Detailed information for compound 1684182

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 486.627 | Formula: C25H34N4O4S
  • H donors: 1 H acceptors: 5 LogP: 2.13 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CC1(CC1)NC(=O)[C@@H]1CCCC[C@H]1C(=O)N1CCN(CC1(C)C)c1ccc(cc1)S(=O)(=O)C
  • InChi: 1S/C25H34N4O4S/c1-24(2)17-28(18-8-10-19(11-9-18)34(3,32)33)14-15-29(24)23(31)21-7-5-4-6-20(21)22(30)27-25(16-26)12-13-25/h8-11,20-21H,4-7,12-15,17H2,1-3H3,(H,27,30)/t20-,21-/m1/s1
  • InChiKey: VMWCTYONHSDNMV-NHCUHLMSSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cathepsin L Starlite/ChEMBL References
Homo sapiens cathepsin K Starlite/ChEMBL References
Homo sapiens cathepsin B Starlite/ChEMBL References
Homo sapiens cathepsin S Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin B-like cysteine proteinase Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01363 cathepsin B [EC3.4.22.1], putative Get druggable targets OG5_127800 All targets in OG5_127800
Neospora caninum Cathepsin B-like protease (Precursor), related Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni SmCB2 peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin S 281 aa 226 aa 34.1 %
Plasmodium falciparum dipeptidyl aminopeptidase 1 cathepsin B 339 aa 368 aa 26.9 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin L 333 aa 359 aa 30.1 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin K 329 aa 349 aa 33.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0053 0.0674 0.068
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0181 0.3345 0.4623
Loa Loa (eye worm) hypothetical protein 0.0043 0.0472 0.0477
Brugia malayi hypothetical protein 0.0037 0.0334 0.042
Loa Loa (eye worm) hypothetical protein 0.0079 0.1227 0.1238
Toxoplasma gondii cathepsin B 0.007 0.1024 0.7277
Schistosoma mansoni acetylcholine receptor-related 0.0037 0.0334 0.0462
Onchocerca volvulus 0.0059 0.0804 0.0804
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.007 0.1024 0.1416
Giardia lamblia Cathepsin B precursor 0.007 0.1024 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0079 0.1227 0.1543
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0674 0.0848
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0079 0.1227 0.1543
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0079 0.1227 0.1238
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0037 0.0334 0.0337
Schistosoma mansoni neurotransmitter gated ion channel 0.0043 0.0462 0.0639
Trypanosoma cruzi cysteine peptidase, putative 0.0047 0.0543 0.0541
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0079 0.1227 0.1238
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0317 0.0251
Onchocerca volvulus 0.0046 0.054 0.054
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0037 0.0334 0.042
Entamoeba histolytica cysteine proteinase, putative 0.0059 0.0804 0.4457
Entamoeba histolytica cysteine proteinase 1, putative 0.0047 0.0543 0.187
Schistosoma mansoni Smad4 0.0025 0.0082 0.0114
Toxoplasma gondii ABC1 family protein 0.0036 0.0317 0.1584
Brugia malayi prolyl oligopeptidase family protein 0.0168 0.3083 0.3878
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0082 0.0083
Entamoeba histolytica cysteine protease, putative 0.0086 0.1362 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0027 0.0128 0.0129
Echinococcus granulosus mitogen activated protein kinase 3 0.0053 0.0682 0.0689
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0804 0.1872
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0377 0.0381
Onchocerca volvulus Cathepsin F homolog 0.0086 0.1362 0.1362
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0079 0.1227 0.1238
Onchocerca volvulus 0.0086 0.1362 0.1362
Onchocerca volvulus 0.0086 0.1362 0.1362
Brugia malayi cathepsin L-like precursor 0.0059 0.0804 0.1011
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0037 0.0334 0.042
Onchocerca volvulus 0.0037 0.0334 0.0334
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0039 0.0377 0.0474
Leishmania major cathepsin L-like protease 0.0086 0.1362 0.1587
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.1362 0.1587
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0187 0.3471 0.3504
Schistosoma mansoni hypothetical protein 0.0038 0.0355 0.0491
Plasmodium falciparum cysteine proteinase falcipain 3 0.0086 0.1362 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0462 0.0467
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0377 0.0328
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.1362 1
Schistosoma mansoni cathepsin F (C01 family) 0.0086 0.1362 0.1883
Plasmodium vivax unspecified product 0.0027 0.0128 0.0938
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.1362 0.1587
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.1511 0.2088
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0086 0.1362 1
