenase AdhA 0.0241 0.03 0.0379
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks4 0.0595 0.0784 0.0994
Loa Loa (eye worm) hypothetical protein 0.0631 0.0832 0.0939
Echinococcus multilocularis chromobox protein 1 0.0023 0.0001 0.0008
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.009 0.0093 0.051
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.003 0.0011 0.0087
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0396 0.0512 0.0649
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0025 0.0004 0.0017
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0023 0.0002 0.0012
Loa Loa (eye worm) hypothetical protein 0.0595 0.0784 0.0884
Mycobacterium leprae PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase 0.0249 0.0311 0.0394
Loa Loa (eye worm) hypothetical protein 0.0127 0.0144 0.0161
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0111 0.0122 0.067
Echinococcus multilocularis sphingomyelin synthase protein 1 0.005 0.0038 0.0212
Schistosoma mansoni hypothetical protein 0.0057 0.0048 0.021
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0025 0.0004 0.0003
Echinococcus multilocularis expressed conserved protein 0.0083 0.0084 0.0463
Schistosoma mansoni patched 1 0.0038 0.0022 0.0098
Schistosoma mansoni pyruvate dehydrogenase 0.0082 0.0082 0.0357
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0024 0.0025
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.2551 0.3457 0.4389
Brugia malayi CHE-14 protein 0.0038 0.0022 0.0021
Schistosoma mansoni bromodomain containing protein 0.0036 0.0019 0.0084
Schistosoma mansoni jumonji/arid domain-containing protein 0.021 0.0258 0.1123
Echinococcus granulosus lysine specific demethylase 5A 0.021 0.0258 0.1417
Schistosoma mansoni Protein aveugle 0.005 0.0038 0.0168
Schistosoma mansoni pyruvate dehydrogenase 0.0082 0.0082 0.0357
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.3865 0.5253 0.5252
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0025 0.0004 0.0021
Toxoplasma gondii 3-oxoacyl-acyl-carrier protein synthase I/II, putative 0.0974 0.1301 0.233
Echinococcus granulosus zinc finger protein 0.0046 0.0033 0.0181
Mycobacterium tuberculosis Hypothetical protein 0.1169 0.1568 0.199
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0001 0.0003
Brugia malayi RNA recognition motif domain containing protein 0.0172 0.0205 0.0204
Schistosoma mansoni zinc finger protein 0.0034 0.0017 0.0075
Schistosoma mansoni steroid hormone receptor ad4bp 0.0025 0.0004 0.0017
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.005 0.0039 0.0216
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.0249 0.0311 0.2326
Onchocerca volvulus 0.0411 0.0532 0.0558
Schistosoma mansoni inositol monophosphatase 0.005 0.0039 0.0171
Loa Loa (eye worm) acyl carrier protein 0.1784 0.2408 0.2718
Mycobacterium leprae PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) 0.1219 0.1636 0.2076
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0001 0.0009
Toxoplasma gondii type I fatty acid synthase, putative 0.4107 0.5583 1
Echinococcus multilocularis muscleblind protein 0.0631 0.0832 0.4577
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0023 0.0001 0.0006
Schistosoma mansoni hypothetical protein 0.0037 0.0021 0.009
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0393 0.0507 0.0642
Brugia malayi mbt repeat family protein 0.0546 0.0717 0.0716
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.2206 0.2985 0.3789
Onchocerca volvulus 0.0241 0.03 0.0313
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0112 0.0123 0.0678
Toxoplasma gondii aminopeptidase N protein 0.0375 0.0483 0.0865
Schistosoma mansoni hypothetical protein 0.009 0.0093 0.0405
Onchocerca volvulus Glucosylceramidase homolog 0.0118 0.0131 0.0136
Brugia malayi hypothetical protein 0.0079 0.0078 0.0077
Toxoplasma gondii PHD-finger domain-containing protein 0.0034 0.0017 0.003
Echinococcus multilocularis mitochondrial trans 2 enoyl coenzyme A reductase 0.0241 0.03 0.1648
Echinococcus granulosus PHD and RING finger domain containing protein 1 0.0034 0.0017 0.0095
Schistosoma mansoni dpf3 0.0034 0.0017 0.0075
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.3761 0.511 0.6488
Mycobacterium ulcerans non-ribosomal peptide synthetase 0.0393 0.0507 0.0642
Trypanosoma cruzi trypanothione reductase, putative 0.0043 0.0029 0.0223
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0025 0.0004 0.0003
