Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | zinc finger protein | 0.002 | 0.0333 | 0.0188 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.0199 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0022 | 0.0518 | 0.0411 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0199 | 0.5 |
Brugia malayi | Bromodomain containing protein | 0.004 | 0.3599 | 0.3469 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0.0199 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0062 | 0.7332 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0038 | 0.3186 | 0.4188 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.4024 | 0.4348 |
Schistosoma mansoni | bromodomain containing protein | 0.0066 | 0.7956 | 1 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0024 | 0.0851 | 0.0914 |
Brugia malayi | PHD-finger family protein | 0.0026 | 0.1264 | 0.1086 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.002 | 0.0199 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.002 | 0.0199 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.3611 | 0.3902 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.002 | 0.0199 | 0.5 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.002 | 0.0199 | 0.5 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.002 | 0.0199 | 0.5 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0062 | 0.7332 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0038 | 0.3186 | 0.4188 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.002 | 0.0199 | 0.0215 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.9254 | 1 |
Echinococcus multilocularis | zinc finger protein | 0.002 | 0.0333 | 0.0188 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0022 | 0.0518 | 0.0559 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0024 | 0.0851 | 0.084 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.002 | 0.0199 | 0.5 |
Toxoplasma gondii | exonuclease III APE | 0.002 | 0.0199 | 0.5 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.002 | 0.0199 | 0.5 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.0199 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.0199 | 0.5 |
Schistosoma mansoni | zinc finger protein | 0.002 | 0.0333 | 0.0173 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0024 | 0.0851 | 0.0914 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0199 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.4357 | 0.4709 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.0199 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.