TDR Targets

Basic information

Technical information

TDR Targets ID: 168720
Name: 5-(propylaminomethyl)thieno[2,3-b]furan-2-sul fonamide
MW: 274.36 | Formula: C10H14N2O3S2
H donors: 2 H acceptors: 2 LogP: 1.54 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CCCNCc1cc2c(s1)oc(c2)S(=O)(=O)N
InChi: 1S/C10H14N2O3S2/c1-2-3-12-6-8-4-7-5-9(17(11,13)14)15-10(7)16-8/h4-5,12H,2-3,6H2,1H3,(H2,11,13,14)
InChiKey: XEAIBUNVRIOXEM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

5-(propylaminomethyl)-2-thieno[2,3-b]furansulfonamide
5-(propylaminomethyl)thieno[3,2-d]furan-2-sulfonamide
5-(propylaminomethyl)-2-thieno[3,2-d]furansulfonamide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	carbonic anhydrase II	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania mexicana	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Echinococcus granulosus	carbonic anhydrase II	Get druggable targets OG5_127628	All targets in OG5_127628
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	Get druggable targets OG5_127628	All targets in OG5_127628
Trypanosoma congolense	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	Get druggable targets OG5_127628	All targets in OG5_127628
Trypanosoma brucei gambiense	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Trypanosoma brucei	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	Get druggable targets OG5_127628	All targets in OG5_127628
Leishmania major	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Leishmania donovani	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Loa Loa (eye worm)	carbonic anhydrase 3	Get druggable targets OG5_127628	All targets in OG5_127628
Echinococcus multilocularis	carbonic anhydrase II	Get druggable targets OG5_127628	All targets in OG5_127628
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	Get druggable targets OG5_127628	All targets in OG5_127628
Brugia malayi	Putative carbonic anhydrase 5 precursor	Get druggable targets OG5_127628	All targets in OG5_127628
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	Get druggable targets OG5_127628	All targets in OG5_127628
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	Get druggable targets OG5_127628	All targets in OG5_127628
Leishmania infantum	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Trypanosoma congolense	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Leishmania braziliensis	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Schistosoma japonicum	ko:K01672 carbonic anhydrase [EC4.2.1.1], putative	Get druggable targets OG5_127628	All targets in OG5_127628

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Carbonic anhydrase like protein 2 precursor	carbonic anhydrase II	260 aa	259 aa	32.0 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	carboxylesterase, LipT	0.0471	0.1583	1
Schistosoma mansoni	pyruvate carboxylase	0.0195	0.0581	0.0581
Echinococcus multilocularis	serotonin receptor	0.0038	0.0009	0.0009
Schistosoma mansoni	methylcrotonyl-CoA carboxylase	0.0195	0.0581	0.0581
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0089	0.0196	0.0196
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0038	0.0009	0.0009
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0089	0.0196	0.0196
Brugia malayi	MH2 domain containing protein	0.0117	0.0296	0.0296
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0009	0.0009
Brugia malayi	Serotonin receptor	0.0038	0.0009	0.0009
Loa Loa (eye worm)	carboxyl transferase domain-containing protein	0.0494	0.1668	0.1668
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0147	0.0407	0.1592
Onchocerca volvulus		0.0038	0.0009	0.0055
Onchocerca volvulus		0.0038	0.0009	0.0055
Brugia malayi	AKH receptor	0.0038	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0471	0.1583	0.1583
Loa Loa (eye worm)	hypothetical protein	0.0471	0.1583	0.1583
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0089	0.0196	0.0196
Echinococcus granulosus	neuropeptide FF receptor 2	0.0038	0.0009	0.0009
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0009	0.0009
Mycobacterium leprae	Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP)	0.0195	0.0581	1