Echinococcus multilocularis acetylcholinesterase 0.0074 0.1112 0.1123
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0079 0.1227 0.1238
Trypanosoma brucei C-8 sterol isomerase, putative 0.0401 0.795 1
Brugia malayi MAP kinase sur-1 0.0053 0.0682 0.0858
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0079 0.1227 0.1238
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0057 0.0751 0.1038
Loa Loa (eye worm) hypothetical protein 0.0079 0.1227 0.1238
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0082 0.0114
Brugia malayi Carboxylesterase family protein 0.0074 0.1112 0.1399
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0674 0.068
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.0128 0.001
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0682 0.0718
Loa Loa (eye worm) hypothetical protein 0.0043 0.0462 0.0467
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0079 0.1227 0.1238
Brugia malayi hypothetical protein 0.0037 0.0334 0.042
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.012 0.088
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0401 0.795 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.1511 0.1525
Echinococcus granulosus metabotropic glutamate receptor 5 0.0053 0.0668 0.0674
Loa Loa (eye worm) hypothetical protein 0.0059 0.0804 0.0812
Entamoeba histolytica cysteine proteinase, putative 0.0086 0.1362 1
Plasmodium vivax vivapain-2 0.0086 0.1362 1
Echinococcus granulosus nAChR subunit 0.0043 0.0462 0.0467
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0057 0.0751 0.0806
Echinococcus granulosus cathepsin l cysteine peptidase 0.0086 0.1362 0.1375
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.1362 1
Echinococcus granulosus polycomb protein SCMH1 0.0046 0.054 0.0545
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0079 0.1227 0.1238
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0543 0.0541
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.1511 0.2088
Echinococcus granulosus mitogen activated protein kinase 0.0053 0.0682 0.0689
Schistosoma mansoni acetylcholine receptor subunit beta 0.0037 0.0334 0.0462
Entamoeba histolytica cysteine protease, putative 0.0047 0.0543 0.187
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0682 0.3494
Trypanosoma cruzi cysteine proteinase, putative 0.0047 0.0543 0.0541
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.1362 1
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0046 0.054 0.054
Schistosoma mansoni nAChR subunit 0.0079 0.1227 0.1696
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0377 0.0328
Leishmania major cathepsin L-like protease 0.0086 0.1362 0.1587
Loa Loa (eye worm) hypothetical protein 0.0036 0.0317 0.032
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0079 0.1227 0.1696
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0086 0.1362 1
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0682 0.3494
Leishmania major cathepsin L-like protease 0.0086 0.1362 0.1587
Echinococcus granulosus neuropeptide s receptor 0.0495 0.9907 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.1227 0.1238
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0086 0.1362 0.1375
Brugia malayi Cation transporter family protein 0.0079 0.1227 0.1543
Loa Loa (eye worm) hypothetical protein 0.0027 0.0128 0.0129
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.054 0.0746
Loa Loa (eye worm) hypothetical protein 0.0465 0.9284 0.9371
Entamoeba histolytica cysteine proteinase 2 0.0047 0.0543 0.187
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0082 0.0083
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.1362 0.1587
Schistosoma mansoni hypothetical protein 0.0286 0.5546 0.7666
Loa Loa (eye worm) hypothetical protein 0.0036 0.0317 0.032
Loa Loa (eye worm) hypothetical protein 0.0036 0.0317 0.032
Entamoeba histolytica cysteine proteinase, putative 0.0086 0.1362 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.1227 0.1238
Echinococcus multilocularis nAChR subunit 0.0079 0.1227 0.1238
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0804 0.0874
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0027 0.0128 0.0161
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0053 0.0682 0.0718
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.1362 0.1587
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0058 0.0775 0.0782
Entamoeba histolytica cysteine protease, putative 0.0047 0.0543 0.187
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0079 0.1227 0.1696
Trypanosoma brucei protein kinase, putative 0.0053 0.0682 0.0718
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0079 0.1227 0.1238
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0187 0.3471 0.3504
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.1511 0.19
Loa Loa (eye worm) hypothetical protein 0.0053 0.0668 0.0674
