Detailed information for compound 168609

Basic information

Technical information
  • TDR Targets ID: 168609
  • Name: (E)-3-(3-amino-4-methoxyphenyl)-2-(3,4,5-trim ethoxyphenyl)prop-2-enenitrile
  • MW: 340.373 | Formula: C19H20N2O4
  • H donors: 1 H acceptors: 1 LogP: 2.91 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#C/C(=C/c1ccc(c(c1)N)OC)/c1cc(OC)c(c(c1)OC)OC
  • InChi: 1S/C19H20N2O4/c1-22-16-6-5-12(8-15(16)21)7-14(11-20)13-9-17(23-2)19(25-4)18(10-13)24-3/h5-10H,21H2,1-4H3/b14-7-
  • InChiKey: NBGTZBKNZLIMFN-AUWJEWJLSA-N  


Substructure search Similarity search

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Synonyms

  • (E)-3-(3-amino-4-methoxy-phenyl)-2-(3,4,5-trimethoxyphenyl)prop-2-enenitrile
  • (E)-3-(3-amino-4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)-2-propenenitrile
  • (E)-3-(3-azanyl-4-methoxy-phenyl)-2-(3,4,5-trimethoxyphenyl)prop-2-enenitrile
  • (E)-3-(3-amino-4-methoxy-phenyl)-2-(3,4,5-trimethoxyphenyl)acrylonitrile

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens tubulin, beta 2B class IIb Starlite/ChEMBL No references
Bos taurus Tubulin Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin alpha-1 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) BEN-1 protein Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin alpha-3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin alpha-1 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha 3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Giardia lamblia Alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Toxoplasma gondii beta-1 tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin alpha-2/alpha-4 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Neospora caninum tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin alpha-1 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei gambiense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha 3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium knowlesi alpha tubulin, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha 1C chain Get druggable targets OG5_126605 All targets in OG5_126605
Theileria parva Tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Babesia bovis tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma cruzi beta tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus peroxisome assembly protein 26 Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma congolense alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) BEN-1 protein Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium berghei alpha tubulin 2 Get druggable targets OG5_126605 All targets in OG5_126605
Cryptosporidium hominis alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Theileria parva tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha 2 Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis hypothetical protein Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium vivax tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei gambiense alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Toxoplasma gondii beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium vivax tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Theileria parva tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi Tubulin alpha-2 chain Get druggable targets OG5_126605 All targets in OG5_126605
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium yoelii Tubulin/FtsZ family, putative Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum ko:K07374 tubulin alpha, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin beta-1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin alpha 1C chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania braziliensis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania donovani alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha-2 chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta-2A chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin beta 4A class IVa Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi Tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin alpha 1C chain Get druggable targets OG5_126605 All targets in OG5_126605
Candida albicans cytoskeletal structural protein Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Toxoplasma gondii alpha-tubulin I, putative Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium vivax tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin alpha chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Entamoeba histolytica tubulin family protein Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium knowlesi alpha-tubulin II, putative Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin beta-1 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Entamoeba histolytica tubulin alpha-1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Babesia bovis tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin alpha-1C chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit alpha Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum ko:K07375 tubulin beta, putative Get druggable targets OG5_126611 All targets in OG5_126611
Cryptosporidium parvum tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-1 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum ko:K07374 tubulin alpha, putative Get druggable targets OG5_126605 All targets in OG5_126605
