TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 363.456 | Formula: C21H25N5O
H donors: 1 H acceptors: 4 LogP: 3.5 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: N#CC1(CC1)n1nnc(c1)[C@H](C1CCCCC1)NC(=O)c1ccccc1C
InChi: 1S/C21H25N5O/c1-15-7-5-6-10-17(15)20(27)23-19(16-8-3-2-4-9-16)18-13-26(25-24-18)21(14-22)11-12-21/h5-7,10,13,16,19H,2-4,8-9,11-12H2,1H3,(H,23,27)/t19-/m0/s1
InChiKey: KGOIGGKBRPMSPK-IBGZPJMESA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cathepsin S	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin S	281 aa	226 aa	34.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.8761	0.8595
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.8761	0.8595
Trichomonas vaginalis	CMGC family protein kinase	0.0051	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.4283	0.3518
Entamoeba histolytica	cysteine protease, putative	0.0027	0.4283	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.2168	0.2168
Onchocerca volvulus		0.0027	0.4283	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.2168	0.2168
Plasmodium vivax	vivapain-1	0.0014	0.1181	0.2757
Leishmania major	cathepsin L-like protease	0.0027	0.4283	0.2521
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.2168	0.1119
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.4283	0.3518
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.2356	0.2356
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.8761	0.8595
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.8761	0.8761
Leishmania major	cathepsin L-like protease	0.0027	0.4283	0.2521
Schistosoma mansoni	cathepsin F (C01 family)	0.0018	0.2168	0.2168
Trypanosoma cruzi	cysteine peptidase, putative	0.0027	0.4283	0.4283
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.4283	0.3518
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0051	1	1
Onchocerca volvulus		0.0027	0.4283	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0027	0.4283	0.4283
Echinococcus multilocularis	cathepsin L cysteine protease	0.0027	0.4283	0.3518
Trypanosoma brucei	protein kinase, putative	0.0051	1	1
Plasmodium vivax	vivapain-2	0.0027	0.4283	1
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.2356	0.1333
Schistosoma mansoni	ap endonuclease	0.0019	0.2356	0.2356
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0051	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0027	0.4283	0.4283
Leishmania major	cathepsin L-like protease	0.0027	0.4283	0.2521
Schistosoma mansoni	serine/threonine protein kinase	0.0051	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.4283	0.3518
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.2168	0.1119
Onchocerca volvulus		0.0027	0.4283	1
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.2356	0.1333
Leishmania major	cathepsin L-like protease	0.0027	0.4283	0.2521
Brugia malayi	Papain family cysteine protease containing protein	0.0014	0.1181	0.1181
Onchocerca volvulus	Cathepsin L homolog	0.0027	0.4283	1
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0019	0.2356	0.5
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0051	1	1
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0051	1	1
Leishmania major	cathepsin L-like protease	0.0027	0.4283	0.2521
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.4283	0.3518
Plasmodium vivax	vivapain-2	0.0027	0.4283	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.4283	0.3518
Toxoplasma gondii	cathepsin CPL	0.0027	0.4283	0.2521
Echinococcus multilocularis	cysteine protease	0.0027	0.4283	0.3518
Leishmania major	cysteine peptidase A (CPA)	0.0027	0.4283	0.2521
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0051	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.4283	0.3518
Giardia lamblia	Kinase, CMGC MAPK	0.0051	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0027	0.4283	0.3518
Plasmodium vivax	unspecified product	0.0014	0.1181	0.2757
Brugia malayi	Cathepsin L-like precursor	0.0027	0.4283	0.4283
Onchocerca volvulus	Cathepsin L homolog	0.0027	0.4283	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.4283	0.3518
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0027	0.4283	0.4283
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0019	0.2356	0.2356
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0014	0.1181	0.1181
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0027	0.4283	0.4283
Schistosoma mansoni	cathepsin F (C01 family)	0.0027	0.4283	0.4283
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.4283	0.3518
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.4283	0.3518
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0014	0.1181	0.1181
Echinococcus granulosus	mitogen activated protein kinase	0.0051	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.4283	0.3518
Onchocerca volvulus		0.0027	0.4283	1
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.2356	0.1333
Loa Loa (eye worm)	hypothetical protein	0.0018	0.2168	0.2168
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0027	0.4283	0.3518
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0051	1	1
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0051	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.4283	0.3518
Loa Loa (eye worm)	fibroinase	0.0027	0.4283	0.4283
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0014	0.1181	0.1181
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0019	0.2356	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.4283	0.3518
Brugia malayi	Cathepsin L-like precursor	0.0027	0.4283	0.4283
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.4283	0.3518
Brugia malayi	Cathepsin L-like precursor	0.0027	0.4283	0.4283
Echinococcus granulosus	mitogen activated protein kinase 3	0.0051	1	1
Brugia malayi	Cathepsin L-like precursor	0.0027	0.4283	0.4283
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0018	0.2168	0.2168