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.1362 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0181 0.3345 0.4118
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0079 0.1227 0.1238
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.1362 1
Entamoeba histolytica cysteine protease, putative 0.0047 0.0543 0.187
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0047 0.0543 0.0751
Loa Loa (eye worm) hypothetical protein 0.0465 0.9284 0.9371
Echinococcus granulosus glycine receptor subunit beta 0.0079 0.1227 0.1238
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0086 0.1362 0.1375
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0037 0.0334 0.0337
Brugia malayi cathepsin F-like cysteine proteinase 0.0027 0.0128 0.0161
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0043 0.0462 0.0639
Brugia malayi Smad1 0.0025 0.0082 0.0104
Echinococcus multilocularis SAM and MBT domain containing protein 0.0046 0.054 0.0545
Loa Loa (eye worm) ACC-1 protein 0.0079 0.1227 0.1238
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.1362 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0059 0.0804 0.0874
Brugia malayi Cation transporter family protein 0.0079 0.1227 0.1543
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0317 0.0438
Mycobacterium ulcerans epoxide hydrolase EphA 0.0161 0.2922 1
Plasmodium falciparum cysteine proteinase falcipain 1 0.0047 0.0543 0.3989
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0057 0.0751 0.0806
Loa Loa (eye worm) carboxylesterase 0.0074 0.1112 0.1123
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.1362 1
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.012 0.088
Entamoeba histolytica cysteine protease, putative 0.0047 0.0543 0.187
Brugia malayi hypothetical protein 0.0037 0.0334 0.042
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0079 0.1227 0.1543
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0543 0.2169
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.1511 0.1525
Brugia malayi Metabotropic glutamate receptor precursor. 0.0043 0.0462 0.0581
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0217 0.4091 0.413
Schistosoma mansoni family S28 unassigned peptidase (S28 family) 0.0367 0.7235 1
Echinococcus granulosus glycine receptor subunit alpha 1 0.0079 0.1227 0.1238
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.1362 1
Trypanosoma cruzi cysteine peptidase, putative 0.0086 0.1362 0.1587
Brugia malayi hydrolase, alpha/beta fold family protein 0.025 0.4794 0.603
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0674 0.068
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0079 0.1227 0.1238
Echinococcus multilocularis tumor protein p63 0.0353 0.6948 0.7013
Loa Loa (eye worm) hypothetical protein 0.0039 0.0377 0.038
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.1362 1
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0079 0.1227 0.1543
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0057 0.0751 0.0758
Schistosoma mansoni smad1 5 8 and 0.0025 0.0082 0.0114
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0181 0.3345 0.4623
Loa Loa (eye worm) hypothetical protein 0.0037 0.0334 0.0337
Trypanosoma cruzi cysteine peptidase, putative 0.0086 0.1362 0.1587
Entamoeba histolytica cysteine protease, putative 0.0047 0.0543 0.187
Leishmania major cathepsin L-like protease 0.0086 0.1362 0.1587
Onchocerca volvulus 0.0086 0.1362 0.1362
Plasmodium vivax vivapain-1 0.0047 0.0543 0.3989
Loa Loa (eye worm) acetylcholinesterase 1 0.0074 0.1112 0.1123
Loa Loa (eye worm) hypothetical protein 0.0043 0.0462 0.0467
Echinococcus multilocularis mitogen activated protein kinase 3 0.0053 0.0682 0.0689
Toxoplasma gondii cathepsin CPL 0.0086 0.1362 1
Onchocerca volvulus 0.0036 0.0317 0.0317
Loa Loa (eye worm) hypothetical protein 0.0037 0.0334 0.0337
Loa Loa (eye worm) hypothetical protein 0.0036 0.0317 0.032
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0049 0.0584 0.0807
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.1362 1
Echinococcus multilocularis nAChR subunit 0.0043 0.0462 0.0467
Loa Loa (eye worm) hypothetical protein 0.0217 0.4091 0.4129
Echinococcus multilocularis cysteine protease 0.0086 0.1362 0.1375
Echinococcus multilocularis muscleblind protein 0.0156 0.2831 0.2858
Loa Loa (eye worm) hypothetical protein 0.0026 0.012 0.0121
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0053 0.0682 0.0718
Onchocerca volvulus Cathepsin L homolog 0.0086 0.1362 0.1362
Trypanosoma cruzi cysteine peptidase, putative 0.0086 0.1362 0.1587
Loa Loa (eye worm) hypothetical protein 0.0043 0.0462 0.0467
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0079 0.1227 0.1543
Schistosoma mansoni cathepsin F (C01 family) 0.0086 0.1362 0.1883
Echinococcus multilocularis acetylcholinesterase 0.0074 0.1112 0.1123
Echinococcus granulosus cathepsin b 0.0181 0.3345 0.3376