Brugia malayi beta-tubulin, identical Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi tubulin alpha chain - mouse Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin, beta 4A class IVa Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Entamoeba histolytica tubulin family protein Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma congolense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin alpha 1C chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit alpha Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha 2 Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit alpha Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi Tubulin alpha-2 chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania mexicana alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium falciparum alpha tubulin 1 Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium berghei tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin alpha-1 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium yoelii tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-4 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha 2 Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) alpha-tubulin isotype 2 Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium berghei alpha tubulin 1 Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Toxoplasma gondii beta-tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-7 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania braziliensis alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin alpha 3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Babesia bovis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium yoelii tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin subunit TubB Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin subunit TubB Get druggable targets OG5_126605 All targets in OG5_126605
Brugia malayi Tubulin beta-1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin gamma chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum ko:K07375 tubulin beta, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta-4 chain Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Cryptosporidium parvum alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium falciparum alpha tubulin 2 Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin beta 1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei gambiense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis peroxisome assembly protein 26 Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma cruzi alpha tubulin, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha 3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Entamoeba histolytica tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Giardia lamblia Alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Brugia malayi tubulin alpha-2 chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin beta 1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Cryptosporidium hominis beta-catenin-like repeat protein Get druggable targets OG5_126611 All targets in OG5_126611
Toxoplasma gondii alpha tubulin TUBA1 Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium falciparum tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum tubulin gamma chain tubulin, beta 2B class IIb 445 aa 438 aa 32.9 %
Leishmania mexicana epsilon tubulin, putative Tubulin   445 aa 469 aa 30.9 %
Babesia bovis tubulin, putative Tubulin   445 aa 459 aa 21.1 %
Schistosoma japonicum ko:K10389 tubulin gamma, putative Tubulin   445 aa 436 aa 34.2 %
Giardia lamblia Beta tubulin Tubulin   445 aa 428 aa 88.3 %
Plasmodium vivax tubulin gamma chain, putative Tubulin   445 aa 438 aa 33.3 %
Loa Loa (eye worm) BEN-1 protein Tubulin   445 aa 427 aa 57.1 %
Onchocerca volvulus Tubulin   445 aa 427 aa 49.9 %
Onchocerca volvulus Tubulin   445 aa 445 aa 36.2 %
Theileria parva tubulin gamma chain, putative Tubulin   445 aa 420 aa 34.5 %
Leishmania braziliensis epsilon tubulin, putative Tubulin   445 aa 465 aa 30.1 %
Echinococcus multilocularis tubulin, beta 4A class IVa Tubulin   445 aa 381 aa 71.1 %
Plasmodium falciparum tubulin gamma chain Tubulin   445 aa 438 aa 32.9 %
Trypanosoma brucei epsilon tubulin Tubulin   445 aa 443 aa 29.3 %
Onchocerca volvulus Putative methyltransferase KIAA1456 Tubulin   445 aa 426 aa 49.8 %
Echinococcus multilocularis tubulin delta chain Tubulin   445 aa 461 aa 25.8 %
Trichomonas vaginalis tubulin epsilon chain, putative Tubulin   445 aa 428 aa 80.8 %
Giardia lamblia Epsilon tubulin Tubulin   445 aa 442 aa 27.6 %
Giardia lamblia Beta tubulin Tubulin   445 aa 428 aa 88.3 %
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein Tubulin   445 aa 433 aa 30.7 %
Trypanosoma cruzi tubulin gamma chain Tubulin   445 aa 436 aa 33.5 %
Entamoeba histolytica tubulin gamma chain Tubulin   445 aa 428 aa 33.2 %
Echinococcus granulosus tubulin gamma 1 chain Tubulin   445 aa 436 aa 34.4 %
Schistosoma mansoni tubulin subunit beta Tubulin   445 aa 430 aa 92.3 %
Leishmania infantum epsilon tubulin, putative Tubulin   445 aa 475 aa 30.3 %
Trichomonas vaginalis tubulin, putative Tubulin   445 aa 428 aa 80.8 %
Cryptosporidium parvum gamma tubulin Tubulin   445 aa 436 aa 37.6 %
Onchocerca volvulus Tubulin   445 aa 433 aa 39.0 %
Schistosoma mansoni tubulin subunit beta Tubulin   445 aa 430 aa 95.8 %
Loa Loa (eye worm) tubulin beta-2A chain Tubulin   445 aa 430 aa 91.4 %
