Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | farnesyltransferase, CAAX box, alpha | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0072 | 0.1976 | 0.2228 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0073 | 0.2035 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0072 | 0.1976 | 0.2228 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0072 | 0.1976 | 0.1976 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0072 | 0.1976 | 0.2228 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0072 | 0.1976 | 0.2228 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.1976 | 0.2228 |
Brugia malayi | nuclear receptor NHR-88 | 0.0072 | 0.1976 | 0.2228 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0072 | 0.1976 | 0.785 |
Entamoeba histolytica | Rab geranylgeranyltransferase alpha subunit, putative | 0.005 | 0.069 | 0.0693 |
Echinococcus granulosus | FTZ F1 alpha | 0.0072 | 0.1976 | 0.2228 |
Schistosoma mansoni | thyroid hormone receptor | 0.0213 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.1976 | 0.2228 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0072 | 0.1976 | 0.2228 |
Echinococcus multilocularis | geranylgeranyl transferase type 2 subunit alpha | 0.005 | 0.069 | 0.069 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0019 | 0.0022 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0072 | 0.1976 | 0.1976 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0073 | 0.2035 | 0.2295 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0073 | 0.2035 | 0.2295 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0038 | 0.0019 | 0.0022 |
Onchocerca volvulus | 0.0082 | 0.2517 | 1 | |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0072 | 0.1976 | 0.2228 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0072 | 0.1976 | 0.1976 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.1976 | 0.2228 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0072 | 0.1976 | 0.1976 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0073 | 0.2035 | 1 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0038 | 0.0019 | 0.0019 |
Echinococcus granulosus | protein farnesyltransferase alpha subunit | 0.0193 | 0.8869 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.0081 | 0.0081 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0019 | 0.0022 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0072 | 0.1976 | 0.2228 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0072 | 0.1976 | 0.2228 |
Echinococcus granulosus | protein prenyltransferase alpha subunit | 0.005 | 0.069 | 0.0778 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0073 | 0.2035 | 0.2224 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0072 | 0.1976 | 0.2228 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0043 | 0.0263 | 0.0263 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0072 | 0.1976 | 0.1976 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0072 | 0.1976 | 0.1976 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0072 | 0.1976 | 0.1976 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0072 | 0.1976 | 0.785 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0072 | 0.1976 | 0.2228 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0019 | 0.0022 |
Loa Loa (eye worm) | prenyltransferase alpha subunit repeat containing protein | 0.0193 | 0.8869 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0039 | 0.0081 | 0.0091 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0072 | 0.1976 | 0.1976 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.005 | 0.069 | 0.069 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0072 | 0.1976 | 0.1976 |
Echinococcus multilocularis | protein prenyltransferase alpha subunit | 0.005 | 0.069 | 0.069 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0039 | 0.0081 | 0.0081 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0072 | 0.1976 | 0.1976 |
Brugia malayi | Protein prenyltransferase alpha subunit repeat containing protein | 0.005 | 0.069 | 0.0778 |
Schistosoma mansoni | coup transcription factor | 0.0072 | 0.1976 | 0.1976 |
Brugia malayi | ecdysteroid receptor | 0.0072 | 0.1976 | 0.2228 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.1976 | 0.2228 |
Schistosoma mansoni | hypothetical protein | 0.014 | 0.5852 | 0.5852 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0072 | 0.1976 | 0.2228 |
Toxoplasma gondii | hypothetical protein | 0.0143 | 0.6006 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0072 | 0.1976 | 0.2228 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0038 | 0.0019 | 0.0019 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0072 | 0.1976 | 0.1976 |
Schistosoma mansoni | thyroid hormone receptor | 0.0213 | 1 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0038 | 0.0019 | 0.0022 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.1976 | 0.2228 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.1976 | 0.2228 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0072 | 0.1976 | 0.2228 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0019 | 0.0022 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative | 0.0143 | 0.6006 | 0.65 |