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.1511 0.2088
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0682 0.3494
Loa Loa (eye worm) hypothetical protein 0.0079 0.1227 0.1238
Plasmodium vivax unspecified product 0.0047 0.0543 0.3989
Loa Loa (eye worm) hypothetical protein 0.0027 0.0128 0.0129
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.1362 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0128 0.0129
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.1362 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.1362 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0377 0.0328
Brugia malayi hypothetical protein 0.0038 0.0355 0.0447
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0543 0.0541
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.1362 0.1587
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.012 0.088
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0168 0.3083 0.4262
Echinococcus multilocularis cathepsin L cysteine protease 0.0086 0.1362 0.1375
Loa Loa (eye worm) hypothetical protein 0.0052 0.0649 0.0655
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0804 0.1872
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0317 0.5
Onchocerca volvulus 0.0079 0.1227 0.1227
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0047 0.0543 0.0541
Entamoeba histolytica cysteine protease, putative 0.0047 0.0543 0.187
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.1362 1
Loa Loa (eye worm) hypothetical protein 0.0181 0.3345 0.3376
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0804 0.1872
Onchocerca volvulus 0.0036 0.0317 0.0317
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0074 0.1112 0.1537
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0217 0.4091 0.5146
Schistosoma mansoni nAChR subunit 0.0079 0.1227 0.1696
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0079 0.1227 0.1696
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0401 0.795 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0317 0.032
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.1362 0.1587
Loa Loa (eye worm) hypothetical protein 0.0156 0.2831 0.2858
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0037 0.0334 0.042
Echinococcus multilocularis Smad4 0.0025 0.0082 0.0083
Trypanosoma cruzi cysteine peptidase, putative 0.0086 0.1362 0.1587
Leishmania major cathepsin L-like protease 0.0086 0.1362 0.1587
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.1362 0.1587
Loa Loa (eye worm) hypothetical protein 0.0037 0.0334 0.0337
Brugia malayi beta-lactamase family protein 0.0036 0.0317 0.0398
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0377 0.0576
Loa Loa (eye worm) hypothetical protein 0.0059 0.0804 0.0812
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0682 0.0943
Echinococcus granulosus nAChR subunit 0.0079 0.1227 0.1238
Schistosoma mansoni nAChR subunit 0.0079 0.1227 0.1696
Brugia malayi Cathepsin L-like precursor 0.0059 0.0804 0.1011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.1362 0.1587
Loa Loa (eye worm) GABA receptor subunit 0.0043 0.0462 0.0467
Schistosoma mansoni nAChR subunit 0.0079 0.1227 0.1696
Schistosoma mansoni metabotropic glutamate receptor 0.0036 0.0317 0.0438
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0804 0.1211
Brugia malayi follicle stimulating hormone receptor 0.0254 0.4884 0.6143
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0053 0.0682 0.0718
Schistosoma mansoni nAChR subunit 0.0037 0.0334 0.0462
Schistosoma mansoni cathepsin s 0.0027 0.0128 0.0177
Leishmania major hypothetical protein, conserved 0.0036 0.0317 0.0251
Entamoeba histolytica cysteine protease, putative 0.0047 0.0543 0.187
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.0543 0.187
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0037 0.0334 0.0337
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0079 0.1227 0.1543
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0079 0.1227 0.1543
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0377 0.0576
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0079 0.1227 0.1238
Echinococcus multilocularis glycine receptor subunit beta 0.0079 0.1227 0.1238
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.007 0.1024 0.1155
Loa Loa (eye worm) acetylcholine receptor protein 0.0037 0.0334 0.0337
Loa Loa (eye worm) hypothetical protein 0.0037 0.0334 0.0337
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0079 0.1227 0.1543
Trypanosoma cruzi cruzipain precursor, putative 0.0086 0.1362 0.1587
Loa Loa (eye worm) hypothetical protein 0.0079 0.1227 0.1238
Loa Loa (eye worm) mbt repeat family protein 0.0046 0.054 0.0545
Brugia malayi Cathepsin L-like precursor 0.0086 0.1362 0.1714
Brugia malayi Muscleblind-like protein 0.0156 0.2831 0.3561
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0674 0.0931