Trypanosoma cruzi epsilon tubulin, putative Tubulin   445 aa 456 aa 31.4 %
Echinococcus granulosus tubulin beta 4A class IVa Tubulin   445 aa 381 aa 71.1 %
Trypanosoma brucei gambiense epsilon tubulin Tubulin   445 aa 443 aa 29.3 %
Neospora caninum tubulin alpha chain, putative Tubulin   445 aa 433 aa 30.9 %
Plasmodium berghei tubulin epsilon chain, putative Tubulin   445 aa 445 aa 29.4 %
Trypanosoma brucei epsilon tubulin Tubulin   445 aa 443 aa 29.3 %
Onchocerca volvulus Tyrosine kinase homolog Tubulin   445 aa 434 aa 38.2 %
Leishmania mexicana gamma-tubulin Tubulin   445 aa 438 aa 34.2 %
Trypanosoma brucei gambiense gamma tubulin Tubulin   445 aa 436 aa 33.5 %
Plasmodium knowlesi tubulin epsilon chain, putative Tubulin   445 aa 441 aa 29.0 %
Plasmodium falciparum tubulin epsilon chain, putative Tubulin   445 aa 461 aa 27.8 %
Onchocerca volvulus Tubulin   445 aa 427 aa 82.4 %
Leishmania infantum gamma-tubulin Tubulin   445 aa 438 aa 34.2 %
Onchocerca volvulus Tubulin   445 aa 434 aa 39.9 %
Echinococcus multilocularis tubulin gamma 1 chain Tubulin   445 aa 436 aa 34.4 %
Entamoeba histolytica tubulin family protein Tubulin   445 aa 428 aa 56.3 %
Plasmodium berghei tubulin gamma chain, putative Tubulin   445 aa 438 aa 33.3 %
Trypanosoma brucei tubulin gamma chain Tubulin   445 aa 436 aa 33.5 %
Leishmania donovani epsilon tubulin, putative Tubulin   445 aa 475 aa 30.3 %
Leishmania donovani tubulin gamma chain Tubulin   445 aa 438 aa 34.2 %
Onchocerca volvulus 60S ribosomal protein L13 homolog Tubulin   445 aa 430 aa 91.4 %
Echinococcus granulosus Tubulin beta 2C chain Tubulin   445 aa 430 aa 94.4 %
Giardia lamblia Gamma tubulin Tubulin   445 aa 460 aa 32.4 %
Leishmania braziliensis gamma-tubulin Tubulin   445 aa 438 aa 34.2 %
Schistosoma mansoni tubulin subunit epsilon Tubulin   445 aa 464 aa 31.7 %
Leishmania mexicana beta tubulin Tubulin   445 aa 429 aa 85.8 %
Onchocerca volvulus Tubulin   445 aa 433 aa 40.0 %
Neospora caninum hypothetical protein Tubulin   445 aa 430 aa 89.8 %
Toxoplasma gondii beta-1 tubulin, putative Tubulin   445 aa 430 aa 89.1 %
Schistosoma mansoni tubulin subunit gamma Tubulin   445 aa 436 aa 33.7 %
Babesia bovis tubulin gamma chain Tubulin   445 aa 441 aa 34.0 %
Echinococcus granulosus tubulin alpha Tubulin   445 aa 440 aa 30.2 %
Onchocerca volvulus Tubulin   445 aa 441 aa 31.7 %
Plasmodium knowlesi tubulin gamma chain, putative Tubulin   445 aa 438 aa 33.3 %
Trichomonas vaginalis tubulin alpha chain, putative Tubulin   445 aa 428 aa 80.8 %
Onchocerca volvulus Tubulin   445 aa 435 aa 39.5 %
Onchocerca volvulus 1D304 homolog Tubulin   445 aa 433 aa 40.4 %
Brugia malayi beta-tubulin, identical Tubulin   445 aa 430 aa 90.5 %
Dictyostelium discoideum beta tubulin Tubulin   445 aa 432 aa 75.7 %
Entamoeba histolytica tubulin family protein Tubulin   445 aa 429 aa 57.8 %
Neospora caninum hypothetical protein Tubulin   445 aa 430 aa 89.1 %
Echinococcus multilocularis Tubulin beta 2C chain Tubulin   445 aa 430 aa 93.7 %
Echinococcus multilocularis tubulin alpha Tubulin   445 aa 443 aa 30.5 %
Loa Loa (eye worm) BEN-1 protein Tubulin   445 aa 427 aa 82.2 %
Onchocerca volvulus Putative cytochrome c-type heme lyase Tubulin   445 aa 429 aa 87.4 %
Toxoplasma gondii beta tubulin Tubulin   445 aa 430 aa 89.1 %
Leishmania major epsilon tubulin, putative Tubulin   445 aa 469 aa 30.9 %
Trichomonas vaginalis tubulin beta chain, putative Tubulin   445 aa 428 aa 80.6 %
Brugia malayi Tubulin gamma chain Tubulin   445 aa 440 aa 31.8 %
Leishmania major gamma-tubulin Tubulin   445 aa 438 aa 34.0 %
Trypanosoma brucei epsilon tubulin Tubulin   445 aa 443 aa 29.1 %
Plasmodium yoelii tubulin beta chain Tubulin   445 aa 445 aa 29.7 %
Onchocerca volvulus Regulatory-associated protein of mTOR homolog Tubulin   445 aa 440 aa 38.4 %
Neospora caninum hypothetical protein Tubulin   445 aa 430 aa 89.1 %
Plasmodium vivax tubulin epsilon chain, putative Tubulin   445 aa 444 aa 28.6 %
Schistosoma japonicum Tubulin beta chain, putative Tubulin   445 aa 436 aa 96.3 %
Plasmodium yoelii tubulin gamma chain Tubulin   445 aa 438 aa 33.1 %
Toxoplasma gondii beta-tubulin, putative Tubulin   445 aa 430 aa 89.8 %
Echinococcus multilocularis Tubulin beta 2C chain Tubulin   445 aa 428 aa 92.5 %
Trypanosoma congolense tubulin gamma chain Tubulin   445 aa 436 aa 33.3 %
Trypanosoma congolense epsilon tubulin Tubulin   445 aa 464 aa 29.1 %
Cryptosporidium hominis gamma-tubulin Tubulin   445 aa 436 aa 37.6 %
Trypanosoma cruzi epsilon tubulin, putative Tubulin   445 aa 456 aa 31.4 %
Drosophila melanogaster gamma-Tubulin at 23C Tubulin   445 aa 439 aa 34.6 %
Dictyostelium discoideum gamma tubulin Tubulin   445 aa 429 aa 34.0 %
Loa Loa (eye worm) tubulin beta-1 chain Tubulin   445 aa 432 aa 88.0 %
Neospora caninum Beta-tubulin, related Tubulin   445 aa 446 aa 35.2 %
Brugia malayi Tubulin beta-1 chain Tubulin   445 aa 429 aa 87.4 %
Trichomonas vaginalis tubulin gamma chain, putative Tubulin   445 aa 415 aa 33.3 %
Echinococcus granulosus Tubulin beta 2C chain Tubulin   445 aa 428 aa 92.3 %
Giardia lamblia Beta tubulin Tubulin   445 aa 428 aa 88.3 %
Drosophila melanogaster beta-Tubulin at 60D Tubulin   445 aa 435 aa 90.6 %
Echinococcus granulosus beta tubulin Tubulin   445 aa 427 aa 82.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.0685 0.1092
Leishmania major methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein 0.0101 0.2898 0.2898
