Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0021 | 0.1713 | 1 |
Echinococcus multilocularis | dna polymerase eta | 0.0021 | 0.1713 | 0.1713 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.028 | 0.1635 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0021 | 0.1713 | 1 |
Trypanosoma brucei | unspecified product | 0.0021 | 0.1713 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0071 | 0.6925 | 0.6925 |
Brugia malayi | CXXC zinc finger family protein | 0.0031 | 0.2769 | 0.2769 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0059 | 0.5647 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0021 | 0.1713 | 1 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0021 | 0.1713 | 0.1713 |
Trypanosoma brucei | unspecified product | 0.0014 | 0.1042 | 0.55 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0021 | 0.1713 | 0.1713 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0021 | 0.1713 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0071 | 0.6925 | 0.6925 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.1713 | 1 |
Onchocerca volvulus | 0.0031 | 0.2769 | 1 | |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0009 | 0.0534 | 0.0534 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.028 | 0.1635 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0021 | 0.1713 | 0.1713 |
Schistosoma mansoni | cpg binding protein | 0.0033 | 0.2952 | 0.2952 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0021 | 0.1713 | 0.1713 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.1713 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0021 | 0.1713 | 1 |
Brugia malayi | TAR-binding protein | 0.0071 | 0.6925 | 0.6925 |
Schistosoma mansoni | cpg binding protein | 0.0033 | 0.2952 | 0.2952 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0021 | 0.1713 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0021 | 0.1713 | 1 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0008 | 0.035 | 0.035 |
Echinococcus multilocularis | tar DNA binding protein | 0.0071 | 0.6925 | 0.6925 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0014 | 0.1042 | 0.55 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0021 | 0.1713 | 1 |
Echinococcus granulosus | cpg binding protein | 0.0033 | 0.2952 | 0.2952 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.6925 | 0.6925 |
Trypanosoma brucei | unspecified product | 0.0014 | 0.1042 | 0.55 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.6925 | 0.6925 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0101 | 1 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0008 | 0.035 | 0.035 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.2769 | 0.2769 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.028 | 0.1635 |
Brugia malayi | RNA binding protein | 0.0071 | 0.6925 | 0.6925 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.028 | 0.1635 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.1713 | 1 |
Echinococcus granulosus | dna polymerase eta | 0.0021 | 0.1713 | 0.1713 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.1713 | 1 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0021 | 0.1713 | 0.1713 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0008 | 0.035 | 0.035 |
Leishmania major | DNA polymerase kappa, putative | 0.0021 | 0.1713 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0101 | 1 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.001 | 0.0547 | 0.0547 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.028 | 0.1635 |
Giardia lamblia | DINP protein human, muc B family | 0.0021 | 0.1713 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0021 | 0.1713 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.1713 | 0.1713 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0021 | 0.1713 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0021 | 0.1713 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.1713 | 1 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0007 | 0.028 | 0.1635 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0021 | 0.1713 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.028 | 0.1635 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0101 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0021 | 0.1713 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.028 | 0.1635 |
Echinococcus multilocularis | cpg binding protein | 0.0033 | 0.2952 | 0.2952 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0031 | 0.2769 | 0.2769 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.028 | 0.1635 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.001 | 0.0547 | 0.0547 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.028 | 0.1635 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.028 | 0.1635 |
Plasmodium falciparum | DNA repair protein REV1, putative | 0.0006 | 0.0222 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.028 | 0.1635 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0008 | 0.035 | 0.035 |
Schistosoma mansoni | DNA polymerase IV / kappa | 0.0006 | 0.0222 | 0.0222 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0066 | 0.6376 | 0.6376 |
Echinococcus granulosus | tar DNA binding protein | 0.0071 | 0.6925 | 0.6925 |
Echinococcus granulosus | dna polymerase kappa | 0.0021 | 0.1713 | 0.1713 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0021 | 0.1713 | 0.1713 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0222 | 0.0222 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.6925 | 0.6925 |
Schistosoma mansoni | DNA polymerase eta | 0.0021 | 0.1713 | 0.1713 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0101 | 1 | 1 |
Loa Loa (eye worm) | histone methyltransferase | 0.001 | 0.0547 | 0.0547 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.1713 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.1713 | 1 |
Echinococcus multilocularis | dna polymerase kappa | 0.0021 | 0.1713 | 0.1713 |
Loa Loa (eye worm) | TAR-binding protein | 0.0071 | 0.6925 | 0.6925 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0021 | 0.1713 | 0.1713 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0021 | 0.1713 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.028 | 0.1635 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0004 | 0.0013 | 0.0013 |
Trichomonas vaginalis | helicase, putative | 0.0007 | 0.028 | 0.1635 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.028 | 0.1635 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0014 | 0.1042 | 0.55 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0008 | 0.035 | 0.035 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.028 | 0.1635 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.1713 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0014 | 0.1042 | 0.55 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.028 | 0.1635 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0021 | 0.1713 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0021 | 0.1713 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.6925 | 0.6925 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0021 | 0.1713 | 0.5 |
Plasmodium vivax | DNA repair protein REV1, putative | 0.0006 | 0.0222 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.1713 | 1 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0007 | 0.028 | 0.1635 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.1713 | 1 |
Brugia malayi | polk-prov protein | 0.0006 | 0.0222 | 0.0222 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0071 | 0.6925 | 0.6925 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.6925 | 0.6925 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0101 | 1 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0101 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0101 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0101 | 1 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0021 | 0.1713 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 2.6 % | Inhibition of human DAT expressed in HEK293 cells assessed as inhibition of dopamine reuptake at 0.1 uM after 15 mins by fluorescence assay | ChEMBL. | 22938049 |
Inhibition (binding) | = 3.9 % | Inhibition of human SERT expressed in HEK293 cells assessed as inhibition of serotonin reuptake at 0.1 uM after 15 mins by fluorescence assay | ChEMBL. | 22938049 |
Inhibition (binding) | = 7.7 % | Inhibition of human NET expressed in HEK293 cells assessed as inhibition of noradrenaline reuptake at 0.1 uM after 15 mins by fluorescence assay | ChEMBL. | 22938049 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.