Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0002 | 0.0005 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0018 | 0.0002 | 0.0002 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.1767 | 0.3848 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0002 | 0.0005 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0018 | 0.0002 | 0.5 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0018 | 0.0002 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0074 | 0.4591 | 0.4591 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0058 | 0.3289 | 0.3289 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0018 | 0.0002 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0074 | 0.4591 | 1 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0018 | 0.0002 | 0.5 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0018 | 0.0002 | 0.5 |
Brugia malayi | Isocitrate dehydrogenase | 0.0018 | 0.0002 | 0.0002 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.4591 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.4591 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0058 | 0.3289 | 0.3289 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0018 | 0.0002 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.014 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.3289 | 0.3289 |
Brugia malayi | isocitrate dehydrogenase | 0.0018 | 0.0002 | 0.0002 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.4591 | 1 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0018 | 0.0002 | 0.0005 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0018 | 0.0002 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1767 | 0.1767 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0018 | 0.0002 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0074 | 0.4591 | 0.4591 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.4591 | 1 |
Brugia malayi | TAR-binding protein | 0.0074 | 0.4591 | 0.4591 |
Echinococcus granulosus | tar DNA binding protein | 0.0074 | 0.4591 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.014 | 1 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0018 | 0.0002 | 0.0005 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0018 | 0.0002 | 0.0005 |
Loa Loa (eye worm) | TAR-binding protein | 0.0074 | 0.4591 | 0.4591 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.004 | 0.1767 | 0.1767 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.4591 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0002 | 0.0005 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0002 | 0.0005 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0018 | 0.0002 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0058 | 0.3289 | 0.3289 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0074 | 0.4591 | 0.4591 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0018 | 0.0002 | 0.5 |
Brugia malayi | RNA binding protein | 0.0074 | 0.4591 | 0.4591 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.