Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | protein kinase C, alpha | Starlite/ChEMBL | References |
Homo sapiens | protein kinase C, eta | Starlite/ChEMBL | References |
Homo sapiens | protein kinase C, delta | Starlite/ChEMBL | References |
Homo sapiens | protein kinase C, beta | Starlite/ChEMBL | References |
Homo sapiens | protein kinase C, theta | Starlite/ChEMBL | References |
Homo sapiens | protein kinase C, epsilon | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | serine/threonine protein kinase | 0.0216 | 0.3952 | 0.5865 |
Onchocerca volvulus | 0.0333 | 0.7801 | 0.5 | |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0287 | 0.6292 | 0.6292 |
Brugia malayi | protein kinase C II. | 0.0287 | 0.6292 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0333 | 0.7801 | 0.7801 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.0103 | 0.0246 | 0.0246 |
Loa Loa (eye worm) | hypothetical protein | 0.0333 | 0.7801 | 0.7801 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0168 | 0.2397 | 0.381 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0216 | 0.3952 | 0.6281 |
Echinococcus granulosus | protein kinase c iota type | 0.0115 | 0.0633 | 0.1006 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0287 | 0.6292 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.1555 | 0.1555 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0234 | 0.4539 | 0.7214 |
Loa Loa (eye worm) | hypothetical protein | 0.0381 | 0.9356 | 0.9356 |
Echinococcus granulosus | protein kinase C gamma type | 0.0168 | 0.2397 | 0.381 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0168 | 0.2388 | 0.3795 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0287 | 0.6292 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0333 | 0.7801 | 0.7801 |
Echinococcus multilocularis | protein kinase c iota type | 0.0115 | 0.0633 | 0.1006 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0287 | 0.6292 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0216 | 0.3952 | 0.5865 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0216 | 0.3952 | 0.6281 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0168 | 0.2388 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 735 nM | Inhibition of recombinant human PKCeta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity assay | ChEMBL. | 22078216 |
IC50 (binding) | = 802 nM | Inhibition of recombinant human PKCepsilon assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity assay | ChEMBL. | 22078216 |
IC50 (binding) | > 1000 nM | Inhibition of recombinant human PKCalpha assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity assay | ChEMBL. | 22078216 |
IC50 (binding) | > 1000 nM | Inhibition of recombinant human PKCbeta1 assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity assay | ChEMBL. | 22078216 |
IC50 (binding) | > 1000 nM | Inhibition of recombinant human PKCdelta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity assay | ChEMBL. | 22078216 |
IC50 (binding) | > 1000 nM | Inhibition of recombinant human PKCtheta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity assay | ChEMBL. | 22078216 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.