Loa Loa (eye worm) hypothetical protein 0.0156 0.2831 0.2858
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.0543 0.187
Entamoeba histolytica hypothetical protein 0.0043 0.0462 0.1065
Loa Loa (eye worm) hypothetical protein 0.0037 0.0334 0.0337
Echinococcus granulosus Smad4 0.0025 0.0082 0.0083
Giardia lamblia Kinase, CMGC MAPK 0.0053 0.0682 0.4716
Brugia malayi Cathepsin L-like precursor 0.0086 0.1362 0.1714
Loa Loa (eye worm) MH2 domain-containing protein 0.036 0.7097 0.7163
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0377 0.0381
Loa Loa (eye worm) hypothetical protein 0.0079 0.1227 0.1238
Onchocerca volvulus 0.0079 0.1227 0.1227
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0037 0.0334 0.042
Echinococcus granulosus tumor protein p63 0.0353 0.6948 0.7013
Echinococcus granulosus neuropeptide receptor A26 0.0495 0.9907 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0317 0.032
Loa Loa (eye worm) hypothetical protein 0.0079 0.1227 0.1238
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0217 0.4091 0.413
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0804 0.1112
Loa Loa (eye worm) hypothetical protein 0.0079 0.1227 0.1238
Loa Loa (eye worm) hypothetical protein 0.0037 0.0334 0.0337
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0039 0.0377 0.0217
Echinococcus granulosus cysteine protease 0.0047 0.0543 0.0549
Brugia malayi Cation transporter family protein 0.0079 0.1227 0.1543
Brugia malayi Cathepsin L-like precursor 0.0086 0.1362 0.1714
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.1511 0.1525
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.1362 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0355 0.0358
Loa Loa (eye worm) hypothetical protein 0.0043 0.0462 0.0467
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0217 0.4091 0.413
Echinococcus granulosus glycine receptor subunit alpha 1 0.0079 0.1227 0.1238
Echinococcus multilocularis cathepsin L cysteine protease 0.0086 0.1362 0.1375
Onchocerca volvulus 0.0043 0.0462 0.0462
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.1511 0.1525
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0079 0.1227 0.1543
Schistosoma mansoni metabotropic glutamate receptor 0.0021 0.0004 0.0006
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0079 0.1227 0.1238
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0053 0.0682 0.4525
Plasmodium vivax vivapain-2 0.0086 0.1362 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.054 0.0545
Brugia malayi mbt repeat family protein 0.0046 0.054 0.0679
Entamoeba histolytica cysteine protease, putative 0.0047 0.0543 0.187
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0168 0.3083 0.3112
Onchocerca volvulus Putative nachr subunit 0.0217 0.4091 0.4091
Echinococcus multilocularis carboxylesterase 5A 0.0074 0.1112 0.1123
Loa Loa (eye worm) hypothetical protein 0.0086 0.1362 0.1375
Brugia malayi Cathepsin L-like cysteine proteinase 0.0059 0.0804 0.1011
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0057 0.0751 0.5078
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.1362 0.1587
Loa Loa (eye worm) hypothetical protein 0.0079 0.1227 0.1238
Onchocerca volvulus 0.0052 0.0649 0.0649
Loa Loa (eye worm) hypothetical protein 0.0079 0.1227 0.1238
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0079 0.1227 0.1543
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0082 0.0083
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0682 0.3494
Loa Loa (eye worm) hypothetical protein 0.0074 0.1112 0.1123
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0168 0.3083 0.3083
Loa Loa (eye worm) hypothetical protein 0.0079 0.1227 0.1238
Echinococcus multilocularis cysteine protease 0.0086 0.1362 0.1375
Loa Loa (eye worm) hypothetical protein 0.0036 0.0317 0.032
Loa Loa (eye worm) ACC-1 protein 0.0079 0.1227 0.1238
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0039 0.0377 0.0521
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0377 0.0381
Loa Loa (eye worm) hypothetical protein 0.0079 0.1227 0.1238
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0086 0.1362 0.1375
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0037 0.0334 0.0337
Schistosoma mansoni nAChR subunit 0.0037 0.0334 0.0462
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0217 0.4091 0.413
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0217 0.4091 0.413
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0804 0.466
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0377 0.0576
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0355 0.0491
Loa Loa (eye worm) hypothetical protein 0.0079 0.1227 0.1238
Echinococcus granulosus smad 0.0025 0.0082 0.0083
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.0543 0.187
Brugia malayi beta-lactamase family protein 0.0036 0.0317 0.0398
Onchocerca volvulus 0.0086 0.1362 0.1362