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0038	0.0009	0.0009
Trypanosoma cruzi	3-methylcrotonyl-CoA carboxylase, putative	0.0195	0.0581	0.2272
Brugia malayi	Dopamine receptor protein 2	0.0038	0.0009	0.0009
Schistosoma mansoni	hypothetical protein	0.0038	0.0009	0.0009
Loa Loa (eye worm)	acetylcholinesterase 1	0.2786	1	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0089	0.0196	0.0196
Leishmania major	carbamoyl-phosphate synthase, putative	0.0044	0.0032	0.0126
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0471	0.1583	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0009	0.0009
Trypanosoma cruzi	glutamine-dependent carbamoyl-phosphate synthetase, putative	0.0044	0.0032	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0009	0.0009
Brugia malayi	ORL1-like opioid receptor	0.0038	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0009	0.0009
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.005	0.005
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0009	0.0009
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0038	0.0009	0.0009
Brugia malayi	hypothetical protein	0.0038	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0009	0.0009
Echinococcus granulosus	neuropeptide receptor	0.0038	0.0009	0.0009
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.0739	0.2557	1
Echinococcus granulosus	neuropeptide s receptor	0.0038	0.0009	0.0009
Trichomonas vaginalis	spcc417.12 protein, putative	0.0471	0.1583	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0009	0.0009
Echinococcus multilocularis	acetylcholinesterase	0.2786	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0009	0.0009
Plasmodium vivax	biotin carboxylase subunit of acetyl CoA carboxylase, putative	0.0371	0.1219	1
Mycobacterium leprae	Probable propionyl-CoA carboxylase beta chain 5 AccD5 (PCCASE) (PROPANOYL-COA:CARBON DIOXIDE LIGASE)	0.0069	0.0124	0.2139
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0009	0.0009
Mycobacterium ulcerans	propionyl-CoA carboxylase beta chain 5 AccD5	0.0069	0.0124	0.0785
Echinococcus multilocularis	orexin receptor type 2	0.0038	0.0009	0.0009
Toxoplasma gondii	acetyl-coA carboxylase ACC2	0.0512	0.1733	1
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0038	0.0009	0.0009
Leishmania major	acetyl-CoA carboxylase, putative	0.0512	0.1733	0.6779
Echinococcus multilocularis	acetylcholinesterase	0.2786	1	1
Trypanosoma cruzi	acetyl-CoA carboxylase, putative	0.0069	0.0124	0.0486
Loa Loa (eye worm)	neuropeptide F receptor	0.0038	0.0009	0.0009
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0225	0.0689	0.4354
Mycobacterium leprae	ACETYL/PROPIONYL-CoA CARBOXYLASE (BETA SUBUNIT) ACCD6	0.0069	0.0124	0.2139
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.005	0.005
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0038	0.0009	0.0009
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0038	0.0009	0.0009
Schistosoma mansoni	hypothetical protein	0.0166	0.0474	0.0474
Mycobacterium ulcerans	acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2	0.0195	0.0581	0.3669
Leishmania major	carbonic anhydrase-like protein	0.0147	0.0407	0.1592
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0038	0.0009	0.0009
Brugia malayi	hypothetical protein	0.0038	0.0009	0.0009
Echinococcus granulosus	g protein coupled receptor	0.0038	0.0009	0.0009
Onchocerca volvulus		0.0038	0.0009	0.0055
Loa Loa (eye worm)	TYRA-2 protein	0.0038	0.0009	0.0009
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0009	0.0009
Schistosoma mansoni	growth hormone secretagogue receptor	0.0038	0.0009	0.0009
Entamoeba histolytica	acetyl-coA carboxylase, putative	0.0087	0.0189	1
Loa Loa (eye worm)	carboxylesterase	0.0471	0.1583	0.1583
Schistosoma mansoni	hypothetical protein	0.0035	0.0001	0.0001
Loa Loa (eye worm)	transcription factor SMAD2	0.0117	0.0296	0.0296
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0147	0.0407	0.0407
Echinococcus multilocularis	microtubule associated protein 2	0.0679	0.234	0.234
Brugia malayi	G-protein coupled receptor	0.0038	0.0009	0.0009
Brugia malayi	hypothetical protein	0.0038	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0009	0.0009
