Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | tolloid-like 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | geminin | 0.0182 | 1 | 1 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0018 | 0.0001 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.3056 | 0.3056 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0068 | 0.3056 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.3056 | 0.3056 |
Loa Loa (eye worm) | RNA binding protein | 0.0068 | 0.3056 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.3056 | 0.3056 |
Brugia malayi | Fibulin-1 precursor | 0.0018 | 0.0001 | 0.0002 |
Echinococcus granulosus | Tolloid protein 1 | 0.0056 | 0.2292 | 0.2292 |
Leishmania major | hypothetical protein, conserved | 0.0018 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.3056 | 0.3056 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0018 | 0 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0068 | 0.3056 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0001 | 0.0002 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0018 | 0 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0068 | 0.3056 | 0.3056 |
Schistosoma mansoni | hypothetical protein | 0.0182 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.114 | 0.114 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0068 | 0.3056 | 1 |
Brugia malayi | TAR-binding protein | 0.0068 | 0.3056 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0037 | 0.114 | 0.3731 |
Echinococcus multilocularis | laminin | 0.0018 | 0.0001 | 0.0001 |
Brugia malayi | RNA binding protein | 0.0068 | 0.3056 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.2172 | 0.7109 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0018 | 0.0001 | 1 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0018 | 0.0001 | 0.0002 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.114 | 0.3731 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0018 | 0 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0068 | 0.3056 | 0.3056 |
Schistosoma mansoni | hypothetical protein | 0.0182 | 1 | 1 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0056 | 0.2292 | 0.2292 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.2155 | 0.7052 |
Loa Loa (eye worm) | AStacin protease | 0.0035 | 0.1024 | 0.3353 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0056 | 0.2292 | 0.7502 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0054 | 0.2172 | 0.7109 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0056 | 0.2292 | 0.2292 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0018 | 0.0001 | 0.0002 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0054 | 0.2172 | 0.7109 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0287 | 0.094 |
Onchocerca volvulus | 0.0018 | 0 | 0.5 | |
Echinococcus multilocularis | fibrillin 1 | 0.0018 | 0.0001 | 0.0001 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0054 | 0.2172 | 0.7109 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.3056 | 0.3056 |
Echinococcus granulosus | laminin | 0.0018 | 0.0001 | 0.0001 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.03 uM | Inhibition of PCP after 1 hr by fluorescence assay | ChEMBL. | 23134659 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.