Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | protein kinase C, beta | Starlite/ChEMBL | References |
Homo sapiens | protein kinase C, theta | Starlite/ChEMBL | References |
Homo sapiens | protein kinase C, epsilon | Starlite/ChEMBL | References |
Homo sapiens | protein kinase C, eta | Starlite/ChEMBL | References |
Homo sapiens | protein kinase C, alpha | Starlite/ChEMBL | References |
Homo sapiens | protein kinase C, delta | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0168 | 0.303 | 1 |
Treponema pallidum | glucose-6-phosphate 1-dehydrogenase | 0.0132 | 0.1942 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0216 | 0.4462 | 0.6756 |
Echinococcus multilocularis | protein kinase c iota type | 0.0115 | 0.1423 | 0.2155 |
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.0086 | 0.057 | 0.2935 |
Schistosoma mansoni | atypical protein kinase C | 0.0115 | 0.1423 | 0.2155 |
Plasmodium vivax | glucose-6-phosphate 1-dehydrogenase, putative | 0.0132 | 0.1942 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0333 | 0.7987 | 0.7987 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0287 | 0.6605 | 1 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.0132 | 0.1942 | 1 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0168 | 0.303 | 0.4588 |
Loa Loa (eye worm) | hypothetical protein | 0.0381 | 0.941 | 0.941 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.0132 | 0.1942 | 1 |
Brugia malayi | Protein kinase c protein 2 | 0.015 | 0.2493 | 0.3774 |
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.0132 | 0.1942 | 1 |
Trypanosoma cruzi | glucose-6-phosphate 1-dehydrogenase, putative | 0.0132 | 0.1942 | 0.5 |
Chlamydia trachomatis | glucose-6-phosphate 1-dehydrogenase | 0.0132 | 0.1942 | 0.5 |
Loa Loa (eye worm) | glucose-6-phosphate dehydrogenase | 0.0132 | 0.1942 | 0.1942 |
Plasmodium falciparum | glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase | 0.0132 | 0.1942 | 0.5 |
Echinococcus granulosus | protein kinase c iota type | 0.0115 | 0.1423 | 0.2155 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0216 | 0.4462 | 0.6756 |
Echinococcus granulosus | protein kinase C gamma type | 0.0168 | 0.3039 | 0.4601 |
Onchocerca volvulus | 0.0333 | 0.7987 | 0.5 | |
Trichomonas vaginalis | 6-phosphogluconolactonase, putative | 0.0132 | 0.1942 | 1 |
Echinococcus multilocularis | glucose 6 phosphate 1 dehydrogenase | 0.0132 | 0.1942 | 0.294 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.0844 | 0.0844 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0216 | 0.4462 | 0.6756 |
Schistosoma mansoni | glucose-6-phosphate 1-dehydrogenase | 0.0132 | 0.1942 | 0.294 |
Brugia malayi | protein kinase C II. | 0.0287 | 0.6605 | 1 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.0095 | 0.0844 | 0.1278 |
Trypanosoma brucei | glucose-6-phosphate 1-dehydrogenase | 0.0132 | 0.1942 | 1 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0168 | 0.3039 | 0.4601 |
Leishmania major | glucose-6-phosphate 1-dehydrogenase, putative | 0.0132 | 0.1942 | 0.5 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0234 | 0.5 | 0.757 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.0103 | 0.1069 | 0.1069 |
Giardia lamblia | Glucose-6-phosphate 1-dehydrogenase | 0.0132 | 0.1942 | 0.5 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0287 | 0.6605 | 0.6605 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.2267 | 0.2267 |
Mycobacterium ulcerans | glucose-6-phosphate 1-dehydrogenase | 0.0132 | 0.1942 | 1 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.0095 | 0.0844 | 0.1278 |
Brugia malayi | glucose-6-phosphate dehydrogenase | 0.0132 | 0.1942 | 0.294 |
Echinococcus granulosus | glucose 6 phosphate 1 dehydrogenase | 0.0132 | 0.1942 | 0.294 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.0095 | 0.0844 | 0.1278 |
Loa Loa (eye worm) | hypothetical protein | 0.0333 | 0.7987 | 0.7987 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0287 | 0.6605 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0287 | 0.6605 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0333 | 0.7987 | 0.7987 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0216 | 0.4462 | 0.6756 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 52 nM | Inhibition of recombinant human PKCeta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity assay | ChEMBL. | 22078216 |
IC50 (binding) | = 133 nM | Inhibition of recombinant human PKCepsilon assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity assay | ChEMBL. | 22078216 |
IC50 (binding) | = 386 nM | Inhibition of recombinant human PKCdelta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity assay | ChEMBL. | 22078216 |
IC50 (binding) | = 738 nM | Inhibition of recombinant human PKCtheta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity assay | ChEMBL. | 22078216 |
IC50 (binding) | > 1000 nM | Inhibition of recombinant human PKCalpha assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity assay | ChEMBL. | 22078216 |
IC50 (binding) | > 1000 nM | Inhibition of recombinant human PKCbeta1 assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity assay | ChEMBL. | 22078216 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.