Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0738 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0558 | 0.736 | 0.678 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0282 | 0.331 | 1 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0282 | 0.331 | 1 |
Schistosoma mansoni | Nep2 peptidase (M13 family) | 0.0372 | 0.4631 | 0.4631 |
Schistosoma mansoni | endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) | 0.018 | 0.1803 | 0.1803 |
Loa Loa (eye worm) | hypothetical protein | 0.0545 | 0.7172 | 0.655 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0248 | 0.2809 | 0.5 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0282 | 0.331 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0282 | 0.331 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0545 | 0.7172 | 0.655 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0545 | 0.7172 | 0.655 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.018 | 0.1803 | 0.1803 |
Schistosoma mansoni | hypothetical protein | 0.0193 | 0.1991 | 0.1991 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0545 | 0.7172 | 0.655 |
Schistosoma mansoni | endothelin-converting enzyme-related | 0.018 | 0.1803 | 0.1803 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0372 | 0.4631 | 0.4631 |
Loa Loa (eye worm) | hypothetical protein | 0.0558 | 0.736 | 0.678 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0372 | 0.4631 | 0.4631 |
Schistosoma mansoni | hypothetical protein | 0.0193 | 0.1991 | 0.1991 |
Loa Loa (eye worm) | hypothetical protein | 0.0545 | 0.7172 | 0.655 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0193 | 0.1991 | 0.1991 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0282 | 0.331 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0193 | 0.1991 | 0.1991 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0282 | 0.331 | 1 |
Schistosoma mansoni | neprilysin-2 (M13 family) | 0.0372 | 0.4631 | 0.4631 |
Loa Loa (eye worm) | hypothetical protein | 0.0558 | 0.736 | 0.678 |
Onchocerca volvulus | 0.0366 | 0.4532 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0366 | 0.4532 | 0.3329 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.0738 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0193 | 0.1991 | 0.1991 |
Loa Loa (eye worm) | hypothetical protein | 0.0738 | 1 | 1 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0282 | 0.331 | 0.5 |
Mycobacterium leprae | probable zinc metalloprotease | 0.0738 | 1 | 1 |
Toxoplasma gondii | peptidase family M13 protein | 0.0738 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.0738 | 1 | 1 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.018 | 0.1803 | 0.1803 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.018 | 0.1803 | 0.1803 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0248 | 0.2809 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0193 | 0.1991 | 0.1991 |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.0738 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0738 | 1 | 1 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0282 | 0.331 | 0.2767 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0282 | 0.331 | 1 |
Schistosoma mansoni | neprilysin | 0.0193 | 0.1991 | 0.1991 |
Loa Loa (eye worm) | hypothetical protein | 0.0545 | 0.7172 | 0.655 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0738 | 1 | 1 |
Giardia lamblia | Deoxynucleoside kinase | 0.0372 | 0.4621 | 1 |
Mycobacterium ulcerans | zinc metalloprotease | 0.0738 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0282 | 0.331 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0193 | 0.1991 | 0.1991 |
Leishmania major | thymidine kinase, putative | 0.0248 | 0.2809 | 0.5 |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.018 | 0.1803 | 0.1803 |
Trypanosoma brucei | thymidine kinase | 0.0248 | 0.2809 | 0.5 |
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.0738 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0282 | 0.331 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0558 | 0.736 | 0.678 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0282 | 0.331 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0558 | 0.736 | 0.678 |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.0372 | 0.4631 | 0.4631 |
Loa Loa (eye worm) | hypothetical protein | 0.0558 | 0.736 | 0.678 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 40 uM | Cytotoxicity against human SW480 cells after 48 hrs by MTT assay | ChEMBL. | 23088673 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.