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0241 0.03 0.2304
Brugia malayi Sphingomyelin synthase-related 1 0.005 0.0038 0.0037
Brugia malayi glutathione reductase 0.0043 0.0029 0.0028
Brugia malayi Liprin-alpha 2 0.005 0.0038 0.0037
Echinococcus granulosus ecdysone induced protein 78C 0.0025 0.0004 0.0021
Schistosoma mansoni tar DNA-binding protein 0.0172 0.0205 0.0895
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.4106 0.5582 0.7088
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.3865 0.5253 0.667
Mycobacterium ulcerans aldehyde dehydrogenase 0.0111 0.0122 0.0153
Trypanosoma brucei hypothetical protein, conserved 0.0022 0.0001 0.0009
Echinococcus multilocularis Sterile alpha motif SAM 0.005 0.0038 0.0212
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.2517 0.341 0.6108
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0001 0.0009
Mycobacterium ulcerans quinone reductase Qor 0.0241 0.03 0.0379
Schistosoma mansoni hypothetical protein 0.1701 0.2294 1
Brugia malayi cask-interacting protein 2 0.005 0.0038 0.0037
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0134 0.0154 0.0671
Loa Loa (eye worm) tnks protein 0.005 0.0038 0.0042
Echinococcus multilocularis Acyl carrier protein, mitochondrial 0.0392 0.0506 0.2782
Mycobacterium tuberculosis Acyl carrier protein (ACP) MbtL 0.0392 0.0506 0.0641
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.0215 0.1372
Onchocerca volvulus 0.0042 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.6504 0.8858 1
Schistosoma mansoni survival motor neuron protein 0.0064 0.0058 0.0255
Brugia malayi Bromodomain associated family protein 0.0034 0.0017 0.0016
Loa Loa (eye worm) fatty acid synthase 0.3828 0.5202 0.5872
Wolbachia endosymbiont of Brugia malayi NADPH:quinone reductase 0.0241 0.03 0.2236
Mycobacterium ulcerans hypothetical protein 0.0392 0.0506 0.0641
Schistosoma mansoni requim req/dpf2 0.0034 0.0017 0.0075
Onchocerca volvulus 0.0034 0.0017 0.0017
Trypanosoma cruzi Ring finger domain/PHD-finger, putative 0.0034 0.0017 0.0133
Trypanosoma brucei Trans-2-enoyl-ACP reductase 2, putative 0.0241 0.03 0.2304
Echinococcus multilocularis histone acetyltransferase MYST2 0.0189 0.0229 0.126
Echinococcus granulosus GPCR family 2 0.009 0.0093 0.051
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0044 0.0031 0.0169
Echinococcus granulosus peregrin 0.0026 0.0007 0.0036
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0057 0.0048 0.0265
Loa Loa (eye worm) hypothetical protein 0.005 0.0038 0.0042
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0022 0.0001 0.0005
Onchocerca volvulus 0.0241 0.03 0.0313
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.009 0.0093 0.0092
Echinococcus granulosus inositol monophosphatase 1 0.005 0.0039 0.0215
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0025 0.0004 0.0003
Echinococcus granulosus PHD finger protein 14 0.0034 0.0017 0.0095
Schistosoma mansoni fyve-containing 0.0034 0.0017 0.0075
Mycobacterium ulcerans aldehyde dehydrogenase 0.0111 0.0122 0.0153
Echinococcus granulosus Protein patched homolog 1 0.0038 0.0022 0.0123
Echinococcus granulosus cpg binding protein 0.0076 0.0074 0.0408
Trichomonas vaginalis esterase, putative 0.0022 0.0001 0.0007
Trichomonas vaginalis D-aminoacylase, putative 0.0022 0.0001 0.0007
Mycobacterium ulcerans polyketide synthase 0.4106 0.5582 0.7088
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0044 0.0031 0.0196
Mycobacterium ulcerans short-chain dehydrogenase 0.0256 0.032 0.0405
Chlamydia trachomatis 3-oxoacyl-ACP synthase 0.0974 0.1301 1
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.0215 0.1372
Echinococcus multilocularis microtubule associated protein 2 0.1352 0.1819 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0004 0.0003
Mycobacterium ulcerans thioesterase TesA 0.3233 0.4389 0.5572
Loa Loa (eye worm) hypothetical protein 0.2159 0.2921 0.3297
Trypanosoma brucei oxidoreductase, putative 0.0241 0.03 0.2304
Schistosoma mansoni hypothetical protein 0.0064 0.0058 0.0255
Schistosoma mansoni PHD zinc finger protein XAP135-related 0.0034 0.0017 0.0075
Schistosoma mansoni alcohol dehydrogenase 0.0241 0.03 0.1306
Schistosoma mansoni 3-oxoacyl-[ACP] synthase 0.0974 0.1301 0.5671
Echinococcus granulosus sphingomyelin synthase protein 1 0.005 0.0038 0.0212
Mycobacterium tuberculosis Probable oxidoreductase 0.0109 0.0119 0.015
Mycobacterium ulcerans Type I modular polyketide synthase 0.3865 0.5253 0.667
