Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0184 | 0.183 | 0.3224 |
Schistosoma mansoni | cytochrome B5 | 0.0055 | 0.0258 | 0.0197 |
Trichomonas vaginalis | chromobox protein, putative | 0.0076 | 0.0519 | 0.0763 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.048 | 0.5439 | 1 |
Brugia malayi | Cytochrome b5-like Heme/Steroid binding domain containing protein | 0.0055 | 0.0258 | 0.0197 |
Schistosoma mansoni | jumonji domain containing protein | 0.0083 | 0.0601 | 0.0542 |
Loa Loa (eye worm) | galactoside-binding lectin family protein | 0.0855 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0319 | 0.3474 | 0.6312 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0297 | 0.3203 | 0.3161 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0319 | 0.3474 | 0.6312 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0066 | 0.0393 | 0.0393 |
Brugia malayi | jmjC domain containing protein | 0.0104 | 0.0861 | 0.0804 |
Trichomonas vaginalis | chromobox protein, putative | 0.0076 | 0.0519 | 0.0763 |
Plasmodium falciparum | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.0184 | 0.183 | 0.3033 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0184 | 0.183 | 0.3224 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.048 | 0.5439 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0257 | 0.0257 |
Brugia malayi | flavodoxin family protein | 0.048 | 0.5439 | 0.5411 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0076 | 0.0519 | 0.0519 |
Loa Loa (eye worm) | diaphorase | 0.0055 | 0.0258 | 0.0258 |
Loa Loa (eye worm) | flavodoxin family protein | 0.0184 | 0.183 | 0.183 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0319 | 0.3474 | 0.6312 |
Loa Loa (eye worm) | galactoside-binding lectin family protein | 0.0855 | 1 | 1 |
Loa Loa (eye worm) | galactoside-binding lectin family protein | 0.0855 | 1 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0046 | 0.0151 | 0.0074 |
Loa Loa (eye worm) | galectin | 0.0855 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0855 | 1 | 1 |
Brugia malayi | Galactoside-binding lectin family protein | 0.0855 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.048 | 0.5439 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.048 | 0.5439 | 0.5411 |
Echinococcus granulosus | cytochrome b5 reductase 4 | 0.0055 | 0.0258 | 0.0197 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0238 | 0.2494 | 1 |
Loa Loa (eye worm) | cytochrome b5 reductase 4 | 0.0055 | 0.0258 | 0.0258 |
Onchocerca volvulus | 0.0055 | 0.0258 | 0.0258 | |
Echinococcus multilocularis | chromobox protein 1 | 0.0076 | 0.0519 | 0.0459 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0104 | 0.0861 | 0.0804 |
Echinococcus multilocularis | chromobox protein 1 | 0.0076 | 0.0519 | 0.0459 |
Schistosoma mansoni | NADH-cytochrome B5 reductase | 0.0055 | 0.0258 | 0.0197 |
Schistosoma mansoni | chromobox protein | 0.0076 | 0.0519 | 0.0459 |
Echinococcus granulosus | cytochrome b5 reductase 4 | 0.0055 | 0.0258 | 0.0197 |
Trypanosoma cruzi | NADPH--cytochrome P450 reductase, putative | 0.0184 | 0.183 | 0.3033 |
Treponema pallidum | flavodoxin | 0.0184 | 0.183 | 0.4886 |
Echinococcus granulosus | methionine synthase reductase | 0.0297 | 0.3203 | 0.3161 |
Loa Loa (eye worm) | galectin | 0.0855 | 1 | 1 |
Brugia malayi | diaphorase | 0.0055 | 0.0258 | 0.0197 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0242 | 0.2539 | 0.2492 |
Trichomonas vaginalis | sulfite reductase, putative | 0.048 | 0.5439 | 1 |
Echinococcus granulosus | Galectin carbohydrate recognition domain | 0.0855 | 1 | 1 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0043 | 0.0112 | 0.0112 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0112 | 0.0112 |
Leishmania major | cytochrome P450 reductase, putative | 0.0426 | 0.4775 | 0.8717 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.048 | 0.5439 | 0.5411 |
Trypanosoma cruzi | p450 reductase, putative | 0.048 | 0.5439 | 1 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.048 | 0.5439 | 0.5411 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.0184 | 0.183 | 0.3033 |
Plasmodium vivax | hypothetical protein, conserved | 0.0184 | 0.183 | 0.3033 |
Brugia malayi | galectin | 0.0855 | 1 | 1 |
Brugia malayi | Galactoside-binding lectin family protein | 0.0855 | 1 | 1 |
Brugia malayi | galectin | 0.0855 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.048 | 0.5439 | 0.5439 |
Trichomonas vaginalis | chromobox protein, putative | 0.0046 | 0.0151 | 0.0074 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.0184 | 0.183 | 0.3033 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0038 | 0.0062 | 0.0062 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0184 | 0.183 | 0.3224 |
Schistosoma mansoni | diflavin oxidoreductase | 0.0238 | 0.2494 | 0.2447 |
Onchocerca volvulus | Galectin homolog | 0.0855 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0426 | 0.4775 | 1 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0156 | 0.1489 | 0.2376 |
