Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0055 | 0.0863 | 0.1114 |
Echinococcus multilocularis | peroxidasin | 0.026 | 0.7743 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0126 | 0.3246 | 0.8342 |
Loa Loa (eye worm) | animal heme peroxidase | 0.026 | 0.7743 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.026 | 0.7743 | 1 |
Brugia malayi | glutathione reductase | 0.0055 | 0.0863 | 0.1114 |
Onchocerca volvulus | 0.026 | 0.7743 | 1 | |
Schistosoma mansoni | peroxidasin | 0.026 | 0.7743 | 0.7743 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0126 | 0.3246 | 0.8342 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.014 | 0.3719 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0055 | 0.0863 | 0.5 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0126 | 0.3246 | 0.8342 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0123 | 0.3129 | 0.4042 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0123 | 0.3129 | 0.4042 |
Loa Loa (eye worm) | hypothetical protein | 0.026 | 0.7743 | 1 |
Onchocerca volvulus | 0.026 | 0.7743 | 1 | |
Trypanosoma brucei | trypanothione reductase | 0.0055 | 0.0863 | 0.5 |
Brugia malayi | Thioredoxin reductase | 0.0055 | 0.0863 | 0.1114 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0126 | 0.3246 | 0.8342 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0055 | 0.0863 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0418 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.026 | 0.7743 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.026 | 0.7743 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.026 | 0.7743 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.026 | 0.7743 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0126 | 0.3246 | 0.8342 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0418 | 0.0418 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0418 | 0.5 |
Mycobacterium tuberculosis | Probable reductase | 0.0126 | 0.3246 | 0.8342 |
Loa Loa (eye worm) | animal heme peroxidase | 0.026 | 0.7743 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.026 | 0.7743 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0042 | 0.0418 | 0.054 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0042 | 0.0418 | 0.054 |
Loa Loa (eye worm) | hypothetical protein | 0.026 | 0.7743 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.026 | 0.7743 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0055 | 0.0863 | 0.5 |
Brugia malayi | hypothetical protein | 0.0042 | 0.0418 | 0.054 |
Onchocerca volvulus | Dual oxidase homolog | 0.026 | 0.7743 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.026 | 0.7743 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0042 | 0.0418 | 0.0418 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0418 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.026 | 0.7743 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.003 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.026 | 0.7743 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.026 | 0.7743 | 1 |
Brugia malayi | Peroxidasin | 0.026 | 0.7743 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0123 | 0.3129 | 0.4042 |
Onchocerca volvulus | Peroxidasin homolog | 0.026 | 0.7743 | 1 |
Schistosoma mansoni | peroxidasin | 0.026 | 0.7743 | 0.7743 |
Plasmodium falciparum | glutathione reductase | 0.0055 | 0.0863 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0418 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.026 | 0.7743 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0055 | 0.0863 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.026 | 0.7743 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.026 | 0.7743 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0055 | 0.0863 | 0.1114 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0055 | 0.0863 | 0.1114 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.026 | 0.7743 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.026 | 0.7743 | 1 |
Onchocerca volvulus | 0.026 | 0.7743 | 1 | |
Brugia malayi | hypothetical protein | 0.026 | 0.7743 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.026 | 0.7743 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.014 | 0.3719 | 1 |
Echinococcus granulosus | peroxidasin | 0.026 | 0.7743 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0055 | 0.0863 | 0.1114 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.014 | 0.3719 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.026 | 0.7743 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.026 | 0.7743 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.026 | 0.7743 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.026 | 0.7743 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.014 | 0.3719 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.026 | 0.7743 | 1 |
Leishmania major | trypanothione reductase | 0.0055 | 0.0863 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.026 | 0.7743 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.026 | 0.7743 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0055 | 0.0863 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.026 | 0.7743 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 300 uM | Inhibitory activity against human cytomegalovirus (HCMV) protease | ChEMBL. | 9667976 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.