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.4283	0.3518
Plasmodium vivax	vivapain-3	0.0014	0.1181	0.2757
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0.2356	0.5
Onchocerca volvulus		0.0027	0.4283	1
Loa Loa (eye worm)	cysteine protease	0.0027	0.4283	0.4283
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0027	0.4283	0.3518
Echinococcus multilocularis	mitogen activated protein kinase	0.0051	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.4283	0.3518
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.4283	0.3518
Onchocerca volvulus	Cathepsin F homolog	0.0027	0.4283	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.8761	0.8761
Trichomonas vaginalis	CMGC family protein kinase	0.0051	1	1
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0019	0.2356	0.1333
Leishmania major	cathepsin L-like protease	0.0027	0.4283	0.2521
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0027	0.4283	0.3518
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0027	0.4283	0.3518
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.4283	0.3518
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.8761	0.8595
Brugia malayi	Cathepsin L-like precursor	0.0027	0.4283	0.4283
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.4283	0.3518
Trypanosoma cruzi	cysteine proteinase, putative	0.0014	0.1181	0.1181
Leishmania major	cathepsin L-like protease	0.0027	0.4283	0.2521
Brugia malayi	cathepsin L-like precursor	0.0018	0.2168	0.2168
Trichomonas vaginalis	CMGC family protein kinase	0.0051	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0027	0.4283	0.4283
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.4283	0.3518
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0027	0.4283	0.3518
Trypanosoma cruzi	cysteine proteinase, putative	0.0014	0.1181	0.1181
Brugia malayi	Cathepsin L-like precursor	0.0027	0.4283	0.4283
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.2356	0.379
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.4283	0.3518
Trypanosoma cruzi	cruzipain precursor, putative	0.0027	0.4283	0.4283
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.2356	0.1333
Entamoeba histolytica	cysteine proteinase, putative	0.0027	0.4283	1
Leishmania major	cathepsin L-like protease	0.0027	0.4283	0.2521
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0027	0.4283	1
Echinococcus multilocularis	cysteine protease	0.0027	0.4283	0.3518
Onchocerca volvulus		0.0027	0.4283	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.4283	0.3518
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.8761	0.8761
Trypanosoma cruzi	cysteine peptidase, putative	0.0027	0.4283	0.4283
Brugia malayi	Cathepsin L-like precursor	0.0018	0.2168	0.2168
Loa Loa (eye worm)	hypothetical protein	0.0027	0.4283	0.4283
Loa Loa (eye worm)	ctsf protein	0.0027	0.4283	0.4283
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.2356	0.5502
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.4283	0.3518
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.8761	0.8761
Entamoeba histolytica	cysteine proteinase, putative	0.0027	0.4283	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0027	0.4283	1
Echinococcus granulosus	cathepsin l1	0.0027	0.4283	0.3518
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0019	0.2356	0.379
Schistosoma mansoni	ap endonuclease	0.0019	0.2356	0.2356
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0051	1	1
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0019	0.2356	0.2356
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.4283	0.3518
Brugia malayi	Papain family cysteine protease containing protein	0.0027	0.4283	0.4283
Brugia malayi	Cathepsin L-like precursor	0.0018	0.2168	0.2168
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.4283	0.3518
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.4283	0.3518
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.2356	0.2356
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.8761	0.8761
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.4283	0.3518
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.4283	0.3518
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0051	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0014	0.1181	0.1181
Entamoeba histolytica	cysteine proteinase, putative	0.0018	0.2168	0.3182
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0051	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0014	0.1181	0.1181
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.4283	0.3518
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.4283	0.3518
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0014	0.1181	0.1181
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.4283	0.3518
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.4283	0.3518
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.4283	0.3518
Echinococcus granulosus	cathepsin l1	0.0018	0.2168	0.1119
Onchocerca volvulus		0.0027	0.4283	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0027	0.4283	0.3518
Trypanosoma cruzi	cysteine protease, putative	0.0014	0.1181	0.1181
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0027	0.4283	1
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0019	0.2356	0.5
Trichomonas vaginalis	CMGC family protein kinase	0.0051	1	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0018	0.2168	0.2168
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.4283	0.3518

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 44 nM	Inhibition of cathepsin S using FR-aminoluciferin as substrate preincubated for 15 mins before substrate addition measured after 1 hr by luminescence assay	ChEMBL.	23084902

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2207173

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1686987