Onchocerca volvulus 0.0035 0.0447 0.5
Trypanosoma cruzi DNA polymerase eta, putative 0.0033 0.0367 0.0367
Mycobacterium tuberculosis Acetyl/propionyl-CoA carboxylase (beta subunit) AccD6 0.0036 0.0486 0.0169
Mycobacterium leprae Probable propyonyl-CoA carboxylase beta chain 4 AccD4 (Pccase) 0.0036 0.0486 0.0129
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.0101 0.2898 0.3226
Trichomonas vaginalis tubulin beta chain, putative 0.0033 0.038 0.2834
Trichomonas vaginalis tubulin beta chain, putative 0.0033 0.038 0.2834
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0033 0.0367 0.0416
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.4213 0.4683
Entamoeba histolytica deoxycytidyl transferase, putative 0.0033 0.0367 0.4338
Trichomonas vaginalis tubulin epsilon chain, putative 0.0041 0.0685 0.516
Leishmania major beta tubulin 0.0041 0.0685 0.0685
Toxoplasma gondii acetyl-coA carboxylase ACC2 0.0266 0.8983 1
Trypanosoma brucei DNA polymerase IV, putative 0.0059 0.1322 0.1322
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0059 0.1322 1
Plasmodium vivax tubulin epsilon chain, putative 0.0023 0.0012 0.0019
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4 0.0036 0.0486 0.0998
Trypanosoma brucei tubulin gamma chain 0.0023 0.0012 0.0012
Echinococcus multilocularis Tubulin beta 2C chain 0.0041 0.0685 0.0751
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.1013 0.1013
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0447 0.0485
Toxoplasma gondii alpha-tubulin I, putative 0.0033 0.038 0.0423
Echinococcus multilocularis tubulin beta 1 chain 0.0041 0.0685 0.0751
Mycobacterium tuberculosis Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie 0.0101 0.2898 0.3591
Echinococcus multilocularis tubulin alpha 3 chain 0.0033 0.038 0.041
Leishmania major beta tubulin 0.0041 0.0685 0.0685
Entamoeba histolytica tubulin alpha-1 chain 0.0033 0.038 0.4498
Wolbachia endosymbiont of Brugia malayi Acetyl-CoA carboxylase, carboxyltransferase component 0.0036 0.0486 0.1676
Echinococcus granulosus acetyl coenzyme A carboxylase 1 0.0266 0.8983 1
Brugia malayi acetyltransferase, GNAT family protein 0.0141 0.4359 0.5039
Plasmodium falciparum tubulin epsilon chain, putative 0.0023 0.0012 0.0019
Loa Loa (eye worm) alpha-tubulin 0.0033 0.038 0.0432
Wolbachia endosymbiont of Brugia malayi Acetyl/propionyl-CoA carboxylase, alpha subunit 0.0101 0.2898 1
Plasmodium falciparum alpha tubulin 2 0.0033 0.038 0.0606
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0852 0.1359
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.0685 0.5153
Leishmania major propionyl-coa carboxylase beta chain, putative 0.0036 0.0486 0.0486
Leishmania major epsilon tubulin, putative 0.0023 0.0012 0.0012
Plasmodium falciparum biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.0192 0.6267 1
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0852 0.0979
Leishmania major beta tubulin 0.0041 0.0685 0.0685
Leishmania major beta tubulin 0.0041 0.0685 0.0685
Entamoeba histolytica tubulin family protein 0.0041 0.0685 0.8234
Echinococcus multilocularis flap endonuclease 1 0.0025 0.0089 0.0086
Loa Loa (eye worm) hypothetical protein 0.0035 0.0447 0.0509
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0025 0.0089 0.0089
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.1322 0.1322
Schistosoma mansoni tubulin subunit alpha 0.0033 0.038 0.0423
Trichomonas vaginalis tubulin, putative 0.0041 0.0685 0.516
Brugia malayi Flap endonuclease-1 0.0025 0.0089 0.009
Echinococcus multilocularis tubulin alpha 1C chain 0.0033 0.038 0.041
Leishmania major beta tubulin 0.0041 0.0685 0.0685
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0447 0.0485
Leishmania major beta tubulin 0.0041 0.0685 0.0685
Giardia lamblia Flap structure-specific endonuclease 0.0025 0.0089 0.0945
Mycobacterium ulcerans DNA polymerase IV 0.0059 0.1322 0.2716
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0679 0.0679
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0447 0.0114
Mycobacterium ulcerans acetyl/propionyl CoA carboxylase subunit beta 0.0036 0.0486 0.0998
Echinococcus multilocularis Tubulin beta 2C chain 0.0041 0.0685 0.0751
Trypanosoma brucei trypanothione reductase 0.0046 0.0852 0.0852
Brugia malayi beta-tubulin, identical 0.0041 0.0685 0.0781
Brugia malayi Tubulin alpha-2 chain 0.0033 0.038 0.0427
Leishmania major trypanothione reductase 0.0046 0.0852 0.0852
Echinococcus multilocularis peroxisome assembly protein 26 0.0033 0.038 0.041
Mycobacterium ulcerans hypothetical protein 0.0035 0.0447 0.0918
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.3027 0.3775
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 0.0101 0.2898 0.5954
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0447 0.0114
Leishmania major beta tubulin 0.0041 0.0685 0.0685
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0227 0.0227
Trypanosoma brucei acetyl-CoA carboxylase 0.0266 0.8983 0.8983
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0485 0.0485
Echinococcus granulosus tubulin alpha chain 0.0033 0.038 0.041
Brugia malayi Thioredoxin reductase 0.0046 0.0852 0.0974
Trichomonas vaginalis flap endonuclease-1, putative 0.0025 0.0089 0.0622
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0447 0.0447
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0447 0.0504
Toxoplasma gondii thioredoxin reductase 0.0046 0.0852 0.0948