Echinococcus multilocularis | NADH cytochrome b5 reductase 3 | 0.0055 | 0.0258 | 0.0197 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.048 | 0.5439 | 1 |
Chlamydia trachomatis | sulfite reductase | 0.0297 | 0.3203 | 1 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0426 | 0.4775 | 1 |
Brugia malayi | Galactoside-binding lectin family protein | 0.0855 | 1 | 1 |
Echinococcus granulosus | chromobox protein 1 | 0.0076 | 0.0519 | 0.0459 |
Loa Loa (eye worm) | hypothetical protein | 0.0855 | 1 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.048 | 0.5439 | 1 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0156 | 0.1489 | 0.5 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0044 | 0.0132 | 0.0071 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0319 | 0.3474 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.048 | 0.5439 | 1 |
Echinococcus granulosus | NADH cytochrome b5 reductase 3 | 0.0055 | 0.0258 | 0.0197 |
Loa Loa (eye worm) | hypothetical protein | 0.0855 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0184 | 0.183 | 0.3033 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0238 | 0.2494 | 1 |
Schistosoma mansoni | chromobox protein | 0.0076 | 0.0519 | 0.0459 |
Echinococcus multilocularis | Galectin, carbohydrate recognition domain | 0.0855 | 1 | 1 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0426 | 0.4775 | 0.8753 |
Echinococcus multilocularis | methionine synthase reductase | 0.0297 | 0.3203 | 0.3161 |
Echinococcus multilocularis | cytochrome b5 reductase 4 | 0.0055 | 0.0258 | 0.0197 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0319 | 0.3474 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.048 | 0.5439 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0319 | 0.3474 | 0.6312 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.048 | 0.5439 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.048 | 0.5439 | 1 |
Onchocerca volvulus | Galectin homolog | 0.0855 | 1 | 1 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0184 | 0.183 | 0.3224 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0426 | 0.4775 | 0.8717 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0319 | 0.3474 | 0.7121 |
Echinococcus granulosus | chromobox protein 1 | 0.0076 | 0.0519 | 0.0459 |
Schistosoma mansoni | cytochrome P450 reductase | 0.048 | 0.5439 | 0.5411 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0319 | 0.3474 | 0.6312 |
Plasmodium falciparum | NADPH--cytochrome P450 reductase, putative | 0.0184 | 0.183 | 0.3033 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0319 | 0.3474 | 0.6312 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0156 | 0.1489 | 1 |
Brugia malayi | chromobox protein homolog 3 | 0.0043 | 0.0112 | 0.005 |
Brugia malayi | flavodoxin family protein | 0.0184 | 0.183 | 0.1779 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.048 | 0.5439 | 1 |
Brugia malayi | Heterochromatin protein 1 | 0.0076 | 0.0519 | 0.0459 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0319 | 0.3474 | 0.6312 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.048 | 0.5439 | 0.5411 |
Trypanosoma brucei | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.0184 | 0.183 | 0.3033 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.048 | 0.5439 | 0.5411 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0046 | 0.0151 | 0.0151 |
Leishmania major | p450 reductase, putative | 0.048 | 0.5439 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0319 | 0.3474 | 0.6312 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0319 | 0.3474 | 1 |
Echinococcus granulosus | jumonji domain containing protein | 0.0044 | 0.0132 | 0.0071 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0104 | 0.0861 | 0.0804 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.048 | 0.5439 | 0.5439 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.048 | 0.5439 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0297 | 0.3203 | 0.3203 |
Brugia malayi | FAD binding domain containing protein | 0.0297 | 0.3203 | 0.3161 |
Schistosoma mansoni | galectin | 0.0855 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 2 uM | Antiproliferative activity of compound was tested against bladder carcinoma (T-24) human tumor cells | ChEMBL. | No reference |
IC50 (functional) | = 10 uM | Antiproliferative activity of compound was tested against colon carcinoma (WiDr) human tumor cells | ChEMBL. | No reference |
IC50 (functional) | = 17 uM | Antiproliferative activity of compound was tested against rhabdomyosarcoma (A-204) human tumor cells | ChEMBL. | No reference |
IC50 (functional) | = 96 uM | Antiproliferative activity of compound was tested against melanoma (IgR-37) human tumor cells | ChEMBL. | No reference |
IC50 (functional) | = 370 uM | Antiproliferative activity of compound was tested against mammary carcinoma (MCF-7) human tumor cells | ChEMBL. | No reference |
T1/2 (ADMET) | 0 min | Compound was tested for enzyme activation by measuring its halftime; not determined | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.