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0082 0.0083
Echinococcus granulosus muscleblind protein 0.0156 0.2831 0.2858
Onchocerca volvulus 0.0086 0.1362 0.1362
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0543 0.2169
Echinococcus granulosus metabotropic glutamate receptor 2 0.0036 0.0317 0.032
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0079 0.1227 0.1238
Schistosoma mansoni nAChR subunit 0.0079 0.1227 0.1696
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0079 0.1227 0.1696
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.1362 1
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0039 0.0377 0.0328
Echinococcus granulosus cathepsin l1 0.0059 0.0804 0.0812
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0057 0.0751 0.0806
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) 0.0161 0.2922 0.6469
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.1362 1
Brugia malayi prolyl oligopeptidase family protein 0.0057 0.0751 0.0944
Echinococcus granulosus carboxylesterase 5A 0.0074 0.1112 0.1123
Brugia malayi mbt repeat family protein 0.0046 0.054 0.0679
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0037 0.0334 0.0337
Entamoeba histolytica cysteine protease, putative 0.0047 0.0543 0.187
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0086 0.1362 0.1375
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0053 0.0668 0.0674
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0037 0.0334 0.042
Onchocerca volvulus 0.0036 0.0317 0.0317
Echinococcus multilocularis cathepsin L 0.0047 0.0543 0.0549
Loa Loa (eye worm) transcription factor SMAD2 0.036 0.7097 0.7163
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0043 0.0462 0.0582
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0079 0.1227 0.1238
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0254 0.4884 0.4929
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0057 0.0751 0.0806
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0079 0.1227 0.1238
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0053 0.0682 0.0718
Echinococcus granulosus Dipeptidyl peptidase 9 0.0057 0.0751 0.0758
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0804 0.5509
Echinococcus multilocularis muscleblind protein 1 0.0156 0.2831 0.2858
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0086 0.1362 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0355 0.0358
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0804 0.0812
Loa Loa (eye worm) hypothetical protein 0.0079 0.1227 0.1238
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0367 0.7235 0.7303
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0181 0.3345 0.4623
Loa Loa (eye worm) MBCTL1 0.0053 0.0674 0.068
Loa Loa (eye worm) prolyl oligopeptidase 0.0168 0.3083 0.3112
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.1362 1
Loa Loa (eye worm) fibroinase 0.0086 0.1362 0.1375
Loa Loa (eye worm) hypothetical protein 0.0074 0.1112 0.1123
Brugia malayi Cathepsin L-like precursor 0.0059 0.0804 0.1011
Echinococcus granulosus cathepsin L 0.0047 0.0543 0.0549
Brugia malayi Cathepsin L-like precursor 0.0086 0.1362 0.1714
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0079 0.1227 0.1238
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0043 0.0462 0.0639
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0217 0.4091 0.413
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.1362 1
Echinococcus multilocularis glycine receptor subunit beta 0.0079 0.1227 0.1238
Brugia malayi Carboxylesterase family protein 0.0074 0.1112 0.1399
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.1511 0.1525
Loa Loa (eye worm) hypothetical protein 0.0079 0.1227 0.1238
Echinococcus granulosus SAM and MBT domain containing protein 0.0046 0.054 0.0545
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0079 0.1227 0.1543
Mycobacterium leprae Probable lipase LipE 0.0036 0.0317 0.5
Echinococcus multilocularis mitogen activated protein kinase 0.0053 0.0682 0.0689
Brugia malayi excitatory GABA receptor EXP-1A 0.0079 0.1227 0.1543
Echinococcus multilocularis polycomb protein SCMH1 0.0046 0.054 0.0545
Loa Loa (eye worm) Smad1 0.0025 0.0082 0.0083
Brugia malayi hypothetical protein 0.0043 0.0472 0.0594
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.007 0.1024 0.1155
Loa Loa (eye worm) hypothetical protein 0.0037 0.0334 0.0337
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0082 0.0083
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0039 0.0377 0.0521
Echinococcus granulosus cathepsin l1 0.0086 0.1362 0.1375
Giardia lamblia Cathepsin B precursor 0.007 0.1024 1
Brugia malayi Papain family cysteine protease containing protein 0.0086 0.1362 0.1714
Entamoeba histolytica cysteine protease, putative 0.0047 0.0543 0.187
Schistosoma mansoni neurotransmitter gated ion channel 0.0037 0.0334 0.0462