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.1322 0.1322
Mycobacterium ulcerans pyruvate carboxylase 0.0101 0.2898 0.5954
Loa Loa (eye worm) flap endonuclease-1 0.0025 0.0089 0.0095
Toxoplasma gondii hypothetical protein 0.0047 0.0903 0.1005
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0447 0.0114
Mycobacterium tuberculosis Conserved protein 0.0035 0.0447 0.0114
Echinococcus multilocularis tubulin alpha 3 chain 0.0033 0.038 0.041
Trypanosoma brucei beta tubulin 0.0023 0.0012 0.0012
Schistosoma mansoni pyruvate carboxylase 0.0101 0.2898 0.3226
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0033 0.038 0.2834
Echinococcus granulosus tubulin alpha chain 0.0033 0.038 0.041
Trichomonas vaginalis tubulin epsilon chain, putative 0.0033 0.038 0.2834
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.346 0.4388
Trypanosoma brucei epsilon tubulin 0.0023 0.0012 0.0012
Toxoplasma gondii beta-tubulin, putative 0.0041 0.0685 0.0763
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.346 0.4388
Leishmania major DNA polymerase eta, putative 0.0033 0.0367 0.0367
Schistosoma mansoni DNA polymerase eta 0.0033 0.0367 0.0408
Echinococcus granulosus beta tubulin 0.0041 0.0685 0.0751
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.0685 0.0762
Leishmania major alpha tubulin 0.0033 0.038 0.038
Toxoplasma gondii beta-1 tubulin, putative 0.0041 0.0685 0.0763
Trypanosoma brucei unspecified product 0.0052 0.1085 0.1085
Trypanosoma brucei DNA polymerase IV, putative 0.0052 0.1085 0.1085
Leishmania major alpha tubulin 0.0033 0.038 0.038
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.1322 0.1322
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.1322 0.1322
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0033 0.0367 0.0408
Schistosoma mansoni tubulin subunit alpha 0.0033 0.038 0.0423
Loa Loa (eye worm) tubulin alpha-2 chain 0.0033 0.038 0.0432
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.3027 0.3775
Echinococcus granulosus Tubulin beta 2C chain 0.0041 0.0685 0.0751
Mycobacterium tuberculosis Probable reductase 0.0105 0.3027 0.3775
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0447 0.3344
Plasmodium vivax tubulin beta chain, putative 0.0041 0.0685 0.1094
Mycobacterium tuberculosis Probable propionyl-CoA carboxylase beta chain 5 AccD5 (pccase) (propanoyl-CoA:carbon dioxide ligase) 0.0036 0.0486 0.0169
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0227 0.0227
Trichomonas vaginalis tubulin beta chain, putative 0.0041 0.0685 0.516
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.1322 0.1322
Loa Loa (eye worm) tubulin beta-4 chain 0.0041 0.0685 0.0786
Trichomonas vaginalis tubulin gamma chain, putative 0.0041 0.0685 0.516
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0293 1 1
Toxoplasma gondii beta tubulin 0.0041 0.0685 0.0763
Echinococcus granulosus peroxisome assembly protein 26 0.0033 0.038 0.041
Trypanosoma cruzi epsilon tubulin, putative 0.0023 0.0012 0.0012
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0852 0.0688
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0679 0.0679
Leishmania major beta tubulin 0.0041 0.0685 0.0685
Echinococcus multilocularis dna polymerase eta 0.0033 0.0367 0.0396
Leishmania major beta tubulin 0.0041 0.0685 0.0685
Trichomonas vaginalis tubulin alpha chain, putative 0.0023 0.0012 0.0034
Giardia lamblia DINP protein human, muc B family 0.0039 0.0604 0.7233
Leishmania major beta tubulin 0.0041 0.0685 0.0685
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0557 0.0889
Toxoplasma gondii acetyl-CoA carboxylase ACC1 0.0266 0.8983 1
Mycobacterium ulcerans beta-lactamase 0.0035 0.0447 0.0918
Trypanosoma brucei DNA polymerase IV, putative 0.0059 0.1322 0.1322
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4_2 0.0036 0.0486 0.0998
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.0101 0.2898 0.2898
Brugia malayi tubulin alpha chain - mouse 0.0033 0.038 0.0427
Plasmodium vivax biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.0192 0.6267 1
Trypanosoma cruzi epsilon tubulin, putative 0.0023 0.0012 0.0012
Giardia lamblia Alpha-tubulin 0.0033 0.038 0.4498
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0604 0.0604
Schistosoma mansoni propionyl-CoA carboxylase beta chain mitochondrial precursor 0.0036 0.0486 0.0541
Echinococcus multilocularis dna polymerase kappa 0.0059 0.1322 0.146
Leishmania major beta tubulin 0.0041 0.0685 0.0685
Brugia malayi Carboxyl transferase domain containing protein 0.0256 0.8638 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.346 1
Mycobacterium ulcerans lipase LipD 0.0035 0.0447 0.0918
Trypanosoma brucei beta tubulin 0.0041 0.0685 0.0685
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.4287 0.4287
Trypanosoma cruzi tubulin gamma chain 0.0023 0.0012 0.0012
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0447 0.0497
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0041 0.0685 0.0751
Loa Loa (eye worm) tubulin beta-1 chain 0.0041 0.0685 0.0786
Echinococcus multilocularis hypothetical protein 0.0033 0.038 0.041
Giardia lamblia Beta tubulin 0.0041 0.0685 0.8234
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0852 0.0852
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0852 0.0937
Trypanosoma cruzi alpha tubulin, putative 0.0033 0.038 0.038
Echinococcus granulosus tubulin subunit TubB 0.0033 0.038 0.041
Leishmania major alpha tubulin 0.0033 0.038 0.038
