Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0035 | 0.1162 | 0.1162 |
Brugia malayi | Carboxylesterase family protein | 0.0122 | 0.8186 | 0.8186 |
Onchocerca volvulus | 0.0021 | 0 | 0.5 | |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.1162 | 0.142 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1162 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0122 | 0.8186 | 0.8186 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.8186 | 0.8186 |
Brugia malayi | Carboxylesterase family protein | 0.0122 | 0.8186 | 0.8186 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0021 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0122 | 0.8186 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1162 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0021 | 0 | 0.5 |
Onchocerca volvulus | 0.0021 | 0 | 0.5 | |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1162 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.1162 | 0.142 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0021 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.8186 | 0.8186 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0021 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0122 | 0.8186 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.1162 | 0.142 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0021 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.1162 | 0.142 |
Onchocerca volvulus | 0.0021 | 0 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.0122 | 0.8186 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1162 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0122 | 0.8186 | 1 |
Onchocerca volvulus | 0.0021 | 0 | 0.5 | |
Onchocerca volvulus | 0.0021 | 0 | 0.5 | |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0122 | 0.8186 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0122 | 0.8186 | 0.8186 |
Echinococcus granulosus | carboxylesterase 5A | 0.0122 | 0.8186 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0122 | 0.8186 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0021 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (ADMET) | = 31.7 uM | Cytotoxicity against human Hep2 cells by Cell Titer-Glo assay | ChEMBL. | 23043370 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.