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0025 0.0004 0.0003
Mycobacterium ulcerans short chain dehydrogenase 0.0222 0.0274 0.0347
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0044 0.0031 0.0033
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.3865 0.5253 0.667
Entamoeba histolytica hypothetical protein 0.0041 0.0026 0.0497
Mycobacterium leprae Probable alcohol dehydrogenase AdhA 0.0241 0.03 0.0379
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0001 0.0009
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.005 0.0039 0.0069
Plasmodium vivax malonyl CoA-acyl carrier protein transacylase precursor, putative 0.0245 0.0305 0.2338
Mycobacterium tuberculosis Meromycolate extension acyl carrier protein AcpM 0.0392 0.0506 0.0641
Schistosoma mansoni bromodomain containing protein 0.0074 0.0071 0.0311
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0134 0.0154 0.0671
Schistosoma mansoni chromobox protein 0.0023 0.0001 0.0006
Onchocerca volvulus 0.0034 0.0017 0.0017
Trichomonas vaginalis glucosylceramidase, putative 0.0118 0.0131 0.0836
Mycobacterium ulcerans polyketide synthase MbtD 0.1193 0.1601 0.2031
Echinococcus multilocularis tumor suppressor p53 binding protein 1 0.0647 0.0854 0.4696
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0134 0.0154 0.0847
Brugia malayi steroid hormone receptor 0.0025 0.0004 0.0003
Loa Loa (eye worm) AMP-binding enzyme family protein 0.3629 0.493 0.5565
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0134 0.0154 0.0671
Loa Loa (eye worm) hypothetical protein 0.0025 0.0004 0.0003
Loa Loa (eye worm) hypothetical protein 0.005 0.0038 0.0042
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0241 0.03 0.0299
Trichomonas vaginalis inhibitor of growth, putative 0.0034 0.0017 0.011
Mycobacterium leprae PROBABLE NADP-DEPENDENT ALCOHOL DEHYDROGENASE ADHC 0.0241 0.03 0.0379
Loa Loa (eye worm) jmjC domain-containing protein 0.0297 0.0376 0.0424
Schistosoma mansoni hypothetical protein 0.0034 0.0017 0.0075
Loa Loa (eye worm) hypothetical protein 0.0034 0.0017 0.0018
Brugia malayi jmjC domain containing protein 0.0112 0.0123 0.0122
Onchocerca volvulus Bile acid receptor homolog 0.0025 0.0004 0.0003
Trichomonas vaginalis D-aminoacylase, putative 0.0022 0.0001 0.0007
Trichomonas vaginalis glucosylceramidase, putative 0.0118 0.0131 0.0836
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0241 0.03 0.5689
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0001 0.0028
Plasmodium falciparum JmjC domain-containing protein, putative 0.0064 0.0057 0.0429
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0024 0.0004 0.0016
Plasmodium falciparum histone-lysine N-methyltransferase, H3 lysine-4 specific 0.0034 0.0017 0.0121
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0025 0.0004 0.0003
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.003 0.0012 0.0075
Echinococcus multilocularis lysine specific demethylase 5A 0.0176 0.0211 0.116
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0025 0.0004 0.0017
Mycobacterium tuberculosis Probable oxidoreductase 0.0241 0.03 0.0379
Brugia malayi jmjC domain containing protein 0.0297 0.0376 0.0375
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0571 0.0751 0.5765
Echinococcus multilocularis uro adherence factor A 0.0034 0.0017 0.0095
Echinococcus granulosus dnaJ subfamily B 0.0264 0.0331 0.1822
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0001 0.0028
Brugia malayi Bromodomain containing protein 0.0025 0.0004 0.0003
Brugia malayi CHD4 protein 0.0057 0.0048 0.0047
Trypanosoma cruzi hypothetical protein 0.005 0.0038 0.0296
Loa Loa (eye worm) hypothetical protein 0.0903 0.1205 0.1359
Echinococcus multilocularis liprin alpha 2 0.005 0.0038 0.0212
Loa Loa (eye worm) hypothetical protein 0.0025 0.0004 0.0003
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0189 0.0229 0.0228
Schistosoma mansoni sex comb on midleg homolog 0.0525 0.0688 0.2998
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase Adh 0.0241 0.03 0.0379
Echinococcus granulosus histone acetyltransferase MYST2 0.0189 0.0229 0.126
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0001 0.0009
Plasmodium falciparum thioredoxin reductase 0.0043 0.0029 0.0212
Schistosoma mansoni chromobox protein 0.0389 0.0503 0.219
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0048 0.0035 0.0155