Entamoeba histolytica | protein farnesyltransferase alpha subunit, putative | 0.0193 | 0.8869 | 1 |
Plasmodium falciparum | protein farnesyltransferase subunit alpha | 0.0193 | 0.8869 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0039 | 0.0081 | 0.0081 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0038 | 0.0019 | 0.0022 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit, putative | 0.0193 | 0.8869 | 1 |
Plasmodium vivax | prenyltransferase alpha subunit, putative | 0.0193 | 0.8869 | 1 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0073 | 0.2035 | 0.2035 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0072 | 0.1976 | 0.2228 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0072 | 0.1976 | 0.2228 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0073 | 0.2035 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0072 | 0.1976 | 0.785 |
Echinococcus multilocularis | protein farnesyltransferase alpha subunit | 0.0193 | 0.8869 | 0.8869 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0038 | 0.0019 | 0.0022 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0072 | 0.1976 | 0.1976 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.1976 | 0.2228 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0072 | 0.1976 | 0.2228 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0072 | 0.1976 | 0.1976 |
Onchocerca volvulus | 0.0072 | 0.1976 | 0.785 | |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0072 | 0.1976 | 0.1976 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0019 | 0.0022 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0072 | 0.1976 | 0.2228 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0072 | 0.1976 | 0.2228 |
Schistosoma mansoni | protein farnesyltransferase alpha subunit | 0.0193 | 0.8869 | 0.8869 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0072 | 0.1976 | 0.1976 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0073 | 0.2035 | 0.2295 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.014 | 0.5852 | 0.6599 |
Brugia malayi | hypothetical protein | 0.0039 | 0.0081 | 0.0091 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0072 | 0.1976 | 0.2228 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0072 | 0.1976 | 0.2228 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0072 | 0.1976 | 0.2228 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0072 | 0.1976 | 0.1976 |
Brugia malayi | nuclear hormone receptor | 0.0072 | 0.1976 | 0.2228 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0072 | 0.1976 | 0.2228 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0072 | 0.1976 | 0.2228 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0072 | 0.1976 | 0.2228 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0073 | 0.2035 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0072 | 0.1976 | 0.2228 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0072 | 0.1976 | 0.2228 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0072 | 0.1976 | 0.2228 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0072 | 0.1976 | 0.2228 |
Schistosoma mansoni | nuclear hormone receptor | 0.0072 | 0.1976 | 0.1976 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative | 0.0193 | 0.8869 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0072 | 0.1976 | 0.2228 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0072 | 0.1976 | 0.1976 |
Loa Loa (eye worm) | prenyltransferase alpha subunit repeat containing protein | 0.005 | 0.069 | 0.0778 |
Brugia malayi | steroid hormone receptor | 0.0072 | 0.1976 | 0.2228 |
Brugia malayi | hypothetical protein | 0.0038 | 0.0019 | 0.0022 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0038 | 0.0019 | 0.0022 |
Onchocerca volvulus | 0.005 | 0.069 | 0.2743 | |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.014 | 0.5852 | 0.5852 |
Brugia malayi | Protein prenyltransferase alpha subunit repeat containing protein | 0.0193 | 0.8869 | 1 |
Giardia lamblia | Rab geranylgeranyltransferase | 0.0193 | 0.8869 | 1 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit, putative | 0.0193 | 0.8869 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.8869 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0072 | 0.1976 | 0.2228 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0073 | 0.2035 | 0.2035 |
Brugia malayi | Thrombospondin type 1 domain containing protein | 0.0082 | 0.2517 | 0.2838 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0072 | 0.1976 | 0.2228 |
Echinococcus granulosus | geranylgeranyl transferase type 2 subunit alpha | 0.005 | 0.069 | 0.0778 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.2517 | 0.2517 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.1976 | 0.2228 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0043 | 0.0263 | 0.0297 |
Brugia malayi | hypothetical protein | 0.0038 | 0.0019 | 0.0022 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0072 | 0.1976 | 0.2228 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0038 | 0.0019 | 0.0019 |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.0082 | 0.2517 | 0.2838 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.