Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | arginine vasopressin receptor 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Treponema pallidum | diphosphate--fructose-6-phosphate 1-phosphotransferase | 0.0105 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.4911 | 0.4911 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.2936 | 0.2936 |
Echinococcus granulosus | 6 phosphofructokinase | 0.0105 | 1 | 1 |
Schistosoma mansoni | bromodomain containing protein | 0.0061 | 0.4904 | 0.4904 |
Plasmodium vivax | 6-phosphofructokinase, putative | 0.0028 | 0.1098 | 0.5 |
Trypanosoma cruzi | ATP-dependent 6-phosphofructokinase, glycosomal | 0.0105 | 1 | 0.5 |
Brugia malayi | 6-phosphofructokinase | 0.0105 | 1 | 1 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0022 | 0.0333 | 0.0333 |
Giardia lamblia | Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit | 0.0028 | 0.1098 | 0.5 |
Leishmania major | ATP-dependent phosphofructokinase | 0.0105 | 1 | 0.5 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0022 | 0.0333 | 0.0333 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0061 | 0.4911 | 0.485 |
Brugia malayi | Bromodomain containing protein | 0.0073 | 0.6219 | 0.5978 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0105 | 1 | 1 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0105 | 1 | 1 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0105 | 1 | 1 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0105 | 1 | 1 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0105 | 1 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0035 | 0.1835 | 0.1835 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0061 | 0.4911 | 0.4587 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0105 | 1 | 1 |
Loa Loa (eye worm) | phosphofructokinase | 0.0105 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.2936 | 0.2936 |
Toxoplasma gondii | phosphofructokinase PFKII | 0.0028 | 0.1098 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.2109 | 0.2014 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.4911 | 0.4911 |
Chlamydia trachomatis | fructose-6-phosphate phosphotransferase | 0.0028 | 0.1098 | 0.5 |
Mycobacterium tuberculosis | Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) | 0.0105 | 1 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0061 | 0.4911 | 0.4911 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0058 | 0.4502 | 0.4502 |
Toxoplasma gondii | 6-phosphofructokinase | 0.0028 | 0.1098 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0061 | 0.4911 | 0.485 |
Plasmodium falciparum | ATP-dependent 6-phosphofructokinase | 0.0028 | 0.1098 | 0.5 |
Plasmodium falciparum | ATP-dependent 6-phosphofructokinase | 0.0028 | 0.1098 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.4911 | 0.4911 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.2589 | 0.25 |
Mycobacterium ulcerans | 6-phosphofructokinase | 0.0105 | 1 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.2936 | 0.2936 |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.0119 | 0.0119 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.5739 | 0.5688 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0105 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.2936 | 0.2936 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.2936 | 0.2936 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.2936 | 0.2936 |
Loa Loa (eye worm) | RNA binding protein | 0.0061 | 0.4911 | 0.485 |
Brugia malayi | TAR-binding protein | 0.0061 | 0.4911 | 0.4587 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0105 | 1 | 1 |
Brugia malayi | RNA binding protein | 0.0061 | 0.4911 | 0.4587 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0035 | 0.1835 | 0.1835 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0105 | 1 | 1 |
Toxoplasma gondii | phosphofructokinase domain-containing protein | 0.0028 | 0.1098 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.2936 | 0.2851 |
Brugia malayi | Bromodomain containing protein | 0.0037 | 0.2101 | 0.1598 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0105 | 1 | 1 |
Plasmodium vivax | 6-phosphofructokinase, putative | 0.0028 | 0.1098 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.2374 | 0.2283 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0058 | 0.4502 | 0.4502 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0105 | 1 | 1 |
Mycobacterium leprae | PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) | 0.0105 | 1 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.4911 | 0.4911 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.2936 | 0.2486 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.4911 | 0.4911 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.2936 | 0.2936 |
Chlamydia trachomatis | fructose-6-phosphate phosphotransferase | 0.0028 | 0.1098 | 0.5 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0022 | 0.0333 | 0.0333 |
Trypanosoma brucei | ATP-dependent 6-phosphofructokinase, glycosomal | 0.0105 | 1 | 0.5 |
Brugia malayi | 6-phosphofructokinase | 0.0105 | 1 | 1 |
Echinococcus multilocularis | 6 phosphofructokinase | 0.0105 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0061 | 0.4911 | 0.4911 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 25.3 nM | Displacement of [3H]-AVP from human vasopressin V2 receptor expressed in CHO cells after 30 mins | ChEMBL. | 22984902 |
Kinact (functional) | = 3.8 nM | Antagonist activity at human vasopressin V2 receptor expressed in CHO cells assessed as inhibition of AVP-induced cAMP accumulation after 30 mins by TR-FRET based HTRF assay | ChEMBL. | 22984902 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.