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0001 0.0003
Mycobacterium tuberculosis Polyketide synthase Pks13 0.5784 0.7875 1
Leishmania major hypothetical protein, conserved 0.0245 0.0305 0.1946
Trichomonas vaginalis myo inositol monophosphatase, putative 0.005 0.0039 0.025
Echinococcus multilocularis chromobox protein 2 0.0389 0.0503 0.2763
Trypanosoma cruzi PAB1-binding protein , putative 0.0127 0.0144 0.1106
Trichomonas vaginalis inositol monophosphatase, putative 0.005 0.0039 0.025
Entamoeba histolytica acyl-CoA synthetase, putative 0.0407 0.0527 1
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0595 0.0784 0.0994
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0087 0.009 0.0494
Schistosoma mansoni hypothetical protein 0.0034 0.0017 0.0075
Mycobacterium leprae Probable oxidireductase 0.0241 0.03 0.0379
Schistosoma mansoni [ACP] S-malonyltransferase 0.0245 0.0305 0.133
Wolbachia endosymbiont of Brugia malayi ACP S-malonyltransferase 0.0245 0.0305 0.2278
Brugia malayi Alcohol dehydrogenase class III 0.0241 0.03 0.0299
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0283 0.0357 0.0402
Toxoplasma gondii AP2 domain transcription factor AP2VIIa-7 0.0034 0.0017 0.003
Schistosoma mansoni hypothetical protein 0.005 0.0038 0.0168
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0179 0.0215 0.0242
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.009 0.0093 0.051
Schistosoma mansoni hypothetical protein 0.0264 0.0331 0.1444
Echinococcus multilocularis protein dispatched 1 0.0043 0.003 0.0164
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.0068 0.0375
Giardia lamblia Giardia trophozoite antigen GTA-1 0.005 0.0038 0.0246
Echinococcus multilocularis histone acetyltransferase myst3 0.0084 0.0085 0.0469
Echinococcus multilocularis sterol regulatory element binding protein 0.0038 0.0022 0.0123
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.0215 0.1372
Onchocerca volvulus 0.0064 0.0058 0.006
Echinococcus granulosus polycomb protein SCMH1 0.0525 0.0688 0.3783
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.009 0.0093 0.051
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0235 0.0292 0.1604
Onchocerca volvulus Matrilysin homolog 0.0071 0.0068 0.007
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0023 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0025 0.0004 0.0003
Loa Loa (eye worm) transcription factor SMAD2 0.0165 0.0196 0.022
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0001 0.0009
Echinococcus multilocularis zinc finger protein 0.0046 0.0033 0.0181
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0034 0.0017 0.0095
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0001 0.0009
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0144 0.0167 0.021
Echinococcus granulosus Chromobox protein 3 0.0023 0.0001 0.0008
Brugia malayi Thioredoxin reductase 0.0043 0.0029 0.0028
Onchocerca volvulus 0.005 0.0038 0.0039
Loa Loa (eye worm) hypothetical protein 0.0034 0.0017 0.0018
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.1569 0.2114 0.2684
Loa Loa (eye worm) hypothetical protein 0.0245 0.0305 0.0343
Onchocerca volvulus Huntingtin homolog 0.0079 0.0078 0.0081
Echinococcus multilocularis SAM and MBT domain containing protein 0.076 0.101 0.5551
Mycobacterium ulcerans NADP-dependent oxidoreductase 0.0241 0.03 0.0379
Echinococcus granulosus pdz domain containing protein 0.005 0.0038 0.0212
Echinococcus multilocularis GPCR, family 2 0.009 0.0093 0.051
Loa Loa (eye worm) hypothetical protein 0.0163 0.0193 0.0216
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.2787 0.3779 0.4798
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0017 0.011
Schistosoma mansoni lar interacting protein (lip)-related protein 0.005 0.0038 0.0168
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.4106 0.5582 0.7088
Loa Loa (eye worm) alcohol dehydrogenase class III 0.0241 0.03 0.0337
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0974 0.1301 1
Loa Loa (eye worm) hypothetical protein 0.0241 0.03 0.0337
Loa Loa (eye worm) F/Y-rich family protein 0.0034 0.0017 0.0018
Leishmania major hypothetical protein, conserved 0.0022 0.0001 0.0007
Echinococcus multilocularis remodeling and spacing factor 1 0.0034 0.0017 0.0095
Loa Loa (eye worm) mbt repeat family protein 0.0546 0.0717 0.0808
Mycobacterium ulcerans dehydrogenase 0.0241 0.03 0.0379
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0025 0.0004 0.0021