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0036 0.0486 0.0486
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0447 0.3344
Leishmania major alpha tubulin 0.0033 0.038 0.038
Trichomonas vaginalis tubulin gamma chain, putative 0.0023 0.0012 0.0034
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0141 0.4359 0.4846
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0557 0.6664
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.0685 0.0762
Echinococcus granulosus Tubulin beta 2C chain 0.0041 0.0685 0.0751
Schistosoma mansoni tubulin subunit beta 0.0041 0.0685 0.0763
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.3027 0.3775
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0141 0.4359 0.4853
Loa Loa (eye worm) hypothetical protein 0.0035 0.0447 0.0509
Trichomonas vaginalis tubulin beta chain, putative 0.0033 0.038 0.2834
Trypanosoma cruzi acetyl-CoA carboxylase, putative 0.0036 0.0486 0.0486
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0447 0.0447
Echinococcus granulosus tubulin beta 4A class IVa 0.0041 0.0685 0.0751
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0293 1 1
Echinococcus granulosus tubulin alpha 1C chain 0.0033 0.038 0.041
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0447 0.0509
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0023 0.0012 0.0013
Entamoeba histolytica Flap nuclease, putative 0.0025 0.0089 0.0945
Loa Loa (eye worm) BEN-1 protein 0.0041 0.0685 0.0786
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0447 0.0114
Echinococcus multilocularis Tubulin alpha 1 chain 0.0033 0.038 0.041
Leishmania major beta tubulin 0.0041 0.0685 0.0685
Entamoeba histolytica tubulin alpha chain, putative 0.0033 0.038 0.4498
Giardia lamblia Beta tubulin 0.0041 0.0685 0.8234
Trichomonas vaginalis tubulin alpha chain, putative 0.0041 0.0685 0.516
Trypanosoma brucei DNA polymerase eta, putative 0.0033 0.0367 0.0367
Leishmania major beta tubulin 0.0041 0.0685 0.0685
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.3027 0.8565
Echinococcus granulosus tubulin subunit beta 0.0041 0.0685 0.0751
Loa Loa (eye worm) BEN-1 protein 0.0041 0.0685 0.0786
Schistosoma mansoni tubulin subunit gamma 0.0023 0.0012 0.0013
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0447 0.0114
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.346 0.4388
Loa Loa (eye worm) tubulin beta-2A chain 0.0041 0.0685 0.0786
Brugia malayi ImpB/MucB/SamB family protein 0.0033 0.0367 0.0411
Brugia malayi beta-lactamase family protein 0.0035 0.0447 0.0504
Brugia malayi beta-lactamase family protein 0.0035 0.0447 0.0504
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0227 0.0227
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.1322 0.1322
Echinococcus multilocularis tubulin alpha chain 0.0033 0.038 0.041
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.1322 0.1322
Plasmodium vivax tubulin gamma chain, putative 0.0023 0.0012 0.0019
Trypanosoma brucei beta tubulin 0.0041 0.0685 0.0685
Loa Loa (eye worm) hypothetical protein 0.0033 0.0367 0.0416
Trichomonas vaginalis tubulin epsilon chain, putative 0.0041 0.0685 0.516
Echinococcus granulosus Tubulin beta 2C chain 0.0041 0.0685 0.0751
Mycobacterium tuberculosis Conserved protein 0.0035 0.0447 0.0114
Trypanosoma brucei 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0036 0.0486 0.0486
Echinococcus multilocularis tubulin alpha chain 0.0033 0.038 0.041
Echinococcus granulosus Tubulin alpha 1 chain 0.0033 0.038 0.041
Loa Loa (eye worm) hypothetical protein 0.0035 0.0447 0.0509
Loa Loa (eye worm) alpha-tubulin 0.0033 0.038 0.0432
Echinococcus multilocularis Tubulin beta 2C chain 0.0041 0.0685 0.0751
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0447 0.0497
Trypanosoma brucei epsilon tubulin 0.0023 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0035 0.0447 0.0509
Loa Loa (eye worm) tubulin alpha chain 0.0033 0.038 0.0432
Trichomonas vaginalis tubulin gamma chain, putative 0.0023 0.0012 0.0034
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0139 0.4287 0.4287
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0025 0.0089 0.0089
Echinococcus granulosus tubulin alpha 3 chain 0.0033 0.038 0.041
Loa Loa (eye worm) tubulin alpha chain 0.0033 0.038 0.0432
Trypanosoma brucei alpha tubulin 0.0033 0.038 0.038
Mycobacterium ulcerans bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 0.0101 0.2898 0.5954
Brugia malayi Tubulin alpha chain 0.0033 0.038 0.0427
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.1322 0.1322
Trypanosoma brucei beta tubulin 0.0041 0.0685 0.0685
Echinococcus granulosus propionyl coenzyme A carboxylase beta chain 0.0036 0.0486 0.0528
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.7415 1
Echinococcus multilocularis tubulin alpha 1C chain 0.0033 0.038 0.041
Schistosoma mansoni tubulin subunit beta 0.0041 0.0685 0.0763
Loa Loa (eye worm) acetyltransferase 0.0141 0.4359 0.5042
Schistosoma mansoni tubulin subunit beta 0.0041 0.0685 0.0763
Brugia malayi glutathione reductase 0.0046 0.0852 0.0974
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 5 AccD5 0.0036 0.0486 0.0998
Brugia malayi beta-lactamase 0.0035 0.0447 0.0504
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0293 1 1
Chlamydia trachomatis biotin carboxylase 0.0092 0.2553 1
Plasmodium vivax tubulin alpha chain, putative 0.0033 0.038 0.0606
Leishmania major gamma-tubulin 0.0023 0.0012 0.0012