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0038	0.0009	0.0009
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0038	0.0009	0.0009
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0009	0.0009
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0038	0.0009	0.0009
Onchocerca volvulus		0.0038	0.0009	0.0055
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0038	0.0009	0.0009
Echinococcus multilocularis	neuropeptides capa receptor	0.0038	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.2786	1	1
Onchocerca volvulus	Huntingtin homolog	0.0121	0.031	0.1959
Onchocerca volvulus		0.0038	0.0009	0.0055
Echinococcus granulosus	7tm_1 domain containing protein	0.0038	0.0009	0.0009
Echinococcus granulosus	microtubule associated protein 2	0.0679	0.234	0.234
Giardia lamblia	Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative	0.0087	0.0189	0.5
Schistosoma mansoni	hypothetical protein	0.0038	0.0009	0.0009
Trypanosoma brucei	carbonic anhydrase-like protein	0.0147	0.0407	0.1592
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0009	0.0009
Brugia malayi	follicle stimulating hormone receptor	0.0038	0.0009	0.0009
Schistosoma mansoni	opsin-like receptor	0.0038	0.0009	0.0009
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0038	0.0009	0.0055
Mycobacterium tuberculosis	Acetyl/propionyl-CoA carboxylase (beta subunit) AccD6	0.0069	0.0124	0.0785
Loa Loa (eye worm)	hypothetical protein	0.0121	0.031	0.031
Loa Loa (eye worm)	hypothetical protein	0.0471	0.1583	0.1583
Schistosoma mansoni	carbamoyl-phosphate synthetase	0.0044	0.0032	0.0032
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0038	0.0009	0.0009
Echinococcus multilocularis	serotonin receptor	0.0038	0.0009	0.0009
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0009	0.0009
Echinococcus multilocularis	somatostatin receptor	0.0038	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0009	0.0009
Schistosoma mansoni	acetyl-CoA carboxylase	0.0512	0.1733	0.1733
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0169	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0009	0.0009
Plasmodium falciparum	biotin carboxylase subunit of acetyl CoA carboxylase, putative	0.0371	0.1219	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0009	0.0009
Echinococcus multilocularis	para nitrobenzyl esterase	0.0471	0.1583	0.1583
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0009	0.0009
Echinococcus multilocularis	neuropeptides capa receptor	0.0038	0.0009	0.0009
Brugia malayi	Putative carbonic anhydrase 5 precursor	0.0147	0.0407	0.0407
Plasmodium vivax	carbamoyl phosphate synthetase, putative	0.0044	0.0032	0.0265
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0038	0.0009	0.0009
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0038	0.0009	0.0009
Echinococcus multilocularis	sex peptide receptor	0.0038	0.0009	0.0009
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0471	0.1583	0.1583
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0009	0.0009
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0038	0.0009	0.0009
Schistosoma mansoni	amine GPCR	0.0038	0.0009	0.0009
Echinococcus granulosus	BC026374 protein S09 family	0.0471	0.1583	0.1583
Onchocerca volvulus	Huntingtin homolog	0.0121	0.031	0.1959
Trypanosoma cruzi	glutamine dependent carbamoyl-phosphate synthase, putative	0.0044	0.0032	0.0126
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0009	0.0009
Echinococcus multilocularis	acetyl coenzyme A carboxylase 1	0.0512	0.1733	0.1733
Echinococcus multilocularis	g protein coupled receptor	0.0038	0.0009	0.0009
Schistosoma mansoni	neuropeptide receptor	0.0038	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0009	0.0009
Echinococcus granulosus	tm gpcr rhodopsin	0.0038	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0009	0.0009
Onchocerca volvulus		0.0471	0.1583	1
Trypanosoma cruzi	acetyl-CoA carboxylase	0.0317	0.1024	0.4006
Echinococcus multilocularis	carboxylesterase 5A	0.2786	1	1
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0038	0.0009	0.0009
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0009	0.0009
Onchocerca volvulus		0.0038	0.0009	0.0055
