Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.1767 | 0.1767 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.3289 | 0.3289 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0059 | 0.4591 | 0.4591 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0032 | 0.1767 | 0.1767 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0047 | 0.3289 | 0.3289 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0047 | 0.3289 | 0.3289 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.1767 | 0.3848 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0111 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0059 | 0.4591 | 0.4591 |
Schistosoma mansoni | tar DNA-binding protein | 0.0059 | 0.4591 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0059 | 0.4591 | 0.4591 |
Echinococcus granulosus | tar DNA binding protein | 0.0059 | 0.4591 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0059 | 0.4591 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0059 | 0.4591 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0111 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0059 | 0.4591 | 0.4591 |
Schistosoma mansoni | tar DNA-binding protein | 0.0059 | 0.4591 | 1 |
Brugia malayi | TAR-binding protein | 0.0059 | 0.4591 | 0.4591 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0047 | 0.3289 | 0.3289 |
Brugia malayi | RNA binding protein | 0.0059 | 0.4591 | 0.4591 |
Schistosoma mansoni | tar DNA-binding protein | 0.0059 | 0.4591 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0059 | 0.4591 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 0.013 uM | Cytotoxicity against human HCT116 cells incubated for 72 hrs by MTT assay | ChEMBL. | 22867019 |
IC50 (binding) | > 100 uM | Inhibition of equine serum BChE by Ellman's method | ChEMBL. | 24819955 |
IC50 (binding) | > 100 uM | Inhibition of electric eel AChE by Ellman's method | ChEMBL. | 24819955 |
Inhibition (binding) | Inhibition of Top1 assessed as suppression of supercoiled pBR322 DNA relaxation measuring appearance of short DNA fragments at 100 uM incubated for 15 mins by electrophoresis method | ChEMBL. | 22867019 | |
Inhibition (binding) | = 29 % | Inhibition of electric eel AChE at 10 uM by Ellman's method | ChEMBL. | 24819955 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.