Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0067 | 1 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.6531 | 0.6394 |
Trichomonas vaginalis | flap endonuclease-1, putative | 0.0025 | 0.3535 | 1 |
Trypanosoma brucei | flap endonuclease-1 (FEN-1), putative | 0.0025 | 0.3535 | 1 |
Entamoeba histolytica | Flap nuclease, putative | 0.0025 | 0.3535 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0067 | 1 | 1 |
Toxoplasma gondii | flap structure-specific endonuclease 1, putative | 0.0025 | 0.3535 | 1 |
Plasmodium falciparum | exonuclease I, putative | 0.0005 | 0.038 | 0.1076 |
Brugia malayi | TAR-binding protein | 0.0067 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0067 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.6531 | 0.6394 |
Schistosoma mansoni | flap endonuclease-1 | 0.0023 | 0.3155 | 0.2884 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.6531 | 0.6394 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.6531 | 0.6394 |
Loa Loa (eye worm) | flap endonuclease-1 | 0.0025 | 0.3535 | 0.328 |
Plasmodium vivax | flap endonuclease 1, putative | 0.0025 | 0.3535 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.6531 | 0.6394 |
Echinococcus granulosus | flap endonuclease 1 | 0.0025 | 0.3535 | 0.328 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0067 | 1 | 1 |
Plasmodium vivax | DNA repair protein RAD2, putative | 0.0005 | 0.038 | 0.1076 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.6531 | 0.6394 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0067 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 1 | 1 |
Giardia lamblia | Flap structure-specific endonuclease | 0.0025 | 0.3535 | 1 |
Plasmodium falciparum | DNA repair protein RAD2, putative | 0.0005 | 0.038 | 0.1076 |
Trypanosoma cruzi | flap endonuclease-1 (FEN-1), putative | 0.0025 | 0.3535 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.6531 | 0.6394 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.6531 | 0.6394 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 1 | 1 |
Brugia malayi | Flap endonuclease-1 | 0.0025 | 0.3535 | 0.328 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.6531 | 0.6394 |
Leishmania major | flap endonuclease-1 (FEN-1), putative | 0.0025 | 0.3535 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0067 | 1 | 1 |
Plasmodium falciparum | flap endonuclease 1 | 0.0025 | 0.3535 | 1 |
Plasmodium vivax | exonuclease I, putative | 0.0005 | 0.038 | 0.1076 |
Echinococcus multilocularis | flap endonuclease 1 | 0.0025 | 0.3535 | 0.328 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (ADMET) | = 29.9 uM | Cytotoxicity against human Hep2 cells by Cell Titer-Glo assay | ChEMBL. | 23043370 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.