Trichomonas vaginalis tubulin beta chain, putative 0.0033 0.038 0.2834
Echinococcus granulosus tubulin alpha chain 0.0033 0.038 0.041
Echinococcus granulosus dna polymerase kappa 0.0059 0.1322 0.146
Leishmania major alpha tubulin 0.0033 0.038 0.038
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0447 0.3344
Schistosoma mansoni terminal deoxycytidyl transferase 0.0033 0.0367 0.0408
Mycobacterium ulcerans hypothetical protein 0.0154 0.4867 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.1322 0.1322
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0025 0.0089 0.0099
Mycobacterium leprae Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) 0.0101 0.2898 0.8135
Echinococcus multilocularis propionyl coenzyme A carboxylase beta chain 0.0036 0.0486 0.0528
Leishmania major beta tubulin 0.0041 0.0685 0.0685
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0039 0.0604 0.0336
Leishmania major alpha tubulin 0.0033 0.038 0.038
Trichomonas vaginalis tubulin beta chain, putative 0.0033 0.038 0.2834
Plasmodium falciparum thioredoxin reductase 0.0046 0.0852 0.1359
Schistosoma mansoni tubulin subunit beta 0.0041 0.0685 0.0763
Toxoplasma gondii ABC1 family protein 0.0035 0.0447 0.0497
Leishmania major beta tubulin 0.0041 0.0685 0.0685
Loa Loa (eye worm) hypothetical protein 0.0036 0.0485 0.0554
Giardia lamblia Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative 0.0045 0.083 1
Brugia malayi alpha-tubulin 0.0033 0.038 0.0427
Entamoeba histolytica tubulin family protein 0.0041 0.0685 0.8234
Schistosoma mansoni tubulin subunit beta 0.0041 0.0685 0.0763
Echinococcus granulosus flap endonuclease 1 0.0025 0.0089 0.0086
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0485 0.0485
Mycobacterium tuberculosis Probable pyruvate carboxylase Pca (pyruvic carboxylase) 0.0101 0.2898 0.3591
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0685 0.5153
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.0101 0.2898 0.2898
Echinococcus granulosus Tubulin beta 2C chain 0.0041 0.0685 0.0751
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.1322 0.1322
Trypanosoma brucei alpha tubulin 0.0033 0.038 0.038
Toxoplasma gondii pyruvate carboxylase 0.0101 0.2898 0.3226
Schistosoma mansoni acetyl-CoA carboxylase 0.0266 0.8983 1
Leishmania major alpha tubulin 0.0033 0.038 0.038
Leishmania major alpha tubulin 0.0033 0.038 0.038
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0447 0.0713
Plasmodium vivax flap endonuclease 1, putative 0.0025 0.0089 0.0142
Loa Loa (eye worm) hypothetical protein 0.0035 0.0447 0.0509
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.1322 0.1322
Loa Loa (eye worm) glutathione reductase 0.0046 0.0852 0.0979
Schistosoma mansoni tubulin subunit alpha 0.0033 0.038 0.0423
Echinococcus granulosus alpha tubulin 0.0033 0.038 0.041
Trichomonas vaginalis DNA polymerase eta, putative 0.0059 0.1322 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0447 0.0918
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 0.0101 0.2898 0.5954
Leishmania major DNA polymerase kappa, putative 0.0039 0.0604 0.0604
Loa Loa (eye worm) hypothetical protein 0.0033 0.038 0.0432
Loa Loa (eye worm) beta-tubulin 0.0041 0.0685 0.0786
Leishmania major beta tubulin 0.0041 0.0685 0.0685
Echinococcus multilocularis tubulin subunit TubB 0.0033 0.038 0.041
Trypanosoma brucei alpha tubulin 0.0033 0.038 0.038
Toxoplasma gondii acyl-CoA carboxyltransferase beta chain, putative 0.0036 0.0486 0.0541
Brugia malayi ImpB/MucB/SamB family protein 0.0033 0.0367 0.0411
Leishmania major alpha tubulin 0.0033 0.038 0.038
Echinococcus multilocularis acetyl coenzyme A carboxylase 1 0.0266 0.8983 1
Plasmodium vivax glutathione reductase, putative 0.0046 0.0852 0.1359
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0033 0.0367 0.0396
Echinococcus multilocularis Tubulin beta 2C chain 0.0041 0.0685 0.0751
Echinococcus multilocularis beta tubulin 0.0041 0.0685 0.0751
Echinococcus granulosus tubulin beta 1 chain 0.0041 0.0685 0.0751
Leishmania major beta tubulin 0.0041 0.0685 0.0685
Mycobacterium tuberculosis Conserved protein 0.0035 0.0447 0.0114
Trypanosoma brucei unspecified product 0.0067 0.1615 0.1615
Schistosoma mansoni alpha tubulin 0.0033 0.038 0.0423
Echinococcus multilocularis Tubulin alpha 1 chain 0.0033 0.038 0.041
Mycobacterium ulcerans acetyl-coenzyme a carboxylase carboxyl transferase (subunit beta) AccD3 0.0036 0.0486 0.0998
Plasmodium falciparum tubulin gamma chain 0.0023 0.0012 0.0019
Mycobacterium leprae Probable propionyl-CoA carboxylase beta chain 5 AccD5 (PCCASE) (PROPANOYL-COA:CARBON DIOXIDE LIGASE) 0.0036 0.0486 0.0129
Leishmania major carboxylase, putative 0.0101 0.2898 0.2898
Trypanosoma brucei beta tubulin 0.0041 0.0685 0.0685
Loa Loa (eye worm) carboxyl transferase domain-containing protein 0.0256 0.8638 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0154 0.4867 0.6385
Leishmania major acetyl-CoA carboxylase, putative 0.0266 0.8983 0.8983
Mycobacterium ulcerans acetyl-/propionyl-CoA carboxylase subunit beta 0.0036 0.0486 0.0998
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0447 0.0918
Echinococcus multilocularis tubulin alpha chain 0.0033 0.038 0.041
Echinococcus multilocularis beta tubulin 0.0041 0.0685 0.0751
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.1322 0.1322
Schistosoma mansoni alpha tubulin 0.0033 0.038 0.0423
Echinococcus multilocularis propionyl coenzyme A carboxylase alpha chain 0.0101 0.2898 0.3217