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0082 0.0083
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.1362 0.1587
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0053 0.0682 0.0688
Entamoeba histolytica cysteine protease, putative 0.0047 0.0543 0.187
Entamoeba histolytica cysteine protease, putative 0.0047 0.0543 0.187
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0367 0.7235 0.7303
Schistosoma mansoni neurotransmitter gated ion channel 0.0037 0.0334 0.0462
Brugia malayi metabotropic glutamate receptor type 2 0.0021 0.0004 0.0005
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0086 0.1362 1
Brugia malayi MH2 domain containing protein 0.0025 0.0082 0.0104
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0229 0.4343 1
Brugia malayi hypothetical protein 0.0037 0.0334 0.042
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0047 0.0543 0.0751
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0317 0.0398
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.1362 1
Brugia malayi Papain family cysteine protease containing protein 0.0047 0.0543 0.0684
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.0543 0.187
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0317 0.0251
Brugia malayi MH1 domain containing protein 0.0025 0.0082 0.0104
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0682 0.0718
Entamoeba histolytica cysteine protease, putative 0.0047 0.0543 0.187
Loa Loa (eye worm) hypothetical protein 0.0043 0.0462 0.0467
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0317 0.2324
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0674 0.068
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0217 0.4091 0.4129
Echinococcus multilocularis cathepsin b 0.0181 0.3345 0.3376
Loa Loa (eye worm) glutamate receptor 0.0043 0.0462 0.0466
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.1362 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0086 0.1362 0.1375
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0057 0.0751 0.0806
Onchocerca volvulus 0.0079 0.1227 0.1227
Loa Loa (eye worm) hypothetical protein 0.0079 0.1227 0.1238
Plasmodium vivax vivapain-3 0.0047 0.0543 0.3989
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0053 0.0682 0.0718
Brugia malayi MH1 domain containing protein 0.0025 0.0082 0.0104
Onchocerca volvulus 0.0086 0.1362 0.1362
Echinococcus granulosus cathepsin b 0.0181 0.3345 0.3376
Loa Loa (eye worm) LGC-31 protein 0.0079 0.1227 0.1238
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0079 0.1227 0.1696
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0317 0.032
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0043 0.0462 0.0582
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0804 0.0812
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0037 0.0334 0.0337
Leishmania major cathepsin L-like protease 0.0086 0.1362 0.1587
Loa Loa (eye worm) hypothetical protein 0.0037 0.0334 0.0337
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0317 0.0251
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0079 0.1227 0.1696
Loa Loa (eye worm) hypothetical protein 0.0079 0.1227 0.1238
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0039 0.0378 0.0475
Onchocerca volvulus 0.0086 0.1362 0.1362
Echinococcus multilocularis ubiquitin specific protease 41 0.0039 0.0377 0.0381
Echinococcus granulosus acetylcholinesterase 0.0074 0.1112 0.1123
Echinococcus multilocularis smad 0.0025 0.0082 0.0083
Brugia malayi Cathepsin L-like precursor 0.0086 0.1362 0.1714
Echinococcus multilocularis neuropeptide s receptor 0.0495 0.9907 1
Brugia malayi cathepsin B-like cysteine proteinase 0.0181 0.3345 0.4207
Loa Loa (eye worm) hypothetical protein 0.0043 0.0462 0.0467
Loa Loa (eye worm) cathepsin B 0.007 0.1024 0.1034
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0674 0.068
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.1362 1
Loa Loa (eye worm) hydrolase 0.0495 0.9908 1
Echinococcus granulosus acetylcholinesterase 0.0074 0.1112 0.1123
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.1362 1
Onchocerca volvulus Cathepsin L homolog 0.0086 0.1362 0.1362
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0317 0.032
Loa Loa (eye worm) hypothetical protein 0.0037 0.0334 0.0337
Loa Loa (eye worm) ctsf protein 0.0086 0.1362 0.1375
Onchocerca volvulus 0.0079 0.1227 0.1227
Echinococcus granulosus glycine receptor subunit beta 0.0079 0.1227 0.1238
Leishmania major cysteine peptidase A (CPA) 0.0086 0.1362 0.1587
Loa Loa (eye worm) beta-lactamase 0.0036 0.0317 0.032
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0168 0.3083 0.3112
Onchocerca volvulus 0.0079 0.1227 0.1227
Brugia malayi Papain family cysteine protease containing protein 0.0047 0.0543 0.0684
Schistosoma mansoni smad1 5 8 and 0.0025 0.0082 0.0114
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0036 0.0317 0.032
