Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | purinergic receptor P2Y, G-protein coupled, 12 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | PAB1-binding protein , putative | 0.0029 | 0.2749 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0029 | 0.2749 | 0.5 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0067 | 1 | 0.5 |
Echinococcus granulosus | lamin | 0.0031 | 0.3146 | 0.3146 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.3146 | 0.3446 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0.2749 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0029 | 0.2749 | 0.5 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0067 | 1 | 1 |
Echinococcus multilocularis | lamin | 0.0031 | 0.3146 | 0.3146 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0067 | 1 | 0.5 |
Loa Loa (eye worm) | intermediate filament protein | 0.0031 | 0.3146 | 0.3446 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0067 | 1 | 1 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0062 | 0.9129 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.2749 | 0.3011 |
Echinococcus multilocularis | musashi | 0.0031 | 0.3146 | 0.3146 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.3035 | 0.3324 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0735 | 0.0425 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.0323 | 0.0354 |
Onchocerca volvulus | 0.0031 | 0.3146 | 0.5 | |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0067 | 1 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0031 | 0.3146 | 0.2917 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0.2749 | 0.5 |
Brugia malayi | hypothetical protein | 0.0029 | 0.2749 | 0.2507 |
Echinococcus granulosus | lamin dm0 | 0.0031 | 0.3146 | 0.3146 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0029 | 0.2749 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0029 | 0.2749 | 0.5 |
Brugia malayi | intermediate filament protein | 0.0031 | 0.3146 | 0.2917 |
Echinococcus multilocularis | lamin dm0 | 0.0031 | 0.3146 | 0.3146 |
Onchocerca volvulus | 0.0031 | 0.3146 | 0.5 | |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0067 | 1 | 0.5 |
Echinococcus granulosus | intermediate filament protein | 0.0031 | 0.3146 | 0.3146 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0067 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0031 | 0.3146 | 0.3446 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 219 nM | Displacement of [33P]2-MeS-ADP from human recombinant P2Y12 receptor expressed in CHO cell membranes by scintillation counting method | ChEMBL. | 22984835 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.