Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | TAR-binding protein | 0.0074 | 1 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0074 | 1 | 0.5 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0059 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0074 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0074 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0074 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0074 | 1 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0074 | 1 | 1 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0059 | 0 | 0.5 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0059 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0059 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 0 % | Inhibition of recombinant human DNA topoisomerase-1-mediated relaxation of supercoiled pBR322 at 100 uM after 30 mins using ethidium bromide staining by agarose gel electrophoresis | ChEMBL. | 22503656 |
Inhibition (binding) | = 13.9 % | Inhibition of human DNA topoisomerase-2alpha-mediated relaxation of supercoiled pBR322 at 100 uM after 30 mins using ethidium bromide staining by agarose gel electrophoresis | ChEMBL. | 22503656 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.