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.1362 0.1587
Loa Loa (eye worm) hypothetical protein 0.0401 0.795 0.8024
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0043 0.0462 0.0582
Loa Loa (eye worm) hypothetical protein 0.0037 0.0334 0.0337
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0046 0.054 0.0746
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0181 0.3345 0.4623
Onchocerca volvulus 0.0043 0.0462 0.0462
Loa Loa (eye worm) cysteine protease 0.0086 0.1362 0.1375
Brugia malayi MH2 domain containing protein 0.036 0.7097 0.8928
Loa Loa (eye worm) hypothetical protein 0.0043 0.0462 0.0467
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0037 0.0334 0.0337
Schistosoma mansoni nAChR subunit 0.0079 0.1227 0.1696
Onchocerca volvulus 0.0037 0.0334 0.0334
Leishmania major cathepsin L-like protease 0.0086 0.1362 0.1587
Giardia lamblia Cathepsin B precursor 0.007 0.1024 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0804 0.466
Echinococcus multilocularis neuropeptide receptor A26 0.0495 0.9907 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.007 0.1024 0.6764
Trypanosoma cruzi cysteine protease, putative 0.0047 0.0543 0.0541
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0317 0.0438
Brugia malayi Cathepsin L-like precursor 0.0086 0.1362 0.1714
Brugia malayi beta-lactamase 0.0036 0.0317 0.0398
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0079 0.1227 0.1543
Schistosoma mansoni nAChR subunit 0.0079 0.1227 0.1696
Brugia malayi Cathepsin L-like precursor 0.0027 0.0128 0.0161
Trypanosoma cruzi cysteine proteinase, putative 0.0047 0.0543 0.0541
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0058 0.0775 0.0782
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0079 0.1227 0.1543
Echinococcus granulosus glycine receptor subunit alpha 1 0.0079 0.1227 0.1238
Echinococcus multilocularis cathepsin b 0.0181 0.3345 0.3376
Leishmania major C-8 sterol isomerase-like protein 0.0401 0.795 1
Echinococcus granulosus ubiquitin specific protease 41 0.0039 0.0377 0.0381
Loa Loa (eye worm) hypothetical protein 0.0043 0.0462 0.0467
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0079 0.1227 0.1238
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0804 0.1112
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0043 0.0462 0.0582
Brugia malayi MH2 domain containing protein 0.0025 0.0082 0.0104
Leishmania major cathepsin L-like protease 0.0086 0.1362 0.1587
Onchocerca volvulus 0.0037 0.0334 0.0334
Loa Loa (eye worm) hypothetical protein 0.0037 0.0334 0.0337
Trypanosoma cruzi cruzipain precursor, putative 0.0027 0.0128 0.001
Echinococcus granulosus cathepsin L cysteine protease 0.0047 0.0543 0.0549
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.054 0.0746
Schistosoma mansoni smad1 5 8 and 0.0025 0.0082 0.0114
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0649 0.0898
Loa Loa (eye worm) hypothetical protein 0.0037 0.0334 0.0337
Loa Loa (eye worm) hypothetical protein 0.0037 0.0334 0.0337
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0079 0.1227 0.1543
Trypanosoma brucei cysteine peptidase C (CPC) 0.007 0.1024 0.1155
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0079 0.1227 0.1543
Schistosoma mansoni smad 0.0025 0.0082 0.0114
Loa Loa (eye worm) hypothetical protein 0.0037 0.0334 0.0337
Schistosoma mansoni lipoxygenase 0.0058 0.0775 0.1071
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0037 0.0334 0.042
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0377 0.0381
Loa Loa (eye worm) hypothetical protein 0.0205 0.3853 0.3889
Brugia malayi hypothetical protein 0.0026 0.012 0.0151
Brugia malayi hypothetical protein 0.0037 0.0334 0.042
Loa Loa (eye worm) hypothetical protein 0.0059 0.0804 0.0812
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0047 0.0543 0.0751
Schistosoma mansoni cathepsin F (C01 family) 0.0059 0.0804 0.1111
Loa Loa (eye worm) hypothetical protein 0.0037 0.0334 0.0337
Onchocerca volvulus 0.0079 0.1227 0.1227

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.045 uM Inhibition of human recombinant cathepsin-k using Z-Phe-Arg-AMC as substrate preincubated for 15 mins measured after 1 hr by QFRET assay ChEMBL. 22984809
IC50 (binding) = 3.51 uM Inhibition of human recombinant cathepsin-B using Z-Arg-Arg-AMC as substrate preincubated for 15 mins measured after 1 hr by QFRET assay ChEMBL. 22984809
IC50 (binding) = 3.75 uM Inhibition of human recombinant cathepsin-S using Z-Val-Val-Arg-AMC as substrate preincubated for 15 mins measured after 1 hr by QFRET assay ChEMBL. 22984809
IC50 (binding) > 10 uM Inhibition of human recombinant cathepsin-L using Z-Phe-Arg-AMC as substrate preincubated for 15 mins measured after 1 hr by QFRET assay ChEMBL. 22984809

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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