Mycobacterium ulcerans	pyruvate carboxylase	0.0195	0.0581	0.3669
Leishmania major	propionyl-coa carboxylase beta chain, putative	0.0069	0.0124	0.0486
Echinococcus granulosus	neuropeptides capa receptor	0.0038	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0009	0.0009
Schistosoma mansoni	opsin-like receptor	0.0038	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0049	0.005	0.005
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0038	0.0009	0.0009
Brugia malayi	Carboxylesterase family protein	0.0471	0.1583	0.1583
Trypanosoma cruzi	3-methylcrotonoyl-CoA carboxylase beta subunit, putative	0.0069	0.0124	0.0486
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0471	0.1583	0.1583
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0038	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0009	0.0009
Schistosoma mansoni	microtubule-associated protein tau	0.0679	0.234	0.234
Brugia malayi	Carboxylesterase family protein	0.2786	1	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0009	0.0009
Mycobacterium ulcerans	carbamoyl phosphate synthase large subunit	0.0044	0.0032	0.0204
Echinococcus granulosus	dro:myosuppressin receptor	0.0038	0.0009	0.0009
Mycobacterium ulcerans	bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3	0.0195	0.0581	0.3669
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0038	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0009	0.0009
Onchocerca volvulus		0.0038	0.0009	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0009	0.0009
Trypanosoma cruzi	3-methylcrotonoyl-CoA carboxylase beta subunit, putative	0.0069	0.0124	0.0486
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.0082	0.0169	0.0169
Brugia malayi	ERG2 and Sigma1 receptor like protein	0.0739	0.2557	0.2557
Echinococcus multilocularis	geminin	0.0166	0.0474	0.0474
Brugia malayi	hypothetical protein	0.0038	0.0009	0.0009
Echinococcus multilocularis	dro:myosuppressin receptor	0.0038	0.0009	0.0009
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0038	0.0009	0.0009
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0009	0.0009
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.005	0.005
Trypanosoma brucei	glutamine hydrolysing (not ammonia-dependent) carbomoyl phosphate synthase, putative	0.0044	0.0032	0.0126
Schistosoma mansoni	hypothetical protein	0.0038	0.0009	0.0009
Onchocerca volvulus		0.0471	0.1583	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0038	0.0009	0.0009
Mycobacterium tuberculosis	Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie	0.0195	0.0581	0.3669
Brugia malayi	G protein-coupled receptor F59B2.13	0.0038	0.0009	0.0009
Mycobacterium tuberculosis	Probable propionyl-CoA carboxylase beta chain 5 AccD5 (pccase) (propanoyl-CoA:carbon dioxide ligase)	0.0069	0.0124	0.0785
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0009	0.0009
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0147	0.0407	0.0407
Echinococcus multilocularis	propionyl coenzyme A carboxylase alpha chain	0.0195	0.0581	0.0581
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0038	0.0009	0.0009
Trypanosoma brucei	3-methylcrotonoyl-CoA carboxylase beta subunit, putative	0.0069	0.0124	0.0486
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0009	0.0009
Brugia malayi	GnHR receptor homolog	0.0038	0.0009	0.0009
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0009	0.0009
Brugia malayi	hypothetical protein	0.0038	0.0009	0.0009
Schistosoma mansoni	BC026374 protein (S09 family)	0.0471	0.1583	0.1583
Echinococcus granulosus	propionyl coenzyme A carboxylase beta chain	0.0069	0.0124	0.0124
Onchocerca volvulus		0.0038	0.0009	0.0055
Brugia malayi	hypothetical protein	0.0471	0.1583	0.1583
Echinococcus granulosus	biogenic amine 5HT receptor	0.0038	0.0009	0.0009
Echinococcus multilocularis	neuropeptide receptor A26	0.0038	0.0009	0.0009
Leishmania major	methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein	0.0195	0.0581	0.2272
Schistosoma mansoni	adenoreceptor	0.0038	0.0009	0.0009
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0038	0.0009	0.0009
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0009	0.0009