Brugia malayi PHD-finger family protein 0.0034 0.0017 0.0016
Echinococcus multilocularis pdz domain containing protein 0.005 0.0038 0.0212
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0111 0.0122 0.0777
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative 0.0974 0.1301 1
Schistosoma mansoni hypothetical protein 0.009 0.0093 0.0405
Brugia malayi TAR-binding protein 0.0172 0.0205 0.0204
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0134 0.0154 0.0847
Toxoplasma gondii LsmAD domain-containing protein 0.0127 0.0144 0.0257
Schistosoma mansoni hepatitis B virus X associated protein hbxa 0.0034 0.0017 0.0075
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0026 0.0114
Loa Loa (eye worm) hypothetical protein 0.0038 0.0022 0.0024
Schistosoma mansoni zinc binding dehydrogenase 0.0241 0.03 0.1306
Loa Loa (eye worm) hypothetical protein 0.0089 0.0092 0.0102
Mycobacterium tuberculosis Probable NADP-dependent alcohol dehydrogenase AdhC 0.0241 0.03 0.0379
Echinococcus granulosus polyhomeotic protein 2 0.005 0.0038 0.0212
Mycobacterium ulcerans acyl carrier protein 0.0392 0.0506 0.0641
Mycobacterium leprae Probable S-nitrosomycothiol reductase MscR 0.0241 0.03 0.0379
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0044 0.0031 0.0236
Trypanosoma brucei acyl transferase-like protein 0.0245 0.0305 0.2345
Trypanosoma cruzi Ring finger domain/PHD-finger, putative 0.0034 0.0017 0.0133
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0026 0.0144
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0025 0.0004 0.0003
Mycobacterium tuberculosis Probable thioesterase TesA 0.3233 0.4389 0.5572
Echinococcus granulosus TAF3 RNA polymerase II TATA box binding protein 0.0034 0.0017 0.0095
Trichomonas vaginalis glucosylceramidase, putative 0.0118 0.0131 0.0836
Mycobacterium tuberculosis Possible dehydrogenase 0.0241 0.03 0.0379
Mycobacterium ulcerans acyl carrier protein 0.0392 0.0506 0.0641
Echinococcus multilocularis polyhomeotic protein 2 0.005 0.0038 0.0212
Loa Loa (eye worm) hypothetical protein 0.0061 0.0053 0.0059
Entamoeba histolytica NADP-dependent alcohol dehydrogenase 0.0241 0.03 0.5689
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0087 0.009 0.0494
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0014 0.0092
Schistosoma mansoni pyruvate dehydrogenase 0.0086 0.0089 0.0386
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0134 0.0154 0.0847
Loa Loa (eye worm) hypothetical protein 0.0194 0.0235 0.0264
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0393 0.0507 0.0642
Schistosoma mansoni thyroid hormone receptor 0.0025 0.0004 0.0017
Brugia malayi CXXC zinc finger family protein 0.0042 0.0027 0.0026
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0025 0.0004 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0017 0.011
Brugia malayi nuclear receptor NHR-88 0.0025 0.0004 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0017 0.011
Trichomonas vaginalis glucosylceramidase, putative 0.0118 0.0131 0.0836
Loa Loa (eye worm) hypothetical protein 0.0025 0.0004 0.0003
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.4106 0.5582 0.7088
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0098 0.0104 0.0131
Brugia malayi hypothetical protein 0.0041 0.0026 0.0025
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.003 0.0011 0.0011
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.0068 0.0375
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0023 0.0001 0.0002
Loa Loa (eye worm) MBCTL1 0.0189 0.0229 0.0257
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.3865 0.5253 0.667
Plasmodium falciparum 3-oxoacyl-acyl-carrier protein synthase I/II 0.0974 0.1301 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 8.94 um PUBCHEM_BIOASSAY: Inhibitors of Plasmodium falciparum M1- Family Alanyl Aminopeptidase (M1AAP). Inhibition of the rate of hydrolysis of fluorogenic peptide substrate (H-Leu-NHMec). Secondary screen (Class of assay: confirmatory) ChEMBL. No reference
IC50 (binding) = 187.7 uM Inhibition of porcine kidney microsome aminopeptidase using L-Leu-p-nitroanilide as substrate after 30 mins ChEMBL. 22901392
Potency (functional) 5.6234 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 5.6234 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 30.1313 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 37.6505 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.