Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0047 | 0.0346 | 0.5 | |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.018 | 0.371 | 0.5 |
Echinococcus multilocularis | neuroligin | 0.0047 | 0.0346 | 0.0434 |
Echinococcus granulosus | acetylcholinesterase | 0.0275 | 0.611 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0047 | 0.0346 | 0.0434 |
Brugia malayi | Carboxylesterase family protein | 0.0275 | 0.611 | 1 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.018 | 0.371 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0047 | 0.0346 | 0.0434 |
Trichomonas vaginalis | hypothetical protein | 0.018 | 0.371 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0275 | 0.611 | 0.611 |
Brugia malayi | Carboxylesterase family protein | 0.0047 | 0.0346 | 0.0567 |
Trypanosoma brucei | ubiquitin carboxyl-terminal hydrolase, putative | 0.0036 | 0.0085 | 0.5 |
Brugia malayi | hypothetical protein | 0.0047 | 0.0346 | 0.0567 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0047 | 0.0346 | 0.0434 |
Giardia lamblia | Ubiquitin carboxyl-terminal hydrolase 4 | 0.0036 | 0.0085 | 0.5 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0047 | 0.0346 | 0.0434 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0047 | 0.0346 | 0.0434 |
Echinococcus granulosus | acetylcholinesterase | 0.0275 | 0.611 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0047 | 0.0346 | 0.0567 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0047 | 0.0346 | 0.0434 |
Entamoeba histolytica | ubiquitin carboxyl-terminal hydrolase domain containing protein | 0.0036 | 0.0085 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0346 | 0.0346 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.611 | 0.611 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0047 | 0.0346 | 0.0434 |
Onchocerca volvulus | 0.0047 | 0.0346 | 0.5 | |
Brugia malayi | Ubiquitin carboxyl-terminal hydrolase family protein | 0.0036 | 0.0085 | 0.0138 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0047 | 0.0346 | 0.0722 |
Brugia malayi | Carboxylesterase family protein | 0.0047 | 0.0346 | 0.0567 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.611 | 0.611 |
Onchocerca volvulus | 0.0047 | 0.0346 | 0.5 | |
Echinococcus multilocularis | carboxylesterase 5A | 0.0275 | 0.611 | 1 |
Onchocerca volvulus | 0.0047 | 0.0346 | 0.5 | |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0036 | 0.0085 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0047 | 0.0346 | 0.0567 |
Brugia malayi | Carboxylesterase family protein | 0.0275 | 0.611 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0047 | 0.0346 | 0.0722 |
Loa Loa (eye worm) | hypothetical protein | 0.043 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0275 | 0.611 | 1 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.018 | 0.371 | 1 |
Echinococcus granulosus | neuroligin | 0.0047 | 0.0346 | 0.0434 |
Loa Loa (eye worm) | carboxylesterase | 0.0047 | 0.0346 | 0.0346 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0047 | 0.0346 | 0.0434 |
Leishmania major | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative | 0.0036 | 0.0085 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0275 | 0.611 | 1 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.018 | 0.371 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0346 | 0.0346 |
Schistosoma mansoni | gliotactin | 0.0047 | 0.0346 | 0.0434 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.018 | 0.371 | 0.5 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0047 | 0.0346 | 0.0434 |
Onchocerca volvulus | 0.0047 | 0.0346 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0346 | 0.0346 |
Loa Loa (eye worm) | carboxylesterase | 0.0275 | 0.611 | 0.611 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0047 | 0.0346 | 0.0434 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0346 | 0.0346 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0047 | 0.0346 | 0.0434 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.018 | 0.371 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0085 | 0.0085 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0346 | 0.0346 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.018 | 0.371 | 0.5 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.018 | 0.371 | 0.5 |
Schistosoma mansoni | acetylcholinesterase | 0.0047 | 0.0346 | 0.0434 |
Loa Loa (eye worm) | carboxylesterase | 0.0047 | 0.0346 | 0.0346 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0275 | 0.611 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0346 | 0.0346 |
Echinococcus multilocularis | acetylcholinesterase | 0.0275 | 0.611 | 1 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0036 | 0.0085 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0346 | 0.0346 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 0 % | Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF2 receptor expressed in CHO cells at 500 nM by scintillation counting | ChEMBL. | 23131340 |
Inhibition (binding) | = 26 % | Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF2 receptor expressed in CHO cells at 5 uM by scintillation counting | ChEMBL. | 23131340 |
Inhibition (binding) | = 32 % | Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF1 receptor expressed in CHO cells at 500 nM by scintillation counting | ChEMBL. | 23131340 |
Inhibition (binding) | = 76 % | Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF1 receptor expressed in CHO cells at 5 uM by scintillation counting | ChEMBL. | 23131340 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.