Onchocerca volvulus		0.0038	0.0009	0.0055
Echinococcus granulosus	g protein coupled receptor	0.0038	0.0009	0.0009
Leishmania major	carboxylase, putative	0.0195	0.0581	0.2272
Brugia malayi	larval opioid receptor	0.0038	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0009	0.0009
Echinococcus granulosus	carboxylesterase 5A	0.2786	1	1
Brugia malayi	G-protein coupled receptor	0.0038	0.0009	0.0009
Mycobacterium tuberculosis	Probable pyruvate carboxylase Pca (pyruvic carboxylase)	0.0195	0.0581	0.3669
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0471	0.1583	0.1583
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0471	0.1583	0.1583
Chlamydia trachomatis	biotin carboxylase	0.0177	0.0516	1
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0038	0.0009	0.0009
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0038	0.0009	0.0009
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0089	0.0196	0.0196
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0009	0.0009
Brugia malayi	Carboxyl transferase domain containing protein	0.0494	0.1668	0.1668
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0009	0.0009
Schistosoma mansoni	neuropeptide f receptor 76f	0.0038	0.0009	0.0009
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0471	0.1583	1
Echinococcus granulosus	sex peptide receptor	0.0038	0.0009	0.0009
Echinococcus granulosus	allatostatin A receptor	0.0038	0.0009	0.0009
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0038	0.0009	0.0009
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0471	0.1583	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0038	0.0009	0.0009
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0089	0.0196	0.0196
Mycobacterium ulcerans	propionyl-CoA carboxylase beta chain 4 AccD4	0.0069	0.0124	0.0785
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0009	0.0009
Trypanosoma brucei	C-8 sterol isomerase, putative	0.0739	0.2557	1
Echinococcus granulosus	acetylcholinesterase	0.2786	1	1
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0471	0.1583	0.1583
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0009	0.0009
Mycobacterium ulcerans	acetyl/propionyl CoA carboxylase subunit beta	0.0069	0.0124	0.0785
Echinococcus granulosus	acetylcholinesterase	0.2786	1	1
Brugia malayi	sulfakinin receptor protein	0.0038	0.0009	0.0009
Brugia malayi	hypothetical protein	0.0035	0.0001	0.0001
Brugia malayi	hypothetical protein	0.0038	0.0009	0.0009
Schistosoma mansoni	opsin-like receptor	0.0038	0.0009	0.0009
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0038	0.0009	0.0009
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0147	0.0407	0.0407
Brugia malayi	Carboxylesterase family protein	0.0471	0.1583	0.1583
Echinococcus granulosus	serotonin receptor	0.0038	0.0009	0.0009
Echinococcus granulosus	G protein coupled receptor 139	0.0038	0.0009	0.0009
Brugia malayi	Carboxylesterase family protein	0.0471	0.1583	0.1583
Mycobacterium ulcerans	acetyl-/propionyl-CoA carboxylase subunit beta	0.0069	0.0124	0.0785
Onchocerca volvulus		0.0038	0.0009	0.0055
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0038	0.0009	0.0009
Schistosoma mansoni	acetylcholinesterase	0.0471	0.1583	0.1583
Brugia malayi	Dopamine receptor protein 1	0.0038	0.0009	0.0009
Leishmania major	C-8 sterol isomerase-like protein	0.0739	0.2557	1
Schistosoma mansoni	carbamoyl-phosphate synthetase	0.0044	0.0032	0.0032
Echinococcus multilocularis	neuropeptide s receptor	0.0038	0.0009	0.0009
Echinococcus multilocularis	G protein coupled receptor 139	0.0038	0.0009	0.0009
Echinococcus granulosus	g-protein coupled receptor	0.0038	0.0009	0.0009
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0038	0.0009	0.0009
Toxoplasma gondii	acyl-CoA carboxyltransferase beta chain, putative	0.0069	0.0124	0.0717
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0009	0.0009
Onchocerca volvulus		0.0471	0.1583	1
Schistosoma mansoni	hypothetical protein	0.0038	0.0009	0.0009
Trypanosoma brucei	3-methylcrotonyl-CoA carboxylase alpha subunit, putative	0.0195	0.0581	0.2272
Onchocerca volvulus		0.0038	0.0009	0.0055
Echinococcus granulosus	somatostatin receptor	0.0038	0.0009	0.0009
