Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | platelet-derived growth factor receptor, beta polypeptide | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.002 | 0.0622 | 0.0647 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1688 | 0.1764 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0043 | 0.1688 | 0.2198 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0354 | 0.0206 |
Schistosoma mansoni | vesicular amine transporter | 0.0011 | 0.0178 | 0.0252 |
Echinococcus granulosus | geminin | 0.0154 | 0.705 | 1 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0015 | 0.0354 | 0.0257 |
Echinococcus multilocularis | methyl CpG binding domain protein 2 | 0.0015 | 0.0382 | 0.0297 |
Trypanosoma cruzi | ISWI complex protein | 0.0014 | 0.0305 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0043 | 0.1688 | 0.2394 |
Brugia malayi | Pre-SET motif family protein | 0.0189 | 0.8742 | 1 |
Echinococcus multilocularis | neuroglian | 0.0014 | 0.0316 | 0.0201 |
Brugia malayi | Bromodomain containing protein | 0.0035 | 0.1312 | 0.1324 |
Schistosoma mansoni | hypothetical protein | 0.0154 | 0.705 | 1 |
Plasmodium vivax | SET domain protein, putative | 0.0027 | 0.0942 | 0.5 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0054 | 0.2248 | 0.3013 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0033 | 0.1208 | 0.1499 |
Brugia malayi | Pre-SET motif family protein | 0.0027 | 0.0942 | 0.0892 |
Trypanosoma cruzi | ISWI complex protein | 0.0014 | 0.0305 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.273 | 0.298 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0189 | 0.8742 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0493 | 0.0368 |
Schistosoma mansoni | hypothetical protein | 0.0014 | 0.0305 | 0.0433 |
Leishmania major | hypothetical protein, conserved | 0.0014 | 0.0305 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0043 | 0.1688 | 0.2394 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0043 | 0.1688 | 0.2198 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0033 | 0.1208 | 0.1499 |
Echinococcus multilocularis | roundabout 2 | 0.0018 | 0.0493 | 0.0458 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0016 | 0.0403 | 0.0264 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0027 | 0.0942 | 0.1336 |
Echinococcus granulosus | twitchin | 0.0014 | 0.0316 | 0.0201 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0015 | 0.0382 | 0.0542 |
Trypanosoma brucei | ISWI complex protein | 0.0014 | 0.0305 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0027 | 0.0942 | 0.1336 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0027 | 0.0942 | 0.1112 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1502 | 0.1546 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0539 | 0.0764 |
Schistosoma mansoni | hypothetical protein | 0.0154 | 0.705 | 1 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.002 | 0.0622 | 0.0647 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0054 | 0.2248 | 0.3013 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0493 | 0.0368 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0011 | 0.0178 | 0.0252 |
Echinococcus granulosus | neuroglian | 0.0014 | 0.0316 | 0.0201 |
Schistosoma mansoni | cell adhesion molecule | 0.0015 | 0.0354 | 0.0502 |
Brugia malayi | Bromodomain containing protein | 0.0068 | 0.2917 | 0.3199 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0026 | 0.0894 | 0.1042 |
Schistosoma mansoni | bromodomain containing protein | 0.0057 | 0.2405 | 0.3411 |
Echinococcus multilocularis | geminin | 0.0154 | 0.705 | 1 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0016 | 0.0409 | 0.027 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.002 | 0.0622 | 0.0883 |
Echinococcus granulosus | roundabout 2 | 0.0018 | 0.0493 | 0.0458 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0027 | 0.0942 | 0.5 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0011 | 0.0178 | 0.0252 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0016 | 0.0403 | 0.0264 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0015 | 0.0382 | 0.0542 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1418 | 0.1449 |
Schistosoma mansoni | zinc finger protein | 0.0014 | 0.0305 | 0.0433 |
Echinococcus multilocularis | zinc finger protein | 0.0018 | 0.0492 | 0.0458 |
Trichomonas vaginalis | set domain proteins, putative | 0.0215 | 1 | 0.5 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0019 | 0.0539 | 0.0422 |
Schistosoma mansoni | zinc finger protein | 0.0018 | 0.0492 | 0.0698 |
Echinococcus granulosus | methyl CpG binding domain protein 2 | 0.0015 | 0.0382 | 0.0297 |
Schistosoma mansoni | nephrin | 0.0014 | 0.0316 | 0.0448 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1315 | 0.1328 |
Brugia malayi | PHD-finger family protein | 0.0023 | 0.0726 | 0.064 |
Echinococcus granulosus | zinc finger protein | 0.0018 | 0.0492 | 0.0458 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 6.25 uM l-1 | Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells | ChEMBL. | 12941321 |
IC50 (functional) | = 6.25 uM l-1 | Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells | ChEMBL. | 12941321 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.