Echinococcus granulosus Tubulin beta 2C chain 0.0041 0.0685 0.0751
Plasmodium falciparum alpha tubulin 1 0.0033 0.038 0.0606
Trypanosoma cruzi beta tubulin, putative 0.0041 0.0685 0.0685
Leishmania major alpha tubulin 0.0033 0.038 0.038
Trypanosoma cruzi acetyl-CoA carboxylase 0.0165 0.5239 0.5239
Loa Loa (eye worm) tubulin gamma chain 0.0023 0.0012 0.0005
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.0101 0.2898 0.2898
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0852 0.0937
Echinococcus granulosus Tubulin alpha 1 chain 0.0033 0.038 0.041
Trypanosoma brucei epsilon tubulin 0.0023 0.0012 0.0012
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0447 0.0114
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.0101 0.2898 0.2898
Leishmania major 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0036 0.0486 0.0486
Echinococcus multilocularis Tubulin beta 2C chain 0.0041 0.0685 0.0751
Leishmania major alpha tubulin 0.0033 0.038 0.038
Echinococcus multilocularis tubulin alpha chain 0.0033 0.038 0.041
Echinococcus granulosus Tubulin alpha 1 chain 0.0033 0.038 0.041
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0447 0.3344
Brugia malayi Tubulin beta-1 chain 0.0041 0.0685 0.0781
Trichomonas vaginalis tubulin beta chain, putative 0.0033 0.038 0.2834
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.4287 0.4287
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0036 0.0486 0.0486
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.3027 0.3775
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0557 0.6664
Trichomonas vaginalis tubulin epsilon chain, putative 0.0033 0.038 0.2834
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0039 0.0604 0.0604
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0679 0.0679
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0447 0.0114
Onchocerca volvulus 0.0035 0.0447 0.5
Onchocerca volvulus 0.0035 0.0447 0.5
Toxoplasma gondii alpha tubulin TUBA1 0.0033 0.038 0.0423
Echinococcus multilocularis tubulin alpha chain 0.0033 0.038 0.041
Echinococcus granulosus tubulin alpha 3 chain 0.0033 0.038 0.041
Giardia lamblia Alpha-tubulin 0.0033 0.038 0.4498
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0447 0.0447
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.0101 0.2898 0.3226
Loa Loa (eye worm) tubulin beta chain 0.0041 0.0685 0.0786
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0679 0.0679
Schistosoma mansoni alpha tubulin 0.0033 0.038 0.0423
Leishmania major alpha tubulin 0.0033 0.038 0.038
Loa Loa (eye worm) beta-lactamase 0.0035 0.0447 0.0509
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.3027 0.3775
Schistosoma mansoni tubulin subunit beta 0.0041 0.0685 0.0763
Trypanosoma brucei alpha tubulin 0.0033 0.038 0.038
Echinococcus granulosus tubulin alpha chain 0.0033 0.038 0.041
Schistosoma mansoni tubulin subunit epsilon 0.0023 0.0012 0.0013
Giardia lamblia Beta tubulin 0.0041 0.0685 0.8234
Trichomonas vaginalis esterase, putative 0.0035 0.0447 0.3344
Echinococcus granulosus propionyl coenzyme A carboxylase alpha chain 0.0101 0.2898 0.3217
Echinococcus granulosus beta tubulin 0.0041 0.0685 0.0751
Echinococcus multilocularis Tubulin alpha 1 chain 0.0033 0.038 0.041
Echinococcus granulosus tubulin alpha chain 0.0033 0.038 0.041
Brugia malayi Tubulin alpha-2 chain 0.0033 0.038 0.0427
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0447 0.3344
Entamoeba histolytica acetyl-coA carboxylase, putative 0.0045 0.083 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0033 0.0367 0.0396
Plasmodium vivax tubulin alpha chain, putative 0.0033 0.038 0.0606
Plasmodium falciparum glutathione reductase 0.0046 0.0852 0.1359
Echinococcus granulosus tubulin alpha 1C chain 0.0033 0.038 0.041
Mycobacterium ulcerans DNA polymerase IV 0.0059 0.1322 0.2716
Brugia malayi polk-prov protein 0.0036 0.0485 0.0549
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.1322 0.1322
Leishmania major hypothetical protein, conserved 0.0035 0.0447 0.0447
Plasmodium falciparum tubulin beta chain 0.0041 0.0685 0.1094
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0025 0.0089 0.0089
Leishmania major beta tubulin 0.0041 0.0685 0.0685
Mycobacterium leprae ACETYL/PROPIONYL-CoA CARBOXYLASE (BETA SUBUNIT) ACCD6 0.0036 0.0486 0.0129
Echinococcus multilocularis tubulin subunit beta 0.0041 0.0685 0.0751
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.0685 0.075
Brugia malayi tubulin alpha-2 chain 0.0033 0.038 0.0427
Plasmodium falciparum flap endonuclease 1 0.0025 0.0089 0.0142
Loa Loa (eye worm) hypothetical protein 0.0035 0.0447 0.0509
Echinococcus granulosus dna polymerase eta 0.0033 0.0367 0.0396

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 5 Inhibition of tubulin polymerization in Homo sapiens (human) solid tumor cells ChEMBL. No reference
IC50 (functional) = 5.9 nM Growth inhibition of colon 26 adenocarcinoma cells by 50 %. ChEMBL. 9685242
IC50 (functional) = 5.9 nM Growth inhibition of colon 26 adenocarcinoma cells by 50 %. ChEMBL. 9685242
IC50 (binding) = 10 uM Inhibitory activity against tubulin polymerization ChEMBL. 9685242
IC50 (binding) = 10 uM Inhibitory activity against tubulin polymerization ChEMBL. 9685242

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Mus musculus ChEMBL23 9685242

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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