Echinococcus granulosus	acetyl coenzyme A carboxylase 1	0.0512	0.1733	0.1733
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0038	0.0009	0.0009
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0038	0.0009	0.0009
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0038	0.0009	0.0009
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0038	0.0009	0.0055
Loa Loa (eye worm)	carbonic anhydrase 3	0.0147	0.0407	0.0407
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0009	0.0009
Schistosoma mansoni	biogenic amine receptor	0.0038	0.0009	0.0009
Brugia malayi	RE15519p	0.0038	0.0009	0.0009
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0471	0.1583	0.1583
Schistosoma mansoni	biogenic amine receptor	0.0038	0.0009	0.0009
Echinococcus multilocularis	neuropeptide receptor	0.0038	0.0009	0.0009
Echinococcus multilocularis	fmrfamide receptor	0.0038	0.0009	0.0009
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0038	0.0009	0.0009
Schistosoma mansoni	aspartate carbamoyltransferase	0.0044	0.0032	0.0032
Brugia malayi	Melatonin receptor type 1A	0.0038	0.0009	0.0009
Echinococcus multilocularis	g protein coupled receptor	0.0038	0.0009	0.0009
Echinococcus multilocularis	propionyl coenzyme A carboxylase beta chain	0.0069	0.0124	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0009	0.0009
Schistosoma mansoni	gliotactin	0.0471	0.1583	0.1583
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0038	0.0009	0.0009
Brugia malayi	hypothetical protein	0.0038	0.0009	0.0009
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0038	0.0009	0.0009
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0089	0.0196	0.0196
Loa Loa (eye worm)	hypothetical protein	0.0471	0.1583	0.1583
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0009	0.0009
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0038	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0121	0.031	0.031
Echinococcus granulosus	para nitrobenzyl esterase	0.0471	0.1583	0.1583
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0009	0.0009
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0147	0.0407	0.1592
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0038	0.0009	0.0009
Echinococcus granulosus	tm gpcr rhodopsin	0.0038	0.0009	0.0009
Schistosoma mansoni	neuropeptide receptor	0.0038	0.0009	0.0009
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0038	0.0009	0.0009
Schistosoma mansoni	amine GPCR	0.0038	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0378	0.1244	0.1244
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0038	0.0009	0.0009
Echinococcus granulosus	propionyl coenzyme A carboxylase alpha chain	0.0195	0.0581	0.0581
Schistosoma mansoni	neuropeptide F-like receptor	0.0038	0.0009	0.0009
Schistosoma mansoni	histamine h1 receptor	0.0038	0.0009	0.0009
Echinococcus granulosus	geminin	0.0166	0.0474	0.0474
Onchocerca volvulus		0.0038	0.0009	0.0055
Echinococcus multilocularis	L aminoadipate semialdehyde	0.0082	0.0169	0.0169
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0001	0.0001
Onchocerca volvulus		0.0038	0.0009	0.0055
Onchocerca volvulus		0.0082	0.0169	0.107
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0009	0.0009
Onchocerca volvulus		0.0471	0.1583	1
Brugia malayi	neuropeptide F receptor	0.0038	0.0009	0.0009
Schistosoma mansoni	neuropeptide F-like receptor	0.0038	0.0009	0.0009
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0038	0.0009	0.0009
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0038	0.0009	0.0009
Echinococcus granulosus	g protein coupled receptor	0.0038	0.0009	0.0009
Brugia malayi	hypothetical protein	0.0121	0.031	0.031
Schistosoma mansoni	propionyl-CoA carboxylase beta chain mitochondrial precursor	0.0069	0.0124	0.0124
Brugia malayi	putative neuropeptide receptor	0.0038	0.0009	0.0009
Echinococcus granulosus	neuropeptide receptor	0.0038	0.0009	0.0009
Echinococcus granulosus	biogenic amine 5HT receptor	0.0038	0.0009	0.0009
Wolbachia endosymbiont of Brugia malayi	Acetyl-CoA carboxylase, carboxyltransferase component	0.0069	0.0124	0.1676
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0038	0.0009	0.0009
Echinococcus multilocularis	neuropeptide Y receptor	0.0038	0.0009	0.0009
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0038	0.0009	0.0009
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0038	0.0009	0.0009
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0038	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0009	0.0009
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0038	0.0009	0.0009
Loa Loa (eye worm)	G-protein coupled receptor	0.0038	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0009	0.0009
Toxoplasma gondii	acetyl-CoA carboxylase ACC1	0.0512	0.1733	1
Schistosoma mansoni	neuropeptide receptor	0.0038	0.0009	0.0009
Echinococcus multilocularis	g-protein coupled receptor	0.0038	0.0009	0.0009
Echinococcus multilocularis	neuroligin	0.0471	0.1583	0.1583
Schistosoma mansoni	myosin xvIII	0.0038	0.0009	0.0009
Loa Loa (eye worm)	carboxylesterase	0.0471	0.1583	0.1583
Brugia malayi	Serotonin receptor	0.0038	0.0009	0.0009
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0038	0.0009	0.0009
Echinococcus granulosus	orexin receptor type 2	0.0038	0.0009	0.0009
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0147	0.0407	0.0407
Trypanosoma brucei	acetyl-CoA carboxylase	0.0512	0.1733	0.6779
Schistosoma mansoni	amine GPCR	0.0038	0.0009	0.0009
Loa Loa (eye worm)	MH2 domain-containing protein	0.0117	0.0296	0.0296
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0798	0.2772	0.2772
Loa Loa (eye worm)	G-protein coupled receptor	0.0038	0.0009	0.0009
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.0082	0.0169	0.0169
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0009	0.0009
Echinococcus multilocularis	neuropeptide receptor	0.0038	0.0009	0.0009
Onchocerca volvulus		0.0471	0.1583	1
Loa Loa (eye worm)	carboxylesterase	0.2786	1	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0009	0.0009
Wolbachia endosymbiont of Brugia malayi	Acetyl/propionyl-CoA carboxylase, alpha subunit	0.0195	0.0581	1
Brugia malayi	neuropeptide F receptor	0.0038	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0009	0.0009
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0009	0.0009
Echinococcus granulosus	hypothetical protein	0.0038	0.0009	0.0009
Brugia malayi	hypothetical protein	0.0038	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0739	0.2557	0.2557
Onchocerca volvulus		0.0038	0.0009	0.0055
Schistosoma mansoni	biogenic amine receptor	0.0038	0.0009	0.0009
Trypanosoma brucei	3-methylcrotonyl-CoA carboxylase alpha subunit, putative	0.0195	0.0581	0.2272
Echinococcus granulosus	neuropeptides capa receptor	0.0038	0.0009	0.0009
Echinococcus multilocularis	fmrfamide receptor	0.0038	0.0009	0.0009
Mycobacterium ulcerans	acetyl-coenzyme a carboxylase carboxyl transferase (subunit beta) AccD3	0.0069	0.0124	0.0785
Brugia malayi	hypothetical protein	0.0038	0.0009	0.0009
Brugia malayi	G protein-coupled receptor	0.0038	0.0009	0.0009
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0471	0.1583	0.1583
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0038	0.0009	0.0009
Brugia malayi	Carboxylesterase family protein	0.0471	0.1583	0.1583
Onchocerca volvulus		0.0038	0.0009	0.0055
Echinococcus granulosus	neuropeptide receptor A26	0.0038	0.0009	0.0009
Trypanosoma brucei	unspecified product	0.0128	0.0338	0.1322
Trypanosoma cruzi	3-methylcrotonyl-CoA carboxylase, putative	0.0195	0.0581	0.2272
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0009	0.0009
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0009	0.0009
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0038	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0009	0.0009
Echinococcus multilocularis	carbonic anhydrase II	0.0147	0.0407	0.0407
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0009	0.0009
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0089	0.0196	0.0196
Schistosoma mansoni	neuropeptide receptor	0.0038	0.0009	0.0009
Echinococcus granulosus	carbonic anhydrase II	0.0147	0.0407	0.0407
Onchocerca volvulus		0.0038	0.0009	0.0055
Echinococcus granulosus	L aminoadipate semialdehyde	0.0082	0.0169	0.0169
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0471	0.1583	1
Toxoplasma gondii	carbamoylphosphate synthetase	0.0044	0.0032	0.0186
Echinococcus granulosus	neuropeptide Y receptor	0.0038	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0471	0.1583	0.1583
Echinococcus granulosus	tm gpcr rhodopsin	0.0038	0.0009	0.0009
Schistosoma mansoni	methylcrotonyl-CoA carboxylase	0.0195	0.0581	0.0581
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0089	0.0196	0.0196
Brugia malayi	hypothetical protein	0.0038	0.0009	0.0009
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0038	0.0009	0.0009
Echinococcus granulosus	neuropeptide Y receptor	0.0038	0.0009	0.0009
Echinococcus multilocularis	allatostatin A receptor	0.0038	0.0009	0.0009
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.2786	1	1
Echinococcus granulosus	neuroligin	0.0471	0.1583	0.1583
Echinococcus multilocularis	neuropeptide Y receptor	0.0038	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0471	0.1583	0.1583
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0471	0.1583	0.1583
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0009	0.0009
Loa Loa (eye worm)	melatonin receptor type 1A	0.0038	0.0009	0.0009
Schistosoma mansoni	hypothetical protein	0.0166	0.0474	0.0474
Toxoplasma gondii	pyruvate carboxylase	0.0195	0.0581	0.3352
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0009	0.0009
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0038	0.0009	0.0009
Onchocerca volvulus		0.0038	0.0009	0.0055
Brugia malayi	putative neuropeptide receptor NPR1	0.0038	0.0009	0.0009
Echinococcus granulosus	fmrfamide receptor	0.0038	0.0009	0.0009
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0038	0.0009	0.0009
Brugia malayi	Dopamine receptor	0.0038	0.0009	0.0009
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0001	0.0001
Mycobacterium leprae	Probable propyonyl-CoA carboxylase beta chain 4 AccD4 (Pccase)	0.0069	0.0124	0.2139
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0009	0.0009
Echinococcus multilocularis	g protein coupled receptor	0.0038	0.0009	0.0009
Mycobacterium ulcerans	propionyl-CoA carboxylase beta chain 4 AccD4_2	0.0069	0.0124	0.0785
Leishmania major	3-methylcrotonoyl-CoA carboxylase beta subunit, putative	0.0069	0.0124	0.0486
Schistosoma mansoni	amine GPCR	0.0038	0.0009	0.0009
Mycobacterium ulcerans	acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1	0.0195	0.0581	0.3669
Loa Loa (eye worm)	hypothetical protein	0.2786	1	1
Schistosoma mansoni	amine GPCR	0.0038	0.0009	0.0009
Echinococcus granulosus	7TM GPCR rhodopsin	0.0038	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0009	0.0009

Activities

Activity type	Activity value	Assay description	Source	Reference
I50 (binding)	= 0.000000008 M	Inhibition of human erythrocyte carbonic anhydrase II	ChEMBL.	1501230
IC50 (binding)	= 0.000000008 M	Inhibition of human erythrocyte carbonic anhydrase II	ChEMBL.	1501230
Inhibition (functional)	= 63 %	Inhibition of albino rabbit iris and ciliary body carbonic anhydrase II after topical administration ex vivo	ChEMBL.	1501230
Inhibition (functional)	= 63 %	Inhibition of albino rabbit iris and ciliary body carbonic anhydrase II after topical administration ex vivo	ChEMBL.	1501230
Inhibition (functional)	= 89 %	Inhibition of albino rabbit iris and ciliary body carbonic anhydrase II after topical administration ex vivo	ChEMBL.	1501230
Inhibition (functional)	= 89 %	Inhibition of albino rabbit iris and ciliary body carbonic anhydrase II after topical administration ex vivo	ChEMBL.	1501230
PC	= 1.06	Partition coefficient(PC) was determined by equilibrating compound between 1-octanol and 0.1 ionic strength pH 7.4 buffer	ChEMBL.	1501230
Pigment binding (functional)	= 68 %	Percentage binding of the compound to bovine iris and ciliary body	ChEMBL.	1501230
pKa	= 7.85	pKa of the compound was determined in water	ChEMBL.	1501230
pKa	= 9.4	pKa of the compound was determined in 30% ethanol	ChEMBL.	1501230
Solubility	> 22.5 mg ml-1	Solubility of the compound was evaluated in water at 25 degree centigrade	ChEMBL.	1501230

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL322014
PubChem: 14327021

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 168720